Articles tagged with Lipids
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Tufts University have successfully produced bulk fat tissue in a lab that has a similar texture and makeup to natural animal fat. The aggregated fat cells can be fine-tuned to resemble real-life fat within meat, offering a key step towards mass production of cultured meat.
Researchers have developed a new type of nanoparticle that can efficiently deliver CRISPR/Cas9 components to the lungs, allowing for targeted gene editing. In mice studies, the particles delivered mRNA to up to 60% of lung epithelial cells, offering a promising approach to treating genetic diseases such as cystic fibrosis.
Researchers discovered that lipid deposition on medical implant surfaces can signal to the immune system whether to attack or ignore the implant. This knowledge could help develop biomaterials that deflect host immune aggression, reducing malfunction rates for devices like pacemakers and surgical mesh.
Scientists at the University of Missouri have developed a novel method to detect food adulteration using nuclear magnetic resonance (NMR) spectroscopy. The technique can identify vegetable oil adulterants in hard cheese products with high accuracy, leading to improved consumer safety and product authenticity.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Gene therapy using CRISPR-Cas9 lipid nanoparticles has been shown to be highly effective in reducing target protein expression in mice. The new delivery system increases the efficiency of in vivo gene therapy, paving the way for safe and effective treatment.
Researchers created human organoid models of fatty liver disease to shed light on drug responses and disease biology. The models identified a common mechanism for effective drugs that block lipid generation from sugars, suggesting personalized medicine applications.
A recent UBC study has found that southern resident killer whales require high-energy prey to survive, with spring-run Chinook salmon being the most suitable. The study's findings have significant implications for managing both species and mitigating the decline of this critically endangered population.
Scientists at the University of Illinois Chicago have found a way to selectively degrade disease-causing proteins in specific parts of cells. By studying the movement of enzymes inside cells, they discovered that attaching or detaching a fat molecule can direct where these enzymes go.
A study published in the Journal of Biological Chemistry found that a fish oil derivative called DHEA can reduce inflammation and disease severity in mice with multiple sclerosis. By supplementing the diet of mice with DHEA, researchers noticed a decrease in MS-like disease symptoms and an improvement in the immune system's response.
Researchers at Tufts University School of Medicine found that p97 protein mutations can cause organelle miscommunication, leading to the accumulation of molecules on mitochondria-endoplasmic reticulum contacts. This miscommunication can modulate membrane rigidity and impact interorganelle interactions.
A recent study published in BMJ Open Sport & Exercise Medicine suggests that golf may be just as healthy or even healthier than Nordic walking for older adults. The research compared the acute effects of three aerobic exercises: an 18-hole round of golf, 6km of Nordic walking, and a 6km walk. The results showed that all three types of ...
A new study led by Massachusetts General Hospital researchers reveals that an investigational drug called YTX-7739 can delay the growth of brain tumors and increase their sensitivity to conventional chemotherapy. The drug works by inhibiting de novo lipid synthesis, a process used by cancer cells for energy production.
A new approach to gene therapy for inherited blindness uses lipid nanoparticles to deliver mRNA inside the eye, targeting light-sensitive cells and creating proteins that edit vision-harming gene mutations. The technology has shown promising results in animal studies, including mice and nonhuman primates.
A common fatty acid found in the Western diet contributes to increased temperature and pain sensitivity in psoriatic lesions. The findings could lead to improved pain treatments for psoriasis patients.
Researchers at Johns Hopkins Medicine discovered that regulating the electrical charge on the inner side of the cell membrane can activate pathways responsible for cell movement. This finding has potential implications for understanding cancer cell migration and immune cell function.
A new analytical method has been developed to map climatic and environmental processes at high temporal resolution, revealing an abrupt intensification of seasonality in the tropical ocean during the last period of global climate change. This provides evidence of how global climate changes affect local, seasonal temperature variations.
A study suggests that visceral fat cells, rather than subcutaneous fat cells, are more susceptible to infection by the COVID-19 virus. This increased susceptibility leads to a higher viral load and production of pro-inflammatory cytokines, which can exacerbate severe disease.
Researchers used mass spectrometry to analyze complex biological samples, including Salvia miltiorrhiza Bge and Astragali Radix. The studies identified metabolites and compounds with immunoregulatory effects, highlighting the potential for new drugs and improving plant quality.
Researchers developed a new method to target and treat visceral adiposity using positively charged P-G3 nanomaterials, which inhibit unhealthy lipid storage in enlarged fat cells. This approach also rejuvenates healthy fat cells, promoting metabolically healthy fat cell formation.
A study found that ocean warming and acidification decrease the nutritional quality of coccolithophores, a crucial food source for zooplankton species. The study's experiment showed an increase in lipid availability under ocean warming but reduced nutritional content under acidification.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
A recent study from the University of Eastern Finland found that genetic background has an effect on the metabolism of essential polyunsaturated fatty acids alpha-linolenic acid and linoleic acid. The study showed that the FADS1 genotype modifies the responses to diets rich in alpha-linolenic acid and linoleic acid.
Researchers at Weill Cornell Medicine have discovered a mechanism by which lipids regulate pacemaker ion channel proteins in the heart. By disrupting a specific molecular connection, certain lipids can enhance pacemaker channel activity, leading to potential treatments for cardiac arrhythmias and other conditions.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
Researchers have identified a class of lipids called SGDGs that decline in the brain with age and may have anti-inflammatory effects. These findings could lead to new therapeutic interventions for age-related neurological diseases. Further research will be needed to explore the role of SGDGs in human neuroinflammation.
A critical new pathway to treating glioblastoma, a deadly brain tumor, may be found in the complex diversity of tumor tissue. CDI scientists identified lipids with potential therapeutic value, highlighting the importance of targeting signaling pathways in relation to cell function and resistance to therapy.
Researchers at Harvard Medical School have made progress in understanding the mechanism underlying a type of dementia that strikes early in life. A genetic form of frontotemporal dementia is associated with accumulation of specific lipids in the brain, which results from a protein deficiency that interferes with cell metabolism.
Researchers developed a new method to study membrane proteins in their native environment, the cell, using electron spin resonance spectroscopy. This technique allows for precise determination of protein properties and could lead to better understanding and targeting of membrane proteins involved in anti-cancer drug resistance.
Helmholtz Munich researchers identified a novel strategy to alter glucagon receptor signaling by changing its intracellular localization. This approach offers therapeutic potential for treating type 2 diabetes by uncoupling glucose and lipid metabolism-related effects.
Researchers have identified an endocannabinoid, 2-linoleoyl glycerol (2-LG), responsible for activating TRP channels in photoreceptor cells. This discovery sheds light on the visual transduction process and may have implications for other sensory systems.
Engineered duckweed produces up to 10% oil content, a 100-fold increase over wild-type plants, with synergistic effects seen when combining gene modifications. The oil-rich plant can be easily harvested for biofuels or bioproducts, reducing competition with food crops and environmental waste.
Researchers found pre-existing differences in gut bacteria between people with and without HIV, including decreased Bacteroides species and increased Megasphaera elsdenii. These changes were present even before infection occurred, suggesting a potential link between gut microbiome and HIV susceptibility.
Researchers introduce synthetic catalysts into algae cells, enabling chemical reaction upgrades to produce building blocks for polymers and chemicals. The process reduces reliance on fossil raw materials, using atmospheric carbon dioxide as a carbon source.
A study at Michigan Medicine found multiple lipid biomarkers linked to diabetic neuropathy in patients with type 2 diabetes. High scores for neuropathy were associated with changes in lipids reflecting impaired energy metabolism, suggesting a potential target for testing and managing the condition.
A deficiency in gene regulation disrupts the clearance of surfactant lipids in alveolar macrophages, leading to their bloating and foaming. This defect is associated with conditions like pulmonary alveolar proteinosis, obesity, and atherosclerosis.
A team of scientists from Ural Federal University has developed a complex mathematical model to understand the dynamics of nanoparticles and viruses in cells. The model reveals how viruses cluster inside endosomes and interact with cellular proteins, shedding light on their behavior and replication mechanisms. This breakthrough can hel...
Researchers at La Jolla Institute for Immunology discovered how Zika virus forces dendritic cells to churn out lipid molecules, allowing the virus to build copies of itself. This study provides a major step forward in developing antiviral therapies against multiple flavivirus infections.
Researchers at Penn State have identified a crucial step in the formation of glycerol dibiphytanyl glycerol tetraether (GDGT), a lipid molecule found in extreme environments. The discovery could improve the use of GDGT as an indicator of past climates.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Gut bacteria produce inositol lipids, vital for cellular processes in humans, and these substances impact the symbiosis between bacteria and their hosts. The discovery sheds light on how gut bacteria thrive in their human hosts.
Researchers at Georgia Institute of Technology have developed a new screening technique called DNA barcoding, which accelerates the discovery of effective lipid nanoparticle carriers. The technique allows for simultaneous testing of many experiments and has improved nanoparticle pre-clinical screening.
Researchers at Hokkaido University identified over 1,300 types of ceramides in the top layer of human skin, including their chain lengths and fatty acid compositions. The discovery could improve understanding of skin barrier function and disease pathology.
Researchers identify AgRP neurons as key players in regulating food intake by releasing endogenous lysophospholipids, which stimulate cerebral cortex activity. Administering autotaxin inhibitors can significantly reduce excessive food intake and obesity in animal models.
Researchers at Chalmers University of Technology have developed a groundbreaking microscopy technique that allows for the study of proteins, DNA, and other biological particles in their natural state. This innovation enables earlier detection of promising drug candidates and provides valuable insights into cell communication processes.
Researchers at the University of Cincinnati are studying how lipids help fortify lung cancer cells and if targeting them can lead to better outcomes. The team discovered that lipids play a crucial role in cancer cell growth, membrane fortification, and energy production.
Researchers developed an algorithm to classify patients into disease subtypes based on molecular changes, enabling more targeted treatments. The tool has shown potential in a study on non-alcoholic fatty liver disease, identifying lipid biomarkers for disease progression.
A meta-analysis published in the European Journal of Clinical Nutrition found that diets containing red meat did not impact glycemic and insulinemic risk factors for type 2 diabetes. The study suggests that more research is needed to fully understand the relationship between red meat consumption and the development of type 2 diabetes.
Breast cancer cells accumulate intracellular lipid droplets in acidic environments, leading to poor outcomes and disease progression. Targeting the acid-sensing receptor OGR1 may inhibit stress responses and cell growth.
A new study published in Scientific Reports reveals that regular high-intensity interval training exercise can significantly decrease fasting glucose levels and waist circumference, while improving oxygen consumption rates in patients with non-alcoholic fatty liver disease. Exercise also modifies amino acid metabolism in adipose tissue...
The 100-year-old BCG vaccine has been found to protect newborns and young infants against multiple bacterial and viral infections, including COVID-19. The study identified changes in metabolite and lipid profiles that correlate with innate immune system responses.
The University at Buffalo is developing new treatments for ovarian cancer by targeting the apelin receptor. Ovarian cancer cells rely on lipids for energy and survival, making this a promising therapeutic target.
Researchers at Universitat Autonoma de Barcelona developed a new treatment that reduces chronic inflammation in multiple sclerosis mice models by administering Maresin-1, a lipid mediator. The substance significantly reduced cytokine levels and protected neurons from demyelination.
Researchers discovered that lipid droplets play a crucial role in mitochondrial recycling, and impairing DGAT1 activity leads to reduced recycling and increased cell stress. The study provides new insights into iron homeostasis and its impact on cellular metabolism.
Researchers at NTU Singapore's Lee Kong Chian School of Medicine found that saturated fatty acids degrade protein FIT2, leading to insulin-producing cells' loss of function and death. This impairs the body's ability to secrete enough insulin, resulting in diabetes.
Researchers at EPFL's School of Life Sciences have identified a critical link between cellular lipids and the determination of cell fate. They found that changes in lipid composition can influence the behavior of cells in response to external stimuli, even if the original cell type is identical.
Researchers at Tel Aviv University developed a drug delivery system based on lipid nanoparticles that utilize RNA to boost personalized cancer care. The nanodrug enhances chemotherapy effectiveness and reinvigorates the immune system, increasing sensitivity to cancer cells.
Researchers at LSU Health New Orleans and Karolinska Institutet found that intranasal application of pro-resolving lipid mediators arrested memory loss and brain degeneration in an experimental Alzheimer's model. This discovery opens up new possibilities for therapeutic interventions for Alzheimer's disease.
Scientists analyzed ancient vessels from India and discovered that prehistoric people used a variety of ingredients, including foraged plants, cultivated crops, and traded goods. The study found no evidence of cultural change impacting food processing during the Copper Age to Indus Valley Civilization transition.
A new study reveals that simultaneous measurement of dozens of types of fats in the blood can predict the risk of developing type 2 diabetes and cardiovascular disease years in advance. The researchers found that individuals with a certain lipid profile are at increased risk, while those with a different profile have lower risk. This d...