Cancer cells may be using lipids to hide from the immune system
Researchers discover cancer cells rely on sphingolipids for immune evasion and signaling. The findings suggest targeting lipid production could enhance existing immunotherapies.
Lipids
Articles tagged with Lipids
Breakthrough in fertility treatment: Prostaglandin receptors found to promote embryo implantation
Researchers from Kumamoto University discovered that prostaglandin receptors in the uterus enhance decidualization, a crucial process for successful pregnancy. This finding opens the door to developing new fertility treatments targeting these receptors.
Microbe dietary preferences influence the effectiveness of carbon sequestration in the deep ocean
Research found that bacteria have specific dietary preferences for lipids, influencing their degradation rates and efficiency in the ocean's mesopelagic zone. This study highlights the importance of microbial interactions and community dynamics in controlling global carbon fluxes.
Med school scientist receives prestigious NSF award for inflammation research
Associate Professor Justine Tigno-Aranjuez received a $1 million NSF CAREER Award to study the impact of the NOD2 pathway on inflammation. Her research aims to understand how lipid mediators are produced and how they influence inflammation.
Not just a ‘bad guy,’ Tau also plays a ‘good guy’ role protecting our brains
A study by Baylor College of Medicine researchers reveals that Tau protein mitigates neuronal damage caused by reactive oxygen species and promotes healthy aging. The findings support a new neuroprotective role for Tau against the toxicity associated with ROS.
New chemical tool for infection research: Visualizing the sphingomyelin metabolism
Scientists have created a new chemical probe to visualize the distribution of sphingomyelin and its degradation by sphingomyelinase during infections. The researchers observed increased metabolization of sphingomyelin molecules during Chlamydia infection, paving the way for targeted strategies against infectious diseases.
TB under the sea: A marine sponge microbe provides insights into the evolution of tuberculosis
Researchers discovered a non-virulent bacterium, Mycobacterium spongiae, that shares 80% of its genetic material with M. tuberculosis, shedding light on the disease's origins. The study provides valuable insights into the evolution and virulence of TB.
Consensus paper: Carcinogenicity of gene therapies
Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·TypeCommentary/editorial·DateAug 29, 2024
Lipid nanoparticle mRNA therapy improves survival in mouse models of maple syrup urine disease
Researchers developed a treatment approach using lipid nanoparticles to deliver mRNA therapy for MSUD, extending survival and reducing serum leucine levels. The study also identified a novel AAV variant with desirable biodistribution properties for targeting peripheral organs.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·TypeExperimental study·DateAug 21, 2024
Females’ and males’ muscles differ in sugar and fatty acid handling
A new study found that females' and males' muscles handle glucose and fatty acids differently, but regular physical activity cancels out these differences and triggers similar beneficial metabolic changes in both sexes. This research has important implications for preventing type 2 diabetes.
Lipid accumulation drives cellular senescence in dopaminergic neurons
Researchers found that artificial induction of GluCer leads to cellular senescence in DA neurons, highlighting the role of lipid aggregation in PD. The study proposes that lysosomal impairment and lipid accumulation trigger expression of a cellular senescence phenotype in vulnerable DA neurons.
Drug-chemo combo increases cancer treatment efficacy
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
SourceMichigan Medicine - University of Michigan·Journalnpj Breast Cancer·TypeExperimental study·DateJul 30, 2024
UMass Amherst food scientist rises to the challenge of giving marbled fatty feel and taste to plant-based meat
Researchers at UMass Amherst have developed a novel extrusion segment that can create the marbled appearance and texture of plant-based whole-cut meat products. This technology has the potential to revolutionize the plant-based meat industry, expanding its product offerings and appealing to a wider audience.
Blood fat profiles confirm health benefits of replacing butter with high-quality plant oils
A recent study published in Nature Medicine confirms the health benefits of a diet high in unsaturated plant fats, such as the Mediterranean diet. The research used lipidomics to measure diet-related fat changes in the blood and link them to disease risk.
Penn pioneers a 'one-pot platform' to promptly produce mRNA delivery particles
The University of Pennsylvania team has pioneered a novel 'one-pot platform' to produce mRNA delivery particles, accelerating the synthesis process and enabling precise targeting of specific organs. The approach leverages click-like chemistry to create lipid nanoparticles with biodegradable components, enhancing mRNA delivery into cells.
Under pressure: How comb jellies have adapted to life at the bottom of the ocean
Deep-sea organisms have developed biophysical adaptations to survive harsh conditions, including unique lipid structures. Researchers found that ctenophores have exaggerated cone-shaped lipids that help them withstand intense pressure.
Potential new treatment option for diabetic retinopathy
Researchers have developed a new treatment for diabetic retinopathy that addresses the root cause of the disease, preventing progression and potential blindness. The anti-ceramide immunotherapy has been shown to be effective in animal and cell culture models, offering a safer alternative to current treatments.
The body’s own lipids affect mental disorders: Can specific inhibitors help?
Research suggests that altered lipid signaling in brain cells contributes to mental disorders, with specific inhibitors showing promise in rebalancing this mechanism. The study found similar changes in both human patients and healthy relatives, as well as mice with genetic disorders, opening up new treatment opportunities.
RNA inhibitor is shown safe and effective in reducing a wide range of cholesterol and triglyceride levels in the blood in Mount Sinai-led clinical trial
A clinical trial led by Mount Sinai researchers shows zodasiran, an RNA inhibitor targeting ANGPTL3, significantly reduces various types of cholesterol and triglycerides. The therapy also lowers apolipoprotein B, a lipid-transporting protein linked to heart disease.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateMay 29, 2024
‘Cloaked’ proteins deliver cancer-killing therapeutics into cells
Researchers have designed a method to 'cloak' proteins for targeted delivery into cells, utilizing lipid nanoparticles. The cloaked proteins can be captured by the nanoparticles and exert their therapeutic effect once inside the cell. This approach shows promise for repurposing antibodies and other proteins for cancer treatment.
USask researchers identify promising protein candidate for metabolic disease treatment
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
SourceUniversity of Saskatchewan·JournalCommunications Biology·TypeExperimental study·DateMay 27, 2024
New resource pinpoints inner workings of sorghum plant cells
A new resource has been created to provide a deeper understanding of the bioenergy crop sorghum and its potential for genetic modification. The study identified gene expression patterns in sorghum stem cells, which can help researchers design cell-type specific promoters for targeted gene expression.
SourceUniversity of Illinois at Urbana-Champaign Institute for Sustainability, Energy, and Environment·JournalThe Plant Journal·TypeExperimental study·DateMay 22, 2024
Scientists discover mechanism of sugar signaling in plants
Researchers have discovered the detailed mechanism of sugar signaling in plants, which involves a protein called KIN10 that acts as a 'sensor kinase' controlling biochemical pathways. The study reveals how sugar levels affect plant growth and oil production, providing insights into potential engineering of proteins to increase oil prod...
THC lingers in breastmilk with no clear peak point
A recent study found that breastfeeding mothers who use cannabis have detectable amounts of THC in their milk, even after 12 hours of abstinence. The amount of THC detected is low, but its impact on infants is unknown.
Archaea can be picky parasites
Researchers discovered that certain archaea parasites selectively consume lipids from their host, altering its membrane structure. This change enables the parasite to survive while also affecting the host's response to environmental changes.
SourceRoyal Netherlands Institute for Sea Research·JournalNature Communications·TypeExperimental study·DateMay 1, 2024
An omega-6 fatty acid may reduce the risk for bipolar disorder
Researchers found a genetic link between higher circulating levels of arachidonic acid and lower risk for bipolar disorder. The study suggests that altering arachidonic acid synthesis pathways may reduce bipolar disorder risk, particularly in those with compromised pathways.
New cancer research made possible as Surrey scientists study lipids cell by cell
Researchers at the University of Surrey have developed a technique to study lipids in live cancer cells, one by cell. This breakthrough could lead to more targeted treatments and better understanding of how individual cells communicate with their neighbors.
Innovative microscopy demystifies metabolism of Alzheimer’s
Researchers used state-of-the-art imaging techniques to discover the metabolism driving Alzheimer's disease, suggesting new treatment strategies. Lipid droplet metabolism can malfunction in Alzheimer's, leading to a cycle of stress and inflammation that worsens the disease.
Unveiling the molecular functions of lipid droplet proteins in Arabidopsis thaliana leaves
A study published in Frontiers in Plant Science reveals that leaf lipid droplets contain myosin-binding proteins and enzymes associated with furan-containing fatty acid biosynthesis. This discovery paves the way for future research into leaf lipid droplet functions, potentially leading to advancements in lipid production technology.
Researchers investigate the dietary impacts of dairy within the Japanese population
A recent study by Tohoku University researchers investigated the association between dairy product consumption and odd-number carbon chain fatty acids (odd-FA) within the Japanese population. The study found a correlation between dairy consumption and odd-FA, which was previously confirmed in Europe and Oceania.
Presence of specific lipids indicate tissue ageing and can be decreased through exercise
Research reveals specific lipids accumulate in tissues as we age and can be decreased through exercise, according to a recent study published in Nature Aging. The findings suggest that exercise may have a role in reversing age-related changes in human muscle tissue.
SourceAmsterdam University Medical Center·JournalNature Aging·TypeRandomized controlled/clinical trial·DateApr 12, 2024
CMS121 mitigates aging-related obesity and metabolic dysfunction
Researchers found that CMS121 reduced body weight gain by 40% and improved glucose and lipid indexes in aging mice. The compound also showed anti-inflammatory effects and increased mitochondrial biogenesis, suggesting potential therapeutic applications for metabolic diseases.
Vaping additives harm a vital membrane in the lungs, according to new Concordia research
Vaping additives, particularly vitamin E, can damage the lungs by inhibiting gas exchange and lung stability. The study used Langmuir films to simulate the expansion and compression of the pulmonary surfactant, observing how the additive changed its properties and monitored changes as more were added.
Lipids with potential health benefits in herbal teas
Researchers at Hokkaido University identified 341 different molecular species of lipids in four types of herbal tea, which may contribute to the teas' health benefits. The study reveals significant variations in lipids among the teas, with some containing novel short-chain fatty acid esters and polyunsaturated fatty acids.
Bedrest may affect cholesterol dynamics differently depending on age
A recent study examined cholesteryl esters and found that prolonged inactivity may affect people of different ages differently. The researchers observed changes in middle-aged subjects but not in older adults when comparing pre- and post-bed-rest levels.
Why killer T cells lose energy inside of solid tumors
A study by UNC researchers found that a metabolic enzyme called Acetyl-CoA Carboxylase (ACC) causes T cells to store fat rather than burning it for energy in solid tumors. Inhibiting ACC expression allowed T cells to persist better in tumors, leading to potential breakthroughs in immunotherapies like CAR T-cell therapies.
Progress in fluorescent dyes to better visualize lipid membrane order in live cells
Scientists developed a novel solvatochromic probe to study lipid membrane fluidity and its correlation with cellular functions. The new dye offers exceptional stability, low toxicity, and fluorescent properties, allowing real-time visualization of lipid membrane order during complex processes.
Lighting the way to noninvasive blood glucose monitoring using portable devices
A novel approach estimates metabolic activity and infers blood glucose levels from near-infrared measurements in commercial smartphones and smartwatches. The phase delay between oxyhemoglobin and deoxyhemoglobin signals closely relates to oxygen consumption during cardiac cycles, serving as a gauge for metabolism.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateMar 8, 2024
Precision pulmonary medicine: Penn engineers target lung disease with lipid nanoparticles
Researchers at the University of Pennsylvania have developed a new method to efficiently determine which lipid nanoparticles are likely to bind to the lungs, rather than the liver. This breakthrough enables targeted delivery of mRNA therapeutics beyond the liver, offering new hope for treatments of cystic fibrosis and lung cancer.
SourceUniversity of Pennsylvania School of Engineering and Applied Science·JournalNature Communications·TypeExperimental study·DateMar 1, 2024
New study shows a role for cholesterol in pain perception
Researchers found that physical pressure on cells reduces pain signals, but excess cholesterol can interfere with this process. The study shows how cell membrane lipids help send electrical pulses into cells after experiencing pressure and force.
A moonshot for obesity: New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control
Researchers at the University of Pennsylvania School of Engineering and Applied Science have invented a new way to synthesize key components of lipid nanoparticles, simplifying their manufacture while boosting efficacy. The new method involves combining three chemicals to create branched lipidoids that promote mRNA delivery to target c...
SourceUniversity of Pennsylvania School of Engineering and Applied Science·JournalNature Communications·TypeExperimental study·DateFeb 26, 2024
WVU pharmacy faculty member launches study to make vaccines more effective
A new study aims to enhance and prolong vaccine effectiveness by delivering adjuvants to white blood cells using lipid nanoparticles. The research, led by WVU professor Sharan Bobbala, has the potential to provide broader protection against evolving viruses and multiple diseases.
Access to prescribed PCSK9 inhibitors remains a significant barrier leaving patients at risk for heart attacks and strokes
A new study reveals that utilization of PCSK9 inhibitors is low among high-risk patients, despite extensive evidence documenting their role in LDL-C reduction and the prevention of heart attacks. The study found that insurance coverage rejection or abandonment leads to significantly more cardiovascular events within 12 months.
SourceFamily Heart Foundation·JournalCirculation Cardiovascular Quality and Outcomes·TypeData/statistical analysis·DateFeb 20, 2024
Scientists develop color-changing dyes that light up cellular activity and enable “time travel” within cells
Researchers have created fluorescent, colour-changing dyes that can visualise multiple distinct biological environments using only one dye. These dyes enable 'time travel' within cells by allowing scientists to distinguish between cellular and delivery vessel environments in real-time. The breakthrough has significant implications for ...
Protein accumulation on fat droplets implicated in late-onset Alzheimer’s disease
Researchers found that APOE4 accumulates on fat droplets in astrocytes, damaging brain cells and preventing them from cleaning up toxic lipids. This mechanism could explain why APOE4 increases Alzheimer's disease risk.
Protecting the protector boosts plant oil content
Scientists at Brookhaven Lab demonstrate new genetic strategy to boost plant oil content by protecting the oil-protector protein, resulting in 54% more oil accumulation in leaves and 13% more in seeds. This approach can increase biomass energy content and provide sustainable fuels.
Little-known protein choline transporter in brain may be key therapeutic target for ageing and Alzheimer’s disease
Researchers discovered a new role for Mfsd7c in exporting excessive choline from the brain. The study suggests that targeting this protein could lead to therapeutic interventions for Alzheimer's disease and other neurological disorders.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalCell Research·TypeMeta-analysis·DateFeb 2, 2024
The underground network: Decoding the dynamics of plant-fungal symbiosis
Groundbreaking research reveals key insights into plant-AM fungi interactions, including the roles of two proteins, CKL1 and CKL2, which control lipid flow essential for fungal survival. This symbiosis could lead to advances in agricultural sustainability and crop resilience.
New study unveils machine learning-aided non-invasive imaging for rapid liver fat visualization
A new study introduces a machine learning-aided non-invasive imaging technique that can rapidly visualize liver fat distribution, enabling early diagnosis and treatment of liver diseases. The method uses near-infrared hyperspectral imaging and machine learning to differentiate between types of lipids in the liver.
Study unveils a role of mitochondria in dietary fat processing
A recent study published in Nature reveals that mitochondrial dysfunction disrupts dietary lipid processing in enterocytes, leading to abnormal fat accumulation and impaired nutrient delivery. The findings provide new insights into the gastrointestinal symptoms of mitochondrial disease and may lead to novel therapeutic approaches.
Discovery: Plants use “trojan horse” to fight mold invasions
Plant scientists have discovered a sophisticated RNA defense system that plants use to attack gray mold cells, sending mRNA molecules that disrupt fungal cellular processes. This innovative approach could lead to the development of eco-friendly fungicides with minimal environmental impact and no harm to humans or animals.
Memory CD8 T cells promote pathogenic plaque buildup of the arteries in aged mice
Researchers identify memory CD8 T cells as potential therapeutic targets for atherosclerosis in aging. The study shows that these immune cells enhance plaque buildup in the arteries of aged mice, which could lead to heart attacks and strokes.
SourceUniversity of Alabama at Birmingham·JournalNature Aging·TypeExperimental study·DateDec 13, 2023
University of Toronto researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects.
Researchers at the University of Toronto have discovered a novel ionizable lipid nanoparticle that enables efficient muscle-focused mRNA delivery while minimizing off-target effects. The study demonstrates potent cellular immune responses and potential as a viable candidate for cancer vaccine development.
SourceUniversity of Toronto - Leslie Dan Faculty of Pharmacy·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 8, 2023
Cracking 6mA code to enhance lipid accumulation in microalgae
The study reveals the critical role of 6mA in lipid accumulation in Nannochloropsis oceanica under high light conditions. Disruption of 6mA levels affects gene expression and biomass production, highlighting its importance in optimizing microalgae for industrial uses.
SourceChinese Academy of Sciences Headquarters·JournalPlant Communications·TypeExperimental study·DateDec 7, 2023
New findings reveal important insights into age-related nonresolving inflammation
Researchers discovered that RvD2, a specialized proresolving lipid mediator, can alleviate established liver scarring or fibrosis. Treatment with RvD2 improved liver histopathology and increased bone marrow and blood monocytes.
Cellular postal service delivers messages from non-human cells, too
Extracellular vesicles have been found to transport bacterial products into human cells, alerting the immune system and potentially affecting physiology. This discovery explains a key mechanism by which bacteria impact our health, with implications for both infections and normal bodily functions.
Materials scientist finds clue to treat deadly hereditary illness
Researchers have discovered a root cause of Barth syndrome, a deadly metabolic illness, by analyzing faulty cardiolipin molecules and their interaction with cytochrome c. The study used solid-state NMR technology to demonstrate the structural changes that lead to toxic oxidation in mitochondrial membranes.
Novel method facilitates study of oxidized lipids involved in neurodegenerative diseases
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalFree Radical Biology and Medicine·DateNov 15, 2023
A new connection between the gut microbiota and prostate inflammation in aging men
A new study found that the gut microbiota plays a significant role in prostate inflammation in aging men, particularly those with metabolic syndrome. The researchers discovered a strong relationship between IL-6 and IL-18 expression and lipid parameters in the prostate tissue of men with BPH + MetS.
5 finalists announced in global Health Tech Competition
The American Heart Association has selected five finalists in its 6th annual Health Tech Competition to present their innovative technologies. The competition aims to drive technology innovation and transform the landscape of heart and brain health.