Researchers developed a method to inhibit lipid nanoparticle migration into the liver by coating hepatic sinusoidal walls with polyethylene glycol. This coating reduced liver accumulation by several dozen times and increased protein expression in the spleen, promoting safer nanomedicine with lower dosages.
Researchers developed an AI approach that identifies nanoparticle morphology using data from standard NTA measurements, achieving high classification accuracies. The method integrates two types of information and performs multi-class classification with stable performance even at reduced data amounts.
A comprehensive review reveals how phospholipid asymmetry governs EV surface charge, providing a unified framework for classification, functional understanding, and standardization in nanomedicine. The study highlights the importance of membrane lipid composition and surface charge in determining EV function.
Researchers developed a novel method to immobilize proteins onto magnetic microbeads, allowing precise measurement of binding strength and efficient selection of target peptides. The technique achieved a 10,000-fold concentration in a single sorting step, significantly enhancing the efficiency of drug discovery research.
The 4th annual symposium of Project CHANGE will focus on addressing Japan's future healthcare workforce shortage, particularly the nursing shortage, through collaboration with engineering. The event will feature a keynote speech by Prof. Sei-Kwang Hahn and presentations on nursing engineering.
A novel optical microneedle device developed by researchers can quantify glucose levels in ultra-trace samples with high precision, offering a potential solution for blood-sampling-free clinical testing. The device features a functional hydrogel at its tip that reversibly binds to glucose, enabling accurate analysis without consuming t...
Researchers developed nanomachines that can function stably within living organisms, enabling starvation therapy to treat refractory pancreatic cancer. This approach improved treatment outcomes by depleting essential nutrients for cancer cell growth.
The seminar, part of a DAAD-JSPS collaboration, will cover the latest topics on drug design and treatment protocols for photodynamic therapy. Researchers from Japan and Germany will present their recent research results on PDT, including nano-DDS applications.
Researchers developed nanomachines that can efficiently deliver antisense oligonucleotides to sentinel lymph nodes, reducing TGF-β1 levels and reactivating depleted CD8-positive T cells. This enhances cancer treatment outcomes for advanced breast cancers with no effective treatments.
Researchers developed a novel AAV-equipped nanomachine that successfully overcame gene therapy challenges in mice, including reduced efficiency due to neutralizing antibodies and hepatotoxicity. The nanomachine demonstrated sufficient gene transfer activity and suppressed liver toxicity markers.
A new method to construct protein complex-based therapeutics has been discovered using a polymer cloak, which stabilizes the delivery of protein complexes and enables tumor-targeted immunomodulation. The study presents an IL-15 nanosuperagonist with enhanced efficacy and specificity, promising a safer therapy for cancer treatment.
Researchers found that a 10-nanometer-sized nanoruler achieves the highest brain tumor accumulation, outperforming larger sizes. This discovery offers guidance for designing future brain tumor nanomedicines.
Researchers developed a simple and efficient method for diversifying reactive end-groups on poly(2-oxazoline)s, enabling rapid exploration of poly(2-oxazoline)-based nanomedicine platforms. The approach was shown to produce POx-based lipid nanoparticles comparable in transfection capability to their PEGylated counterparts.
A groundbreaking study demonstrates that intradermal administration of naked mRNA induces robust vaccination against SARS CoV-2 in mice and primates. The novel approach avoids the use of lipid nanoparticles, which can cause adverse reactions, allowing for multiple doses over a lifetime.
A new property evaluation method for nanoparticles' shape anisotropy has been developed using deep learning, achieving classification accuracy of approximately 80% on single particle basis. This breakthrough solves a long-standing issue in nanoparticle evaluation dating back to Einstein's time.
A new mRNA derivative, comb-structured RNA, has been developed to enhance anti-cancer activities by activating immune cells and demonstrating high tumor effects in mice models. The study shows the potential of this novel cancer mRNA vaccine as a safe and effective treatment.
A new nanomedicine platform targets brain lipid metabolism to reduce food intake and body weight in mice, offering a promising approach for managing metabolic diseases like obesity. The study demonstrates the effectiveness of this novel treatment, which could potentially provide an innovative solution for controlling energy balance.
Researchers developed a novel pH-activated nanocytokine system using IL-12, which enhances immunity and eradicates tumors in murine models. The nanocytokine controls inflammation through spatiotemporal regulation, blocking counteractive immune responses and reducing toxicity.
Researchers developed polymeric micelles to reprogram tumor microenvironment, enhancing nano-immunotherapy efficacy in mouse breast cancer models. The treatment response can be predicted from ultrasound shear wave elastography measurements prior to treatment initiation.
Researchers developed bioresponsive polymers for targeted delivery and controlled release of therapeutic agents. However, achieving exclusive selectivity remains a challenge due to complex biology.
Researchers developed size-tunable PEG-grafted copolymers to target muscle tissues by exploiting the blood-muscle barrier. The optimal size range for extravasation was found to be between 11-32 nm, with accumulation in skeletal muscles of Duchenne muscular dystrophy model mice being significantly higher than in normal mice.
Researchers developed nanoparticles with a changeable net charge that facilitates intratumor accumulation and penetration, achieving 32.1% of injected dose/g of tissue. This study suggests using the changeable net charge as a promising strategy for tumor-targeted delivery based on the EPR effect.
Non-viral mRNA and pDNA delivery systems have shown promising results in vaccine development against COVID-19 and are being explored for therapeutic applications. These systems aim to improve upon current formulations by enhancing stability, targeting specific tissues, and stimulating innate immune responses.
Recent progress in targeted nanomedicine for managing resistance and toxicity of cisplatin in cancer therapy is reviewed. The article highlights strategies to increase cisplatin sensitivity through improved intracellular concentration and combination therapy, as well as novel approaches targeting tumor microenvironment and immunotherapy.
Recent nanomedicines are being explored for brain cancer treatment due to their ability to improve bioavailability and evade the blood-brain barrier. These supramolecular nanomedicines show potential in promoting superior therapeutic effects by targeting brain tumors specifically.
Researchers have developed a novel nanocarrier system that synergizes poly(l-ornithine) for mRNA protection with charge-conversion polymer for endosomal escape. This innovation enhances protein expression efficiency by approximately 80-fold, outperforming traditional PLL-based systems.
Researchers examine ways to target specific neurons using nanomedicine, aiming to improve treatment options for neurodegenerative diseases like Alzheimer's and Parkinson's. The study highlights the challenges of delivering drugs to specific populations of neurons in the brain.
Researchers created polymersomes that target highly invasive cancer cells, delivering anticancer drugs and preventing metastasis. The nanomachines showed strong antitumor effects in breast cancer models, inhibiting lung metastasis and prolonging survival.
A new antibody delivery technology enhances anti-PD-L1 antibody accumulation in glioblastoma by 33-fold, achieving a 60% complete response rate with long-term immune memory. The technology also suppresses immune-related adverse events.
Researchers have developed poly-ion complex (PIC) nanomicelles loaded with CPT1A inhibitors to deliver drugs into brain cells, reducing fatty acid oxidation and improving treatment for glioblastoma. The delivery system successfully increased cellular concentration of the cargo and biological activity.
A research team has developed a novel nano-micelle packaging method for delivering CRISPR/Cas9 components, allowing for efficient genome editing in the mouse brain. The optimized nano-micelles enable targeted and precise editing of genomic sequences with minimal off-target effects.
Researchers developed polymeric nano-micelles that target specific levels of c-Myc expression, a key factor in cancer cell proliferation. The study showed varying efficacy depending on tumor c-Myc expression levels, with higher expression associated with better antitumor activity.
Researchers have developed ultra-small nanomedicines that stably deliver oligonucleotides to refractory cancers, such as brain tumors and pancreatic cancer. These nanomedicines use Y-shaped block copolymers and nucleic acid drugs, achieving high permeability in cancer tissues and stability in the bloodstream.
The Kawasaki Institute of Industrial Promotion has opened a new website for Project COINS, which aims to establish an in-body hospital network by 2045. The initiative is part of the Center of Innovation Program (COI) and will focus on creating innovative healthcare and medical technologies.
Researchers have created a polymeric nanomicelle that effectively delivers the potent mitotic inhibitor desacetyl vinblastine hydrazide (DAVBNH) to glioblastoma, showing improved survival rates in mice. The developed nanomicelle accurately senses the pH lowering in tumor tissue and releases the contained anticancer drug.
The 7th COINS Symposium aims to realize 'in-body hospitals' by 2045, with a focus on innovative medicines and treatments. The symposium features keynote speakers discussing the latest trends and medicine development.
Researchers developed a nanomedicine-based strategy for chemo-immunotherapy that eradicated PTEN-negative glioblastoma cells. The combination of epirubicin-encapsulating nano-micelles and immune checkpoint inhibitors increased tumor-infiltrating T cells and reduced immunosuppressive cells, effectively killing cancer cells.
Researchers developed a novel two-step targeting strategy to selectively deliver therapies to the brain by exploiting the high impermeability of the BBB. This approach allows for specific brain targeting with minimal accumulation in peripheral organs, paving the way for increased clinical translation of nanoparticle-based therapies.
Researchers from Innovation Center of NanoMedicine and Tokyo Metropolitan Institute of Medical Science are developing an mRNA vaccine with immunostimulatory adjuvant functionality. The technology uses smart nanomachines to produce vaccines efficiently and at a low cost, tackling the ongoing COVID-19 pandemic and potential future new co...
Researchers have developed a reagent for selective and safe coating of the liver sinusoidal walls to control clearance of gene therapy drugs. The coating agent improved gene transfer efficacy by 2-4 times to the myocardium and skeletal muscles, and 10 times to colorectal cancer, reducing medical costs and adverse effects.