A research team has developed a reliable and economical method for studying proteins with sugar molecules attached to them in blood and tissue samples. The method uses commercially available magnetic particles and has the potential to aid in disease diagnosis and treatment.
Researchers have documented glycan-glycan interactions between gangliosides and their impact on EGF receptor dimerization and activation. This study provides a new mechanism regulating EGFR activity, which may have implications for future cancer research.
Researchers developed a new cell-based approach to produce several sugars naturally found in human breastmilk, including complex oligosaccharides. The method involves engineering cultured mammalian cells to express essential enzymes, allowing for the production of structurally diverse HMOs with potential applications in infant nutrition.
Researchers discovered branched O-mannose glycans play a crucial role in maintaining nodes of Ranvier and efficient nerve signaling. The study found that these sugar structures help preserve the narrow architecture required for fast and reliable communication.
A team of scientists discovered that the mannose pathway plays a crucial role in regulating cell fate decisions in low glucose environments, particularly in cancer cells. They found that reducing mannose pathway activity led to impaired N-glycan biosynthesis and activated pro-survival signals, which can contribute to cancer progression.
Researchers at the Institute for Glyco-core Research discovered how FUT8 is regulated by proteases SPP and SPPL3, essential for core fucosylation. This understanding may lead to new treatments targeting this cellular pathway, particularly in cancer and immune disorders.
A brain-specific enzyme reshapes protein-linked sugar chains to facilitate the formation of complex glycans essential for normal brain function. This process is critical for efficient keratan sulfate formation and has implications for research into glycan-related brain disorders.
Researchers investigated GnT-V, a cancer-related glycosylation enzyme, and found its selectivity relies on protein structure and subcellular trafficking. Two enzymes, metalloproteases, were identified as major substrates in the kidney.
A team of researchers has revealed the molecular mechanisms underlying the binding of small extracellular vesicles to host cells, which could lead to the development of more effective cancer treatments. The study found that EVs primarily bind to laminin via CD151-associated integrin heterodimers and GM1, eliciting responses in recipien...
Researchers discovered a new process by which cancer cells use small extracellular vesicles to spread to healthy tissue. The study found that these vesicles are primarily internalized by clathrin-independent endocytosis via galectin-3, which is facilitated by an increase in intracellular calcium concentration.
Researchers uncover the relationship between lysosomal exocytosis and focal adhesions, structures critical for cell anchoring and communication. The study identifies MYO18B as a key regulator of lysosomal exocytosis through focal adhesion maturation.
Researchers found that glycans attached to glycosylation enzymes' lectin domains inhibit the enzymes' activity, leading to self-regulation of their own biosynthesis. This unique mechanism sheds light on how glycosylation enzymes choose their substrate proteins in cells.
A team of researchers developed a new chemical reaction to synthesize ADP- and ATP-containing molecules with high yields, overcoming limitations of traditional methods. The reaction uses a hydrolysis-stable reagent and achieves reproducible access to these molecules.
Researchers discovered Pradimicin A's molecular basis for binding to viral N-glycan, showing promise as an anti-SARS-CoV-2 drug. The compound inhibits SARS-CoV-2 infectivity by interacting with branched oligomannose-containing glycans.
Biologists discovered a key enzyme's interaction with a small structure in glycans that contributes to the malfunctioning of carbohydrates' attachment process. This process is essential for numerous physiological processes and can lead to diseases such as cancer, diabetes, Alzheimer's, and muscular dystrophy.
Researchers discovered two novel GNE gene mutations that may cause a rare blood disorder called macrothrombocytopenia. The mutations affect the synthesis of sialic acid, critical for brain development and angiogenesis. Further studies are needed to understand the mechanism underlying this disorder and explore therapeutic interventions.
Researchers provide new insights into STING's function in innate immunity, revealing its role as a scaffold that activates TBK1. They also found that cholesterol plays a crucial role in STING clustering and activation, offering a potential target for treating diseases associated with STING inflammation.
Researchers at iGCORE in Japan developed two synthetic versions of an ADP-ribose fragment to study cellular functions. The approach enables the production of structurally well-defined oligo- and poly(ADP-ribose) samples, accelerating ADP-ribose biology research.
Researchers have created an 'immune cell map' that reveals the origin of neutrophils' subcellular response to microbes. The study found that a specific type of glycoprotein is responsible for the restricted subcellular origin, and this discovery may lead to refined personalized immune responses.