HKUST-led research reveals a novel molecular mechanism that regulates secretion of sonic hedgehog, shedding light on cancer treatments
A novel SURF4-to-proteoglycan relay mechanism regulates the secretion of sonic hedgehog (Shh), a key signaling molecule in cancer progression. The study offers new insights into inhibiting Shh secretion and shutting down the Hh signaling pathway to hinder cancer progression.
SourceHong Kong University of Science and Technology·JournalProceedings of the National Academy of Sciences·DateMay 7, 2022