Researchers at University of Texas M.D. Anderson Cancer Center identify IL-6 as a key player in immunotherapy toxicity. A novel strategy combining IL-6 blockade with immune checkpoint blockade shows promise in reducing autoimmune side effects while preserving antitumor efficacy.
Researchers used a mega-electron-volt ultrafast electron diffraction instrument to study vanadium dioxide's insulator-metal transition. The 'stroboscopic camera' captured the hidden trajectory of atomic motion, showing two stages with non-linear atomic motions in the second stage, influenced by electron orbital forces.
Scientists have identified a novel drug target that may help overcome resistance to EZH2 inhibitors in cancers with SMARCB1 mutations. By inhibiting the KDM2A gene, cancer cells can regain sensitivity to EZH2 inhibition, offering new hope for effective treatment.
Research found that bolder marmoset monkeys learn faster than their shy counterparts, with social environment also playing a role. The study suggests that both personality traits and family group membership influence cognitive performance in these monkeys.
A recent study reveals that nearly two-thirds of traditional farmer crop varieties are already represented in genebanks, but conservation gaps persist for key crops like pearl millet and potatoes. The analysis highlights areas with high diversity in landraces, such as Bangladesh, Ethiopia, and India.
Researchers at San Diego State University have identified rare genetic markers in M. tuberculosis that could improve early detection of drug-resistant strains of the disease, helping prevent their spread. These markers may help block common TB drugs from interfering with the pathogen's ability to synthesize proteins.
Researchers developed an ensemble model combining multiple individual predictive models to anticipate COVID-19 hospital demand, achieving a significant reduction in prediction error. The study's findings show that incorporating early predictors such as epidemiological data and mobility data leads to better forecasts.
A new study from the University of Notre Dame found that consumers have mixed feelings about science in product development. When marketing focuses on sensory pleasure, consumers are less likely to buy products described as scientifically developed, but are more likely to buy them when focusing on practicality.
The study reveals significant information on the thermal properties of electric double-layer capacitors, which can help create safer and more reliable energy storage devices. The research team found that charging and discharging alter the heat capacity of EDLCs, leading to a decrease in capacitance.
A University of Auckland research team analyzed the legal documents of Spotify and Tinder to understand their algorithmic recommendations. The study found that both platforms collect and use personal data without transparency, influencing users' choices in various ways.
The study found that even if Earth's climate stopped warming, it would be difficult to rebuild the ice shelf once it has fallen apart. The researchers suggest that the ice shelf may not recover unless the future climate cools considerably. This has significant implications for sea-level rise and the stability of polar ice sheets.
Researchers at Ochsner Health and MD Anderson have discovered that blocking interleukin-6 (IL-6) in lab models improves cancer responses while minimizing inflammation in healthy tissue. By targeting this cytokine, immune checkpoint inhibitors may become more targeted on tumors with fewer side effects.
A new study reveals that global warming will shift the timing of ocean plankton blooms, impacting the marine food web and potentially disrupting the delicate coupling between phytoplankton growth and zooplankton abundance. This change could have severe consequences for high-latitude regions.
A new study suggests that tailoring diabetes screening for Black, Hispanic, and Asian Americans based on lower BMI thresholds and younger ages can significantly reduce disparities in diabetes diagnosis rates. This approach may improve health equity by identifying cases earlier and reducing mortality rates associated with diabetes.
The Mekong Delta in Vietnam could be almost completely submerged by sea water by the end of the century if urgent action is not taken. A Politecnico di Milano study identified six measures to increase the survival of the delta, including regulating sediment extraction and implementing natural coastal protection solutions.
Researchers at UBC's Sea Around Us initiative identified four high-traffic areas in the Pacific Ocean as crucial for conserving large pelagic fishes like tuna and swordfish. By analyzing migration routes, genetic sequencing studies, and catch distribution maps, they pinpointed 'blue corridors' where strict fisheries management measures...
Energy researchers have invented a device that electronically converts one metal into behaving like another to use as a catalyst for speeding chemical reactions. The invention opens the door for new catalytic technologies using non-precious metal catalysts, potentially improving efficiency and sustainability in various applications.
A new study published in Cyberpsychology, Behavior, and Social Networking found that virtual reality-based Anger Exposure Training reduced anger provoked by angry expression in both high and low aggression groups. Mindfulness Training also increased comfort levels in both groups, according to the researchers.
A gene therapy approach has effectively reduced neuropathic pain in mice with spinal cord or peripheral nerve injuries without detectable side effects. The treatment, which targets impaired neurons, resulted in long-lasting benefits persisting for at least 2.5 months.
Researchers have discovered a 30-mile-long, 9-mile-wide subglacial lake in East Antarctica that may hold the key to understanding the continent's glaciation history. The sediments at the bottom of Lake Snow Eagle could provide valuable insights into climate change and the ice sheet's possible demise.
A new study reveals that droplets can unexpectedly form complex linear structures when carried by an external flow, buckling and folding onto themselves to create 'folds' and 'strings'. This phenomenon could provide insight into how ordered structures emerge from sequentially generated building blocks.
A recent study led by the University of Southampton reveals that whale sharks are facing a significant threat from industrialised shipping. The research, which tracked over 350 whale sharks across the globe, found that over 90% of their movements overlapped with global fleets of cargo ships.
A bioethicist contends that crisis-care protocols should ignore patients' age, proposing instead a patient-specific values approach. She suggests using a Clinical Frailty Scale to predict near-term survival and considers a lottery as the fairest way to prioritize individuals under dire conditions.
A systematic review and meta-analysis of 81 studies found that COVID-19 patients with cancer had a higher risk of death compared to those without cancer. Younger age, lung, and hematologic cancers were identified as risk factors for poor outcomes from COVID-19
A new paper highlights the need for uniform patient confidentiality policies for adolescents, as state laws vary significantly and often contradict medical societies' standards. The authors argue that this variability can lead to clinically significant consequences for adolescents seeking care for sensitive issues.
Scientists have detected an increase in atmospheric helium levels, which is attributed to the release of helium as a by-product of fossil fuel combustion and extraction. This finding has significant implications for understanding industrial activity and the potential uses of rare helium isotopes.
Researchers found that extinct species had smaller brains than surviving ones, suggesting a link between brain size and adaptability. The study suggests that larger brains helped extant species cope with human activities and climate change.
Researchers found that greater mouse-eared bats imitate the buzzing sound of a stinging insect to avoid predatory owls. The study, published in Current Biology, provides evidence of interspecific mimicry between mammals and insects.
Chronobiologists have identified a crucial mechanism involved in the setting of the circadian clock of cyanobacteria, a model organism for studying circadian systems. The study reveals that the KaiC protein's dual ATPase active sites communicate through an interface to regulate the assembly and disassembly cycle of other clock proteins.
Researchers found that invoking science in marketing pleasurable products like cookies decreases consumer interest. However, pairing science with practicality makes sense to consumers. The study suggests updating public beliefs about scientists and their approach to make science more acceptable for marketing indulgent goods.
A multicentre study has proven personal construct therapy as effective as cognitive-behavioural therapy in improving quality of life and symptoms of depression in patients with fibromyalgia. The therapy focused on people's identity and how they see themselves, offering a personalized approach to treatment.
Benjamin Gatling plans to conduct a survey and inventory of the materials, train in best practices, and purchase equipment. The project aims to preserve and digitize the complete collection, offering a unique window into Soviet Central Asia's cultural patrimony.
Researchers found phosphatidylinositol bisphosphate (PIP2) essential for epithelial cell-cell adhesion and maintaining cellular identity. PIP2 regulates epithelial properties by recruiting Par3 to the plasma membrane, facilitating the formation of adherens junctions and preventing epithelial-mesenchymal transformation.
A new study found that a personalized text messaging support program improved lifestyle measures among heart attack survivors, including exercise habits and cholesterol levels. However, the program had no significant impact on medication adherence.
Research finds that COVID-19 led to a significant decrease in racial inequities in primary care appointments, with Black patients' visit completion rates increasing by 7-8% in the second half of 2020. Telemedicine adoption played a key role in closing this gap.
A new volcanic modeling study found that ice-capped volcanoes like Westdahl Peak are delayed in eruption by approximately seven years due to the added pressure from glacial ice. This increase in time may seem insignificant on a geologic scale, but it's significant on the human time scale.
A recent study found significant racial and ethnic disparities in excess deaths from external causes, including homicide, suicide, and transportation accidents. The study estimated these disparities during the COVID-19 pandemic, highlighting the need for targeted interventions to address health inequities.
A new study by Weill Cornell Medicine investigators found that T cells' genetic program and developmental path affect their response to immunotherapy. The results suggest that infiltrating T cells don't all meet the same fate in every tumor, with long-lived memory programs correlating strongly with overall survival
A new study from McGill University finds that people living near regions prone to wildfires may have a higher incidence of lung cancer and brain tumors. Exposure to carcinogenic wildfire pollutants on a chronic basis increases the risk of certain cancers, according to researchers.
Researchers at H. Lee Moffitt Cancer Center & Research Institute have identified key factors impacting the effectiveness of adaptive therapy in cancer treatment. The study found that spatial organization and competition between drug-resistant cells play a crucial role in determining the success of adaptive therapy.
Heads of State and Government meeting at the United Nations' global conference on land called for immediate action to stem life and livelihood losses due to desertification, land degradation, and drought. The Abidjan Call urges prioritizing drought relief and committing to achieving land degradation neutrality by 2030.
The university's new Robotics and Autonomous Systems Teaching and Innovation Center (RASTIC) will provide students with hands-on experience in robotics, autonomous systems, and self-driving technology. The lab aims to boost Massachusetts' competitiveness in the tech sector by supporting innovative projects and startups.
Physicists from Cracow have developed a new measurement technique to track phenomena lasting attoseconds, using X-ray chronoscopy. This approach potentially makes it possible to infer events in the world of attophysics even at current XFEL technology.
The cosmic time synchronizer uses cosmic rays from deep space to detect specific signatures, allowing devices to synchronize their clocks accurately. This technology has the potential to fill gaps in current time synchronization methods, particularly in remote or underwater locations.
The pandemic has led to increased adoption of virtual meeting platforms like Zoom, affecting team trust and knowledge sharing. This can result in time and cost over-runs or negatively impact work quality.
A new study by the University of South Australia found that up to a quarter of people aged over 50 with undiagnosed visual problems like cataracts or AMD are misdiagnosed with mild cognitive impairment. Cognitive tests relying on vision-dependent tasks can skew results.
Researchers assessed modifiable risk factors for Alzheimer disease and related dementias in the US population, finding significant differences by sex, race, and ethnicity. The study highlights the importance of addressing these disparities to prevent cognitive decline.
A recent study in CMAJ found that nearly half of Canadian drownings were caused by pre-existing medical conditions, with seizure disorders posing a significant risk. Young women aged 20-34 with seizure disorders were particularly vulnerable, facing a risk 23 times higher than the general population.
Researchers have discovered 'proto-peat', a thin layer of organic matter containing high levels of carbon, in the Arctic. This finding suggests new carbon sinks may be forming as the region warms up.
The May issue of the CHEST journal features 56 articles on clinically relevant topics such as asthma, COPD, and critical care. The journal also includes a special Adult Cystic Fibrosis Series with latest epidemiologic data and challenges in managing CF.
Researchers compiled catalog of Lake Erie-area earthquakes between 2013 and 2020 to investigate potential connection to shifting water levels. The study found no conclusive correlation between earthquake rates and water levels.
A new online tool, HazardAware, provides disaster readiness reports for 13.3 million addresses in 196 counties along the Gulf of Mexico, including all of Florida. The tool assesses a property's resilience to hazards such as hurricanes and flooding, and offers customized mitigation information to reduce future hazard loss.
Researchers at Oak Ridge National Laboratory developed an algorithm that guides breakthroughs in new materials using self-driving microscopes. The approach combines physics and machine learning to automate microscopy experiments, enabling faster discoveries of functional materials' properties.
Researchers developed a new test method to detect tuberculosis (TB) progression from latent infection in elephants using IgG antibodies against Antigen 85B. High levels of IgG against ESAT6/CFP10 remained constant, while IgG against Ag85B increased before disease onset and declined with treatment.
A seven-year research project suggests that a short chain of amino acids, the HTL-001 peptide, is effective at targeting and inhibiting Hox genes responsible for GBM growth. The study offers hope for finding a solution to this devastating form of brain cancer.
Researchers developed nanoparticles with a changeable net charge that facilitates intratumor accumulation and penetration, achieving 32.1% of injected dose/g of tissue. This study suggests using the changeable net charge as a promising strategy for tumor-targeted delivery based on the EPR effect.
A new study reveals that future super cyclones will disproportionately affect populations in South Asia, particularly India, with increased exposure to extreme flooding. If greenhouse gas emissions continue at current levels, over 250% of India's population may experience flooding exceeding 1 meter by 2050.
The electrochemistry designette is a pedagogical tool that enables instructors to visualize students' competence and misconceptions on electrochemical principles. Developed by SUTD researchers, the designette has proven highly effective in allowing instructors to spot misconceptions and provide prompt intervention.
The study identifies two subpopulations of liver ILC1s, Ly49E+ and Ly49E-, with distinct origins and functions. The Ly49E+ subset is produced by embryonic hematopoietic precursors and exhibits stronger cytotoxicity, while the Ly49E- subset has stronger immune memory potential.
Researchers have discovered a way to suppress a specific protein that promotes resistance to drugs commonly used to treat AML patients. This breakthrough has the potential to revolutionize treatment and prolong survival for those affected by the disease.