A large population study found that smoking increases the risk of dying from prostate cancer, regardless of tumor stage, and is associated with a poorer prognosis. Smokers have a lower risk of developing prostate cancer but are more likely to be diagnosed at an advanced stage.
Researchers at Weill Cornell Medicine found that tumors recruit nearby cells called fibroblasts to work as their enablers by releasing lactate. This finding suggests that future drug treatments could target this defense mechanism to help cancer patients.
Researchers have discovered that a human enzyme converts marine sponge chemicals into cell-killing compounds, which could lead to the development of new cancer and infection treatments. The findings identified an untapped toolbox of natural and synthetic compounds that can be converted by widespread enzymes into potentially useful drugs.
Scientists have developed a new method of recording data using light on silicon waveguides, enabling non-volatile and high-performance magneto-optical memories. This breakthrough could lead to all-optical alternatives in telecommunications infrastructure and applications in optical computing.
Researchers proposed an inverse-design methodology for achieving customized dispersions in acoustic metasurfaces, enabling multiple functionalities of high-efficiency and ultra-broadband acoustic directional energy transmission, energy convergence and ultrasound particle levitation. The study demonstrated the feasibility of realizing a...
A study found a connection between learning and memory deficits in children with Joubert Syndrome and defects in the hippocampus. The researchers used animal models to create a genetic mutation that mimicked the human disease, revealing key findings about the role of primary cilia in brain development.
A recent study published in The Lancet Planetary Health found that improving market access has a positive impact on nutritional status in rural sub-Saharan Africa. Meanwhile, increasing crop diversity had little effect on children's growth and nutrition. Diversifying animal production, however, showed positive effects.
Researchers found that australopithecines' smaller brain sizes at birth were likely an adaptation for bipedalism, allowing them to navigate the complex birth canal. The study suggests that prolonged learning outside the womb was crucial for cognitive and cultural development in early humans.
A study published in Journal of Psychiatric Research found a significant biological difference between psychopaths and non-psychopaths, with psychopaths having a larger striatum region in the brain. This finding is linked to increased need for stimulation, impulsive behaviors, and higher likelihood of violent behavior.
A new study found that the Western Interior Seaway in western North America was as warm as today's tropics during the height of the Cretaceous Thermal Maximum. Average water temperatures ranged from 28 to 34 degrees Celsius, consistent with modern tropical extremes like the Indo-Pacific Warm Pool.
A study of 21,083 adults found that coffee consumption is associated with raised cholesterol levels, with brewing methods such as espresso showing the widest gender difference. Drinking 3-5 daily cups of espresso was linked to increased serum total cholesterol, particularly among men.
A study from Edith Cowan University reveals that electrical stimulation on specific nerves and relaxation techniques can reduce neural amplification in the spinal cord, which may help alleviate involuntary muscle spasms. These methods could provide a non-pharmacological alternative to current treatment options.
Researchers at Karolinska Institutet have mapped the formation of hybrid strains in Trypanosoma cruzi, a parasite causing chronic infection and severe symptoms. These hybrids are more effective at evading the immune system and causing disease, but understanding their formation can help develop new diagnostic and treatment methods.
Researchers at the University of Birmingham found that infected fruit flies continue to engage in courtship and mating behaviors, similar to uninfected flies. The study suggests that animals may invest more in reproduction when faced with a potential life threat, potentially to pass on genes to the next generation
Researchers discovered that memory B cells produce non-specific antibodies to combat virus mutants, working alongside phagocytes to screen for variants. This mechanism may offer protection against SARS-CoV2 and HIV variants, and could influence vaccine development.
Researchers studied ultrafast control of single-photon emitters in hexagonal boron nitride using laser pulses. They developed a comprehensive understanding of the dynamics within colour centres, which can help avoid perturbations in future applications.
A study by Hebrew University researchers reveals that individuals overestimate the presence of minority groups in social settings. This 'diversity illusion' can hinder policies promoting diversity and leads to less support for related initiatives. The research team suggests that awareness and education are key to addressing this bias.
A new study from the Regenstrief Institute examines the effects of clinical texting on hospitalist and nurse communication, highlighting both benefits and challenges. The study suggests that clinical texting can improve communication, but also raises concerns about user buy-in and shared understanding.
Researchers estimate that by 2040, up to 80 million metric tons of plastic will be annually released into the ocean. The study reveals that wind transport contributes significantly to plastic particle distribution in remote regions. Integrating microplastic into air pollution measurements is crucial for better understanding its effects.
Researchers use computational detective work to verify the existence of a 3D quantum spin liquid in cerium zirconium pyrochlore, overcoming decades-long challenge. The material exhibits fractionalized spin excitations, where electrons do not arrange their spins in relation to neighbors.
A survey study found that cost was the most common reason for young adults aged 18-25 to avoid seeking depression treatment from 2011 to 2019. Increasing inadequate insurance coverage for mental health treatment also contributed to this issue.
Researchers have discovered a way to mitigate significant losses in spin current transport by integrating an atom-thin insulator between materials. This innovation has important implications for energy-efficient and ultra-fast storage technologies, as well as applications in terahertz emitters and other spintronic devices.
The authors of a Call to Action emphasize the value of incorporating patient perspectives in clinical Parkinson's disease studies and recommend how to include patient researchers effectively. Patient involvement can help design better studies, ensure tolerable protocols, and improve research outcomes. However, specific challenges must ...
Researchers found that elevated plasma levels of proline and a diet rich in this amino acid are associated with severe depression. The study also discovered a link between microbiota alterations and proline metabolism impacting depressive mood.
A new sensor technology allows for real-time monitoring of lactate levels in the brain, providing insights into energy metabolism and potential applications in cancer detection. The sensors corrected for hemodynamic artifacts using MRI-informed corrections enable accurate cell-specific lactate level recordings.
Physicists at the University of Arkansas have discovered a light-induced mechanism to control ferroelectric polarization in a deterministic manner. By applying ultrafast laser pulses, researchers can manipulate and reverse this polarization.
A study published in mBio found that healthy adults with diets rich in soluble fiber and lower animal protein consumption had fewer antibiotic-resistant microbes in their guts. This suggests that modifying the diet through increased fiber intake may help reduce antimicrobial resistance by shaping the gut microbiome.
The American College of Medical Genetics and Genomics has released a new Clinical Practice Resource to guide the treatment of patients with hearing loss. The resource offers information on causes, presentations, and approaches to clinical evaluation and genetic testing.
A new special issue of Applications in Plant Sciences explores techniques for studying gametophytes, essential for understanding biodiversity and conservation. The study reveals the complexity of gametophyte biology, including their limited size and invisibility in some plants.
Latest climate models tend to overestimate future Afro-Asian summer monsoon (AfroASM) rainfall and runoff. By constraining biases, the rainfall increase is 70% of the raw projection.
Researchers found that frozen testicular tissue from rats can be reimplanted and produce viable sperm after over 20 years, but with reduced fertility. The study has important implications for treatment of boys with cancer and may provide a method to recover lost fertility.
A new type of RNA structure targeting tool has been developed to specifically recognise unusual four-strand RNA structures associated with diseases such as cancer and neurological disorders. The L-RNA aptamer-based rG4 targeting approach shows promise for developing new therapeutic tools.
A neural network was trained to differentiate between healthy joints and those with rheumatoid or psoriatic arthritis using finger joint scans. The AI achieved high accuracy rates, detecting 82% of healthy joints, 75% of rheumatoid arthritis cases, and 68% of psoriatic arthritis cases.
Researchers at Concordia University have developed a method to manufacture adaptive compliant trailing edge morphing wings using 4D printing of composites. This technology can make UAV wings cheaper to manufacture and more efficient in flight, supporting good amounts of load for small or medium-sized vehicles.
Researchers at MIT discovered that cells shed 4% of their mass before cell division to eliminate toxic components. This process allows newborn cells to start with fresh, functional contents, which may help explain why neurons accumulate toxic proteins in Alzheimer's disease.
A new fluorescent probe can detect T cells involved in attacking tumors and monitoring treatment effectiveness. The technology could help clinicians develop personalized therapies and clear cancers faster without potential side effects.
Researchers at NIST confirmed that transmission performance is consistent across different mmWave spectrum bands, refuting earlier disputes. Signal losses in secondary paths vary by frequency, with reflective paths losing minimal signal strength.
Chronic bacterial infections can lead to chronic inflammation and DNA damage, increasing CRC risk. Salmonella infections are particularly risky, as they impair immune responses and promote tumorigenesis.
The study analyzes solar thermochemical hydrogen production, a potentially more energy-efficient method than electrolysis. The researchers identified key challenges and provided boundaries for hydrogen production costs, which could be crucial to meeting the Department of Energy's Hydrogen Energy Earthshot goal.
Researchers found a common genetic variant that may protect women with endometriosis or polycystic ovary syndrome from future heart disease. The variant also appears to lower the risk of breast and other cancers in women who experience preeclampsia.
A study reveals the DJ1 protein's role in Parkinson's disease by demonstrating its link to aberrant cell cycle re-entry, which leads to neuronal death. This finding could pave the way for new therapeutic approaches that prevent neuronal death and combat symptoms.
A new study documents multiple small regions of DNA from domestic cattle in North American bison genomes, revealing a shared genetic ancestry. The research reveals that even historically isolated herds contain low levels of cattle genomic introgression, with implications for bison conservation efforts.
A new NIH-funded study will investigate the effects of semi-volatile organic compounds (SVOCs) on infant and childhood immunity, filling a knowledge gap in SVOC health impacts. The research aims to identify specific SVOCs or mixtures that impair immune function, which could lead to new preventive measures and interventions.
Researchers found that maintaining hard water reduces zinc accumulation and oxidative stress in goldfish, mitigating toxic effects. This study provides an eco-friendly approach to address aquatic ecosystem pollution caused by heavy metal contamination.
A new study from the University of Eastern Finland found that climate change is causing the pine beauty moth to shift its range northward 50 years ahead of earlier predictions. The larvae feed on pine needles, and their population size is linked to warmer temperatures and forest health decline.
Researchers applied scRNA-seq to study hypertrophic cardiomyopathy, identifying novel regulatory interactions and genes driving disease-related swelling. This knowledge can be used to develop new drugs that target underlying causes, reducing disease progression.
A University of Otago study analyzed ancient DNA from the eastern moa, finding that the species altered its distribution as the climate warmed and cooled. The research highlights how past climate change impacted different species in unique ways, challenging a 'one size fits all' model.
A team of researchers found that laboratory conditions, rather than the number of experimenters, have a greater influence on animal study results. This suggests that biological variation plays a key role in animal research, even with standardized conditions.
Researchers found that the nervous system explores multiple coordination patterns to learn new movements, then adapts specific aspects for optimal performance. This process reduces energy cost by up to 25%.
A Tokyo University of Agriculture and Technology research team finds that changes in viscoelastic properties affect flow dynamics differently depending on gel elasticity, leading to a reversal of flow effects. This discovery opens new avenues for controlling flow dynamics using chemical reactions.
Researchers from CIIDIR-Oaxaca Amphibian Ecology Laboratory studied the consumption of tadpoles in stone soup, revealing its significance as an indicator of water health and the species' vulnerability to overfishing. The study highlights the importance of accurately documenting human interaction with amphibians.
Scientists use advanced measurement methods to study carotid artery stenosis, discovering significant gaps between their findings and clinical methods. They propose improvements for surgical treatment technology and future medical devices.
A new study found that individuals high in grandiose and vulnerable narcissism are less likely to wear masks or get vaccinated. However, those who do choose to participate may be more likely to encourage others to do so. Researchers suggest using unique messaging strategies to tap into these personalities.
Researchers developed a novel 'Wikiguideline' approach to establish medical guidelines, leveraging online collaboration and high-quality data. The method was tested using osteomyelitis, an infection of the bone, and found sufficient data for only two recommendations: increasing oral antibiotic therapy and limiting therapy duration.
A proof-of-concept study suggests that postnatal gene therapy may prevent or reverse deleterious effects of Pitt-Hopkins syndrome, a rare genetic disorder. The treatment restored normal activity of the deficient gene, preventing anxiety-like behavior and memory problems in an animal model.
Studies in fruit flies reveal coordinated movements of heads and bodies to stabilize vision and improve flight performance. Similar synchronization is observed in other animals, including primates, suggesting evolutionary benefits for energy efficiency and performance.
A study found that informational content in videos, rather than emotional connectivity, encourages family members to donate tissues. The intervention increased willingness among next-of-kin to provide consent for tissue donation in Nevada, where the vast majority do not give consent after death.
Researchers used game theory to create models of cooperative and competitive behaviors in multi-agent systems, focusing on distributed online optimization, federated optimization, and static/dynamic games. The findings have potential applications in smart cities, market competition, information security, and drug development.
A new study identifies 152 genetic variants shared across multiple psychiatric disorders, including schizophrenia and bipolar disorder. This finding could lead to the development of therapies addressing multiple disorders with one treatment.
Researchers found that genes expressed in the brains of fearless birds differ from those of fearful birds, influencing their behavior and adaptation to new environments. This study provides insights into the genetic basis of fear and boldness in wild animals, potentially leading to novel approaches for addressing anxiety disorders.