Overweight and obesity pose significant health risks, including an increased likelihood of developing diabetes, cardiovascular disease, and cancer. Researchers are seeking practical ways to promote the oxidation of lipids, which could help balance energy storage and consumption. A recent study has identified opioid growth factor receptor ( Ogfr ) gene as a promising new target for this process.
Rodents possess thermogenic fat that includes brown and beige adipocytes, which have a high capacity to uptake and utilize glucose and lipids. This promotes lipid oxidation and assists them in surviving environmental challenges such as food scarcity and cold temperatures. Studies conducted on human subjects also demonstrate that adipose tissue activities are responsive to environmental changes or diet, which suggests that they may serve as promising therapeutic targets.
The researchers found that OGFr boosts lipid oxidation and promotes heat production in fat tissues (Figure 1). Ogfr is highly expressed in adipocytes, and it is difficult to maintain core body temperature during exposure to cold challenges in mice with genetic Ogfr deletion in adipocytes. Furthermore, when Ogfr was ablated in adipocytes, fatty acid oxidation was reduced, glucose tolerance impaired, and tissue inflammation increased in mice with diet-induced obesity. Human adipocytes also express OGFr highly, indicating a shared mechanism.
The identification of OGFr as a crucial player for enhancing lipid oxidation provides a new avenue for addressing obesity and related afflictions. Further research on the OGFr-mediated lipid oxidation mechanism could prove helpful in developing novel therapeutic strategies for obesity and metabolic disorders. Additionally, the related functioning of OGFr in human adipocytes opens the possibility of translating these findings to clinical settings, where OGFr-based pharmacological interventions could enhance fat activities and improve metabolic health.
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Reference: Shan Zhang et al . (2023) Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation. Life Metabolism . https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/load018/7151537
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Life Metabolism is a fully open access, peer-reviewed journal that publishes one volume per year online, providing a platform for the publication of works of high significance and broad interest in all areas of metabolism. Life Metabolism welcomes several different article types, including original article, review article, research highlight, letter, editorial, perspective, and so on. Once a paper is accepted, Life Metabolism can publish a precopyedited, preproofed version of the paper online within 48 hours of receiving a signed licence, and this will be replaced by a copyedited, proofed version of the paper as soon as it is ready. The Editors-in-Chief are professors Peng Li at Tsinghua University and John R Speakman at University of Aberdeen, UK. In the first three years, there will be no publication costs for publishing in Life Metabolism , and Open Access fees will be waived.
Life Metabolism
Experimental study
Animal tissue samples
Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation
4-May-2023