A new study by Emory University researchers suggests that antibiotics can accelerate the growth of malignant melanoma in mice by depleting their intestinal flora and weakening their immune response. This depletion leads to a higher tumor burden in infected mice compared to those with intact gut microbiomes.
Researchers at Tokyo Metropolitan University discovered that a protein excreted by type I muscle fibers can differentiate surrounding myoblasts into type I fibers, upending the notion that fiber ratios are fixed at birth. This finding has significant implications for treating conditions such as type 2 diabetes and aging populations.
Scientists have discovered a link between air pollution and lung cancer in people who have never smoked. Exposure to particulate matter (PM2.5) has been shown to promote cancerous changes in airway cells with EGFR and KRAS gene mutations, driving them towards a cancer stem cell-like state.
A phase 3 study shows that tumour-infiltrating lymphocytes (TIL) therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma. The treatment reduces disease progression or death by 50% in patients treated with TILs.
The DeFi trial shows targeting the Notch pathway with nirogacestat improves progression-free survival and reduces symptoms in patients with desmoid tumours. Patients reported a statistically significant benefit in reduced pain, symptom burden, and improved quality of life.
A new study reveals a widening gap in diabetes-related mortality between urban and rural areas in the USA, with significant disparities seen in male and younger patients. The study found that reductions in mortality rates in urban areas were mainly limited to female and older patients, while outcomes worsened for male and younger indiv...
Researchers developed bioresponsive polymers for targeted delivery and controlled release of therapeutic agents. However, achieving exclusive selectivity remains a challenge due to complex biology.
Researchers found that blocking FNDC5, the precursor of irisin, prevents severe muscle atrophy and weakness in cancer-induced cachexia. Mice lacking FNDC5 showed improved body weight and skeletal muscle mass compared to control mice with tumors.