Researchers from Columbia University have validated GLS2's ability to promote ferroptosis in murine models. This study suggests that targeting GLS2 may be a potential therapeutic strategy against liver diseases, particularly hepatocellular carcinoma.
Researchers have developed soft implantable fibers that can deliver light to major nerves through the body, allowing for precise illumination of nerve pain. The fibers are flexible and stretch with the body, enabling scientists to study peripheral nerve disorders in animal models without constraining movement.
Researchers analyzed 48 TV episodes of popular UK programs, finding that midwives and doctors clamping the umbilical cord were shown inaccurately or dramatized in a third of cases. The study highlights the need for safety warnings to inform viewers about outdated practices.
A study published in Psychological Medicine found that the widely prescribed sedative alprazolam XR may be less effective than believed, with publication bias inflating its efficacy by over 40%. This suggests caution for patients and clinicians starting a prescription for panic disorder.
Researchers used molecular dynamics simulations to study how urea and alcohol induce structural changes in proteins, with a focus on stabilizing helices and coils. The team identified preferential binding parameters for both cosolvents, demonstrating opposing effects that can be predicted using computational methods.
A study by UC Riverside researchers found that communities of color in Inland Southern California experienced fear and mistrust of institutions due to historical, cultural, and social traumas. The study highlights the need for culturally sensitive health interventions to address these traumas and promote community-based approaches for ...
A new study by Emory and Harvard researchers found that high air pollution exposure during childhood is associated with earlier onset of menstruation in US girls. This increased risk is linked to cardiovascular disease, Type 2 diabetes, and certain cancers later in life.
Researchers found associations between PTSD and dietary patterns, specifically a Mediterranean diet rich in plant-based foods and fish. The study identified Eubacterium eligens as a protective species that may help alleviate PTSD symptoms.
A large-scale genomic study confirms the heritability of postpartum depression, suggesting a significant genetic component. The research also reveals that the only FDA-approved treatment for PPD, brexanolone, likely acts on GABAergic neurons in specific brain regions.
Researchers found that certain combinations of gene mutations resulted in predictable effects on tomato size, while others yielded random outcomes. The study suggests the role of background mutations demands reassessment for genome editing applications. This new interpretation may help humanity adapt crops to meet evolving societal needs.
Researchers have pinpointed the emergence of muddy flavors in farmed fish by measuring the concentration of geosmin and other compounds. The study highlights the importance of water quality management to prevent the production of off-flavor compounds, which can impact aquaculture industry revenue and sustainability.
A team of scientists has investigated the effect of initial temperature on Li dendrite morphology through temperature-dependent ionic diffusion coefficient, reaction coefficient, and conductivity. They found a unified picture for the seemingly contradictory dendrite-promoting and dendrite-inhibiting effects of increased temperature in ...
Researchers from the University of Plymouth discovered coral reef bleaching at depths previously thought to be resilient, highlighting the vulnerability of mesophotic coral ecosystems to thermal stress. The study suggests that climate change is causing a deepening of the thermocline, leading to increased bleaching in the deeper ocean.
Scientists generate and control coherent polaron oscillations, enabling the manipulation of dynamic electric properties of polar liquids. The study demonstrates the importance of many-body interactions in polar molecular ensembles.
A study at Stanford Medicine found that patients who believed they had received ketamine experienced significant improvements in depression symptoms, even if they hadn't. The researchers suggest that positive expectations and hope may play a key role in ketamine's effectiveness.
Researchers at MIT found that similarity-focused generative AI models falter when tasked with designing new products, highlighting the need to prioritize innovation in engineering tasks. By adjusting training objectives and metrics, AI can be an effective 'co-pilot' for engineers, enabling faster creation of innovative products.
The Center for Advancing Point of Care Technologies (CAPCaT) has received a five-year, $8.9 million award from the NIH to develop innovative point-of-care health technologies. The program aims to address heart, lung, blood and sleep disorders in underserved populations.
Researchers discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy. Cancer cells respond to radiation by rewiring metabolic signaling pathways using lactic acid instead of glucose.
A global team has discovered the most ancient and distant fast radio burst, located 8 billion years ago, confirming that FRBs can be used to measure the 'missing' matter between galaxies. The source was found to be a group of merging galaxies, supporting current theories on the cause of fast radio bursts.
A global team of scientists emphasizes the need for collaboration between experts in AI, medicine, ethics, and beyond to develop fair models. They argue that focusing on equity rather than complete equality is a more reasonable approach, considering factors like race, gender, and patient preferences.
Researchers from NUS have developed a novel magnetic gel that heals diabetic wounds by activating dormant skin cells and repairing damaged blood vessels. The treatment has shown promising results, healing wounds up to three times faster than conventional approaches.
Researchers from HonorHealth Research Institute, City of Hope, and TGen have developed a biomarker panel that detects small amounts of RNA genetic material in the bloodstream, enabling early detection of pancreatic cancer. The test has shown robust diagnostic accuracy and offers promise for improving survival rates.
A new analysis method can map individual company-level connections, revealing up to 13 billion supply connections worldwide. This data could reduce tax evasion (€130 billion) and improve climate and human rights compliance by creating a global supply network map.
Researchers used micro-computed tomography to examine a Rijksmuseum statue and discovered the characteristics of the artist. The study found that the partial fingerprints of the artwork belong to an adult male, corresponding with the attributed model, Laurent Delvaux.
Researchers have proposed using quasiparticles to create ultra-bright light sources, mimicking the properties of particles moving faster than light. These potential light sources could revolutionize fields like non-destructive imaging, computer chip manufacturing, and scientific research.
A new study found that racial and ethnic disparities persist in access to chiropractic care and physical rehabilitation for adults with low back pain, with Hispanic adults being less likely to use these services. The study also found that policy changes are needed to address these gaps in access, particularly in underserved communities.
Researchers introduce NorthPole, a brain-inspired chip architecture that integrates computation and memory for efficient low-energy AI processing. It achieves higher performance, energy-efficiency, and area-efficiency compared to other architectures, making it suitable for real-time AI applications.
A meta-analysis of 22 studies found that willful ignorance is prevalent and harmful, driven by a desire to maintain a positive self-image. People who chose not to learn consequences were less likely to be generous, whereas those who did choose to learn consequences were more likely to exhibit altruism.
Researchers developed a novel physical theory that can accurately predict protein folding, surpassing existing models like AlphaFold 2. The new model, WSME-L, can elucidate folding processes without limitations, enabling a comprehensive understanding of protein structures and behaviors.
Researchers at UC Davis discovered a gene variant in Golden Retrievers that extends their lifespan by nearly two years. This finding has significant implications for human cancer studies, as the same gene is linked to cancer risk in humans.
Recent studies suggest that probiotics may offer a protective effect against hypertension, but the exact mechanisms are unclear. A new study identifies two probiotic strains, Bifidobacterium lactis and Lactobacillus rhamnosus, as promising treatments for high blood pressure.
Lucas Bowman Sutton, a Rensselaer doctoral student, has been awarded the US Department of Energy's Office of Science Graduate Student Research award to conduct research on the circadian clock at Oak Ridge National Laboratory. He will utilize the Spallation Neutron Source to differentiate proteins that regulate timekeeping in living cells.
Researchers identify mechanism by which specific protein condensates transition from liquid to solid states, enabling stability and transmission of mechanical forces. MEC-2 proteins' biological function switches with rigidity maturation, facilitating mechanosensation.
The discovery of FRB 20220610A confirms that fast radio bursts can be used to measure the 'missing' matter between galaxies, providing a new way to weigh the Universe. The burst is also one of the most energetic ever observed, releasing energy equivalent to our Sun's total emission over 30 years.
Advances in VR display technology have overcome the 'screen door effect' by introducing 2117 PPI LCDs with high partition mini LED backlighting. This enhances contrast, color accuracy, and viewing angles, making VR experiences more immersive.
Researchers propose that black holes can exist in equilibrium as 'perfect pairs' within an ever-expanding Universe. This concept challenges traditional understanding of black hole behavior and interactions.
Researchers at Gladstone Institutes found that ApoE4-producing neurons release HMGB1, triggering microglial activation and neurodegeneration. Blocking HMGB1 with experimental drugs offers strong protection against APOE4-driven neurodegeneration.
A team of researchers has created a 'proteomic clock' that can predict a healthy person's age based on their protein profile, revealing accelerated aging due to diseases. The study also detected proteins associated with Parkinson's disease in eye fluid, offering a potential pathway for earlier diagnoses.
A study investigated how algorithms compare to human judgment in music plagiarism disputes, with mixed results. While algorithms matched human decisions in 83% of cases, they struggled with non-musical factors and controversy surrounding high-profile cases.
Researchers at Sainsbury Wellcome Centre find frontal and parietal cortex play key role in encoding value of economic choices when faced with uncertainty. The study provides foundation for understanding neurobiology of risky decisions.
Researchers create a novel type of nano engine made of DNA, powered by RNA polymerases and nucleotide triphosphates. The motor performs pulsing movements using a mechanism similar to a hand grip strength trainer, but scaled down to one million times smaller.
Researchers identified enhanced B-cell and T-cell responses in fully vaccinated individuals who became infected with SARS-CoV-2, generating immunological memory to prevent severe infection. Vaccine-primed memory T cells play a critical role in preventing severe COVID-19.
A new Rowan University study reveals a 50-year trend in Atlantic hurricane intensification linked to human-caused greenhouse gas emissions. The research shows that hurricanes are developing and strengthening faster, with more intense storms along the US east coast.
Researchers from the University of Tokyo have developed a cobalt-free battery alternative that outperforms state-of-the-art battery chemistry. The new lithium-ion batteries boast a 60% higher energy density and can withstand over 1,000 recharge cycles, reducing environmental concerns.
Researchers discovered that gut microbiota-derived 7-DHC regulates circadian rhythms, reduces inflammation in the gut, and treats experimental colitis by targeting key genes. This molecule has potential as a novel therapeutic agent for inflammatory bowel disease (IBD).
Researchers found that Porphyromonas gingivalis inhibits autophagosome-lysosome fusion, worsening cardiac remodeling and causing cardiac rupture after myocardial infarction. The study suggests that treating this oral infection could help prevent fatal heart attacks.
Researchers at the University of California, San Diego have discovered a way to make ceramics tougher and more resistant to cracking. By using metal atoms with more electrons in their outer shell, they unlocked the potential to enable ceramics to handle higher levels of force and stress.
The open-source 'OpenCap' platform enables clinicians to analyze human movement from smartphone videos, significantly reducing analysis time by 25x and costs. The platform is made available for academic research at no cost.
A Rice University scientist used a mixed-reality headset with custom-designed software to measure and analyze forest floor vegetation in Tanzania's Udzungwa Mountains National Park. The study found that mammal diversity increases with forest floor habitat surface area, leading to a greater variety of ecological characteristics.
A new study reveals that periodical cicada emergences have a cascading effect on forest ecosystems, shifting bird diets and leading to increased abundance of caterpillars and subsequent leaf damage. This research has implications for bird conservation and understanding the interconnectedness of complex food webs.
Rising Arctic temperatures are causing a mass migration of zooplankton, which Pacific right whales rely on for food. This shift is also drawing industrial fishing fleets northward, increasing the risk of ship collisions and gear entanglements.
A pivotal trial of wearable treatment Osteoboost for osteopenia in post-menopausal women showed a significant reduction in vertebral bone strength loss. The study found an average bone strength loss of 0.48% in the Active Treatment group, compared to 2.84% in the Sham group.
A team of scientists discovered that the Malvinoxhosan biota, a group of extinct shellfish, declined in numbers due to rising sea levels and warming climate. The research suggests that these changes led to a collapse in polar ecosystems, highlighting the vulnerability of environments to environmental shifts.
The 2021 Brood X cicada emergence caused community-wide shifts in bird predation, leading to a measurable decline in bird predation on oak-feeding caterpillars. This resulted in doubling of both caterpillar densities and herbivory rates on oak saplings during the emergence year.
A potential treatment for Haemolytic Uraemic Syndrome (HUS) has been discovered by an international team of scientists. The breakthrough found that inhibiting the complement pathway early on can successfully treat STEC-HUS, a devastating disease that can lead to life-long dialysis and death in children.
A recent study published in The Journals of Gerontology – Series B found that having more children can produce economic, social, emotional, and biological burdens that impact health, especially chronic conditions and depression. In contrast, adults with fewer children were more likely to report poor self-rated health in certain countries.
Researchers found that job seekers were 20% more likely to search for work at companies with over 500 employees after March 13, 2020. The average size of companies searched increased by 29%, driven by highly-skilled and better-educated candidates, which can impact startup success.
A new electronic health record documentation tool has been shown to improve the accuracy and completeness of clinical documentation for patients undergoing treatment for epilepsy. This tool enables medical providers to identify patients who are failing treatments earlier, allowing for rapid optimization of positive outcomes.
A new study from Columbia University Irving Medical Center suggests that chemotherapy-induced cognitive impairment, or 'chemobrain', may be caused by an excess of calcium floating around inside cells. The research could lead to new treatments to restore cognition in patients experiencing symptoms.
A study by Dr Veronica Lamarche discovered that equal consumption was more important than levels of drunkenness in perceiving consensual sex. Hook-ups where one partner is drunker are more likely to be seen as non-consensual, coercive, and dangerous.