Articles tagged with Kidney
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study found that astronauts' kidneys are 'remodelled' by space flight, with permanent damage and loss of function possible after extended periods. The researchers' findings highlight the importance of kidney health in space travel and may lead to the development of new technologies or pharmaceutical measures to protect astronauts.
Researchers at Duke University created an ultrathin silk membrane that helps cells grow into functional tissues used for research, enabling the development of kidney disease models. The new membrane improves communication and growth between cells, mimicking natural human organ structures.
Researchers found that 6% of patients with heart failure progressed to dialysis within a year, highlighting the need for integrating heart and kidney care. The study emphasizes prioritizing kidney function assessment in all patients with heart failure and promoting systemic changes to manage both conditions simultaneously.
A new study published in JAMA suggests that kidneys from deceased donors on dialysis can be safely transplanted into recipients, reducing the pool of available donors. The study found no significant difference in transplant failure or death rates between recipients of kidneys from donors with and without dialysis.
The SELECT Trial found semaglutide to significantly reduce the risk of kidney-related complications and improve kidney function in individuals with overweight or obesity and cardiovascular disease. The study revealed that semaglutide's ability to prevent macroalbuminuria was a key factor in reducing kidney-related events.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
A groundbreaking study reveals semaglutide significantly reduces the risk of major kidney disease events, cardiovascular outcomes, and all-cause mortality in patients with type 2 diabetes and chronic kidney disease. Semaglutide also shows improved safety and efficacy profiles.
After living kidney donation, donors experience a slower rate of estimated glomerular filtration rate (eGFR) decline compared to non-donors. However, donors are more likely to have an eGFR between 30-60 mL/min/1.73 m2 at least once during follow-up.
Receiving a kidney from a deceased donor who underwent dialysis prior to donation was associated with delayed graft function, while other factors such as graft failure and death were not significantly affected. The study found no significant differences in outcomes between these two groups.
The first pig-to-human kidney xenotransplants detected early signs of antibody-mediated rejection and showed human immune cells rapidly infiltrating the transplanted kidneys. However, the transplanted kidneys also began to repair themselves, with gene expression associated with cell proliferation observed within 24 hours.
A new study led by UT Health San Antonio found that long-term ketogenic diets can induce senescence, or aged cells, in normal tissues, affecting heart and kidney function. However, an intermittent ketogenic diet regimen eliminated these pro-inflammatory effects.
Chronic kidney disease patients at a US-based academic medical center experienced significant sex disparities in primary care management. Females received poorer care compared to males, highlighting the need for further examination of these differences.
A new study analyzed 500,000 individuals and found a strong statistical association between rDNA copy number and well-established markers of systemic inflammation, as well as kidney function. The research suggests that wider genome analysis could bring opportunities for preventative diagnostics and novel therapeutics.
Almost 90% of U.S. adults met criteria for cardiovascular, kidney, and metabolic syndrome (CKM) stage 1 or higher, with 15% meeting advanced stage criteria that did not improve between 2011 and 2020. Advanced stages were associated with increased risk among older age, men, and Black adults.
Researchers, led by Masako Suzuki, aim to understand the effect of dysregulated vitamin D metabolism on preterm infant kidney development. They will study the genome and transcriptome to gain insights into how vitamin D affects podocyte differentiation during preterm development.
Researchers have identified 12 new quinoline and isoquinoline alkaloids with anti-inflammatory properties and the ability to reduce renal fibrosis in cell cultures. These findings could provide a lead for developing treatments for chronic kidney disease, according to the study published by the American Chemical Society.
A Mayo Clinic study found that laparoscopic sleeve gastrectomy can improve the health and eligibility of patients with advanced chronic kidney disease and obesity. The procedure reduced cardiovascular risks, including diabetes and hypertension, and improved access to kidney transplantation.
A team of researchers has developed a hemostasis sponge that swiftly staunchs kidney bleeding and facilitates wound recovery. The material uses kidney-derived decellularized extracellular matrix to recreate the kidney's microenvironment, boasting high biocompatibility.
The study, published in Cell Stem Cell, improves the growth of nephron progenitor cells (NPCs) using a chemical cocktail, enabling sustained growth in a simple 2-dimensional format. The breakthrough has potential for advancing kidney research and discovering new treatments.
A Swedish study published in JAMA Network Open found that over one million newborns were given unnecessary antibiotics for suspected sepsis despite a reduction in sepsis cases. The researchers argue that the treatment burden is too high, suggesting potential to reduce antibiotic use.
A combined mechanical heart pump and gene-edited pig kidney transplant has given new hope to a patient with heart and kidney failure. The surgery was performed in two stages, first implanting the heart pump and later transplanting the gene-edited pig kidney. This innovative approach has shown promise for patients who would otherwise no...
The Kidney-CHAMP study found that the intervention helped primary care physicians identify and triage patients with kidney disease, improving patient access to specialists and educational materials. Despite a null result, the study's findings suggest that the framework is scalable and provides equitable access to healthcare.
Researchers developed a new computer method to clarify the question of whether protein excretion in the urine is caused by severely damaged or moderately damaged glomeruli. The technique uses three-dimensional image processing and a highly parallelized geometric algorithm to determine the fastest route on a two-dimensional map.
Researchers discovered that participants with elevated TMAO blood levels were at increased risk for future development of chronic kidney disease, even after adjusting for other known risk factors. The study also found a faster rate of declining kidney function in people with normal or impaired kidney function.
A study published in JCI Insight reveals that an unexpected mechanism is responsible for the loss of kidney cells' ability to filter toxins from blood in primary membranous nephropathy. The researchers found that signaling in the C3a/C3aR pathway plays a critical role in disease progression.
Researchers at NTU Singapore successfully grew 'mini kidneys' in the lab, grafted them into live mice, and found a potential treatment for polycystic kidney disease by boosting autophagy. The study suggests that minoxidil could be used to reduce cysts in the novel mouse model.
A meta-analysis of 11 trials involving 78,607 patients found a 9% reduction in major adverse cardiovascular events (MACE) and a 14% reduction in cardiovascular death with SGLT2 inhibitors. The analysis showed consistent effects across patient groups and subgroups.
Researchers have shown that a single normal copy of a defective gene can prevent cysts in polycystic kidney disease. Additionally, they found that a type of drug called a glycoside can sidestep the effects of the defective gene and prevent cyst formation.
A study found that structural racism is largely to blame for disparities in tuberculosis (TB) incidence among the U.S.-born population. Researchers analyzed national TB registry data and found that TB incidence ratios were higher for certain racial and ethnic groups, with greater relative disparities among females.
A new machine learning tool, PO-AKID-teller, can accurately predict patients at risk of acute kidney injury requiring dialysis after aortic dissection surgery. The model provides an interpretable explanation of the predicted risk, enabling clinicians to make informed decisions.
A systematic review of 35 years of medical literature finds that poverty is the primary reason people sell their kidneys, while lack of information, debt, and altruism also contribute. Regional variation exists, with poverty being the main driver in the Indian Subcontinent and brokers playing a significant role in other countries.
Researchers created a risk prediction model using patient data from six major US cancer centers. The model found that patients with high blood pressure, diabetes, and lower magnesium levels were at highest risk of moderate-to-severe kidney injury. The tool can help clinicians and patients make informed decisions about cisplatin treatment.
Researchers identified the WWP2 gene as crucial for regulating energy supply to cells responsible for renal failure. Inhibiting this gene may slow kidney damage and halt disease progression.
A recent study in Florida found that nearly all farm workers were dehydrated at the end of their shifts and more than half remained dehydrated the following morning. The researchers emphasized the need for stricter federal regulations and smaller interventions to address this issue.
A five-day course of inorganic nitrate significantly reduces contrast-induced nephropathy rates, improves three-month renal function, and lowers one-year major adverse cardiac events. The trial also shows improved kidney outcomes at three months compared to placebo.
Research highlights new findings on social vulnerability and survivorship after colorectal cancer resection, as well as disparities in kidney recovery among Black donors. Additionally, studies reveal cost savings from implementing quality interventions and explore eligibility for transplants in obese patients with end-stage renal disease.
A study by Linköping University found that a daily intake of liquorice containing 100mg glycyrrhizic acid raised blood pressure by an average of 3.1mmHg in young healthy people. This effect was seen in all participants, but the most sensitive individuals showed increased fluid volume and heart workload.
A collaborative study found that patients with end-stage renal disease who undergo weight loss surgery can experience significant improvements in BMI, hypertension, and diabetes management. This enhancement of overall health and transplant viability offers hope for previously ineligible patients.
A U.S.-Canadian research collaboration identified common blood changes as a risk factor for acute kidney injury (AKI) in over 1 in 5 hospitalized adults. The discovery may lead to new, more effective treatments for AKI and prevent its progression to end-stage renal disease.
A new study found that dialysis facilities serving high-risk populations are more likely to receive lower reimbursement under the End-Stage Renal Disease Treatment Choices Model. The rate of home dialysis and transplant waitlisting is also lower among these facilities.
Researchers at Johns Hopkins Medicine have reported promising results from a clinical trial testing a novel immunotherapy combination to target advanced, potentially lethal skin cancers in kidney transplant patients. Two out of six patients experienced complete tumor regression after adding a second checkpoint inhibitor to the regimen.
A team of researchers from Aarhus University has developed a simple measurement of protein in the urine that can predict which individuals are at high risk of rapid progression of chronic kidney disease. The study found that patients with newly diagnosed mild to moderate chronic kidney disease within three years have a 15% risk of rapi...
Researchers analyzed tissue and fecal samples from 90 stranded marine mammals to study the distribution of toxic elements. The study found that Risso's dolphins and short-finned pilot whales had high concentrations of mercury, cadmium, and lead, while dwarf sperm whales had low levels.
Segregated neighborhoods contribute to racial disparities in live donor kidney transplantation. Targeted interventions, such as community outreach clinics, can help mitigate these effects and promote equitable access.
A recent study found that a commercial machine learning tool was moderately successful in predicting hospitalization-related kidney injury, but struggled to identify high-risk patients. The tool performed better for low-risk patients and Stage 1 HA-AKI cases.
Researchers developed a high-speed modulation system combining digital display with super-resolution imaging, significantly improving lateral and axial resolution. This enables detailed study of subcellular structures in animal cells and plant ultrastructures, paving the way for future biological discoveries.
A recent analysis of the AWAKEN study data found that repeat episodes of acute kidney injury in hospitalized infants do not increase the risk of death but can extend hospitalization. The study suggests that initial AKI is already dangerous and long-term effects are still under investigation.
Research found that boosting weekly total physical activity by just over an hour is associated with a 33% lower risk of progression to chronic kidney disease. The study also showed that longer bouts of moderate-intensity exercise, even those below 10 minutes, contribute to better outcomes.
Researchers found that SGLT2 inhibitors reduced kidney stone rates by 30% compared to GLP1 agonists and 25% compared to DPP4 inhibitors. The study included data from 716,406 adults with type 2 diabetes who took these medications.
A study of over 1.6 million ED visits found that nearly two-thirds of low-risk pulmonary embolism patients were hospitalized, despite evidence suggesting safety in outpatient management. Researchers suggest further investigation into ED triage decisions to improve appropriate use of outpatient care.
Researchers found combining common immune-suppressing drugs with a complement inhibitor effectively managed the initial human immune response against transplanted pig kidneys. The regimen, which relies solely on already FDA-approved medications, showed remarkable success in Parsons model case series.
A survey study found a lower rate of overall fractures among living kidney donors, yet an increased incidence of vertebral fractures after 25 years following donation. Treatment with dietary supplements may help alleviate these issues and patient morbidity.
A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.
Regular NHS Health Checks are associated with reduced risks of dying and developing long-term diseases like dementia and liver cirrhosis. The study analyzed data from 97,204 UK Biobank participants and found that attendees had lower diagnosis rates for these conditions, including a 19% lower rate of dementia diagnosis.
Researchers develop compound that reduces size of kidney cysts and improves kidney function in mouse models of ADPKD. The compound, originally designed to treat cancer, works by exploiting kidney cyst cells' vulnerability to oxidative stress.
Researchers developed an AI-driven algorithm that accurately predicts death and complications after percutaneous coronary intervention (PCI). The tool uses patient feedback to provide a patient-centered, individualized risk prediction score.
Chronic kidney disease and cardiovascular disease significantly worsen prognosis for severely burned patients. The study analyzed data from 1,193 patients and found that nearly half did not survive their burns with impaired kidney function. Researchers highlight the need to integrate these findings into burn treatment scores.
High adolescent BMI significantly increases the risk of developing early chronic kidney disease in young adulthood, according to a recent study published in JAMA Pediatrics. Researchers emphasize the need for preventive measures and management of risk factors associated with CKD in adolescents with elevated BMI.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
Researchers from Osaka University have discovered a link between the rare D-form of the amino acid alanine and the circadian clock's influence on glucose metabolism in the kidney. The study found that D-alanine regulates gluconeogenesis, a process that creates new glucose to maintain energy levels, and is mediated by the protein Cry2.