“[...] we hope that our findings will inform future decisions regarding treatment of liver disease.”
BUFFALO, NY- October 19, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, “ GLS2 shapes ferroptosis in hepatocellular carcinoma .”
In their new editorial, researchers Sawako Suzuki, Divya Venkatesh, Tomoaki Tanaka, and Carol Prives from Columbia University discuss ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases.
“More than a decade has passed since our group (1) as well as Hu et al., (2) identified glutaminase (GLS2) as a p53 target gene that promotes the tricarboxylic acid cycle (TCA) via α-ketoglutarate (αKG) and lowers oxidative stress via increasing glutathione (GSH) [ 1 , 2 ].”
Two years after this Dixon et al., [ 3 ] described a form of cell death they named ferroptosis which is caused by iron-mediated lipid peroxidation. Then, three years later, Gao et al., reported that GLS2 but not GLS1 is an inducer of ferroptosis in human cancer cells [ 4 ]. Ferroptosis had first been shown to be regulated by p53 via repression of SLC7A11 [ 5 ]. The circle was closed by a study from the Murphy group who reported that a cancer-related nonsynonymous mutation in p53 (P47S) is correlated with failure to either activate GLS2 expression or produce ferroptosis [ 6 ].
“Our recent study (Suzuki et al.) [ 7 ] has validated the ability of GLS2 to promote ferroptosis in murine models.”
Continue reading the full paper: DOI: https://doi.org/10.18632/oncotarget.28526
Correspondence to: Carol Prives
Email: clp3@columbia.edu
Keywords: ferroptosis, hepatocellular carcinoma, GLS2, p53, tumor suppression
About Oncotarget : Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
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GLS2 shapes ferroptosis in hepatocellular carcinoma
19-Oct-2023