Nephropathies
Articles tagged with Nephropathies
USC researchers launch study of the most complex lab-grown kidney structures
Expanding Medicaid coverage lowered death rates for young adults with kidney failure
A Brown University study found that expanded Medicaid coverage significantly improves one-year mortality rates for young adults with kidney failure. The researchers discovered improvements in pre-dialysis care, increased use of dialysis, and longer dialysis sessions, all leading to better long-term health outcomes.
Clinical decision support for chronic kidney disease in primary care
Can birth weight influence endurance limits?
A study published in Frontiers in Ecology and Evolution found that optimal birth weight for minimal kidney damage during extreme endurance events is around eight pounds. Individuals with lower or higher birth weights may face a greater risk of kidney stress or damage.
Metabolic reprogramming on demand: enzymatic nanovesicles open a new frontier for acute kidney injury therapy
Scientists create a novel nano-delivery system that boosts NAD+ synthesis and reduces consumption, rapidly restoring energy metabolism in damaged kidneys. The approach halts disease progression and prevents chronic kidney disease, offering a promising drug development platform for AKI and other energy metabolism disorders.
Artificial Intelligence in Nephrology
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
Midlife fitness linked to longer, healthier lives
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
Epigenetic suppression of RASAL1 by HDAC3 and cofactor YY1 promotes fibroblast-myofibroblast transition and renal fibrosis
This study reveals that HDAC3 epigenetically represses RASAL1, a key antifibrotic regulator, leading to enhanced fibroblast activation and extracellular matrix deposition in renal fibrosis. Restoring RASAL1 expression or inhibiting HDAC3 activity attenuates renal fibrosis.
A small molecule drug candidate fully restores survival in a lethal mouse model of a rare kidney stone disease that has no current treatment
Scientists at Buck Institute for Research on Aging developed an orally administered small molecule that completely prevents calcium oxalate kidney stones, protects against kidney failure, and fully restores normal survival in a mouse model of Primary Hyperoxaluria Type 2. The drug candidate, N-propargylglycine (N-PPG), targets a key en...
University of Cincinnati researchers discover clear link between chronic kidney disease and periodontal disease
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
New biomarker for immunoglobulin a nephropathy identified
Researchers have discovered a new biomarker for immunoglobulin A (IgA) nephropathy, which is an autoimmune disease that can lead to kidney failure. Complement pathway proteins, including CFHR1, were found to be overexpressed in patients with IgA nephropathy, suggesting a potential treatment target and diagnostic marker.
Exercise harder, not just longer, to reduce risk of disease and death
Research found that people who spend a higher proportion of their total physical activity doing vigorous activity have substantially lower risks of all eight serious health conditions. The benefits of vigorous activity remained even when the amount of time was modest.
Multi-task deep learning identifies four MASLD subtypes for precision cardiovascular– liver–kidney–metabolic management
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
B-type natriuretic peptide as a predictor of kidney disease progression in diabetes
A recent study found that B-type natriuretic peptide is independently associated with chronic kidney disease progression in individuals with diabetes. Combining BNP with urinary markers such as UACR improves risk prediction, highlighting its potential role in early detection and management of kidney disease.
New mechanism for kidney repair discovered: Immune checkpoint VISTA protects against acute injury and prevents fibrosis
Researchers discovered VISTA as a critical immune checkpoint that balances immune activation and inflammation resolution during kidney injury. Administering exogenous VISTA protein shows potent protection against acute kidney injury and its progression to chronic disease.
Blood marker for Alzheimer’s may also be useful in heart and kidney diseases
Researchers found elevated pTau levels in individuals with transthyretin amyloidosis and immunoglobulin light-chain amyloidosis, suggesting a new diagnostic approach for systemic amyloidosis. The findings may facilitate earlier detection and help confirm suspected cases.
New discovery may improve kidney disease diagnosis in black patients
A new study from Columbia University Vagelos College of Physicians and Surgeons has found that analyzing the APOL1 gene in Black patients with kidney disease can provide more accurate diagnoses. The study suggests that incorporating M1 into routine APOL1 genetic testing could help doctors determine the true cause of a patient's kidney ...
Insilico and TaiGen achieve milestone in collaboration: Out-licensed CKD anemia candidate ISM4808 completes first human enrollment and dosing in Phase I clinical trial
ISM4808, a PHD inhibitor for chronic kidney disease-related anemia, has achieved its first milestone with successful completion of the Phase I clinical trial. The treatment stimulates endogenous erythropoietin production and improves iron utilization, offering improved efficiency and safety compared to existing treatments.
Minimally invasive procedure effectively treats small kidney cancers
A nationwide Danish study comparing outcomes between patients treated with minimally invasive ablation and surgery found no difference in cancer progression but more frequent local recurrence of the disease following ablation. Ablation patients had shorter hospital stays and fewer complications.
COVID-19 infection predicts higher risk of kidney disease, study finds
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
Predicting cardiovascular complications in chronic kidney disease using microRNAs in blood
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
Millions are unaware of heart risks that don’t start in the heart
The American Heart Association reports that millions of US adults with diabetes are unaware they have it, while nine in ten with chronic kidney disease do not know they have it. Regular screening can catch problems early, with approximately 80% of heart attacks and strokes being preventable.
Structural adaptations in aging podocytes
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
Enhancing mortality risk prediction by integrating CKM syndrome stages and CKD-based substaging: evidence from a nationwide cohort study
A nationwide cohort study found that chronic kidney disease significantly heightens mortality risk, even at moderate levels, and exceeds traditional metabolic risk factors. Maintaining renal function and early detection of CKD are critical for reducing both all-cause and cardiovascular mortality.
New therapy could make life better for kidney transplant patients
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
GLP-1 RAs and prior major adverse limb events in patients with diabetes
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly lowers risks of limb events, cardiovascular events, all-cause mortality, and kidney disease progression compared to dipeptidyl peptidase-4 inhibitors in patients with diabetes. GLP-1 RAs are preferred for secondary prevention in this high-risk population.
Could a dietary supplement make the difference between life and death during illness?
Salk Institute scientists discover that dietary supplementation of the amino acid methionine protects infected mice against inflammation-related wasting, blood-brain barrier dysfunction, and death. Methionine boosts kidney filtration, reducing circulating cytokine levels and improving disease outcomes.
Chronic kidney disease poisons patients’ hearts, scientists discover
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
SGLT2 inhibitors vs GLP-1 receptor agonists for kidney outcomes in individuals with type 2 diabetes
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
New blood test offers clearer picture of “clotting risk” in heart disease patients
Researchers developed a highly sensitive blood test that can detect initial thrombin generation, a key trigger in blood clot formation. The test distinguishes between pathway-specific clotting abnormalities and suggests personalized treatment strategies, potentially predicting clinical outcomes.
Simple method can enable early detection and prevention of chronic kidney disease
Researchers have developed a web-based tool to identify people at risk of developing chronic kidney disease through subtle abnormalities in kidney function. The study shows that individuals with an eGFR below the 25th percentile had a markedly higher risk of developing kidney failure.
Movement matters: Light activity led to better survival in diabetes, heart, kidney disease
A new study found that light intensity activities, such as walking or household chores, were associated with a lower risk of death for people with CKM syndrome. The researchers used data from the National Health and Nutrition Examination Survey to compare activity level duration for each CKM syndrome stage.
Early detection and targeted blood purification could prevent kidney failure in ICU patients, new review finds
Early recognition of cast nephropathy through novel biomarkers can guide timely treatment, while tailored extracorporeal therapies show promise in preventing irreversible kidney damage. The review emphasizes the need for standardized biomarker-guided pathways and multicenter trials to advance personalized kidney support.
‘Tubuloids’ offer a realistic platform for modeling chronic kidney disease
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Insilico Medicine and Taigen achieves license agreement to develop and commercialize AI-driven PHD inhibitor for anemia of Chronic Kidney Disease (CKD)
Insilico Medicine and Taigen Biotechnology collaborate to develop and commercialize ISM4808, an AI-driven PHD inhibitor for treating anemia of Chronic Kidney Disease (CKD). The partnership grants TaiGen exclusive rights for further development, commercialization, and sub-licensing in the Greater China area.
Older age, chronic kidney disease and cerebrovascular disease linked with increased risk for paralysis and death after West Nile virus infection
A study published in JAMA Network Open found that older adults with chronic kidney disease or cerebrovascular disease are at double the risk for developing neuroinvasive West Nile virus infection, which can lead to paralysis and death. The study identified several risk factors, including male sex, immune suppressants, and multiple scle...
Possible therapeutic targets for kidney disease identified
Researchers from the University of Missouri-Columbia have identified several genes that may be potential therapeutic targets for Chronic Kidney Disease (CKD) by regulating gene activity. These genes are involved in the signs of kidney damage, including fibrosis and inflammation.
New evidence on the therapeutic potential of extracellular vesicles in kidney injury
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
Explore emerging perspectives on kidney disease in New Bentham Science Publisher’s release
The book covers genetic, epigenetic, and molecular foundations of renal dysfunction, as well as microbiota, immune interactions, and nephrotoxicity. It also highlights novel therapies and precision medicine approaches for better diagnostic and treatment strategies.
Hippo signaling pathway as a therapeutic target for nephronophthisis
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.
FAU Engineering study takes a ‘quantum leap’ to detect kidney disease
A recent FAU Engineering study leverages quantum computing to enhance the accuracy of chronic kidney disease (CKD) diagnosis. The research team developed and compared two automated systems: Classical Support Vector Machine (CSVM) and Quantum Support Vector Machine (QSVM). CSVM achieved remarkable 98.75% accuracy, while QSVM reached 87....
New drug protects mitochondria and prevents kidney injury in mice
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
Chronic kidney disease is now the ninth leading cause of death
A new study estimates that about 14% of adults worldwide have chronic kidney disease, with 1.5 million deaths in 2023. Early detection and treatment are crucial to prevent severe interventions like dialysis and transplantation.
Glycosylation enzyme selectivity in mouse kidney shows promise for future disease research
Researchers investigated GnT-V, a cancer-related glycosylation enzyme, and found its selectivity relies on protein structure and subcellular trafficking. Two enzymes, metalloproteases, were identified as major substrates in the kidney.
Chronic kidney disease has more than doubled since 1990, now affecting nearly 800 million people worldwide
The study found CKD affects nearly 800 million worldwide, with diabetes and high blood pressure driving the greatest loss of healthy years. Access to kidney replacement therapies remains limited, highlighting the need for preventive measures and equitable care.
Disagreement between two kidney function tests predicts serious health problems
A new study reveals that a large gap between two common kidney function tests may indicate future disease, particularly among older adults. The research found that over a third of hospitalized participants had a significant difference in their creatinine and cystatin C readings, which can predict serious health problems.
Reducing reliance on corticosteroids with rituximab: renewed hope for adult-onset patients with relapsing nephrotic syndrome
A randomized clinical trial has shown that rituximab is effective in preventing relapses and reducing the need for corticosteroids in adults with relapsing nephrotic syndrome. The study involved 66 adult patients treated with either rituximab or a placebo, with impressive results at the 49-week follow-up.
University of Cincinnati study urges more reproductive care for those with chronic kidney disease
A new study from the University of Cincinnati College of Medicine calls for more extensive nephrology fellowship training on reproductive health. Females with CKD face increased risks of high-risk pregnancies, preeclampsia, and preterm births, yet their contraceptive use remains relatively low.
First transplant in pigs of modified porcine kidneys with human renal organoids
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
Rapid kidney test in development for early intervention, simple monitoring
A simple blood test is being developed to detect acute kidney injury hours faster, allowing for earlier intervention and better management of chronic kidney disease. The test uses patented DNA aptamers to directly investigate structural kidney damage.
Catching Alport syndrome through universal age-3 urine screening
Researchers found that over 30% of children referred for Alport syndrome testing at age 3 already required therapeutic intervention, highlighting the potential benefits of early detection. The study suggests introducing a urine testing system may enable intervention before kidney dysfunction onset.
Kidney organoid unlocks genetic cause of chronic kidney disease
Researchers have discovered that APOL1 mutations impair mitochondrial function in podocytes, leading to impaired kidney filtering. This finding could explain why inflammation triggers the onset of AMKD in patients, paving the way for targeted treatments.
Study links shift work to higher risk of kidney stones, influenced by lifestyle factors
A study published in Mayo Clinic Proceedings found that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor. Lifestyle factors such as BMI, fluid intake, and smoking habits significantly contribute to the occurrence of kidney stones.
Stem cells may offer new hope for end-stage kidney disease treatment
Researchers at Mayo Clinic found that transplanting patients' own stem cells into their veins can help prevent inflammation and vein narrowing in patients with end-stage kidney disease. This could extend the time before dialysis is required, reducing healthcare costs and improving patient outcomes.
Heat and toxic exposures could harm kidneys in agricultural workers
A new study by the University of Arizona found that heat exposure and toxic metal exposure can increase signs of kidney injury in agricultural workers. The study suggests that providing mandatory breaks, water, electrolyte replacement, and restrooms nearby can help prevent heat-related illnesses and kidney damage.
Discovery of new ciliary proteins suggests link between cell antennae and chronic diseases
Researchers at the University of Copenhagen discovered two new ciliary proteins that regulate cell communication and may lead to the development of new treatments for chronic diseases. The study found that defective cilia can disrupt signaling in almost all tissues and organs, leading to various diseases.
Alliance webinar highlights latest advances in cancer treatment
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
Study used AI models to improve prediction of chronic kidney disease progression to end stage renal disease
Researchers used AI models with integrated clinical and claims data to predict chronic kidney disease (CKD) progression to end-stage renal disease (ESRD). The study found that the models outperformed single data source models and reduced racial bias. The findings can inform likelihood and management of CKD, supporting targeted interven...
USC Stem Cell scientists unlock blueprint for lab-grown kidney cells with preclinical value
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...