Articles tagged with Lipids
Scientists developed a high-spatial-resolution mass spectrometry imaging method to study lipid metabolism heterogeneity during drug-induced cell apoptosis at the single-cell level. The method achieved a spatial resolution of approximately 800 nm, allowing researchers to profile alterations in the cell membrane microenvironment and meta...
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
The updated guideline consolidates evidence-based recommendations for managing dyslipidemias, offering a comprehensive approach to lower risk of atherosclerotic cardiovascular disease. The guideline recommends earlier intervention through healthy lifestyle changes and considers the use of a new cardiovascular disease risk calculator, P...
A new study from the University of Minnesota Medical School has identified certain naturally occurring polyunsaturated lipids that selectively induce death in senescent cells, which are old and damaged cells that accumulate with age. These lipids trigger a process called ferroptosis, which can be used as a potential treatment for age-r...
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
Recent studies identify distinct gut microbial communities in people with dyslipidemia, suggesting a connection between the gut microbiome and heart disease precursor. The researchers found higher levels of Bacteroides caccae and lower levels of bacteria linked to metabolic stability. Future research aims to restore functional balance ...
A new study finds that the quality of macronutrients matters more than their quantity for heart health, with diets rich in whole grains, fruits, and vegetables associated with a lower risk of coronary heart disease. The study also found improved cardiovascular biomarkers in healthy versions of low-carb and low-fat diets.
A new study found that versions of both diet patterns emphasizing healthy foods are associated with a lower risk of coronary heart disease. The study suggests that focusing on overall diet quality may offer flexibility for individuals to choose eating patterns that align with their preferences while still supporting heart health.
Researchers identified a previously unrecognized metabolic defence mechanism in aggressive brain tumours: a sugar-rich shield that protects tumour cells from ferroptosis. The study found that the sugar shield and lipid droplet storage mechanisms cooperate to evade cell death.
A recent study published in the Journal of Nutrition found that higher fat diets were more harmful than high-carbohydrate diets, even when fiber supplementation was added. Mice on high-fat and ketogenic diets experienced weight gain, liver damage, and other negative health effects, while those on a high-carbohydrate diet did not.
Scientists developed a compound that targets Liver X Receptor specifically in liver and gut to lower triglycerides. In first-in-human clinical trial, participants showed significant drops in triglycerides and remnant cholesterol after taking the drug.
A recent review of bamboo consumption found promising health benefits, including improved metabolic health, reduced inflammation, and antioxidant activity. However, caution is advised due to potential risks associated with raw or improperly prepared bamboo.
Researchers from Université de Genève have identified the transporters responsible for each lipid, revealing the complex mechanisms behind their cellular targeting. This study provides valuable insights into lipid biology and its link to various diseases such as Alzheimer's and diabetes.
A study published in EMBO Molecular Medicine has identified a combination of statins and phenothiazines that shows promise in treating aggressive neuroblastoma. The drug combination was found to impede tumour growth and improve survival rates in laboratory trials with mice.
A team of researchers at the University of Pennsylvania has designed a new light-controlled cholesterol molecule that selectively targets two poorly understood sterol transport proteins, ORP1 and ORP2. This breakthrough enables precise spatiotemporal control over cholesterol's biological activity, paving the way for advanced therapeutics.
A large meta-analysis of over 48,000 children found that well-planned plant-based diets can support healthy growth and even offer additional health benefits for children. However, the study also highlights risks of deficiencies in key nutrients such as vitamin B12 and zinc if not obtained through fortified foods or supplements.
The C-COMPASS tool uses neural networks to predict protein localizations and incorporates proteome data for reproducible analyses. It enables the exploration of spatial lipidomics by combining proteome and lipidome data, revealing changes in lipid distribution associated with metabolic perturbations.
A recent study published in the American Journal of Preventive Cardiology found that only 13% of US adults with cardiovascular disease met optimal LDL-C management, highlighting significant gaps between guideline recommendations and clinical care. The study suggests actionable steps to improve adherence, including increased use of non-...
Researchers from UT Health San Antonio discovered that changes in brain fats play a major role in Alzheimer's development and progression. Targeting microglia, the brain's immune cells, may help restore balance and support brain health. Progranulin levels also emerged as a key lipid regulator.
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
A new medication called DR10624 has shown promising results in reducing high triglyceride levels by over 60% in patients with severe hypertriglyceridemia. The treatment also improved cholesterol and liver health, offering a potential alternative for managing this condition.
A study found that combining PCSK9 inhibitor alirocumab with statin rosuvastatin reduced LDL cholesterol levels by more than 50% among patients after a heart transplant. The treatment was safe and showed significant cholesterol-lowering impact, but further studies are needed for confirmation.
A daily oral medication has been shown to lower bad cholesterol levels in people with a previous heart attack or stroke, or those at high risk for one. The study found that participants taking the medication had significant reductions in LDL-C levels and achieved guideline-recommended targets.
A quality improvement program helped reduce 'bad cholesterol' levels among military veterans, according to a preliminary presentation at the American Heart Association's Scientific Sessions 2025. The study found improvements in patient adherence and LDL-cholesterol goal attainment among participating veterans.
In a Phase 1 clinical trial, CRISPR-Cas9 gene-editing therapy CTX310 reduced LDL cholesterol and triglycerides by nearly 50% on average, achieving large reductions in both for the first time. The treatment has shown promise as a one-and-done approach to transform care for patients with lifelong lipid disorders.
The Family Heart Foundation has launched the Lp(a) AW(a)RE initiative to educate primary care clinicians, healthcare insurance providers, and policymakers about high lipoprotein(a). The program aims to increase awareness, screening, and diagnosis of this genetic risk factor for premature cardiovascular disease.
Researchers found that combining three biomarkers – lipoprotein(a), remnant cholesterol, and high-sensitivity C-reactive protein – can reveal a nearly three-fold increase in heart attack risk. This combination approach may aid health care professionals in identifying individuals with high-risk profiles earlier.
A new resource identifies genetic variants associated with elevated 'bad' cholesterol, a major contributor to heart disease. Clinicians can now predict patient risk for heart attacks and strokes, allowing for prevention and early treatment.
Case Western Reserve University researchers discovered pseudo leukotrienes, which may be the dominant players in the inflammatory cascade that causes disease. The findings open new avenues for treating asthma and other inflammatory diseases.
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
A new study found that adipose-derived extracellular vesicles, tiny cell messengers in obese individuals, accelerate the buildup of amyloid-β plaques in the brain, a hallmark of Alzheimer's disease. Researchers hope targeting these tiny cell messengers could reduce the risk of Alzheimer's disease in people with obesity.
A repeated cross-sectional study shows that cardiometabolic risk factors in Spanish children have improved over the last 30 years, with decreases in excess weight, lipid parameters, and blood pressure. The study provides valuable insights into the evolution of cardiometabolic risk in children.
Dr. Peter Tontonoz, a distinguished UCLA professor, will receive the American Heart Association's Basic Research Prize for his groundbreaking contributions to understanding lipid metabolism and its role in cardiometabolic disease. His work has transformed the scientific understanding of this critical heart health factor.
Scientists have developed a new computational method to build the first 4D lipid map of a vertebrate embryo, capturing how lipid distributions change over time. The atlas reveals organized patterns of lipids that match anatomical structures, suggesting key roles in shaping organ function and identity.
Researchers from UNSW identify a crucial protein, CHP1, that acts as a central director in fat metabolism, promoting lipid droplet growth and regulating key enzymes. This discovery advances basic knowledge of cellular fat storage and opens new avenues for future research into metabolic disorders.
Researchers developed a new microfluidic method to preserve worm anatomy, linking lipid signals with body structure using mass spectrometry imaging. They identified several lipids clustering in distinct anatomical regions, providing insight into how fat molecules are organized and function across the worm.
A recent study published in Alzheimer's & Dementia found that women with Alzheimer's disease have a notable loss of unsaturated fats, such as omega-3 fatty acids, in their blood compared to healthy women. This suggests that lipids containing omega-3 fatty acids may play a crucial role in the risk for Alzheimer's between the sexes.
The Family Heart Foundation has partnered with seven leading healthcare systems to accelerate screening in people with cardiovascular disease who have been identified by the find Lp(a) initiative. Individuals with elevated Lp(a) levels are at increased risk of another heart attack or stroke, and early detection can help reduce this risk.
Researchers at UC San Diego developed a computational method to determine omega positions of lipids in complex biological samples. This breakthrough makes omega position information accessible even for lipids in low concentrations, significantly advancing lipid research.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
Researchers from FAU's Schmidt College of Medicine recommend using high-potency statins as the primary pharmacologic approach in treating and preventing cardiovascular disease. Lifestyle changes, such as regular physical activity and a healthy diet, are also crucial in reducing cardiovascular risk.
Researchers at Nagoya University have developed a new lipid nanoparticle that delivers mRNA five times more efficiently, allowing better delivery of genetic instructions to cells. The study showed significant improvements in mRNA delivery and effective suppression of tumor growth in mice.
Elevated lipoprotein(a) is an independent genetic risk factor for cardiovascular disease. Community health centers participating in the Lp(a) Discovery Project and Community Health Centers Discovery Project have successfully added new screening processes, increasing testing at sites.
Researchers at the University of Ottawa have made a breakthrough in developing nanoparticles that not only deliver drugs but also contribute to treatment. Their proof-of-concept study shows that particles can be armed with therapeutic potential, revolutionizing the field of nanomedicine.
Researchers at the University of Pennsylvania designed a new recipe for mRNA vaccines by adding phenol groups, which reduce inflammation and improve vaccine effectiveness. The modified lipids improved vaccine performance in various diseases, including COVID-19, cancer, and genetic diseases, with enhanced efficacy and reduced side effects.
A new study from the University of South Australia confirms that eggs are not high in cholesterol and do not contribute to cardiovascular disease. In contrast, saturated fat intake was found to increase LDL levels, highlighting the importance of dietary balance for heart health.
Researchers found that prostate cancer cells store fats in lipid droplets under low oxygen conditions, making them less vulnerable to ferroptosis. This adaptation allows cancer cells to evade therapies designed to trigger cell death.
A recent study reveals that heat stress directly alters fat metabolism in adipose tissue, regulating genes that promote fat storage. Researchers identified 459 genes that showed different expression levels in response to heat stress, highlighting the active role of adipose tissue in fat deposition.
A study in mice found that pesticide exposure changes specific gut bacteria growth patterns and nutrient processing, hinting at a probiotic approach to preventing health effects. The research identified certain microbes that can degrade pesticides and may lead to therapeutic strategies.
Scientists at The University of Texas at Arlington identified a new enzyme, IDO1, that plays a crucial role in inflammation and cholesterol regulation. By blocking this enzyme, macrophages regain their ability to absorb cholesterol, offering a potential new way to prevent heart disease.
A new study found that eating one avocado daily for six months improved sleep duration and reduced LDL-C and total cholesterol levels in adults. The American Heart Association recognizes healthy sleep duration as a key lifestyle factor in heart health.
A large study has found that cholesterol-lowering drugs do not have an antidepressive effect, contradicting previous small studies. The research, published in JAMA Psychiatry, involved 161 patients with depression and obesity, who received either statins or a placebo for 12 weeks.
A new study suggests that controlling eight key health risk factors can significantly reduce premature death risk in people with high blood pressure. By addressing these risk factors, researchers found a 40% lower risk of early death and up to 53% less risk of death due to cardiovascular disease.
A novel combination of cell biology and molecular computer simulations reveals that sterols' interactions with lipids shape membrane domains in yeast cells. This finding refines a 50-year-old textbook model, suggesting the complexity of sterol metabolism resulted from balancing lipid interactions for membrane organization.
Researchers developed t-SPESI technology to visualize cell parts and analyze lipid distributions in complex biological samples. This enables the detection of abnormal lipids linked to disease, advancing therapies and diagnostic techniques.
Researchers developed an experimental immunotherapy capable of reversing heart energy production damage caused by cholesterol accumulation. The therapy targets the LRP1 receptor, preventing cholesterol from accumulating in mitochondrial membranes and restoring cellular energy production.
A Swedish study discovered that lipolysis is more effective in women than in men, potentially explaining why women are less likely to develop metabolic complications despite having more body fat. The study suggests that understanding this difference could aid in the development of drugs that lower the risk of type 2 diabetes in men.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
Researchers at Scripps Research used computer modeling to illustrate how antibodies recognize lipids in the HIV virus, highlighting a potential new approach for vaccine design. The study identified two key structural features on the antibodies that enable them to target well-defined membrane features.
A new study from the University of Oklahoma is targeting cell communication in the hunt for therapies to slow macular degeneration. The research team is studying how cells in the retina communicate and whether the messages they send could be programmed to treat or slow AMD.