Articles tagged with Kidney
Researchers found combining common immune-suppressing drugs with a complement inhibitor effectively managed the initial human immune response against transplanted pig kidneys. The regimen, which relies solely on already FDA-approved medications, showed remarkable success in Parsons model case series.
A survey study found a lower rate of overall fractures among living kidney donors, yet an increased incidence of vertebral fractures after 25 years following donation. Treatment with dietary supplements may help alleviate these issues and patient morbidity.
A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.
Regular NHS Health Checks are associated with reduced risks of dying and developing long-term diseases like dementia and liver cirrhosis. The study analyzed data from 97,204 UK Biobank participants and found that attendees had lower diagnosis rates for these conditions, including a 19% lower rate of dementia diagnosis.
Researchers develop compound that reduces size of kidney cysts and improves kidney function in mouse models of ADPKD. The compound, originally designed to treat cancer, works by exploiting kidney cyst cells' vulnerability to oxidative stress.
Researchers developed an AI-driven algorithm that accurately predicts death and complications after percutaneous coronary intervention (PCI). The tool uses patient feedback to provide a patient-centered, individualized risk prediction score.
Chronic kidney disease and cardiovascular disease significantly worsen prognosis for severely burned patients. The study analyzed data from 1,193 patients and found that nearly half did not survive their burns with impaired kidney function. Researchers highlight the need to integrate these findings into burn treatment scores.
High adolescent BMI significantly increases the risk of developing early chronic kidney disease in young adulthood, according to a recent study published in JAMA Pediatrics. Researchers emphasize the need for preventive measures and management of risk factors associated with CKD in adolescents with elevated BMI.
Researchers from Osaka University have discovered a link between the rare D-form of the amino acid alanine and the circadian clock's influence on glucose metabolism in the kidney. The study found that D-alanine regulates gluconeogenesis, a process that creates new glucose to maintain energy levels, and is mediated by the protein Cry2.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
A recent study found that alterations in the human microbiome, including those in the gut, urinary, and salivary tracts, are linked to kidney stone formation. The research team discovered changes in these microbiomes were common among patients with kidney stones.
A clinical trial found that an experimental drug, BI 690517, reduced albuminuria in 70% of patients when paired with a standard-care medication. The study also showed that the combination of the two drugs mitigated the risk of hyperkalemia.
A study of 57,000 adults reveals racial disparities in access to living donor kidney transplants, highlighting the need for targeted interventions. The findings emphasize the importance of addressing systemic inequalities in transplant programs and centers.
Researchers at Johns Hopkins Medicine have identified six protein markers that can predict and manage acute kidney injury (AKI), a condition marked by serious inflammation. The study's findings offer hope for non-invasive assessments of AKI, potentially reducing the need for invasive kidney biopsies.
A study found childhood cancer survivors have twice the risk of developing prediabetes as the general public, increasing their risk of life-threatening diseases. Lifestyle interventions may help reduce this risk and improve their life expectancy.
A new study found that a genetic variant in the APOL1 gene reduces the risk of kidney disease in high-risk individuals, particularly those with African ancestry. The discovery may lead to reclassification of patients and expansion of potential kidney donors.
Researchers from Tokyo Medical and Dental University found that people admitted to the hospital for acute hypertension are increasingly likely to need urgent kidney dialysis or die in the hospital. The study's lead author notes that patients with certain traits, such as being younger, male, or overweight, are high-risk groups.
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.
The American College of Physicians has published a new clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus in chronic kidney disease. The guideline includes recommendations for expanding treatment with sofosbuvir-based regimens to patients with CKD glomerular filtration rate categor...
Researchers at Monash University have discovered how anti-obesity drugs like Ozempic interact with the RAGE receptor to control kidney damage in diabetes. This finding opens up new therapeutic drug targets for preventing kidney disease in people with diabetes.
Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
Researchers used 3D eye scans to detect changes in the retina and monitor kidney health, finding that thinner retinas correlated with declining kidney function. The technology has potential to support early diagnosis and aid lifestyle changes to reduce health complications.
According to a new study published in Annals of Internal Medicine, most adults who qualify for statin use for primary prevention are not receiving them. The study found that despite increased overall statin use over time, only 35% of eligible adults were taking statins between 2013 and 2018. The researchers suggest that innovative effo...
Researchers have developed a new mixture, organ agar, that enables them to screen bacteria more efficiently than traditional methods. This innovation allows for the testing of over 1,700 mutants of the UTI-causing bacteria Proteus mirabilis using only a quarter of the mice typically required.
A new Vanderbilt University Medical Center study found that thiazide diuretics were associated with a 15% lower risk of kidney stones. Higher serum calcium levels also linked to thiazides, supporting the notion that they affect kidney stone risk by modulating calcium excretion.
A randomized trial found that unfiltered traffic-related air pollution caused a rapid and significant increase in blood pressure, which persisted for more than 24 hours. The study suggests that effective cabin air filtration may reduce the negative effects of air pollution on blood pressure.
Patients with heart failure treated with dapagliflozin experienced frequent initial estimated glomerular filtration rate declines, but without increased cardiovascular or kidney event risks. The study suggests that sodium-glucose cotransporter-2 inhibitors can be safely continued in patients experiencing eGFR decline.
Treatment with obinutuzumab has been shown to preserve kidney function and prevent flares in patients with lupus nephritis. The addition of obinutuzumab to standard treatment reduced the risk of composite outcomes, such as death or treatment failure, by 60%.
A clinical study found that a ketogenic diet can improve kidney function in patients with hereditary polycystic kidney disease. After three months, positive changes were seen in key parameters, with no unexpected side effects.
Men who are overweight or obese at age 18 have a higher risk of developing 17 different cancers later in life. Higher BMI is also associated with an increased risk of mortality after cancer diagnosis for certain types of cancer.
A real-world analysis of 3,450 kidney transplant patients treated with SGLT2 inhibitors found significant reductions in kidney transplant rejection (59% less likely), kidney transplant failure (33% less likely), major adverse cardiac events (40% less likely), and mortality risk (44% less likely) over a 3-year period.
A novel multicomponent intervention aimed at improving patient access to kidney transplants did not significantly increase the rate of completed steps in a randomized clinical trial involving 20,375 patients. The study highlights the need for sustained efforts to address barriers to transplantation globally.
Sotagliflozin, a dual SGLT1 and 2 inhibitor, has been shown to reduce the risk of sustained decline in estimated glomerular filtration rate and cardiorenal composites by 38% and 23%, respectively. The findings support previously reported benefits of sotagliflozin in reducing cardiovascular events.
Results from high-impact clinical trials will be presented at ASN Kidney Week 2023, offering potential improvements in kidney-related medical care. The trials bring together leading experts and professionals to exchange knowledge and discuss the latest advances.
Researchers found a positive association between elevated urinary albumin and sub-clinical coronary artery pathology, including microcalcifications, in individuals with type 2 diabetes without symptoms of cardiovascular disease. Microcalcification activity was higher in those with albuminuria, indicating potential kidney damage.
Researchers discovered that patients with FSGS who received sparsentan treatment experienced improved kidney function and reduced proteinuria, a key indicator of kidney damage. The study suggests sparsentan may be a potential new treatment option for the disorder, offering hope for patients affected by FSGS.
A new analysis found that county-level structural racism is a significant determinant of death among individuals with kidney failure. Black patients experienced survival advantages at lower levels of structural racism but disadvantages at higher levels.
Researchers have created a comprehensive atlas of human fetal kidney development, revealing transitions between different cell states. The study identifies key genes associated with rare genetic diseases and offers insights into the heritability of adult kidney traits.
Researchers analyzed 43 clinical trials and found that trial participants were less diverse than actual transplant recipients in the US. The study suggests that efforts are needed to improve participant diversity in clinical trials to better reflect real-world patients.
A new study investigated the safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with diabetes who also have cancer. The research revealed a higher risk of diabetic ketoacidosis and fracture, but lower risks of acute kidney injury and urinary tract infection compared to another diabetes medication called GLP-1 RA.
Researchers found that vancomycin treatment reduced inflammation in the kidney and increased beneficial bacteria, while polymyxin B showed no significant effect. The study suggests modifying gut microbiota through antibiotic administration may help alleviate hypertensive organ damage.
A study found that exposure to wildfire smoke and fine particulate matter increased the risk of hospitalization and death among hemodialysis patients by 3% and 5%, respectively. Wildfires pose a significant health risk for vulnerable populations, including those with kidney failure.
Researchers have implemented an automated health maintenance tool to prompt primary care physicians to screen for chronic kidney disease in adult patients with type 2 diabetes. The tool has shown higher rates of testing for kidney function screening tests after implementation.
Researchers identified high levels of silica nanoparticles in kidney tissue of patients with chronic kidney disease. Exposure to sugarcane ash and rice paddies' burning is linked to the disease, suggesting a toxicant released by agricultural activities.
A potential treatment for Haemolytic Uraemic Syndrome (HUS) has been discovered by an international team of scientists. The breakthrough found that inhibiting the complement pathway early on can successfully treat STEC-HUS, a devastating disease that can lead to life-long dialysis and death in children.
A new study published in JAMA Network Open found live vaccinations safe and effective for children who have received liver or kidney transplants, offering protection against life-threatening conditions. The study showed high antibody levels and minimal adverse events following vaccination.
New research reveals that disrupted energy production in the kidneys contributes to progressive kidney disease in diabetes. Monitoring urinary lactate levels may help predict prognosis and guide management for diabetic kidney disease.
A randomized clinical trial found that cefepime increased neurological dysfunction in adults hospitalized with acute infection, while piperacillin-tazobactam did not. The study involved 2,511 participants and suggested that cefepime may be associated with adverse outcomes.
TTUHSC researchers received funding for pilot studies on photothermal tumor therapy, clear cell renal cell carcinoma, and colorectal cancer screening in underserved areas. The grants support the purchase of a cell sorter and address regional health disparities.
Researchers developed a new epigenetic clock that accurately measures biological aging in healthy and unhealthy tissue, outperforming current clocks. The Glasgow-Karolinska Clock showed promise in assessing the impact of chronic kidney disease on aging, even after dialysis treatment.
A Duke University study found glyphosate, active in Roundup, in high levels of wells supplying drinking water to Sri Lankan communities plagued by chronic kidney disease (CKDu). Elevated fluoride and vanadium also linked to CKDu were discovered. Glyphosate's persistence in hard water poses concerns for exposure.
A recent study published in the Journal of Clinical Investigation found that coronavirus vaccines build immune memory in various organs, including the liver, kidneys, and lungs. This local immune response is more effective than circulating antibodies in protecting against infection.
A new American Heart Association advisory introduces the concept of cardiovascular-kidney-metabolic (CKM) syndrome, which affects nearly every major organ. The approach highlights the importance of screening for CKM-related conditions and addressing social factors to prevent progression.
African Americans at increased risk of kidney disease due to genetic mutation now have a protective genetic mutation that eliminates the risk. The study found that medicines blocking the hole in kidney cells are likely to be effective treatment options.
A multi-center study found that stereotactic body radiotherapy (SABR) can achieve 100% local control and cancer-specific survival for longer than three years among patients with inoperable kidney cancer. The treatment was effective in preserving kidney function, with only one patient requiring dialysis.
A study by UC San Francisco researchers found that patients with acute kidney injury on outpatient dialysis may not need lifelong treatment if they have the potential to recover. The study tracked data from over 1,700 patients and showed that approximately three-quarters of those who recovered kidney function discontinued dialysis with...
A new study from Aarhus University found that acute kidney injury causes significant cell death in kidneys, which then spreads to healthy tissue over several days. This finding may increase the risk of patients developing chronic kidney damage and highlights the need for timely intervention measures.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
Over 75% of hospitalized AKI patients lack proper follow-up kidney health testing after discharge. Less than 25% have kidney function monitored with blood and urine tests within 90 days of discharge.
A study of over 15,000 individuals with chronic kidney disease found that young age, Black race, and low education and income were linked to lower flu vaccine uptake. The study suggests that targeted vaccination efforts could improve uptake among those with kidney disease.