Articles tagged with Lipids
A new study found that females' and males' muscles handle glucose and fatty acids differently, but regular physical activity cancels out these differences and triggers similar beneficial metabolic changes in both sexes. This research has important implications for preventing type 2 diabetes.
Researchers found that artificial induction of GluCer leads to cellular senescence in DA neurons, highlighting the role of lipid aggregation in PD. The study proposes that lysosomal impairment and lipid accumulation trigger expression of a cellular senescence phenotype in vulnerable DA neurons.
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
Researchers at UMass Amherst have developed a novel extrusion segment that can create the marbled appearance and texture of plant-based whole-cut meat products. This technology has the potential to revolutionize the plant-based meat industry, expanding its product offerings and appealing to a wider audience.
A recent study published in Nature Medicine confirms the health benefits of a diet high in unsaturated plant fats, such as the Mediterranean diet. The research used lipidomics to measure diet-related fat changes in the blood and link them to disease risk.
The University of Pennsylvania team has pioneered a novel 'one-pot platform' to produce mRNA delivery particles, accelerating the synthesis process and enabling precise targeting of specific organs. The approach leverages click-like chemistry to create lipid nanoparticles with biodegradable components, enhancing mRNA delivery into cells.
Deep-sea organisms have developed biophysical adaptations to survive harsh conditions, including unique lipid structures. Researchers found that ctenophores have exaggerated cone-shaped lipids that help them withstand intense pressure.
Researchers have developed a new treatment for diabetic retinopathy that addresses the root cause of the disease, preventing progression and potential blindness. The anti-ceramide immunotherapy has been shown to be effective in animal and cell culture models, offering a safer alternative to current treatments.
Research suggests that altered lipid signaling in brain cells contributes to mental disorders, with specific inhibitors showing promise in rebalancing this mechanism. The study found similar changes in both human patients and healthy relatives, as well as mice with genetic disorders, opening up new treatment opportunities.
A clinical trial led by Mount Sinai researchers shows zodasiran, an RNA inhibitor targeting ANGPTL3, significantly reduces various types of cholesterol and triglycerides. The therapy also lowers apolipoprotein B, a lipid-transporting protein linked to heart disease.
Researchers have designed a method to 'cloak' proteins for targeted delivery into cells, utilizing lipid nanoparticles. The cloaked proteins can be captured by the nanoparticles and exert their therapeutic effect once inside the cell. This approach shows promise for repurposing antibodies and other proteins for cancer treatment.
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
A new resource has been created to provide a deeper understanding of the bioenergy crop sorghum and its potential for genetic modification. The study identified gene expression patterns in sorghum stem cells, which can help researchers design cell-type specific promoters for targeted gene expression.
Researchers have discovered the detailed mechanism of sugar signaling in plants, which involves a protein called KIN10 that acts as a 'sensor kinase' controlling biochemical pathways. The study reveals how sugar levels affect plant growth and oil production, providing insights into potential engineering of proteins to increase oil prod...
A recent study found that breastfeeding mothers who use cannabis have detectable amounts of THC in their milk, even after 12 hours of abstinence. The amount of THC detected is low, but its impact on infants is unknown.
Researchers discovered that certain archaea parasites selectively consume lipids from their host, altering its membrane structure. This change enables the parasite to survive while also affecting the host's response to environmental changes.
Researchers found a genetic link between higher circulating levels of arachidonic acid and lower risk for bipolar disorder. The study suggests that altering arachidonic acid synthesis pathways may reduce bipolar disorder risk, particularly in those with compromised pathways.
A study published in Frontiers in Plant Science reveals that leaf lipid droplets contain myosin-binding proteins and enzymes associated with furan-containing fatty acid biosynthesis. This discovery paves the way for future research into leaf lipid droplet functions, potentially leading to advancements in lipid production technology.
Researchers at the University of Surrey have developed a technique to study lipids in live cancer cells, one by cell. This breakthrough could lead to more targeted treatments and better understanding of how individual cells communicate with their neighbors.
Researchers used state-of-the-art imaging techniques to discover the metabolism driving Alzheimer's disease, suggesting new treatment strategies. Lipid droplet metabolism can malfunction in Alzheimer's, leading to a cycle of stress and inflammation that worsens the disease.
A recent study by Tohoku University researchers investigated the association between dairy product consumption and odd-number carbon chain fatty acids (odd-FA) within the Japanese population. The study found a correlation between dairy consumption and odd-FA, which was previously confirmed in Europe and Oceania.
Research reveals specific lipids accumulate in tissues as we age and can be decreased through exercise, according to a recent study published in Nature Aging. The findings suggest that exercise may have a role in reversing age-related changes in human muscle tissue.
Researchers found that CMS121 reduced body weight gain by 40% and improved glucose and lipid indexes in aging mice. The compound also showed anti-inflammatory effects and increased mitochondrial biogenesis, suggesting potential therapeutic applications for metabolic diseases.
Vaping additives, particularly vitamin E, can damage the lungs by inhibiting gas exchange and lung stability. The study used Langmuir films to simulate the expansion and compression of the pulmonary surfactant, observing how the additive changed its properties and monitored changes as more were added.
Researchers at Hokkaido University identified 341 different molecular species of lipids in four types of herbal tea, which may contribute to the teas' health benefits. The study reveals significant variations in lipids among the teas, with some containing novel short-chain fatty acid esters and polyunsaturated fatty acids.
A recent study examined cholesteryl esters and found that prolonged inactivity may affect people of different ages differently. The researchers observed changes in middle-aged subjects but not in older adults when comparing pre- and post-bed-rest levels.
A study by UNC researchers found that a metabolic enzyme called Acetyl-CoA Carboxylase (ACC) causes T cells to store fat rather than burning it for energy in solid tumors. Inhibiting ACC expression allowed T cells to persist better in tumors, leading to potential breakthroughs in immunotherapies like CAR T-cell therapies.
Scientists developed a novel solvatochromic probe to study lipid membrane fluidity and its correlation with cellular functions. The new dye offers exceptional stability, low toxicity, and fluorescent properties, allowing real-time visualization of lipid membrane order during complex processes.
A novel approach estimates metabolic activity and infers blood glucose levels from near-infrared measurements in commercial smartphones and smartwatches. The phase delay between oxyhemoglobin and deoxyhemoglobin signals closely relates to oxygen consumption during cardiac cycles, serving as a gauge for metabolism.
Researchers at the University of Pennsylvania have developed a new method to efficiently determine which lipid nanoparticles are likely to bind to the lungs, rather than the liver. This breakthrough enables targeted delivery of mRNA therapeutics beyond the liver, offering new hope for treatments of cystic fibrosis and lung cancer.
Researchers found that physical pressure on cells reduces pain signals, but excess cholesterol can interfere with this process. The study shows how cell membrane lipids help send electrical pulses into cells after experiencing pressure and force.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have invented a new way to synthesize key components of lipid nanoparticles, simplifying their manufacture while boosting efficacy. The new method involves combining three chemicals to create branched lipidoids that promote mRNA delivery to target c...
A new study aims to enhance and prolong vaccine effectiveness by delivering adjuvants to white blood cells using lipid nanoparticles. The research, led by WVU professor Sharan Bobbala, has the potential to provide broader protection against evolving viruses and multiple diseases.
A new study reveals that utilization of PCSK9 inhibitors is low among high-risk patients, despite extensive evidence documenting their role in LDL-C reduction and the prevention of heart attacks. The study found that insurance coverage rejection or abandonment leads to significantly more cardiovascular events within 12 months.
Researchers have created fluorescent, colour-changing dyes that can visualise multiple distinct biological environments using only one dye. These dyes enable 'time travel' within cells by allowing scientists to distinguish between cellular and delivery vessel environments in real-time. The breakthrough has significant implications for ...
Researchers found that APOE4 accumulates on fat droplets in astrocytes, damaging brain cells and preventing them from cleaning up toxic lipids. This mechanism could explain why APOE4 increases Alzheimer's disease risk.
Scientists at Brookhaven Lab demonstrate new genetic strategy to boost plant oil content by protecting the oil-protector protein, resulting in 54% more oil accumulation in leaves and 13% more in seeds. This approach can increase biomass energy content and provide sustainable fuels.
Researchers discovered a new role for Mfsd7c in exporting excessive choline from the brain. The study suggests that targeting this protein could lead to therapeutic interventions for Alzheimer's disease and other neurological disorders.
Groundbreaking research reveals key insights into plant-AM fungi interactions, including the roles of two proteins, CKL1 and CKL2, which control lipid flow essential for fungal survival. This symbiosis could lead to advances in agricultural sustainability and crop resilience.
A new study introduces a machine learning-aided non-invasive imaging technique that can rapidly visualize liver fat distribution, enabling early diagnosis and treatment of liver diseases. The method uses near-infrared hyperspectral imaging and machine learning to differentiate between types of lipids in the liver.
Plant scientists have discovered a sophisticated RNA defense system that plants use to attack gray mold cells, sending mRNA molecules that disrupt fungal cellular processes. This innovative approach could lead to the development of eco-friendly fungicides with minimal environmental impact and no harm to humans or animals.
A recent study published in Nature reveals that mitochondrial dysfunction disrupts dietary lipid processing in enterocytes, leading to abnormal fat accumulation and impaired nutrient delivery. The findings provide new insights into the gastrointestinal symptoms of mitochondrial disease and may lead to novel therapeutic approaches.
Researchers identify memory CD8 T cells as potential therapeutic targets for atherosclerosis in aging. The study shows that these immune cells enhance plaque buildup in the arteries of aged mice, which could lead to heart attacks and strokes.
Researchers at the University of Toronto have discovered a novel ionizable lipid nanoparticle that enables efficient muscle-focused mRNA delivery while minimizing off-target effects. The study demonstrates potent cellular immune responses and potential as a viable candidate for cancer vaccine development.
The study reveals the critical role of 6mA in lipid accumulation in Nannochloropsis oceanica under high light conditions. Disruption of 6mA levels affects gene expression and biomass production, highlighting its importance in optimizing microalgae for industrial uses.
Researchers discovered that RvD2, a specialized proresolving lipid mediator, can alleviate established liver scarring or fibrosis. Treatment with RvD2 improved liver histopathology and increased bone marrow and blood monocytes.
Extracellular vesicles have been found to transport bacterial products into human cells, alerting the immune system and potentially affecting physiology. This discovery explains a key mechanism by which bacteria impact our health, with implications for both infections and normal bodily functions.
Researchers have discovered a root cause of Barth syndrome, a deadly metabolic illness, by analyzing faulty cardiolipin molecules and their interaction with cytochrome c. The study used solid-state NMR technology to demonstrate the structural changes that lead to toxic oxidation in mitochondrial membranes.
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
A new study found that the gut microbiota plays a significant role in prostate inflammation in aging men, particularly those with metabolic syndrome. The researchers discovered a strong relationship between IL-6 and IL-18 expression and lipid parameters in the prostate tissue of men with BPH + MetS.
The American Heart Association has selected five finalists in its 6th annual Health Tech Competition to present their innovative technologies. The competition aims to drive technology innovation and transform the landscape of heart and brain health.
Researchers deciphered when genes responsible for producing 2-methylhopanes were acquired by certain groups of organisms. They found that these genes were likely present in the last common ancestor of Cyanobacteria over two billion years ago.
Researchers at the University of Houston have discovered that microalgae can be used to sequester carbon dioxide and convert it into mass-produced proteins, lipids, and carbohydrates. This process has the potential to transform food production, treat wastewater, and produce sustainable biofuels.
Researchers from Columbia University have validated GLS2's ability to promote ferroptosis in murine models. This study suggests that targeting GLS2 may be a potential therapeutic strategy against liver diseases, particularly hepatocellular carcinoma.
A new blood test has been developed to measure the levels of critical omega-3 fatty acids in the bloodstream, providing a convenient way to assess cardiovascular and cognitive health. The Omega-3 Index (O3I) is derived from two key fatty acids, EPA and DHA, which can be obtained only from certain dietary sources.
Researchers at IISc have developed a novel method to improve pharmacokinetic properties of macrocyclic peptides, which are used in pharmaceutical industries worldwide. By substituting oxygen with sulphur in the backbone of these peptides, they increase resistance to digestive enzymes and lipophilicity, thereby boosting bioavailability.
A new study found three genes strongly linked to vegetarianism, including those involved in lipid metabolism and brain function. The study suggests that genetics play a role in determining whether someone can stick to a strict vegetarian diet.
A genome-wide association study reveals 34 genes potentially involved in choosing a vegetarian diet, including those related to lipid metabolism and brain function. The findings suggest that genetics play a role in the ability to subsist on a vegetarian diet.
Researchers at Kyoto University have discovered two novel yeast species with high oil-forming potential, which could be used to produce alternative biofuels and reduce CO2 emissions. The study also explores the relationship between climate and microbial ecology in Shiga Prefecture.
A team of scientists has developed a method to detect thousands of lipid molecules displayed to T cells in the human immune system. The study reveals rules about lipid size, shape, and chemical content that influence T cell responses.