A new Yale-led study has discovered a previously unknown process by which some NSAIDs reduce inflammation, potentially explaining their unexpected effects on various diseases. The research found that only certain NSAIDs activate the protein NRF2, which triggers anti-inflammatory processes.
Researchers from TROPOS, University of Copenhagen, and Caltech have successfully detected hydrotrioxides (ROOOH) under atmospheric conditions. The formation of these compounds has been estimated to occur through the oxidation of isoprene and other hydrocarbons, with potential implications for health and environmental studies.
Researchers identified 127 genes associated with immune diseases, providing new insights into the sequence and timing of gene activity during T cell activation. The study used single-cell RNA sequencing technology to map the timing of gene activity for each cell subtype in the T cell activation process.
Researchers used heterochronic parabiosis to connect old and young mice, revealing key mediators of systemic rejuvenation. Aged stem cells in bone marrow were revitalized by exposure to young blood, regaining lymphoid differentiation potential.
Researchers have found that mutational signatures, which reflect a collection of mutations across the genome, can accurately predict drug response in cancer cells. The study suggests that these signatures may hold the key to better cancer therapies and could be used to predict treatment response.
Researchers from UToledo found that a dominant gut bacteria species, Coprococcus comes, can break down quinapril and ramipril, reducing their efficacy. This study provides insights into the impact of gut bacteria on blood pressure medication, potentially leading to new ways to overcome treatment-resistant hypertension.
A study using 50 years of satellite imagery found that avulsions occur more frequently in steep, sediment-rich rivers in tropical and desert environments. The research suggests that climate change and land use can increase the risk of avulsions in upstream locations.
A team of researchers at Georgia Tech has developed a custom-built microscope that can reconstruct comprehensive 3D representations with a single camera image. This allows for quantitative analysis of organoids and provides insights into tissue development, drug interaction, and cellular behavior.
Researchers discovered a novel, naturally inspired bifunctional lipopeptide antibiotic cilagicin with potent antimicrobial activity against several Gram-positive bacteria. The compound demonstrated broad efficacy, including resistance to difficult-to-treat strains like C. difficile and vancomycin-resistant Enterococci.
Researchers at the Lew lab have created a novel hardware and algorithm that enables visualization of cell membranes and molecular motions in six dimensions. This breakthrough allows for the observation of 3D structures with additional information on molecular orientation, providing new insights into biological systems.
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
A new UK study has found that only one in three patients with gout were prescribed preventative medication within a year of diagnosis, indicating poor care quality. The study also revealed that just one in six patients achieved the target blood urate level recommended by the British Society for Rheumatology.
Researchers at Cornell University have developed a new algorithm for autonomous underwater sonar imaging that significantly improves speed and accuracy for identifying objects such as explosive mines and sunken ships. The new approach, called informative multi-view planning, integrates information about object locations with sonar proc...
Current predictive models underestimate tsunami severity by as much as 100%, according to USC researchers who found a correlation between tsunami strength and outer wedge width. The study identifies high-risk subduction zones, including Iran and the Cascadia zone, which could experience massive tsunamis.
A new study challenges the separation of starchy vegetables from non-starchy counterparts in nutrition research. Starchy vegetables, including white potatoes, were found to meet the definitions for high-quality carbohydrates using five separate indices, with some even scoring closer to fruits and non-starchy vegetables than sweets.
A team of chemists led by Frank Glorius has successfully synthesized new and medically significant small molecular rings using visible light. The innovative approach enables efficient and mild synthesis under mild reaction conditions, offering opportunities for producing active agents.
Researchers used high-resolution micro-CT scans to reveal key features in Palaeospondylus fossils, placing it as an early ancestor of tetrapods. The study resolves long-standing evolutionary mysteries, including the lack of teeth and dermal bones in the fossil record.
Researchers at the University of Innsbruck have successfully implemented a universal set of gates on encoded logical quantum bits, enabling fault-tolerant quantum computing. The demonstration showcases two essential gates: CNOT and T-gates, which are crucial for programming all algorithms.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that macrophages play a crucial role in cardiac repair after a heart attack by inducing vascular endothelial growth factor C (VEGFC) and promoting healing. This finding offers new hope for developing novel therapeutic approaches to preserve heart function.
Scientists and experts are calling on governments to recognize the importance of animal welfare for sustainable development. The commentary highlights how animal agriculture contributes to climate change, infectious disease emergence, and environmental degradation.
Scientists introduce a new type of structured light as high-dimensional information carriers for free-space optical communication, supporting thousands of independently spatial channels. The novel modal set has a highly consistent propagation behavior, enabling a divergence degeneracy as high as 20.
A recent study published in Clinical Nutrition Journal has established a strong link between sarcopenic obesity and dementia in elderly patients. The research found that individuals with sarcopenic obesity were more likely to experience cognitive impairment and dementia compared to those without muscle loss or obesity.
Research found that hypomethylating agents (HMAs) activated the oncofetal protein SALL4 in up to 40% of patients with MDS, resulting in poor patient survival. This activation is linked to demethylation and upregulation of oncogenes, suggesting a need for additional combination therapy.
Scientists have discovered a small molecule that bypasses ADAR1 suppression and directly activates tumor cell death by ZBP1, inducing highly immunogenic cell death and destroying fibroblasts supporting tumor growth. This approach has the potential to improve the effectiveness of immunotherapy in treating therapy-resistant tumors.
The Fannie and John Hertz Foundation has awarded fellowships to 13 doctoral students who will focus on defending the nation's digital infrastructure against cyberthreats and developing more efficient electronics. The recipients also aim to create biomedical devices to aid rehabilitation and cancer diagnostics.
A new training program at MUSC and Clemson University aims to make future data scientists aware of health inequities, particularly in rural communities. The SC BIDS4HEALTH program will build on existing relationships with HBCUs and community groups across the state.
A study by Flinders University researchers reveals how hospital bacteria adapt and resist antimicrobial medications, including colistin. The findings provide potential new therapies for treating multi-drug resistant bacterial infections, highlighting the growing threat of antibiotic resistance.
MIT researchers develop an interactive design pipeline enabling users to create customized robotic hands with tactile sensors. The platform streamlines the process, allowing users to adjust palm and fingers and integrate tactile sensors, resulting in complex tasks like picking delicate items or using tools being performed flawlessly.
Researchers simulated COVID-19 transmission on a university campus, finding that universal mask usage and high vaccination rates can curb new infections. The study suggests that at least 93% of students should be vaccinated during highly transmissible variant outbreaks.
A community-led network of low-cost sensors found concerning levels of air pollution in Belmont County, Ohio, exceeding WHO guidelines on many days. The study highlights the limitations of EPA sensors and suggests a clear link between fracking and poor air quality.
Northwestern University engineers created a tiny, remote-controlled walking robot resembling a peekytoe crab. The robot is smaller than a flea and can bend, twist, crawl, walk, turn, and jump due to its shape-memory alloy material and elastic resilience.
A team of researchers has identified the ancient bird species behind giant prehistoric eggs in Australia, resolving a years-long debate. The study found that the eggs belonged to a unique duck-like line of megafauna known as the 'Demon Ducks of Doom', which was laid by the Genyornis newtoni bird.
Researchers have identified the genetic causes of three mitochondrial diseases and proposed 20 additional possibilities for further investigation using a new approach. The study provides a platform to better understand how mitochondria's hundreds of proteins work together, which could lead to improved diagnoses and treatments.
A project dubbed Cinderella aims to improve breast cancer surgery patient satisfaction by evaluating aesthetic results objectively. Researchers have developed a software, BCCT.core, that can automatically classify the aesthetic quality of surgery outcomes, distinguishing between good and bad results with high precision.
Researchers will investigate neural mechanisms during learning in individuals with traumatic brain injury (TBI) with and without clinical depression. The study aims to identify new knowledge about the effect of depression on the injured brain, which may lead to interventions for rehabilitation.
A new Virginia Tech study found that anoxic conditions can lead to a vicious cycle of oxygen loss in lakes, causing them to become sources of nutrients downstream. The study's findings suggest that climate change and excess pollutant runoff are exacerbating this issue.
Researchers at Brigham and Women's Hospital studied mRNA vaccine safety in pregnant women, finding no Spike protein expression in placentas. The study provides further evidence of mRNA vaccine safety, supporting expanded vaccination efforts for vulnerable populations.
Researchers used CRISPR technology to modify the ratio of amylose and amylopectin in potatoes, increasing culinary and industrial uses. The study found that potatoes with high amylopectin content have potential applications in bioplastics, food additives, adhesives, and ethanol production.
A study in Hebei Province found low emergy sustainability index and high greenhouse gas emissions from maize production. The research suggests optimizing yield and nitrogen use efficiency gaps and promoting transition towards sustainable agriculture practices, such as adopting technologies like 4R technology and digital agriculture.
Researchers at Tsinghua University Press have developed a novel solution to recycle excavated soil and rock into construction products through sintering utilization. The study found that using this method can save nearly 270 million yuan in disposal costs while meeting environmental standards.
A study by Weill Cornell Medicine investigators has revealed the cause and potential precision therapies for a type of aggressive blood cancer called diffuse large B cell lymphoma (DLBCL). The research found that SETD2 gene mutations can lead to an accumulation of DNA damage, causing cancer cells to grow uncontrollably.
A study discovered that snakes and lizards have lost a major type of T cell, γδ T cells, which has raised questions about their immune system. The loss is believed to be an evolutionary adaptation, prompting research into how these animals compensate for the missing T cells.
Lab-grown plant material can be precisely controlled for physical and mechanical properties, such as stiffness and density. The researchers use a 3D bioprinting process to grow custom shapes and sizes of plant material.
Researchers discovered a specific glycoprotein, RPTP zeta S3L, that connects to CD33 receptors in the brain, limiting its ability to clean up harmful proteins. This finding may lead to new drug targets and early diagnostics for Alzheimer's disease.
Researchers at the University of Chicago Medicine Comprehensive Cancer Center and the University of Amsterdam have identified a new mechanism that prompts T cell responses, including MHC-I cross-dressing. This discovery may lead to improved vaccine design and targeted cancer treatment strategies.
Researchers at TU Darmstadt have developed a scalable quantum network that enables secure key exchange and protection of sensitive information. The system uses entanglement-based time-bin coding to distribute photons to users, ensuring robust security against eavesdropping attacks.
A new study has found that most dinosaurs were warm-blooded, contrary to long-standing debate. By analyzing molecular waste in fossilized bones, researchers inferred dinosaur metabolic rates and found they were generally high.
The study found that the adapted version of the Re-Engineered Discharge (RED) Program, RED for Depression (RED-D), reduced hospital readmissions among patients with depressive symptoms by 48% and 70% at 30- and 90-day marks. The program included post-discharge depression treatment and transition support.
A Concordia study analyzed gender patterns in AI over two decades, finding women are making strides despite underrepresentation. Notably, female-male collaboration has increased, while core positions held by women remain scarce, tied to factors like family obligations and male-dominated environments.
A new study suggests that goldfish pose a significant risk to native biodiversity in rivers and lakes. With insatiable appetites and bold behavior, goldfish can outcompete other species for resources, leading to catastrophic outcomes.
A new method measures individually measurable aerosol values during exercise, revealing moderate aerosol emissions at medium exertion and exponential increases above that point. The study suggests special protective measures are needed for high-intensity training to reduce infection risk.
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.
Researchers at QuTech have demonstrated the first non-adjacent node-to-node teleportation of quantum information in a network, leveraging entangled states and quantum processors. This breakthrough enables future applications like secure data sharing and precise quantum sensors.
Researchers found that birds infected with lipopolysaccharide from bacteria reduced their body temperature by 2°C to conserve energy. In contrast, chicks fed and warm did develop fever. The study suggests that regulated hypothermia is an energy-saving response during severe infection, prioritized over maintaining a fever.
A team of scientists has discovered the molecular triggers of parosmia, a distorted sense of smell, and identified compounds responsible for triggering the sense of disgust. The study found that certain highly potent odor molecules in coffee can lead to this experience.
The Endocrine Society's ENDO 2022 news conferences will showcase the latest research on diabetes, obesity, thyroid health, and reproductive conditions. Key findings include the impact of chemicals in hair care products on breast cancer cells and the effects of childhood obesity on male infertility.
A global analysis of firearm suicide data found that deaths from self-inflicted shootings decreased worldwide between 1990 and 2019. However, an increase in firearm suicides was observed in 31 countries, particularly in developing nations, suggesting a need for targeted public health efforts to reduce these deaths.
Australian researchers have discovered specific gene networks rewired to drive peanut allergy remission through a combination treatment of probiotic and oral immunotherapy. This network reprogramming shuts down the allergic immune response responsible for causing food allergies.
A team of researchers led by Arizona State University's Antia Botana discovered a new high-temperature superconductor in nickelates, a material that could pave the way to room temperature superconductivity. The discovery was made possible by combining theoretical models with experimental results using supercomputers.
Recent research by scientists at Duke University has found that ordinary silicone wristbands can absorb semi-volatile organic compounds firefighters are exposed to while working, tracking their risk of cancer. The study reveals strong associations between active firefighting and exposure to certain contaminants.