A study by researchers found that only 46% of neonatal labeling changes made clear the drug was approved for safety and effectiveness in infants. Few drugs were used in neonatal intensive care units (NICUs) with most studied drugs not tested in over 60 neonates.
The REiNS Collaboration has established a framework for standardized outcome measures in neurofibromatosis clinical trials. The new guidelines address patient-reported outcomes, functional outcomes affecting vision, hearing and facial function, imaging tumor response, and disease biomarkers.
A study by Nationwide Children's Hospital found nearly all high chair-related injuries involve a fall, with 93% of cases reporting a child climbing or standing in the chair. The annual number of injured children increased by almost 90%, with closed head injuries and facial injuries being most common.
Researchers at the University of Oregon have captured fundamental new insights about the stability of gold nanoparticles, which could enhance or destabilize their properties depending on use. Smaller nanoparticles exhibit better structural integrity than larger ones, making them suitable for applications where stability is crucial.
Researchers at Cedars-Sinai have discovered a 10-gene biomarker panel that can identify the aggressiveness of ovarian cancer, predict survival outcomes, and inform novel therapeutic strategies. The study suggests that this biomarker panel may have predictive value and biological relevance for treating patients with ovarian cancer.
Researchers found that chloroquine treatment increased TRAF3 levels in osteoclast precursor cells, limiting osteoclast generation and bone resorption. The study suggests that therapies targeting TRAF3 may help prevent bone loss in individuals with osteoporosis.
Researchers at the Laboratory for Attosecond Physics have developed a system to precisely measure the duration of energetic electron pulses using laser fields. This allows for the investigation of ultrafast processes in atoms and molecules, providing insights into nature's smallest scales.
Researchers at Rutgers University have developed a targeted drug delivery system that successfully treats advanced-stage ovarian cancer in mice. The treatment involves using small inhibiting RNA molecules to decrease excess CD44 protein in cancer cells while treating with anti-cancer drug paclitaxel.
A recent study published in PLoS ONE analyzes how financial connections affect economic crises and suggests modifying links between entities to increase robustness. The research highlights the importance of addressing relationships between banks, rather than just focusing on individual entity capital requirements.
Researchers at IBN and IBM have developed a novel biocompatible material from recycled PET that effectively kills drug-resistant fungi and their biofilms. The material targets fungal cells without harming surrounding healthy cells, displaying great potential as an antifungal agent.
New data from the NLST suggests that low-dose CT screening for lung cancer may overdiagnose up to 22% of non-small cell lung cancers. However, the rate is significantly lower than projected for other cancer screenings, supporting the implementation of lung cancer screening programs.
The study reveals how lymphotoxins control the production of immunoglobulin A (IgA) in the gut, maintaining immunological balance. Lacking lymphotoxins can lead to reduced or halted IgA production and changes in intestinal flora.
Cardiovascular complications and hypoglycemia are common nonfatal complications in older adults with diabetes. The study found that patients with diabetes for a longer duration had higher rates of all outcomes, including mortality.
Researchers launched two small satellites, FIREBIRD, into the outer radiation belt to investigate microbursts, which can pose a risk to spacecraft. The mission aims to improve our understanding of the radiation belts and design more resilient satellites.
The lab, a joint initiative between EcoHealth Alliance and Sabah Wildlife Department, will analyze wildlife health and genetic research, as well as assist in combating the spread of diseases. The facility is part of the USAID-PREDICT Project, aiming to strengthen public health work and protect the region's economic health.
Scientists have successfully restored behavior in rats using a neural prosthesis after brain injury. The device, a closed-loop microelectronic system, recorded signals from one part of the brain and stimulated another to facilitate repair. Two weeks after implantation, rat models recovered nearly all function lost due to injury.
Researchers from NASA's Curiosity rover mission found evidence of a calm and fresh-watered lake on Mars that may have supported simple microbial life. The team believes the lake may have lasted for tens or hundreds of thousands of years, providing perfect conditions for chemolithoautotrophs to thrive.
The new journal Mental Health & Prevention aims to provide a platform for researchers and practitioners to present their work and keep up-to-date with the latest advances in mental health promotion. The journal will publish high-quality reviews, original research, and other papers related to prevention strategies.
Tropical Cyclone Madi is expected to make landfall in southern India on December 12. The storm's heaviest rainfall was observed north of its center, with rates reaching up to 2 inches per hour.
Researchers from Monterey Bay Aquarium Research Institute used underwater robots to survey a marked dump site off the coast of Southern California. The survey revealed numerous 55-gallon drums and other marine debris, but no chemical munitions were detected.
Research analyzed top-grossing children's movies from 2006-2010, finding 70% included weight-related stigmatizing content. The study also reveals that 26% of movie segments showed exaggerated portion sizes and 51% depicted unhealthy snacks.
Narrow-spectrum antibiotics, such as ampicillin and penicillin, are equally effective as broad-spectrum antibiotics in treating less severe childhood pneumonia. The study, published in Pediatrics, compared outcomes among children hospitalized with pneumonia between 2005 and 2011, receiving either narrow-spectrum or broad-spectrum antib...
A new study suggests that accelerated resolution therapy (ART) is a safe and effective treatment for combat-related psychological trauma and post-traumatic stress disorder (PTSD) among veterans. The therapy, which combines evidence-based psychotherapies with eye movements, was found to be shorter and more likely to be completed than co...
The Radiation Assessment Detector measured radiation on Mars' surface, revealing an average GCR dose equivalent rate of 0.67 millisieverts per day. The findings also show that most mission radiation exposure will occur during outbound and return travel, posing a challenge for future human exploration.
A new clinical trial, sponsored by Cancer Research And Biostatistics (CRAB), has been launched to test innovative treatments for lung cancer. The trial, which combines efforts from frontline treating oncologists and pharmaceutical companies, aims to improve patient outcomes and extend overall survival.
Researchers at Harvard University have created a new method to quantify the mechanical forces produced by living cells, which shape tissues and organs. By injecting tiny oil droplets into 3D tissues and embryos, scientists can measure the forces exerted by individual cells, shedding light on the role of mechanics in development and dis...
In a breakthrough discovery, Rice University researchers found that free electrons in metallic and doped carbon nanotubes create plasmons at terahertz frequencies, enabling the potential for advanced optoelectronic devices. This finding clarifies the origin of the previously observed terahertz peak in nanotubes.
System 90L's chances of tropical development dismissed after hostile upper-level winds and diminished showers; no longer considered a threat by NASA. Upper-level conditions made it difficult to identify the low-pressure system, leading to its fizzling out.
A year of resistance and impact training can help older breast cancer survivors preserve bone density, even with less exercise. Muscle strength declines more quickly than bone density and may require continued participation in a supervised exercise program.
The development of UV photodetectors has been driven by numerous applications in the defense, commercial, and scientific arenas. The researchers have brought this AlxGa1-xN-based device closer to reality by developing a compact photodetector with the world's highest quantum efficiency.
A new drug-eluting contact lens has been developed to deliver latanoprost, a common glaucoma medication, continuously for a month. The lens was designed with materials approved by the FDA and achieved comparable concentrations to daily topical treatment in animal studies.
A new study by Woods Hole Oceanographic Institution researchers documents the historic sediment record along the Danube River delta and offers simple and inexpensive strategies to maintain delta environments. The team analyzed sediment cores and found that mimicking natural distributaries can help keep sediment on flood plains, rather ...
Researchers at OHSU discovered a way to use small molecules to fix misfolded proteins, allowing them to function normally again. This technique has the potential to treat diseases such as cystic fibrosis, cataracts, and Alzheimer's disease.
Researchers discovered an association between oncometabolite 2-hydroxyglutarate (2-HG) levels and DNA methylation patterns with breast cancer prognosis. Chloroquine treatment was found to limit osteoclast generation, suggesting potential therapeutic applications.
A Northwestern University study found that individuals with high self-monitoring and diverse social networks are more likely to strongly experience face threats on Facebook. People who felt they had a high level of Facebook skills reported experiencing these kinds of threats less severely.
A new technology grows cord blood stem cells in a lab before transplant, increasing survival rates by 9.6% compared to traditional methods. Patients who received the StemEx transplants engrafted faster and were less vulnerable to infections and bleeding.
A new optical sensor created at MIT can track zinc within cells, shedding light on its functions and helping researchers study zinc trafficking in prostate cells. The sensor supports the theory that cancerous prostate cells banish zinc from mitochondria to produce extra energy.
A new gene sequencing project identifies a family of drugs that enhance oxidative stress to kill rhabdomyosarcoma tumor cells and boost chemotherapy effectiveness. The study offers hope for treating this aggressive childhood cancer, particularly for patients with recurrent disease.
A novel chemical, perfluorotributylamine (PFTBA), has been found to be a long-lived greenhouse gas with the most radiatively efficient impact on climate, according to a study by the University of Toronto chemistry team. Calculated over a 100-year timeframe, PFTBA's global warming potential is equivalent to that of 7100 molecules of CO2.
Researchers find consistent types of organisms in subsurface rocks across globe, challenges imagination to think of nearly identical microbes 16,000 km apart.
Researchers at Umea University found that Tamiflu's active metabolite can contaminate river water in Japan, making the virus resistant to antiviral medications. The team aims to develop a national knowledge center on antiviral drug effects and improve wastewater treatment to prevent pandemics.
Researchers found diverse mineralogy in the South Pole Aitken basin's subsurface, suggesting pre-existing diversity in the Moon's crust and mantle. The study used data from the Moon Mineralogy Mapper to analyze light reflected from central peaks of smaller craters within the basin.
The MIT model suggests that neurons constantly change connections to explore many possible solutions, but with a balance between hyperplasticity and low signal-to-noise ratio. This allows the brain to learn new skills while retaining previously learned ones, especially if they are not similar.
Sandia National Laboratories researchers have devised a novel technique to increase the electrical conductivity of metal-organic framework (MOF) materials by over six orders of magnitude. This breakthrough has significant implications for the development of new electronics, sensors, energy conversion and storage technologies.
A new technique developed by Otger Campas and Donald Ingber enables the measurement of mechanical forces cells generate while building tissues and organs. This breakthrough provides insights into the role of mechanics in morphogenesis and may lead to discoveries about birth defects, tumor growth, and tissue abnormalities.
A new study by UC Irvine researchers links six or more hours of daily exposure to media coverage of the Boston Marathon bombings with increased acute stress symptoms. Repeated exposure to violent images can prolong stress responses and have serious health consequences.
Researchers from Linköping University and five universities worldwide have proven that polymers can exhibit semiconductor-like properties. The discovery paves the way for a new field of research in organic electronics.
A new study from Carnegie Institution researchers used zebrafish to understand the circuitry underlying nicotine addiction. The research confirmed that a specific neural pathway in fish brains responds similarly to nicotine as it does in human brains.
The emergence of fertility loans has raised ethical concerns as doctors market them to patients with potential financial ties to lenders. Experts argue that this practice may exacerbate the anguish of infertility by promoting unsuccessful interventions.
A new set of guidelines assesses pollinator performance using four metrics: single-visit efficiency, abundance, inclement weather behavior, and visitation rate. Small native bees are found to be highly efficient pollinators despite low abundance.
A recent study found that over 18% of lung cancers detected by low-dose computed tomography (LDCT) may be cases of overdiagnosis, where the cancer would not have become clinically apparent without screening. This could lead to unnecessary treatment, anxiety, and increased healthcare costs.
A new study suggests that a head injury can lead to depressive complications years later due to an overactive immune response and inflammation. The research found that brain cells went on 'high alert' after the injury, affecting behavior and leading to symptoms that were linked to inflammation.
A study published online in Cancer found that increased inflammation in the prostate gland may predict a reduced risk of developing prostate cancer. The study's findings suggest that biopsies performed on prostates with high inflammation levels may indicate a lower risk for subsequent cancer detection.
The EUCelLEX Project examines current legislation on somatic cells, assessing relevance and proposing sustainable solutions. It aims to provide a stabilised legal context for the use of stem cells in clinical purposes.
A University of Washington study found that the positive influence of Communities That Care on US teens' behavior was sustained through high school. By the end of 12th grade, 32% of teens in Communities That Care towns had never tried alcohol compared to 23% in control communities.
Researchers found a strong association between high 2-HG levels, DNA methylation patterns, and poor survival outcomes in African-American breast cancer patients. The study identified a distinct breast cancer subtype with elevated 2-HG levels that was associated with reduced survival.
The buff-tailed bumblebee, introduced to Chile in 1998, has spread rapidly throughout South America, outcompeting native species and potentially disrupting the ecosystem. The parasite Crithidia bombi is a key factor in the decline of native bumblebees.
Researchers found temperatures from -92 to -94 degrees Celsius (-134 to -137 Fahrenheit) in a 1,000-kilometer long swath on the highest section of the East Antarctic ice divide. The measurements were made using Landsat 8 and MODIS sensors.
A study published in Nature has cataloged 46 species with their mortality and fertility rates, revealing extraordinary diversity in aging processes. This challenges current explanations, which predict that the probability of dying rises with age, as seen in humans, but contradicted by species like the desert tortoise and white mangrove.
Researchers develop composite material that can change shape in response to temperature, enabling applications such as dynamic scaffolds and implantable materials. The material's reversible properties make it suitable for biomedical applications where shape changes need to be repeated.
A new study reveals that high school athletes playing at higher elevations suffer fewer concussions than those closer to sea-level. The researchers analyzed concussion statistics from athletes playing multiple sports in 497 high schools and found a significant decrease in concussion rates among all sports played above 600 feet.
Robert Mahley and his team will use the funding to identify new chemical compounds that can target apolipoprotein E4 (apoE4), the strongest genetic risk factor for developing Alzheimer's. They aim to develop small-molecule therapies that prevent apoE4's damaging effects on the brain.
A study by Washington State University researchers found that organic milk contains more beneficial fats and a healthier fatty acid ratio than conventional milk. Organic whole milk outperformed conventional milk in improving an individual's fatty acid profile, particularly with omega-3 and omega-6 fatty acids.
Michigan State University researchers discovered a genetic deficiency in male mice that triggers the development of liver cancer and type 2 diabetes. The study found altered NCOA5 gene levels led to glucose intolerance and hepatocellular carcinoma.
Case Western Reserve engineers create nanoscale switches with low power consumption and durability, enabling faster and more efficient computing. The silicon carbide-based technology could lead to significant advancements in electronics and computing.
A study at Johns Hopkins Medicine found that vitamin D appears to block damage-causing immune cells from migrating to the central nervous system, potentially preventing or easing symptoms of multiple sclerosis. The research suggests that vitamin D may slow a process allowing T cells to grab onto blood vessel walls.
Researchers at Monash University have isolated muscle precursor cells from pluripotent stem cells using a purification technique, allowing them to differentiate into muscle cells. This breakthrough could lead to the development of new treatments for degenerative diseases such as Muscular Dystrophy and Parkinson's disease.
Michigan State University's SETS-UP fellowship provides secondary science teaching certification and a master's degree to prepare educators for middle- and high-school science teaching careers in high-need classrooms. The five-year program aims to increase teaching retention rates in these critical schools.
Researchers devised a mathematical model to improve treatment options for coronary heart disease (CHD), which accounts for 18% of US deaths annually. The model helps explain the factors governing drug release and distribution in drug-eluting stents, providing valuable insight into developing better treatments.
Researchers found that blood clots actively soak up lipopolysaccharide, a toxic compound released by Gram-negative bacteria. This protective mechanism may help prevent disease and death from septic shock, which affects 300,000 people annually.
Scientists discovered that ABC transport proteins, found in glandular cells of leaf beetle larvae, enable the accumulation of defensive substances like salicyl aldehyde. This process allows the larvae to save energy by synthesizing toxins only when needed.
The project supports the introduction of two innovative contraceptive vaginal rings in USAID-priority countries, including a one-year ring and a three-month Progesterone Vaginal Ring for breastfeeding women. The rings offer effective, user-controlled methods with no need for healthcare provider insertion or refrigeration.
The €3.6 million CACHE programme will study the effects of ocean warming and acidification on shellfish populations, crucial for the European fishing economy and biodiversity. The project will also explore biomimicry and carbon sequestration opportunities.
Researchers at DESY's PETRA III facility watched organic solar cells degrade in real time, revealing a mechanism of degradation that involves growth and receding of active domains. The study could lead to new approaches for increasing the stability of this promising type of solar cell.
Operations Research Perspectives is an open access journal publishing material on operations research and management science. The journal aims to make fast decisions accessible to a wide audience, bringing together high-quality papers from the field.
The discovery of supervolcanoes in southern Utah reveals massive eruptions that buried a vast region, affecting areas from central Utah to Nebraska. This research has significant implications for understanding geological history and the impact of volcanic activity on ecosystems.
A study by Linda Henkel found that participants had worse memory for objects and specific details when taking photos compared to observing them. Additionally, the data showed that zooming in on a specific detail with the camera preserved memory for the object, not just the focused area.
A study published in BMJ Open found that UK women scientists receive fewer studies funded and less money than their male peers in infectious disease research. Women's total share of funding ranged from 14% to 27%, with men receiving most of the total investment.
Researchers at UC Irvine's Institute for Memory Impairments and Neurological Disorders have received a grant to develop and study patient-derived stem cell lines. The UCI MIND team will create up to 40 sets of induced pluripotent stem cells to explore the biology of Alzheimer's disease and test novel therapeutic approaches.
Researchers discovered HDL acts upon inflammatory processes by activating ATF3, downregulating chronic inflammation in macrophages. This finding suggests a molecular approach for treating inflammation in diseases like diabetes.
A study published in Nature found that rivers and streams emit significantly more carbon dioxide than previously thought, with a global rate of 1.8 billion tons per year. This contradicts the long-held assumption that lakes and reservoirs are the primary source of this emission.
Researchers at Monterey Bay Aquarium Research Institute create detailed map of Campeche Escarpment, a steep underwater cliff near the impact site. The maps reveal that rocks formed before, during, and after the asteroid impact are exposed along different parts of the escarpment.
A massive ejection of material from the sun in 2012 could have created a technological disaster if it hit Earth, short-circuiting satellites and power grids. The event highlights the need for society to prepare for severe space weather events.
Researchers discovered a temperature turnaround point in the atmospheres of Jupiter, Saturn, Uranus, Neptune, and Titan, which may be common to billions of planets. This phenomenon occurs at a pressure of about 0.1 bar and is likely caused by infrared radiation absorption.
The latest themed issue of Reproductive Health Matters explores a new development paradigm to prioritize health, ensuring equitable care for all. The issue critiques the Millennium Development Goals model and advocates for a human rights approach to addressing health disparities.
A large EU study is investigating whether nilvadipine can help patients with Alzheimer's disease by reducing the formation of amyloid plaques in animal brains. The clinical trial will involve 500 patients in nine European countries, who will be treated with nilvadipine or a placebo for eighteen months.
The Green Bank Telescope has captured detailed images of M82, highlighting streamers of material and dense molecular gas surrounding areas of intense star formation. Astronomers hope to understand the connection between dense gas and star formation by creating wide-angle maps of galaxy gas.
Researchers found that home plants excel over visitors due to regional adaptations, which involve tradeoffs in performance. Genetic analysis revealed that only 15 regions of the genome are involved in adaptation, challenging the long-held view that multiple genes fuel these traits.
Researchers discovered imetelstat, a telomerase inhibitor, induces morphologic, molecular and clinical remissions in some patients with myelofibrosis. The study showed five patients achieved complete or partial remissions, including reversal of bone marrow fibrosis.
A team of researchers from the University of Illinois at Urbana-Champaign and the University of Central Florida has developed a way to create large sheets of nanotextured, silicon micro-cell arrays that are lightweight, more efficient, and bendable. This technology could lead to solar-powered homes with reliable stored energy.
The American College of Physicians recommends clinical and administrative changes to deter prescription drug abuse while maintaining patient access to treatment. The guidelines advocate for physician, patient, and public education on the harms of medical and nonmedical use of prescription drugs.
A 35-year study by Cardiff University found that regular exercise significantly reduces the risk of dementia and cognitive decline. The study identified five healthy behaviors as key to a disease-free lifestyle, with exercise being the strongest mitigating factor.
Researchers have identified a specific genetic mutation driving Waldenstrom's Macroglobulinemia in up to 30% of patients. A new drug targeting this mutation shows promise in animal studies, offering hope for targeted treatment options.
IRIS has captured detailed images of the interface region between the sun's surface and corona, revealing more violent and turbulent phenomena than previously understood. The mission's observations also provide new insights into solar eruptive events and the dynamics of the low solar atmosphere.
The UK's failure to implement a comprehensive national policy on childhood physical activity has severe consequences, including obesity and poor health outcomes. Experts warn that this lack of action amounts to 'mass child neglect' and demand a child-centred approach to create opportunities for all children to be active daily.