Articles tagged with Kidney
A new study found that islet transplantation significantly reduces the risk of kidney transplant failure and mortality in patients with type 1 diabetes. The study compared the long-term outcomes of patients who received an islet transplantation with those who underwent kidney transplantation and managed their diabetes with insulin alone.
Researchers at UW–Madison and Stanford University developed a new approach to increase donor and recipient biocompatibility, inducing tolerance in transplanted kidneys. Two monkeys with just one match among key protein strings maintained chimeric immune systems for over four years without rejection or graft-versus-host disease.
A recent study found elevated TonEBP expression in patients with lupus nephritis, correlating with inflammatory cytokines and kidney damage. Suppressing TonEBP was shown to halt lupus progression and mitigate kidney damage in animal models.
Scientists have created chimeric embryos containing a combination of human and pig cells, which developed into structurally normal kidneys with 50-60% human cells. The researchers successfully grew humanized organs inside pigs, offering new possibilities for studying human development and developmental diseases.
A USC Stem Cell-led mouse study reveals that lowering testosterone can improve the resilience of male kidneys by reducing their vulnerability to disease. The researchers also found that three months of calorie restriction has a similar effect, suggesting new potential treatments for kidney diseases.
Researchers at Boston University School of Medicine have discovered a novel protective gene, TMIGD1, that may unravel the mechanism of how kidney damage continues to happen once triggered. The study found that when toxins inactivated the TMIGD1 gene, models were more susceptible to kidney injury.
In a cohort study of 2,055 patients with glomerular diseases, COVID-19 vaccination did not worsen kidney damage or affect proteinuria. The data support vaccination for COVID-19 in patients with glomerular disease.
A novel study from the University of South Australia identified 84 features that could signal increased cancer risk in a dataset of 459,169 UK Biobank participants. The study found several biomarkers linked to cancer risk, including urinary microalbumin and high levels of cystatin C.
Researchers investigated the role of tertiary lymphoid tissues in aging kidney disease, identifying proinflammatory interactions between renal cells and immune cells that promote inflammation and injury. The study suggests targeting proinflammatory cytokines for potential therapeutic strategies.
Scientists at UCSF have developed an artificial kidney that can mimic key functions of a real kidney. The bioreactor keeps kidney cells alive for up to seven days and has shown promising results in animal trials. If successful, the device could improve treatment for kidney disease, making it more effective, tolerable, and comfortable.
Researchers found that urine levels of adenine are predictive and causative biomarkers of looming progressive kidney failure in patients with diabetes. An oral therapeutic drug showed promise in mice by reducing kidney adenine levels and protecting against diabetic kidney disease.
A new immune-infiltrated human kidney organoid-on-chip model enables the assessment of on-target, off-tumor effects of immunotherapeutic T cell bispecific antibody drugs. The study's findings provide important insights into which cells are targeted by a given TCB and what, if any, off-target damage arises.
Researchers identified cuproptosis-related genes that inhibit kidney renal clear cell carcinoma progression by suppressing proliferation and regulating immune cell infiltration. The study found that MTF1 acts as a tumor suppressor and may be involved in the progression of KIRC.
A new matching system enabled by Boston College economists facilitates the world's first four-way liver exchange and a cascade of additional matches. The system increases the number of transplants that can be matched among a larger group of participants, expanding capacity beyond traditional two-way exchanges.
A new study found that a simple blood test can predict the risk of progressive heart and kidney disease in people with Type 2 diabetes. The test measures levels of four biomarkers, which fell after treatment with canagliflozin, a type 2 diabetes medicine.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
A case series shows that pig-to-human xenotransplant can provide normal graft function in a deceased human with chronic kidney disease. Future studies are needed to determine long-term xenograft kidney function and its potential as a bridge or destination therapy for end-stage kidney disease.
A new kidney function equation has been shown to be more accurate than the old equation in estimating kidney function, particularly for Black individuals. This new equation may reduce racial disparities in cardiovascular disease by making previously ineligible patients eligible for heart failure therapies.
Researchers found that inhibiting NLRP3 signaling reduces podocyte senescence, improves lifespan, and slows down healthy podocyte aging in mice. This discovery holds promise for treating age-related kidney diseases.
Researchers have shown a positive association between added sugar consumption and an increased risk of developing kidney stones. Participants with higher intakes of added sugars had greater odds of developing kidney stones over the course of the study.
A recent study found that higher plant protein intake is associated with lower risk of chronic kidney disease. The UK Biobank study data revealed that participants consuming more plant-based protein had a reduced risk of developing CKD.
A new preclinical study reveals that mitochondrial transplantation can lessen the damage to renal cells and kidneys, improving their function. The technology, where healthy mitochondria are injected into damaged tissue or organ, has the potential to transform renal transplant medicine.
A study at Johns Hopkins Medicine found that people living with HIV who donate a kidney to others with HIV have a low risk of developing end-stage kidney disease or other kidney problems. The study, which monitored three donors for two to four years post-transplant, bolsters support for living donations from people with HIV.
Researchers from Singapore have identified a potential dietary supplement that may improve recovery following acute kidney injury (AKI). LPC-DHA has been shown to restore the structure of damaged S3 proximal tubules and reduce inflammation in preclinical models.
Dr. Eric Lazartigues has been recognized for his groundbreaking research on salt-sensitive hypertension and the role of the brain renin-angiotensin system in regulating blood pressure. His work has led to a deeper understanding of hypertension's impact on cardiovascular diseases and mortality.
A study analyzing kidney functions and predictors of disease has identified 28 altered cellular states in injured kidneys. The researchers mapped kidney cell interactions with active immune responses, establishing a data source for therapeutic development.
A new study has created the largest single-cell atlas of the human kidney, mapping healthy and diseased cell states across over 90 patients. The atlas reveals that certain cell types in the kidney get stuck in a 'maladaptive repair state,' leading to disease progression and irreversible reduction of kidney functions.
A nationwide NIH-funded team created the most comprehensive atlas of human kidney cells, enabling comparisons between healthy and injured kidney cells. The atlas will help researchers understand the progression of kidney disease and identify new treatments for chronic kidney disease and acute kidney injury.
Scientists used Insilico Medicine's generative AI platform to identify actionable drug targets for cystinosis and validate them in preclinical models. The study found that hyperactive mTOR signaling drives kidney tubular cell dysfunction, making it a targetable pathway.
Researchers have discovered a way to identify pregnant women at risk of preeclampsia by examining lipids in their blood during pregnancy. The approach worked regardless of whether the women were on aspirin therapy, and could predict the risk of preeclampsia with significant accuracy.
Researchers at the University of Texas at Dallas have discovered a previously unknown self-renewal mechanism in kidney cells that allows them to rejuvenate themselves and remain healthy. This process is fundamentally different from other regenerative processes, such as cell division, and enables kidneys to function normally for life.
Researchers found that acute kidney injury does not predict worsening of kidney function trajectory in patients with CKD, suggesting that pre-existing kidney disease may be a major contributor. The study recommends focusing on flattening the eGFR slope and treating proteinuria to slow CKD progression.
A study from Aarhus University reveals that PCSK9 regulates a receptor in the kidneys controlling protein excretion, leading to potential new treatment strategies for patients with kidney overloads. The researchers hope to further investigate the use of PCSK9 inhibitors in treating kidney diseases.
A new metal-free MRI dye provides accurate spatial data and quantitative glomerular filtration rate measurements for both kidneys, surpassing current clinical methods. This breakthrough enables personalized diagnosis and treatment planning for patients with kidney disease, representing a significant advancement in personalized urology.
Researchers identified a new drug treatment option for peritonitis in patients on peritoneal dialysis, showing that a low dosage of ceftazidime and avibactam is sufficient to treat the infection. The study's findings could help gain control over peritonitis in patients with difficult-to-treat germs.
Researchers have identified a biomarker called CXCL-9 that can be used to diagnose acute tubulointerstitial nephritis (AIN), a condition causing inflammation of the kidneys. The biomarker can be detected via a simple urine test, potentially reducing the need for kidney biopsies.
A study published in The Annals of Thoracic Surgery found that lower oxygen delivery thresholds are associated with reduced risk of kidney injury. Researchers recommend reevaluating current guidelines for oxygen delivery during cardiopulmonary bypass to minimize unnecessary blood transfusions and improve patient outcomes.
A new study finds that long-term disinvestment in health and wealth resources in historically redlined neighborhoods contributes to a disproportionate rate of kidney failure among Black adults. Redlining, the discriminatory federal housing policy from the 1930s, has been associated with current racial inequities in poor health outcomes.
Researchers have identified specific cellular signatures for kidney transplant rejection, which could lead to the development of more effective anti-rejection therapies. The study's findings suggest that treatments often do not thoroughly eliminate T cells responsible for rejection, and new drug targets may be able to address this issue.
A new study has identified 16 new locations in the genome linked to immunoglobulin A (IgA) nephropathy, a common kidney disease. The research confirms an earlier hypothesis that the immune system plays a key role in driving the disease and provides potential drug targets for treatment.
A study of over 8 million Ontario adults found that even a modest loss of kidney function (20-30% below normal) is associated with increased risk of death, cardiovascular events, and kidney failure in young adults. Early conversations about prevention and monitoring are recommended.
A new patient-guided intervention using telemedicine has been shown to improve symptoms of fatigue, pain, and depression in dialysis patients. The Technology Assisted Stepped Collaborative Care (TĀCcare) trial found significant improvements in energy levels and pain severity that persisted for six months after treatment.
The USC Stem Cell team is developing artificial kidney organoids using human stem cells and synthetic biology. They aim to create a functional kidney that resembles the real thing in function but not in form.
A study found that most kidneys offered to transplant centers were given to lower-priority candidates, citing concerns about organ quality. This practice, known as 'list diving,' harms some patients and contributes to disparities in organ transplantation.
Patients with advanced kidney cancer who receive second-line treatment with a combination of atezolizumab and cabozantinib do not experience improved progression-free survival or overall survival compared to those treated with cabozantinib alone. The study also finds higher toxicity levels in patients receiving the combination therapy.
Research identifies Indian Hedgehog protein as a key driver of chronic kidney disease and heart damage, offering new hope for treatments. The findings suggest that blocking the protein's actions could improve kidney function and reduce cardiovascular risk.
Researchers found that a mutated PDE3A gene prevents kidney damage despite severe hypertension. The study suggests that this mutation could be used therapeutically to prevent chronic kidney disease.
Researchers investigate whether pregnant mothers' exposure to toxic metals affects kidney development in their babies, which may set the stage for chronic kidney disease. The team aims to identify key combinations of metal mixtures that could have detrimental effects on developing kidneys.
Researchers propose using blood and urine biomarkers to classify subpopulations of acute kidney injury (AKI) patients, identifying therapies specific to individual patient populations. The study found two molecularly distinct AKI subgroups associated with differing risk profiles and long-term outcomes.
Researchers have found a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment. The aromatic ketone 2',4',6'-trihydroxyacetophenone (THA) inhibits the CCBL1-mediated metabolism of cisplatin, reducing its toxic effects without affecting its potency.
A neglected 80-year-old antibiotic, nourseothricin, has been found to be effective against multi-drug resistant bacterial infections. The improvement in purification of the streptothricins has overcome original toxicity concerns, making it a promising agent for treating difficult-to-treat infections.
Researchers developed a computational approach to predict diabetic kidney disease using DNA methylation markers from a blood sample. The model can use this information to assess current and future kidney function, enabling early detection and prevention of kidney disease in people with type 2 diabetes.
Researchers analyzed outcomes for 144 Colorado patients who had lymph node sampling at the time of surgery for kidney tumors between 2005 and 2019. They found no statistically significant difference in clinically significant complications between patients who underwent more extensive lymph node sampling than those who didn’t.
Children's Hospital Los Angeles researchers have identified a disruption in early kidney progenitor cell development linked to the formation of Wilms tumor. The study found that these cells can reproduce the original tumor and are aggressive, drug-resistant, and metastasize like cancer cells.
A new study suggests that increased exposure to air pollution may be associated with first hospital admissions for acute kidney injury. The research found a link between PM2.5, NO2, and O3 exposure and an increased risk of AKI, even at low annual exposures.
Scientists have identified Norn cells as the primary source of erythropoietin (Epo) in humans, a crucial hormone for red blood cell production. This breakthrough could lead to the development of new treatments for anemia and other conditions related to impaired Epo production.
A growing number of states have implemented policies to cover outpatient hemodialysis for undocumented immigrants with kidney failure. This expansion may be due to increased awareness of poor outcomes with emergency hemodialysis and advocacy efforts. The move towards covering dialysis in all 50 states is called for by experts, who also...
Two recent studies conducted at the University of Eastern Finland found that renal hyperfiltration (RHF) is associated with an increased risk of mortality, independent of diabetes mellitus. A lower kidney filtration rate threshold may serve as a more precise measure for defining RHF.
Researchers found a genetic variant of TNFAIP3, which regulates inflammation, can paradoxically protect the kidneys from damage in the short term. The study could lead to simple genetic tests for predicting kidney disease risk and personalized treatment approaches.
Researchers at University of Pittsburgh have discovered a type of immune cell that drives chronic organ transplant failure and uncovered pathways to improve patient outcomes. Blocking IL-15 signaling has been shown to prolong graft survival in mouse kidney recipients, offering a promising therapeutic target.