Researchers developed a new test method to detect tuberculosis (TB) progression from latent infection in elephants using IgG antibodies against Antigen 85B. High levels of IgG against ESAT6/CFP10 remained constant, while IgG against Ag85B increased before disease onset and declined with treatment.
A seven-year research project suggests that a short chain of amino acids, the HTL-001 peptide, is effective at targeting and inhibiting Hox genes responsible for GBM growth. The study offers hope for finding a solution to this devastating form of brain cancer.
Researchers developed nanoparticles with a changeable net charge that facilitates intratumor accumulation and penetration, achieving 32.1% of injected dose/g of tissue. This study suggests using the changeable net charge as a promising strategy for tumor-targeted delivery based on the EPR effect.
A new study reveals that future super cyclones will disproportionately affect populations in South Asia, particularly India, with increased exposure to extreme flooding. If greenhouse gas emissions continue at current levels, over 250% of India's population may experience flooding exceeding 1 meter by 2050.
The electrochemistry designette is a pedagogical tool that enables instructors to visualize students' competence and misconceptions on electrochemical principles. Developed by SUTD researchers, the designette has proven highly effective in allowing instructors to spot misconceptions and provide prompt intervention.
The study identifies two subpopulations of liver ILC1s, Ly49E+ and Ly49E-, with distinct origins and functions. The Ly49E+ subset is produced by embryonic hematopoietic precursors and exhibits stronger cytotoxicity, while the Ly49E- subset has stronger immune memory potential.
Researchers have discovered a way to suppress a specific protein that promotes resistance to drugs commonly used to treat AML patients. This breakthrough has the potential to revolutionize treatment and prolong survival for those affected by the disease.
Researchers have developed advanced optical 3D printing methods for creating tissue scaffolds with controlled structure and scale, mimicking native extracellular matrices. These methods offer high precision, cost-effectiveness, and potential for broader applications in tissue engineering.