Articles tagged with Lipids
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Researchers from Osaka University have identified a protein complex crucial for male fertility, revealing the TEX38/ZDHHC19 interaction regulates sperm development and structure. The study found that disrupting this complex can cause sperm deformity and infertility, providing insight into the causes of male infertility.
SLC transporters contribute to the development of hepatic steatosis by regulating lipid metabolism, particularly with SLC2A2, GLUT4, and GLUT5. These proteins influence processes like de novo lipogenesis and insulin resistance in hepatocytes.
Researchers developed Janus-type supramolecules that form stable ribbon-type assemblies, guiding the arrangement of ion channels across lipid membranes. The supramolecular channels mediate efficient and selective K+ transport, disrupting cancer cell balance and inducing apoptosis.
Researchers discovered that TANGO2 plays a crucial role in transporting fatty acids into cells, which helps meet energy demands. Children with TANGO2 deficiency struggle to produce energy, leading to severe metabolic crises, highlighting the importance of understanding rare diseases for broader health applications.
Hunter Medical Research Institute has formed a memorandum of understanding with Novartis (Aust & NZ) to explore future research projects focused on improving cardiovascular health. The partnership aims to accelerate innovation and enhance patient care through collaborative research initiatives.
A new study reveals that nematode surfaces are predominantly oily or lipid-based, forming a complex chemical landscape. This discovery provides insights into how animals interact with their environment and each other, and could lead to strategies for overcoming parasitic infections and diseases caused by these worms.
Researchers found that olpasiran significantly lowers lipoprotein(a) levels by over 95% and reduces oxidized phospholipids, which promote atherosclerosis. The study also showed no significant effects on inflammatory markers.
A global team of scientists has made a groundbreaking discovery of a new skeletal tissue called lipocartilage, composed of fat-filled cells that provide super-stable internal support. This unique tissue has immense potential for treating facial defects, birth injuries, and cartilage-related conditions.
Researchers develop BEND lipids to improve LNP mRNA delivery and gene editing by breaking through the endosomal membrane. The new lipids outperform existing LNPs used in COVID-19 vaccines, with improved efficacy rates up to tenfold.
Researchers discovered that the protein PIN1 drives bladder cancer by triggering cholesterol synthesis, which fuels out-of-control cell growth. A combination of statins and a PIN1 inhibitor effectively blocks tumor growth in mice, offering a promising therapeutic approach for this deadly disease.
The accumulation of nuclear lipid droplets (nLDs) is linked to metabolic conditions such as fatty liver disease, obesity-related disorders, and premature aging. Lifestyle interventions like caloric restriction can reduce nLD buildup, suggesting a potential therapeutic target for slowing cellular aging.
Researchers have unveiled a critical mechanism linking cellular stress in the brain to Alzheimer's disease progression, highlighting microglia as central players in both protective and harmful responses. The study reveals that blocking a specific stress pathway reverses symptoms of Alzheimer's disease in preclinical models.
Researchers have discovered that AHCC suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells through two channels. Early administration of AHCC may hold the key to preventing the onset of cirrhosis, a potentially fatal condition.
Researchers have developed peptide-guided nanoparticles that can target specific cells in the brain, including neurons, marking a significant step toward potential mRNA treatments for neurological diseases. The innovation uses peptides to precisely deliver mRNA to endothelial cells lining blood vessels and neurons.
A study published in Nature reveals that dietary fructose promotes tumor growth in animal models of melanoma, breast cancer, and cervical cancer. The liver converts fructose into usable nutrients for cancer cells, a finding that could lead to new treatment avenues.
Researchers at Penn School of Engineering and Applied Science have developed a new method to refine ionizable lipids, key ingredients in lipid nanoparticles. This approach combines precision with rapid output, enabling safer and more effective mRNA vaccines and therapeutics.
Scientists have discovered a plausible explanation for the development of early Earth protocells. The researchers found that a spontaneous reaction between two simple molecules could form lipids and create membrane vesicles, paving the way for the emergence of life. This breakthrough provides new insights into the origin of life on Earth.
Researchers at Hokkaido University discovered unique lipids in sorghum that have anti-diabetic and anti-inflammatory properties. The study suggests that incorporating sorghum into diets could promote cardiovascular health, reduce inflammation, and enhance metabolic health.
A new discovery by Cold Spring Harbor Laboratory's Lloyd Trotman suggests that menadione, a precursor to vitamin K, can slow prostate cancer progression in mice. The supplement depletes a lipid called PI(3)P, killing cancer cells and slowing disease progression significantly.
Researchers discovered a mechanism used by ovarian tumors to cripple immune cells by blocking the energy supply T cells depend on. The discovery points toward a promising new immunotherapy approach for treating ovarian cancer.
Researchers found that ApoE protects melanoma cells from ferroptosis by increasing antioxidant capacity and neutralizing lipids. This discovery highlights the APOE gene as a critical factor in melanoma cell survival, potentially opening new avenues for treatment.
Researchers at Hokkaido University have identified a key gene, glutathione peroxidase 4 (Gpx4), that enables Syrian hamsters to survive extreme cold by limiting cellular damage. The discovery could lead to new treatments for human health, such as improving organ preservation and using hypothermia as a therapeutic tool.
A Virginia Tech research team has identified a molecular mechanism by which Shigella flexneri bacteria manipulate host molecules to ensure their survival. The study provides a new understanding of the infection pathway and its potential implications for preventing similar infections in other bacteria.
Researchers discover cancer cells rely on sphingolipids for immune evasion and signaling. The findings suggest targeting lipid production could enhance existing immunotherapies.
Researchers from Kumamoto University discovered that prostaglandin receptors in the uterus enhance decidualization, a crucial process for successful pregnancy. This finding opens the door to developing new fertility treatments targeting these receptors.
Research found that bacteria have specific dietary preferences for lipids, influencing their degradation rates and efficiency in the ocean's mesopelagic zone. This study highlights the importance of microbial interactions and community dynamics in controlling global carbon fluxes.
Associate Professor Justine Tigno-Aranjuez received a $1 million NSF CAREER Award to study the impact of the NOD2 pathway on inflammation. Her research aims to understand how lipid mediators are produced and how they influence inflammation.
A study by Baylor College of Medicine researchers reveals that Tau protein mitigates neuronal damage caused by reactive oxygen species and promotes healthy aging. The findings support a new neuroprotective role for Tau against the toxicity associated with ROS.
Scientists have created a new chemical probe to visualize the distribution of sphingomyelin and its degradation by sphingomyelinase during infections. The researchers observed increased metabolization of sphingomyelin molecules during Chlamydia infection, paving the way for targeted strategies against infectious diseases.
Researchers discovered a non-virulent bacterium, Mycobacterium spongiae, that shares 80% of its genetic material with M. tuberculosis, shedding light on the disease's origins. The study provides valuable insights into the evolution and virulence of TB.
Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.
Researchers developed a treatment approach using lipid nanoparticles to deliver mRNA therapy for MSUD, extending survival and reducing serum leucine levels. The study also identified a novel AAV variant with desirable biodistribution properties for targeting peripheral organs.
A new study found that females' and males' muscles handle glucose and fatty acids differently, but regular physical activity cancels out these differences and triggers similar beneficial metabolic changes in both sexes. This research has important implications for preventing type 2 diabetes.
Researchers found that artificial induction of GluCer leads to cellular senescence in DA neurons, highlighting the role of lipid aggregation in PD. The study proposes that lysosomal impairment and lipid accumulation trigger expression of a cellular senescence phenotype in vulnerable DA neurons.
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
Researchers at UMass Amherst have developed a novel extrusion segment that can create the marbled appearance and texture of plant-based whole-cut meat products. This technology has the potential to revolutionize the plant-based meat industry, expanding its product offerings and appealing to a wider audience.
A recent study published in Nature Medicine confirms the health benefits of a diet high in unsaturated plant fats, such as the Mediterranean diet. The research used lipidomics to measure diet-related fat changes in the blood and link them to disease risk.
The University of Pennsylvania team has pioneered a novel 'one-pot platform' to produce mRNA delivery particles, accelerating the synthesis process and enabling precise targeting of specific organs. The approach leverages click-like chemistry to create lipid nanoparticles with biodegradable components, enhancing mRNA delivery into cells.
Deep-sea organisms have developed biophysical adaptations to survive harsh conditions, including unique lipid structures. Researchers found that ctenophores have exaggerated cone-shaped lipids that help them withstand intense pressure.
Researchers have developed a new treatment for diabetic retinopathy that addresses the root cause of the disease, preventing progression and potential blindness. The anti-ceramide immunotherapy has been shown to be effective in animal and cell culture models, offering a safer alternative to current treatments.
Research suggests that altered lipid signaling in brain cells contributes to mental disorders, with specific inhibitors showing promise in rebalancing this mechanism. The study found similar changes in both human patients and healthy relatives, as well as mice with genetic disorders, opening up new treatment opportunities.
A clinical trial led by Mount Sinai researchers shows zodasiran, an RNA inhibitor targeting ANGPTL3, significantly reduces various types of cholesterol and triglycerides. The therapy also lowers apolipoprotein B, a lipid-transporting protein linked to heart disease.
Researchers have designed a method to 'cloak' proteins for targeted delivery into cells, utilizing lipid nanoparticles. The cloaked proteins can be captured by the nanoparticles and exert their therapeutic effect once inside the cell. This approach shows promise for repurposing antibodies and other proteins for cancer treatment.
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
A new resource has been created to provide a deeper understanding of the bioenergy crop sorghum and its potential for genetic modification. The study identified gene expression patterns in sorghum stem cells, which can help researchers design cell-type specific promoters for targeted gene expression.
Researchers have discovered the detailed mechanism of sugar signaling in plants, which involves a protein called KIN10 that acts as a 'sensor kinase' controlling biochemical pathways. The study reveals how sugar levels affect plant growth and oil production, providing insights into potential engineering of proteins to increase oil prod...
A recent study found that breastfeeding mothers who use cannabis have detectable amounts of THC in their milk, even after 12 hours of abstinence. The amount of THC detected is low, but its impact on infants is unknown.
Researchers discovered that certain archaea parasites selectively consume lipids from their host, altering its membrane structure. This change enables the parasite to survive while also affecting the host's response to environmental changes.
Researchers found a genetic link between higher circulating levels of arachidonic acid and lower risk for bipolar disorder. The study suggests that altering arachidonic acid synthesis pathways may reduce bipolar disorder risk, particularly in those with compromised pathways.
Researchers at the University of Surrey have developed a technique to study lipids in live cancer cells, one by cell. This breakthrough could lead to more targeted treatments and better understanding of how individual cells communicate with their neighbors.
Researchers used state-of-the-art imaging techniques to discover the metabolism driving Alzheimer's disease, suggesting new treatment strategies. Lipid droplet metabolism can malfunction in Alzheimer's, leading to a cycle of stress and inflammation that worsens the disease.
A study published in Frontiers in Plant Science reveals that leaf lipid droplets contain myosin-binding proteins and enzymes associated with furan-containing fatty acid biosynthesis. This discovery paves the way for future research into leaf lipid droplet functions, potentially leading to advancements in lipid production technology.
A recent study by Tohoku University researchers investigated the association between dairy product consumption and odd-number carbon chain fatty acids (odd-FA) within the Japanese population. The study found a correlation between dairy consumption and odd-FA, which was previously confirmed in Europe and Oceania.
Research reveals specific lipids accumulate in tissues as we age and can be decreased through exercise, according to a recent study published in Nature Aging. The findings suggest that exercise may have a role in reversing age-related changes in human muscle tissue.
Researchers found that CMS121 reduced body weight gain by 40% and improved glucose and lipid indexes in aging mice. The compound also showed anti-inflammatory effects and increased mitochondrial biogenesis, suggesting potential therapeutic applications for metabolic diseases.
Vaping additives, particularly vitamin E, can damage the lungs by inhibiting gas exchange and lung stability. The study used Langmuir films to simulate the expansion and compression of the pulmonary surfactant, observing how the additive changed its properties and monitored changes as more were added.
Researchers at Hokkaido University identified 341 different molecular species of lipids in four types of herbal tea, which may contribute to the teas' health benefits. The study reveals significant variations in lipids among the teas, with some containing novel short-chain fatty acid esters and polyunsaturated fatty acids.
A recent study examined cholesteryl esters and found that prolonged inactivity may affect people of different ages differently. The researchers observed changes in middle-aged subjects but not in older adults when comparing pre- and post-bed-rest levels.
A study by UNC researchers found that a metabolic enzyme called Acetyl-CoA Carboxylase (ACC) causes T cells to store fat rather than burning it for energy in solid tumors. Inhibiting ACC expression allowed T cells to persist better in tumors, leading to potential breakthroughs in immunotherapies like CAR T-cell therapies.
Scientists developed a novel solvatochromic probe to study lipid membrane fluidity and its correlation with cellular functions. The new dye offers exceptional stability, low toxicity, and fluorescent properties, allowing real-time visualization of lipid membrane order during complex processes.