A study found that financial ties between researchers and the drug industry are associated with more favorable trial outcomes. The authors suggest that this could lead to biased evidence and call for increased transparency and disclosure of financial ties. More research is needed to understand the mechanisms behind these findings.
A new drug combination that adds chloroquine to targeted treatment has stabilized a 26-year-old brain cancer patient's disease, increasing both quality and quantity of life. The treatment was effective in two other brain cancer patients with similar diseases.
A large study from Boston Children's Hospital found that epigenetic modifications to DNA, specifically DNA methylation, are linked to an increased risk of obesity-related health problems. The researchers identified 83 sites in the genome where methylation changes were associated with differences in energy balance and lipid metabolism.
A study by TGen has identified aurintricarboxylic acid (ATA) as a compound that can improve drug development against glioblastoma. ATA blocks the chemical cascade that allows glioblastoma cells to invade normal brain tissue and resist chemotherapy and radiation therapy.
A team of researchers has identified genetic mutations that enable microalgae from the Southern Ocean to adapt to extreme and variable climates. The study provides insights into how polar organisms cope with environmental changes induced by human activity.
A team of researchers has found that certain anti-influenza compounds can also inhibit Zika virus infection, providing a potential new treatment for the disease. The study, published in Antiviral Research, shows that these compounds target host cell factors, making them effective against viruses that mutate easily.
A study found that modafinil improves episodic and working memory functions in patients with remitted depression. The results suggest that modafinil may be a feasible option to tackle persistent cognitive problems in depression, improving cognition and motivation.
Researchers found that antiretroviral drugs used to treat HIV infection may increase susceptibility to syphilis by boosting immune system activity and leading to more sexual partners. This could explain the rise in new cases of syphilis among gay/bisexual men over the past decade.
A study published in Nature Genetics has shown that a knowledge bank of patient data can be used to predict the best treatment option for people with acute myeloid leukaemia (AML). The tool takes into account individual genetic features, treatment schedule, and outcome, enabling therapeutic choices to become personalised. This approach...
The Eurasian ice sheet grew from small ice caps to a massive ice mass, nearly three times the size of modern-day Greenland, through a process driven by climate cycles and snowfall. The sheet's growth had a profound impact on regional climates, creating rain-shadow effects and desert conditions in western Russia and Siberia.
A global team of researchers found that ram-pressure stripping is more prevalent than thought, driving gas from galaxies and preventing star formation. The study reveals that this process is potentially the dominant way galaxies are quenched by their surrounds, leading to an early death.
Research suggests that acupuncture can effectively treat infantile colic by reducing the frequency and duration of excessive crying in babies. The study involved 147 babies who received either standard care or tailored acupuncture treatment, resulting in a significant reduction in crying time for those who received acupuncture.
Researchers discovered fossils of a previously unknown trilobite species that left distinctive fossil footprints around the ancient supercontinent Gondwana. The discovery reveals unique leg structures and digestive systems, providing insights into trilobite behavior and biology.
Scientists at the University of Utah have discovered a unique biomarker in the hearts of patients with advanced heart failure who have shown signs of recovery. The biomarker is related to the transverse system, which appears relatively intact in responders.
Recent preclinical research suggests microinfarcts can induce prolonged dysfunction in brain areas estimated 12-times larger than the visible injury site, contributing to cognitive decline and dementia. The study used a mouse model to examine the effects of individual cortical microinfarcts on surrounding tissue function in vivo.
Researchers at DGIST have developed a technology to coat metals with several nanometers of semiconducting materials, enabling various color changes through thin-film interference. This breakthrough allows for the production of colors such as yellow, orange, blue, and purple on demand.
Researchers at Rice University have developed a new theory and computational methods to understand how metallic glasses behave under stress, revealing the formation of shear bands that can lead to breaking. The study provides valuable insights into improving the strength and durability of glass materials.
Researchers have identified multiple targets for Chagas disease chemotherapy, including ergosterol biosynthesis pathway and cruzipain, a key cysteine protease. Novel synthesized anti-T.cruzi compounds with specific single or multi-target assigned have also been described, highlighting potential for effective treatment.
A new study by Professor Catherine Bailey suggests that manipulating employees' desire for meaningful work can damage organizations and alienate staff. The researchers identify two forms of 'acting' used by employees when they perceive organizational efforts to manage meaningfulness, which can lead to negative consequences.
A large randomized trial found that using UVC machines can reduce the transmission of four major superbugs by a cumulative 30 percent, particularly for MRSA. The study suggests that adding UV light to standard cleaning can be an effective strategy in reducing infections in hospitals.
A new study published in Scientific Reports found a significant link between economic growth and deforestation in poor countries, with the effect disappearing in wealthier economies. The research used satellite data and economic data from 130 countries to make comparisons across border regions with similar geography.
Researchers at the University of Bristol propose a cost-effective solution for Intelligent Transportation Systems (ITS) to share high-quality data with drivers in emergency situations. The single frequency network (SFN) approach could improve road safety by providing reliable information, reducing transmission power by up to 20 times.
Researchers at the Buck Institute found that chemotherapy induces widespread cellular senescence, contributing to persistent inflammation and cancer recurrence. Eliminating senescent cells reduced side effects, including fatigue, bone marrow suppression, and toxicity, in mice treated with common chemotherapy drugs.
Researchers at the University of Bath have developed a renewable plastic from pinene found in pine needles, which can replace petroleum-based plastics in food packaging and medical implants. The new plastic is biodegradable and produced from a waste product previously discarded in the paper industry.
Researchers found that persistent infections stimulate the immune system, keeping it primed and ready for future encounters. This leads to long-term immunity, but also carries risks of reactivation and disease. The study aims to design vaccines that elicit life-long immunity without sterilizing the pathogen.
Scientists developed a microfluidics-based technique called SMiLE-seq to characterize DNA-binding proteins, increasing speed, accuracy and efficiency. The technique can analyze over 60 transcription factors, including nine new ones, and has the potential to be extended to other molecules.
The James Bond series has conspicuously absent smoking-related imagery in only one film since its debut in 1962, according to a recent analysis published in Tobacco Control. Despite Bond himself no longer smoking, he is still exposed to second-hand smoke through his sexual partners and other characters.
A new study uses transgenic organisms and biochemistry to test an evolutionary hypothesis on fruit flies' ability to metabolize alcohol. The research found that the amino acid changes in the ADH protein do not improve the fruit flies' tolerance for alcohol, challenging a previous hypothesis.
A synthesized steroid called squalamine has been shown to prevent the buildup of a lethal protein implicated in neurodegenerative diseases like Parkinson's. In an animal model, squalamine reduced the toxicity of alpha-synuclein clumps and protected healthy human neuronal cells from damage.
New research predicts a 11.3-30% intensification of rainfall from extreme precipitation events in Australia with a 2°C rise in global temperatures. This will occur despite some areas becoming increasingly drought-prone, highlighting the need for infrastructure adaptation to extreme rainfall events.
The Robust Rattan Palm has been assessed as Endangered due to habitat loss and over-harvesting. Its limited range of 40 km² in Ghana and Côte d'Ivoire makes it highly vulnerable to extinction.
A comparative genomic analysis of Antarctic diatom Fragillariopsis cylindrus reveals its ability to adapt to extreme cold by selectively expressing variant genes. The study provides insights into the organism's genome structure and evolution, highlighting its unique genetic features that enable survival in harsh environments.
Researchers found that bacteria alters molecules in a tick's gut, allowing it to enter and colonize the gut microbes. This finding could help scientists develop strategies to block tick-borne agents causing disease.
Researchers have revised the earliest known human settlement in North America to 24,000 years ago based on new radiocarbon dating from the Bluefish Caves in Yukon. The findings confirm the 'Beringian standstill hypothesis' suggesting that humans inhabited Eastern Beringia during the last ice age.
Massachusetts General Hospital investigators identified a protein called G3BP2 that helps maintain aggressive tumor-initiating cells in breast cancer. Compounds like C108 can reduce the survival of these cells and slow tumor growth.
Researchers identify three critical areas for climate research to tackle new frontiers of climate study. They include understanding the fate of carbon in the atmosphere and accurately modeling regional climate changes. These efforts require international collaboration and significant computational resources.
Researchers found that mosquitoes responsible for transmitting malaria often rest in cattle sheds and feed on both humans and cattle. The team suggests that extending mosquito-control efforts to include cattle sheds could help reduce transmission dramatically.
Researchers at Helmholtz Zentrum München found that nanoparticles from combustion engines can reactivate latent herpes viruses in lung tissue cells. This process can lead to increased viral proteins and acute infection patterns. Further studies aim to investigate the molecular mechanism of virus reactivation by nanoparticles.
The Harrington Discovery Institute has announced grant funding for 11 physician-scientists from premiere universities. The recipients will receive up to $700,000 in capital to support the transition of their work into the private sector.
A company's failed attempt to bring jamming-based robotic gripper technology to market provides valuable insights into the challenges of product development and commercialization. The authors share their research and product design efforts, highlighting key factors that influenced customer purchasing decisions.
Scientists captured real-time, dynamic visualizations of atoms moving in and out of nanoparticles less than 100 nanometers in size. The experiments provided insight into the chemical and physical sciences, revealing that nanoparticles can self-heal and become more durable energy storage materials.
The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) have released a new guideline for treating hypertension in adults 60 years old and older. The guidelines recommend a less aggressive treatment target for otherwise healthy adults, with a focus on achieving a systolic blood pressure of less tha...
The new guidelines provide a revised conceptual model of VCI and its subtypes, aiming to clarify diagnosis and facilitate collaboration among researchers. The study's findings have the potential to speed up research in this vital area and bring much-needed help to people with vascular cognitive impairment.
Researchers at Argonne have discovered a new approach to detail the formation of material changes at the atomic scale, capturing images of structural defects in palladium when exposed to hydrogen. This imaging capability will help validate models predicting material behavior and enable defect engineering for better materials.
The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) recommend that physicians initiate treatment in adults aged 60 years old and older with persistent systolic blood pressure at or above 150 mm Hg to achieve a target systolic blood pressure of less than 150 mm Hg. The guideline notes that some ...
A joint study by Chinese and international researchers recommends new institutions for science-based fisheries management, secure fishing access, and policy consistency across provinces. The authors believe that China's 13th Five-Year Plan provides a policy platform for the protection of marine ecosystems and restoration of fisheries.
A study by researchers at the University of Basel found that meals trigger an inflammatory response in the body, which plays a crucial role in regulating blood sugar levels. This mechanism is dependent on bacteria and nutrients ingested during meals, highlighting the importance of adequate nutrition for immune function.
The new data from the SMAP satellite is providing significant surprises that will help in the modeling of climate, forecasting of weather, and monitoring of agriculture around the world. The topsoil's 'memory' for weather anomalies persists for a matter of days, contrary to expectations.
Researchers from Ruhr-Universität Bochum used data from the Astrophysical Journal to determine the age of the star, finding it had formed at the same time as our galaxy. The dual star system's companion star transferred matter to 49 Lib, causing incorrect age estimates.
Researchers at Princeton University have identified a potential treatment target for the hepatitis E virus by exploiting its ability to use proteins to escape host cells. The study found that curtailing viroporin production could prevent viral particles from spreading, providing a new avenue for antiviral drugs.
Researchers have found a protein called BCL-2 crucial in controlling the reservoir of NK cells, which may be vulnerable to new medicines that inhibit it. Boosting NK cell numbers with IL-15 could offer a valuable approach to boosting immunity against viral infections or cancer.
A new study by University of Utah Health found that commercial truck drivers with three or more medical conditions are quadruple their chance of being in a crash compared to healthier drivers. The research suggests that a driver's poor health can increase the risk not only for themselves but also for others around them.
Researchers aim to overcome traditional antenna limitations with liquid materials, enabling flexible and compact devices. The project will test liquids for stability and frequency transmission across various temperatures.
A vast collection of genetically modified wheat seeds with over 10 million sequenced mutations has been developed to aid in the study and improvement of wheat plants. This new resource is freely available to researchers and breeders worldwide, enabling them to develop crops with enhanced nutritional value, yields, and climate resilience.
The study found that almost 80% of elderly patients who received an implantable cardioverter-defibrillator survived two years after a sudden cardiac arrest or near-fatal arrhythmia. The researchers also noted substantial care needs among the oldest patients, with high hospitalization and skilled nursing facility admission rates.
A recent study published in Journal of Business Research found that left wing consumers are twice as likely to punish companies for tax avoidance. The study revealed a significant decrease in purchase intentions among left wingers, with an average drop of 16%, compared to 8% among right wingers.
Researchers at Princeton University have developed a technique to create ultra-fine grained films using self-assembling nanoparticles, leading to more efficient and stable perovskite-based LEDs. This advancement brings perovskite technologies closer to commercialization and could speed the adoption of lower-cost and environmentally fri...
A new UBC study found that medications used in highly active antiretroviral therapy (HAART) for HIV may be reducing the body's immune response to certain diseases, including syphilis. Researchers suggest this could be contributing to the recent surge in syphilis cases worldwide.
Researchers at Uppsala University developed a new antibody design that increases brain uptake of antibodies almost 100-fold, offering new opportunities for treating brain diseases. The modified antibodies use the transferrin receptor to transport them across the blood-brain barrier.
A new study reveals the structure of DNA helicase at the replication fork, reversing a long-held assumption about its orientation. The findings provide a crucial piece in understanding how life propagates and may lead to new treatments for diseases such as cancers and anemias.