Research on kidney function and disease. Covers kidney-failure prevention, gestational diabetes links, environmental risks, and gum-kidney connections.
Researchers analyzed 43 clinical trials and found that trial participants were less diverse than actual transplant recipients in the US. The study suggests that efforts are needed to improve participant diversity in clinical trials to better reflect real-world patients.
A novel multicomponent intervention aimed at improving patient access to kidney transplants did not significantly increase the rate of completed steps in a randomized clinical trial involving 20,375 patients. The study highlights the need for sustained efforts to address barriers to transplantation globally.
Sotagliflozin, a dual SGLT1 and 2 inhibitor, has been shown to reduce the risk of sustained decline in estimated glomerular filtration rate and cardiorenal composites by 38% and 23%, respectively. The findings support previously reported benefits of sotagliflozin in reducing cardiovascular events.
Results from high-impact clinical trials will be presented at ASN Kidney Week 2023, offering potential improvements in kidney-related medical care. The trials bring together leading experts and professionals to exchange knowledge and discuss the latest advances.
Researchers found a positive association between elevated urinary albumin and sub-clinical coronary artery pathology, including microcalcifications, in individuals with type 2 diabetes without symptoms of cardiovascular disease. Microcalcification activity was higher in those with albuminuria, indicating potential kidney damage.
Researchers discovered that patients with FSGS who received sparsentan treatment experienced improved kidney function and reduced proteinuria, a key indicator of kidney damage. The study suggests sparsentan may be a potential new treatment option for the disorder, offering hope for patients affected by FSGS.
Researchers have implemented an automated health maintenance tool to prompt primary care physicians to screen for chronic kidney disease in adult patients with type 2 diabetes. The tool has shown higher rates of testing for kidney function screening tests after implementation.
A new study investigated the safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with diabetes who also have cancer. The research revealed a higher risk of diabetic ketoacidosis and fracture, but lower risks of acute kidney injury and urinary tract infection compared to another diabetes medication called GLP-1 RA.
Researchers found that vancomycin treatment reduced inflammation in the kidney and increased beneficial bacteria, while polymyxin B showed no significant effect. The study suggests modifying gut microbiota through antibiotic administration may help alleviate hypertensive organ damage.
A study found that exposure to wildfire smoke and fine particulate matter increased the risk of hospitalization and death among hemodialysis patients by 3% and 5%, respectively. Wildfires pose a significant health risk for vulnerable populations, including those with kidney failure.
Researchers identified high levels of silica nanoparticles in kidney tissue of patients with chronic kidney disease. Exposure to sugarcane ash and rice paddies' burning is linked to the disease, suggesting a toxicant released by agricultural activities.
A potential treatment for Haemolytic Uraemic Syndrome (HUS) has been discovered by an international team of scientists. The breakthrough found that inhibiting the complement pathway early on can successfully treat STEC-HUS, a devastating disease that can lead to life-long dialysis and death in children.
New research reveals that disrupted energy production in the kidneys contributes to progressive kidney disease in diabetes. Monitoring urinary lactate levels may help predict prognosis and guide management for diabetic kidney disease.
A new study published in JAMA Network Open found live vaccinations safe and effective for children who have received liver or kidney transplants, offering protection against life-threatening conditions. The study showed high antibody levels and minimal adverse events following vaccination.
A randomized clinical trial found that cefepime increased neurological dysfunction in adults hospitalized with acute infection, while piperacillin-tazobactam did not. The study involved 2,511 participants and suggested that cefepime may be associated with adverse outcomes.
Researchers developed a new epigenetic clock that accurately measures biological aging in healthy and unhealthy tissue, outperforming current clocks. The Glasgow-Karolinska Clock showed promise in assessing the impact of chronic kidney disease on aging, even after dialysis treatment.
TTUHSC researchers received funding for pilot studies on photothermal tumor therapy, clear cell renal cell carcinoma, and colorectal cancer screening in underserved areas. The grants support the purchase of a cell sorter and address regional health disparities.
A recent study published in the Journal of Clinical Investigation found that coronavirus vaccines build immune memory in various organs, including the liver, kidneys, and lungs. This local immune response is more effective than circulating antibodies in protecting against infection.
A Duke University study found glyphosate, active in Roundup, in high levels of wells supplying drinking water to Sri Lankan communities plagued by chronic kidney disease (CKDu). Elevated fluoride and vanadium also linked to CKDu were discovered. Glyphosate's persistence in hard water poses concerns for exposure.
A new American Heart Association advisory introduces the concept of cardiovascular-kidney-metabolic (CKM) syndrome, which affects nearly every major organ. The approach highlights the importance of screening for CKM-related conditions and addressing social factors to prevent progression.
African Americans at increased risk of kidney disease due to genetic mutation now have a protective genetic mutation that eliminates the risk. The study found that medicines blocking the hole in kidney cells are likely to be effective treatment options.
A multi-center study found that stereotactic body radiotherapy (SABR) can achieve 100% local control and cancer-specific survival for longer than three years among patients with inoperable kidney cancer. The treatment was effective in preserving kidney function, with only one patient requiring dialysis.
A study by UC San Francisco researchers found that patients with acute kidney injury on outpatient dialysis may not need lifelong treatment if they have the potential to recover. The study tracked data from over 1,700 patients and showed that approximately three-quarters of those who recovered kidney function discontinued dialysis with...
A new study from Aarhus University found that acute kidney injury causes significant cell death in kidneys, which then spreads to healthy tissue over several days. This finding may increase the risk of patients developing chronic kidney damage and highlights the need for timely intervention measures.
Over 75% of hospitalized AKI patients lack proper follow-up kidney health testing after discharge. Less than 25% have kidney function monitored with blood and urine tests within 90 days of discharge.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
A study of over 15,000 individuals with chronic kidney disease found that young age, Black race, and low education and income were linked to lower flu vaccine uptake. The study suggests that targeted vaccination efforts could improve uptake among those with kidney disease.
A new study found that islet transplantation significantly reduces the risk of kidney transplant failure and mortality in patients with type 1 diabetes. The study compared the long-term outcomes of patients who received an islet transplantation with those who underwent kidney transplantation and managed their diabetes with insulin alone.
Researchers at UW–Madison and Stanford University developed a new approach to increase donor and recipient biocompatibility, inducing tolerance in transplanted kidneys. Two monkeys with just one match among key protein strings maintained chimeric immune systems for over four years without rejection or graft-versus-host disease.
A recent study found elevated TonEBP expression in patients with lupus nephritis, correlating with inflammatory cytokines and kidney damage. Suppressing TonEBP was shown to halt lupus progression and mitigate kidney damage in animal models.
Scientists have created chimeric embryos containing a combination of human and pig cells, which developed into structurally normal kidneys with 50-60% human cells. The researchers successfully grew humanized organs inside pigs, offering new possibilities for studying human development and developmental diseases.
Researchers at Boston University School of Medicine have discovered a novel protective gene, TMIGD1, that may unravel the mechanism of how kidney damage continues to happen once triggered. The study found that when toxins inactivated the TMIGD1 gene, models were more susceptible to kidney injury.
In a cohort study of 2,055 patients with glomerular diseases, COVID-19 vaccination did not worsen kidney damage or affect proteinuria. The data support vaccination for COVID-19 in patients with glomerular disease.
A USC Stem Cell-led mouse study reveals that lowering testosterone can improve the resilience of male kidneys by reducing their vulnerability to disease. The researchers also found that three months of calorie restriction has a similar effect, suggesting new potential treatments for kidney diseases.
Researchers investigated the role of tertiary lymphoid tissues in aging kidney disease, identifying proinflammatory interactions between renal cells and immune cells that promote inflammation and injury. The study suggests targeting proinflammatory cytokines for potential therapeutic strategies.
A novel study from the University of South Australia identified 84 features that could signal increased cancer risk in a dataset of 459,169 UK Biobank participants. The study found several biomarkers linked to cancer risk, including urinary microalbumin and high levels of cystatin C.
Scientists at UCSF have developed an artificial kidney that can mimic key functions of a real kidney. The bioreactor keeps kidney cells alive for up to seven days and has shown promising results in animal trials. If successful, the device could improve treatment for kidney disease, making it more effective, tolerable, and comfortable.
Researchers found that urine levels of adenine are predictive and causative biomarkers of looming progressive kidney failure in patients with diabetes. An oral therapeutic drug showed promise in mice by reducing kidney adenine levels and protecting against diabetic kidney disease.
A new immune-infiltrated human kidney organoid-on-chip model enables the assessment of on-target, off-tumor effects of immunotherapeutic T cell bispecific antibody drugs. The study's findings provide important insights into which cells are targeted by a given TCB and what, if any, off-target damage arises.
Researchers identified cuproptosis-related genes that inhibit kidney renal clear cell carcinoma progression by suppressing proliferation and regulating immune cell infiltration. The study found that MTF1 acts as a tumor suppressor and may be involved in the progression of KIRC.
A new matching system enabled by Boston College economists facilitates the world's first four-way liver exchange and a cascade of additional matches. The system increases the number of transplants that can be matched among a larger group of participants, expanding capacity beyond traditional two-way exchanges.
A new study found that a simple blood test can predict the risk of progressive heart and kidney disease in people with Type 2 diabetes. The test measures levels of four biomarkers, which fell after treatment with canagliflozin, a type 2 diabetes medicine.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
A case series shows that pig-to-human xenotransplant can provide normal graft function in a deceased human with chronic kidney disease. Future studies are needed to determine long-term xenograft kidney function and its potential as a bridge or destination therapy for end-stage kidney disease.
A new kidney function equation has been shown to be more accurate than the old equation in estimating kidney function, particularly for Black individuals. This new equation may reduce racial disparities in cardiovascular disease by making previously ineligible patients eligible for heart failure therapies.
Researchers found that inhibiting NLRP3 signaling reduces podocyte senescence, improves lifespan, and slows down healthy podocyte aging in mice. This discovery holds promise for treating age-related kidney diseases.
Researchers have shown a positive association between added sugar consumption and an increased risk of developing kidney stones. Participants with higher intakes of added sugars had greater odds of developing kidney stones over the course of the study.
A recent study found that higher plant protein intake is associated with lower risk of chronic kidney disease. The UK Biobank study data revealed that participants consuming more plant-based protein had a reduced risk of developing CKD.
A new preclinical study reveals that mitochondrial transplantation can lessen the damage to renal cells and kidneys, improving their function. The technology, where healthy mitochondria are injected into damaged tissue or organ, has the potential to transform renal transplant medicine.
A study at Johns Hopkins Medicine found that people living with HIV who donate a kidney to others with HIV have a low risk of developing end-stage kidney disease or other kidney problems. The study, which monitored three donors for two to four years post-transplant, bolsters support for living donations from people with HIV.
Researchers from Singapore have identified a potential dietary supplement that may improve recovery following acute kidney injury (AKI). LPC-DHA has been shown to restore the structure of damaged S3 proximal tubules and reduce inflammation in preclinical models.
Dr. Eric Lazartigues has been recognized for his groundbreaking research on salt-sensitive hypertension and the role of the brain renin-angiotensin system in regulating blood pressure. His work has led to a deeper understanding of hypertension's impact on cardiovascular diseases and mortality.
A new study has created the largest single-cell atlas of the human kidney, mapping healthy and diseased cell states across over 90 patients. The atlas reveals that certain cell types in the kidney get stuck in a 'maladaptive repair state,' leading to disease progression and irreversible reduction of kidney functions.
A nationwide NIH-funded team created the most comprehensive atlas of human kidney cells, enabling comparisons between healthy and injured kidney cells. The atlas will help researchers understand the progression of kidney disease and identify new treatments for chronic kidney disease and acute kidney injury.
A study analyzing kidney functions and predictors of disease has identified 28 altered cellular states in injured kidneys. The researchers mapped kidney cell interactions with active immune responses, establishing a data source for therapeutic development.
Researchers have discovered a way to identify pregnant women at risk of preeclampsia by examining lipids in their blood during pregnancy. The approach worked regardless of whether the women were on aspirin therapy, and could predict the risk of preeclampsia with significant accuracy.
Scientists used Insilico Medicine's generative AI platform to identify actionable drug targets for cystinosis and validate them in preclinical models. The study found that hyperactive mTOR signaling drives kidney tubular cell dysfunction, making it a targetable pathway.
Researchers at the University of Texas at Dallas have discovered a previously unknown self-renewal mechanism in kidney cells that allows them to rejuvenate themselves and remain healthy. This process is fundamentally different from other regenerative processes, such as cell division, and enables kidneys to function normally for life.
A study from Aarhus University reveals that PCSK9 regulates a receptor in the kidneys controlling protein excretion, leading to potential new treatment strategies for patients with kidney overloads. The researchers hope to further investigate the use of PCSK9 inhibitors in treating kidney diseases.
Researchers found that acute kidney injury does not predict worsening of kidney function trajectory in patients with CKD, suggesting that pre-existing kidney disease may be a major contributor. The study recommends focusing on flattening the eGFR slope and treating proteinuria to slow CKD progression.