Research on kidney function and disease. Covers kidney-failure prevention, gestational diabetes links, environmental risks, and gum-kidney connections.
Researchers at the University of Virginia Health System have identified a crucial biological switch that regulates renin production in certain cells, allowing them to control blood pressure. This discovery provides important direction for future research into high blood pressure and cardiovascular disease treatment.
A Cleveland Clinic study found bariatric surgery to be more effective in protecting kidney function and reducing the risk of kidney failure compared to GLP-1 medications. The study showed a 60% lower risk of progression of kidney disease and a 44% lower risk of developing kidney failure or death.
Researchers found that gold nanoparticles can accurately assess kidney injuries using X-rays, correlating with nanoparticle accumulation. However, caution is needed when employing nanomedicines to patients with compromised kidneys.
A recent study found that using a handheld ultrasound device to nudge patients' kidney-stone fragments can significantly lower their risk of returning for another operation within five years. The procedure has been shown to reduce the recurrence rate by 70% in patients with small fragments remaining in the kidneys.
Researchers at Kyoto University have developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip that mimics in vivo renal physiology. This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity.
The grant will create the Urinary Stone Disease Hub, combining medical expertise across adult and pediatric urology and nephrology, informatics, and AI to establish a novel data resource. The hub will include clinically important information from CT images, clinical notes, stone composition, and 24-hour urine labs.
Researchers from Aarhus University developed a new method to predict which patients with chronic kidney failure are at risk of losing kidney function over time. The method analyzes acid-base balances in urine samples, revealing early signs of acid buildup that can be harmful to kidney function.
The study found that semaglutide was effective in preventing heart attacks and other major adverse cardiovascular events as well as death in adults with impaired kidney function. The results showed a significant reduction in cardiovascular disease risk with semaglutide, even among those with poor kidney function.
Scientists at St. Jude Children's Research Hospital have elucidated the structural mechanism of URAT1, a protein linked to gout, using cryo-electron microscopy. The findings reveal how URAT1 transports urate and offer new insights for developing more effective treatments for gout.
F18-FDG PET-CT scans showed significantly higher levels of radioactively-labeled glucose in kidneys for patients with ICI-AKI compared to those with AKI from non-ICI causes. This suggests a potential non-invasive testing option for differentiating cause of AKI as being ICI-related vs. non-ICI-related.
Researchers have identified key cellular interactions and microenvironments that contribute to the development of chronic kidney disease (CKD) after acute kidney injury (AKI) in mice. The study, published in Nature Communications, provides new insights into how damaged cells interact within disease-promoting microenvironments.
Researchers created a mouse model to study relative energy deficiency in sport (REDs), revealing the syndrome impacts the entire body and affects males and females differently. REDs leads to hormonal and reproductive issues, insomnia and fatigue, bone weakness and injury, and anxiety and depression.
A new study by NYU Langone Health found that the risk of death for kidney donors has decreased significantly since the 1990s, with fewer than one death occurring for every 10,000 donations. Donors who were male and had a history of high blood pressure were more likely to die within 90 days of surgery.
After three decades, perioperative mortality rates for living kidney donors have decreased substantially, from fewer than 1 event per 10,000 donations in the past decade to even lower numbers. Donor demographics, such as male donors and those with a history of hypertension, are identified as high-risk groups.
Researchers have made a significant breakthrough in vasculitis research using AI-powered big data techniques, enabling more precise identification of disease patterns. The study offers new insights into the diagnosis and treatment of systemic vasculitis, a group of rare autoimmune diseases.
Researchers at Washington State University developed an AI algorithm that optimizes 3D printing settings, reducing time and cost for engineers. The algorithm improved the accuracy and quality of printed models, particularly for complex biomedical devices like kidneys and prostates.
A Vanderbilt University Medical Center study found that higher thiazide doses significantly lower urine calcium, leading to fewer symptomatic kidney stone events. The researchers suggest monitoring calcium excretion while on thiazide therapy to adjust dose and diet.
A University of Gothenburg study found that occupational exposure to particles in the construction industry may increase the risk of chronic kidney disease. Construction workers exposed to high levels of dust and particles were about 15% more likely to be diagnosed with the condition.
A new risk prediction scale specifically for American Indian adults found elevated heart failure rates compared to other population groups. The analysis identified Type 2 diabetes status, kidney damage, and high blood pressure as major modifiable determinants of developing heart failure over 5-10 years.
The new center aims to build on Columbia's groundbreaking work in developing innovative diagnostics and treatments for rare kidney diseases. It will also provide expert care to patients with glomerular disease and expand education and training for medical professionals through a fellowship program.
A Leipzig study found that chronic kidney disease (CKD) activates microglial cells, disrupting potassium balance in nerve cells and leading to cognitive impairment. Researchers identified a mechanism involving the blood-brain barrier and potential therapeutic targets.
A Berlin-led research team has discovered that a small population of immune cells called innate lymphoid cells (ILCs) trigger severe kidney inflammation in patients with lupus. ILCs, which are present in the kidneys, amplify organ damage when activated by NKp46 receptors.
Researchers analyzed 51,000 transplants and found rejection and graft failure rates were similar for toxoplasma-positive and negative donor kidneys. The study suggests it is safe to transplant toxoplasma-positive kidneys with additional monitoring, potentially increasing the supply of donor kidneys.
A five-year randomized control trial found that diets high in fruits and vegetables lower blood pressure, reduce cardiovascular risk, and improve kidney health. The study also suggests that incorporating fruits and vegetables into treatment plans can be more effective than traditional medication approaches.
A new DNA-powered signal amplification technology called ACE significantly enhances the sensitivity of mass cytometry, enabling the detection of multiple proteins in single cells. This breakthrough allows researchers to investigate complex biological processes and study immune cell functions with unprecedented depth.
A recent study published in ESC Heart Failure found that kidney dysfunction can be used as a criterion to stratify patients requiring implantable defibrillators. The research identified two key independent predictors for the risk of sudden cardiac death: left ventricular ejection fraction and estimated glomerular filtration rate.
A newly developed imaging system has allowed researchers to visualize ATP production and utilization in different kidney cell segments. The study found distinct ATP synthesis pathways in proximal tubules and podocytes, suggesting targeting these pathways could lead to more effective treatments for kidney diseases.
A new combined cell therapy for kidney transplants uses a combination of bone marrow cells from the donor and Treg cells from the recipient to reduce the donor-specific reaction. This approach preserves the overall diversity of the T-cell receptor repertoire, crucial for immune defence.
Researchers found that bowel movement frequency is linked to long-term health, with younger people, women, and those with lower BMI tending to have less frequent bowel movements. The study also showed associations between bowel movement frequency and chronic disease risk, mental health history, and gut microbiome composition.
Researchers from Aarhus University have developed a method that can detect the earliest changes in the kidney when scar tissue begins to form. This technology uses hyperpolarized 13C-pyruvate MRI to track fibrosis formation, allowing doctors to start treatment earlier and potentially prevent damage.
A UCLA-led team created a machine-learning model that can accurately predict short-term CRRT survival, providing a data-driven tool for clinical decision-making. The study aims to improve patient outcomes and resource use by serving as a basis for future clinical trials.
Researchers have developed a novel metasurface platform with aggregation induced emissions (AIE) biosensors to enhance human serum albumin detection in urine tests. The system improves readings and reduces consumption, making large-scale surveys more accessible.
Researchers found that combining sodium glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists reduces the risk of major adverse cardiovascular events and chronic kidney disease progression by 11% and 33%, respectively. The study suggests using this combination to further improve outcomes in patients with typ...
A study found that pay-for-performance incentives increased home dialysis use and kidney transplant rates. The End-Stage Renal Disease Treatment Choices model did not associate these outcomes with changes in racial or socioeconomic disparities.
Researchers at USC Keck School of Medicine discovered that a low-salt diet can stimulate kidney regeneration and repair in mice by targeting the macula densa region. This finding holds promise for developing a new therapeutic approach to treat chronic kidney disease, which affects millions worldwide.
A new biomarker has been discovered that can help predict which patients with clear cell renal cancer are at higher risk of recurrence. The 15-gene signature was found to be independently associated with worse disease-free survival and disease-specific survival in two large validation datasets.
A large international study of 1,042 living kidney donors found no significant differences in health indicators compared to non-donors seven years after donation. The study also provides insights into recovery time from living kidney donation, suggesting a longer recovery period than previously thought.
A new study found that astronauts' kidneys are 'remodelled' by space flight, with permanent damage and loss of function possible after extended periods. The researchers' findings highlight the importance of kidney health in space travel and may lead to the development of new technologies or pharmaceutical measures to protect astronauts.
Researchers at Duke University created an ultrathin silk membrane that helps cells grow into functional tissues used for research, enabling the development of kidney disease models. The new membrane improves communication and growth between cells, mimicking natural human organ structures.
Researchers found that 6% of patients with heart failure progressed to dialysis within a year, highlighting the need for integrating heart and kidney care. The study emphasizes prioritizing kidney function assessment in all patients with heart failure and promoting systemic changes to manage both conditions simultaneously.
A new study published in JAMA suggests that kidneys from deceased donors on dialysis can be safely transplanted into recipients, reducing the pool of available donors. The study found no significant difference in transplant failure or death rates between recipients of kidneys from donors with and without dialysis.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
The SELECT Trial found semaglutide to significantly reduce the risk of kidney-related complications and improve kidney function in individuals with overweight or obesity and cardiovascular disease. The study revealed that semaglutide's ability to prevent macroalbuminuria was a key factor in reducing kidney-related events.
A groundbreaking study reveals semaglutide significantly reduces the risk of major kidney disease events, cardiovascular outcomes, and all-cause mortality in patients with type 2 diabetes and chronic kidney disease. Semaglutide also shows improved safety and efficacy profiles.
Receiving a kidney from a deceased donor who underwent dialysis prior to donation was associated with delayed graft function, while other factors such as graft failure and death were not significantly affected. The study found no significant differences in outcomes between these two groups.
After living kidney donation, donors experience a slower rate of estimated glomerular filtration rate (eGFR) decline compared to non-donors. However, donors are more likely to have an eGFR between 30-60 mL/min/1.73 m2 at least once during follow-up.
The first pig-to-human kidney xenotransplants detected early signs of antibody-mediated rejection and showed human immune cells rapidly infiltrating the transplanted kidneys. However, the transplanted kidneys also began to repair themselves, with gene expression associated with cell proliferation observed within 24 hours.
A new study led by UT Health San Antonio found that long-term ketogenic diets can induce senescence, or aged cells, in normal tissues, affecting heart and kidney function. However, an intermittent ketogenic diet regimen eliminated these pro-inflammatory effects.
Chronic kidney disease patients at a US-based academic medical center experienced significant sex disparities in primary care management. Females received poorer care compared to males, highlighting the need for further examination of these differences.
A new study analyzed 500,000 individuals and found a strong statistical association between rDNA copy number and well-established markers of systemic inflammation, as well as kidney function. The research suggests that wider genome analysis could bring opportunities for preventative diagnostics and novel therapeutics.
Almost 90% of U.S. adults met criteria for cardiovascular, kidney, and metabolic syndrome (CKM) stage 1 or higher, with 15% meeting advanced stage criteria that did not improve between 2011 and 2020. Advanced stages were associated with increased risk among older age, men, and Black adults.
Researchers, led by Masako Suzuki, aim to understand the effect of dysregulated vitamin D metabolism on preterm infant kidney development. They will study the genome and transcriptome to gain insights into how vitamin D affects podocyte differentiation during preterm development.
A Mayo Clinic study found that laparoscopic sleeve gastrectomy can improve the health and eligibility of patients with advanced chronic kidney disease and obesity. The procedure reduced cardiovascular risks, including diabetes and hypertension, and improved access to kidney transplantation.
Researchers have identified 12 new quinoline and isoquinoline alkaloids with anti-inflammatory properties and the ability to reduce renal fibrosis in cell cultures. These findings could provide a lead for developing treatments for chronic kidney disease, according to the study published by the American Chemical Society.
A team of researchers has developed a hemostasis sponge that swiftly staunchs kidney bleeding and facilitates wound recovery. The material uses kidney-derived decellularized extracellular matrix to recreate the kidney's microenvironment, boasting high biocompatibility.
The study, published in Cell Stem Cell, improves the growth of nephron progenitor cells (NPCs) using a chemical cocktail, enabling sustained growth in a simple 2-dimensional format. The breakthrough has potential for advancing kidney research and discovering new treatments.
A Swedish study published in JAMA Network Open found that over one million newborns were given unnecessary antibiotics for suspected sepsis despite a reduction in sepsis cases. The researchers argue that the treatment burden is too high, suggesting potential to reduce antibiotic use.
A combined mechanical heart pump and gene-edited pig kidney transplant has given new hope to a patient with heart and kidney failure. The surgery was performed in two stages, first implanting the heart pump and later transplanting the gene-edited pig kidney. This innovative approach has shown promise for patients who would otherwise no...
The Kidney-CHAMP study found that the intervention helped primary care physicians identify and triage patients with kidney disease, improving patient access to specialists and educational materials. Despite a null result, the study's findings suggest that the framework is scalable and provides equitable access to healthcare.
Researchers developed a new computer method to clarify the question of whether protein excretion in the urine is caused by severely damaged or moderately damaged glomeruli. The technique uses three-dimensional image processing and a highly parallelized geometric algorithm to determine the fastest route on a two-dimensional map.