A new study reveals metabolic-associated kidney disease among young girls and women, and those without heat exposure in Nicaragua. The research found a greater prevalence of poor kidney health among young girls and women than previously known, and risk factors for kidney disease are present at younger ages.
A new study published in the Journal of Vascular and Interventional Radiology found that kidney-sparing embolization is associated with lower rates of acute kidney injury and in-hospital mortality compared to nephrectomy in patients with high-grade kidney injuries. The study analyzed 849 cases and found that embolization reduced in-hos...
A study of 1.6 million patients found that the risk of developing chronic kidney disease or heart failure increases substantially over time after a type 2 diabetes diagnosis. Early, proactive management is crucial to reduce the risk of serious complications.
The PKD Foundation has awarded a two-year grant to support research by USC Stem Cell faculty member Zhongwei Li, aiming to develop lab-made tissue for autosomal recessive polycystic kidney disease (ARPKD) research. The project will utilize organoids and assembloids to model the disease and test potential treatments.
Researchers found that frailty is associated with a higher risk of cognitive impairment in men with mild to moderate CKD, but not in women. Men with frailty had more than twice the risk of developing cognitive impairment compared to non-frail men.
Dr. Katherine Tuttle's pioneering work has transformed the treatment of chronic kidney disease, reducing risks of kidney failure and cardiovascular events. Her research has established SGLT2 inhibitors and GLP-1 receptor agonists as breakthrough therapies for CKD and cardiovascular-kidney-metabolic syndrome.
Researchers at the University of Münster have found that using biomarkers to identify high-risk patients can significantly reduce the risk of kidney damage after major surgery. The approach has great potential to help sepsis patients too, and the team is working to incorporate these findings into international guidelines for the treatm...
Researchers analyzed 8.1 million emergency department visits to identify the most at-risk patients during heat waves, offering a near-real-time opportunity to implement protective measures. The study suggests that delays in identifying those most at-risk are no longer necessary, and timely evidence is increasingly essential for effecti...
Txn1 mutant rats exhibit severe kidney deterioration, with hallmarks of human CKD, including oxidative stress, mitochondrial dysfunction, and inflammation. The study identifies a link between chronic thioredoxin deficiency and CKD progression, suggesting promising therapeutic approaches.
The global burden of chronic kidney disease in women has grown, with 359 million cases in 2021, driving increasing mortality rates and disability-adjusted life years. Postmenopausal women and women of reproductive age are particularly vulnerable to metabolic and behavioral drivers that can be modified to reduce risk.
The RadiCaL study, the first randomized trial of a radiopharmaceutical in kidney cancer, found that adding radium-223 to the standard of care does not improve skeletal event-free survival. Patients who received the combination treatment lived a median of 28.3 months, compared with 19.7 months for those who received cabozantinib alone.
A study published in PLOS Medicine found that British Bangladeshi and British Pakistani individuals are more likely to develop multimorbidity, a condition where people experience multiple chronic illnesses simultaneously. The research identified sociodemographic and genetic factors that increase the risk of developing these conditions,...
Researchers found that severe periodontitis was associated with reduced kidney function and increased albuminuria, even at early stages of chronic kidney disease. Systemic inflammation partially explained this relationship, but additional biological mechanisms are also likely involved.
A new study published in Nature links casdatifan, an investigational HIF-2a inhibitor, to improved clinical outcomes in metastatic clear cell renal cell carcinoma (ccRCC) patients. Deep suppression of serum EPO correlated with higher response rates and longer progression-free survival.
A new study by NYU Langone Health researchers found that nearly half of Americans with kidney failure who are referred for transplantation never begin the process required to be considered for a new organ. The study analyzed data from over 720,000 patients and found that those who were unmarried, had severe obesity, or lived in rural a...
Researchers successfully generated rat-derived kidneys in mice using interspecies blastocyst complementation, demonstrating potential for growing transplantable human organs in larger animals. The study represents an important step toward addressing global kidney shortages.
The new clinical guideline identifies excess weight, especially in the abdomen, as a key driver for cardiovascular-kidney-metabolic syndrome. Nearly 9 in 10 adults in the US have at least one condition within this syndrome, which includes high blood pressure, abnormal cholesterol and metabolic conditions like diabetes and obesity.
The new clinical practice guideline provides recommendations for identifying cardiovascular-kidney-metabolic (CKM) syndrome risk earlier and taking action to protect long-term heart, metabolic, and kidney health. Lifestyle modification, including the American Heart Association's Life's Essential 8 measures, can help prevent a range of ...
LRBA deficiency, a rare inherited condition, impairs kidney function by disrupting water and sodium balance, leading to polyuria and electrolyte abnormalities. Treatment with desmopressin may help manage excessive urination in some patients.
In an exploratory analysis, finerenone was found to slow kidney function decline, reduce albuminuria, and lower the risk of kidney failure or substantial loss of kidney function in patients with glomerular diseases. These findings suggest a crucial role for finerenone in preserving kidney function in this population.
A study found that even low levels of particulate matter in the air increased hospitalization risk for men with kidney diseases. Men aged 19-50 were most at risk, with prolonged exposure to high concentrations increasing the risk of chronic kidney disease and acute kidney injury.
Researchers at USC have created complex lab-grown kidney models, known as human synthetic kidney organoids (hSKOs), which can mimic the filtering and urine-collecting functions of a real kidney. The team plans to study how these mini-kidney structures mature over time and test their ability to carry out key kidney functions.
A Brown University study found that expanded Medicaid coverage significantly improves one-year mortality rates for young adults with kidney failure. The researchers discovered improvements in pre-dialysis care, increased use of dialysis, and longer dialysis sessions, all leading to better long-term health outcomes.
A cluster randomized trial found comparable improvements in 6-month outcomes between intervention and control groups, indicating no independent effect of the clinical decision support system. The study suggests that other factors may be responsible for the observed benefits.
A study published in Frontiers in Ecology and Evolution found that optimal birth weight for minimal kidney damage during extreme endurance events is around eight pounds. Individuals with lower or higher birth weights may face a greater risk of kidney stress or damage.
Scientists create a novel nano-delivery system that boosts NAD+ synthesis and reduces consumption, rapidly restoring energy metabolism in damaged kidneys. The approach halts disease progression and prevents chronic kidney disease, offering a promising drug development platform for AKI and other energy metabolism disorders.
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
This study reveals that HDAC3 epigenetically represses RASAL1, a key antifibrotic regulator, leading to enhanced fibroblast activation and extracellular matrix deposition in renal fibrosis. Restoring RASAL1 expression or inhibiting HDAC3 activity attenuates renal fibrosis.
Scientists at Buck Institute for Research on Aging developed an orally administered small molecule that completely prevents calcium oxalate kidney stones, protects against kidney failure, and fully restores normal survival in a mouse model of Primary Hyperoxaluria Type 2. The drug candidate, N-propargylglycine (N-PPG), targets a key en...
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
Researchers have discovered a new biomarker for immunoglobulin A (IgA) nephropathy, which is an autoimmune disease that can lead to kidney failure. Complement pathway proteins, including CFHR1, were found to be overexpressed in patients with IgA nephropathy, suggesting a potential treatment target and diagnostic marker.
Research found that people who spend a higher proportion of their total physical activity doing vigorous activity have substantially lower risks of all eight serious health conditions. The benefits of vigorous activity remained even when the amount of time was modest.
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
A recent study found that B-type natriuretic peptide is independently associated with chronic kidney disease progression in individuals with diabetes. Combining BNP with urinary markers such as UACR improves risk prediction, highlighting its potential role in early detection and management of kidney disease.
Researchers discovered VISTA as a critical immune checkpoint that balances immune activation and inflammation resolution during kidney injury. Administering exogenous VISTA protein shows potent protection against acute kidney injury and its progression to chronic disease.
A new study from Columbia University Vagelos College of Physicians and Surgeons has found that analyzing the APOL1 gene in Black patients with kidney disease can provide more accurate diagnoses. The study suggests that incorporating M1 into routine APOL1 genetic testing could help doctors determine the true cause of a patient's kidney ...
Researchers found elevated pTau levels in individuals with transthyretin amyloidosis and immunoglobulin light-chain amyloidosis, suggesting a new diagnostic approach for systemic amyloidosis. The findings may facilitate earlier detection and help confirm suspected cases.
ISM4808, a PHD inhibitor for chronic kidney disease-related anemia, has achieved its first milestone with successful completion of the Phase I clinical trial. The treatment stimulates endogenous erythropoietin production and improves iron utilization, offering improved efficiency and safety compared to existing treatments.
A nationwide Danish study comparing outcomes between patients treated with minimally invasive ablation and surgery found no difference in cancer progression but more frequent local recurrence of the disease following ablation. Ablation patients had shorter hospital stays and fewer complications.
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
The American Heart Association reports that millions of US adults with diabetes are unaware they have it, while nine in ten with chronic kidney disease do not know they have it. Regular screening can catch problems early, with approximately 80% of heart attacks and strokes being preventable.
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
A nationwide cohort study found that chronic kidney disease significantly heightens mortality risk, even at moderate levels, and exceeds traditional metabolic risk factors. Maintaining renal function and early detection of CKD are critical for reducing both all-cause and cardiovascular mortality.
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly lowers risks of limb events, cardiovascular events, all-cause mortality, and kidney disease progression compared to dipeptidyl peptidase-4 inhibitors in patients with diabetes. GLP-1 RAs are preferred for secondary prevention in this high-risk population.
Salk Institute scientists discover that dietary supplementation of the amino acid methionine protects infected mice against inflammation-related wasting, blood-brain barrier dysfunction, and death. Methionine boosts kidney filtration, reducing circulating cytokine levels and improving disease outcomes.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
Researchers developed a highly sensitive blood test that can detect initial thrombin generation, a key trigger in blood clot formation. The test distinguishes between pathway-specific clotting abnormalities and suggests personalized treatment strategies, potentially predicting clinical outcomes.
Researchers have developed a web-based tool to identify people at risk of developing chronic kidney disease through subtle abnormalities in kidney function. The study shows that individuals with an eGFR below the 25th percentile had a markedly higher risk of developing kidney failure.
A new study found that light intensity activities, such as walking or household chores, were associated with a lower risk of death for people with CKM syndrome. The researchers used data from the National Health and Nutrition Examination Survey to compare activity level duration for each CKM syndrome stage.
Early recognition of cast nephropathy through novel biomarkers can guide timely treatment, while tailored extracorporeal therapies show promise in preventing irreversible kidney damage. The review emphasizes the need for standardized biomarker-guided pathways and multicenter trials to advance personalized kidney support.
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Insilico Medicine and Taigen Biotechnology collaborate to develop and commercialize ISM4808, an AI-driven PHD inhibitor for treating anemia of Chronic Kidney Disease (CKD). The partnership grants TaiGen exclusive rights for further development, commercialization, and sub-licensing in the Greater China area.
A study published in JAMA Network Open found that older adults with chronic kidney disease or cerebrovascular disease are at double the risk for developing neuroinvasive West Nile virus infection, which can lead to paralysis and death. The study identified several risk factors, including male sex, immune suppressants, and multiple scle...
Researchers from the University of Missouri-Columbia have identified several genes that may be potential therapeutic targets for Chronic Kidney Disease (CKD) by regulating gene activity. These genes are involved in the signs of kidney damage, including fibrosis and inflammation.
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
The book covers genetic, epigenetic, and molecular foundations of renal dysfunction, as well as microbiota, immune interactions, and nephrotoxicity. It also highlights novel therapies and precision medicine approaches for better diagnostic and treatment strategies.