Articles tagged with Clinical Research
A landmark EORTC trial with over 20 years of follow-up found that irradiation of internal mammary and medial supraclavicular lymph nodes reduces breast cancer mortality, but does not improve overall survival. Long-term cardiac and pulmonary toxicity was reported more frequently after IM-MS irradiation.
At ASCO 2026, City of Hope experts will present research on innovative treatments for various types of cancer. Their findings include the efficacy and safety of immunotherapy combinations, as well as the potential use of CBM588 to enhance immune checkpoint blockade in metastatic renal cell carcinoma.
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
Glioblastoma is a highly aggressive brain tumor that has seen modest improvements in survival rates over the past decade. Researchers at UCLA's Jonsson Comprehensive Cancer Center are part of a national effort to develop more personalized approaches to care, combining advanced imaging and analysis of tumor tissue samples and blood test...
Young scholars explore how to make clinical decisions from biomarkers to immunotherapy. They present innovative approaches for targeted therapy sensitivity and guidelines, shedding light on neoadjuvant care.
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
Five fellows will receive funding for four years to study hard-to-treat pediatric cancers, reduce treatment toxicity, and develop innovative therapies. Their research focuses on Ewing sarcoma, leukemia, kidney cancer, and immune system vulnerabilities.
The American Geriatrics Society has honored 18 leaders in the field of geriatric medicine for their outstanding contributions to high-quality, person-centered care for older adults. These awards recognize individuals who have made significant impacts through education, research, and clinical practice.
The Alliance for Clinical Trials in Oncology has several active trials specifically designed to help people with head and neck cancers. Trials include testing high-dose prophylactic gabapentin to prevent opioid use during treatment, as well as immunotherapy with nivolumab and cabozantinib for mucosal melanoma and nasopharyngeal carcino...
Researchers found that squalene-based adjuvants activate distinct pathways for vaccine protection and reactogenicity, including the role of IL-1β in enhancing efficacy and IL-1α in triggering local swelling. The study's findings could lead to safer vaccine design by targeting specific immune mechanisms.
Dr. Ariel Green will receive the award for her work on deprescribing research, focusing on optimizing medication use for older adults with multiple chronic conditions. She has garnered several grants as Principal Investigator and serves as Chair of the AGS Clinical Practice Committee.
Researchers develop dynamics-driven models to identify disease transitions before symptoms appear, transforming real-time care and personalized treatment. AI systems analyze health data to detect
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
Dr. Cudjoe's research examines the influence of social connection on health and developing interventions to address social isolation in older adults. He is a recipient of several awards, including the National Institute on Aging GEMSSTAR award and the Robert Wood Johnson Foundation Amos award.
A study published in BMC Public Health found an association between antibiotic use and maternal mental health during pregnancy. Researchers analyzed data from over 94,000 pregnant women and discovered a stepwise pattern of psychological distress linked to increasing antibiotic exposure. The findings suggest that avoiding unnecessary an...
Researchers evaluated the performance of the Phoenix Sepsis Score for predicting in-hospital mortality among pediatric ICU patients in China. They found that a modified version, PSS+, showed substantially improved discrimination without sacrificing clinical usability.
The San Antonio Breast Cancer Symposium generated nearly $40 million in economic impact and drew over 11,000 attendees from 104 countries. The symposium also produced $1.5 million in local tax revenue and supported more than 6,800 jobs.
NRG Oncology has appointed Dr. John Nakayama as Vice Chair of the NRG Ancillary Projects Committee, Dr. Ibrahim Nassour as Vice Chair of the Surgical Oncology Committee, and Dr. Scott Okuno as Vice Chair of the Sarcoma Subcommittee. Dr. Angeles Alvarez Secord was also appointed Chair of the Investigator & Career Development Committee.
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
The Accelerating Cancer Cures Research Symposium brings together Damon Runyon scientists and industry partners to foster communication and collaboration. The symposium features updates on research aimed at developing more precise targeted therapies for cancer treatment.
Researchers explore pragmatic pharmacist-led deprescribing interventions, including ALIGN, to improve medication management in older adults with cognitive impairment. Validation of hospitalization, death, and hospice care data from skilled nursing facility EHRs and Medicare claims shows promise for improved care coordination.
A new study has estimated pediatric sepsis in the US, revealing a significant impact on pediatric hospitalizations. The study found that sepsis affects approximately 1.3% of hospitalizations, resulting in over 18,000 cases and more than 1,800 deaths annually.
Researchers develop new approach to prevent chemotherapy-related leukemia by analyzing blood samples from four clinical trials, showing a 26-36% reduction in blood cell growth with mutated TP53 gene. They also discover that monoclonal antibodies can turn neutrophils into cancer killers and induce tumor eradication in preclinical models.
Dr. Ludwig Kappos has made enormous contributions to MS research, advancing clinical trial conduct and outcome measures, and leading international collaborations. He will formally receive the award at the American Academy of Neurology Annual Meeting in Chicago on April 19, 2026.
A new clinical study aims to improve communication between patients and families about genetic risks of colorectal cancer. The trial will compare two methods of sharing genetic test results with close relatives, with the goal of learning which approach helps more family members get necessary genetic testing.
A new Cochrane review found that sucrose can effectively reduce pain in newborn babies during painful procedures like venepuncture. The study examined 29 clinical trials involving over 2,700 babies and showed that a small amount of sucrose given before the procedure significantly reduces pain when combined with non-nutritive sucking.
A new study found that adding one avocado and a cup of mango to daily meals and snacks for eight weeks improved vascular function among adults with prediabetes, while also reducing diastolic blood pressure. The Avocado-Mango diet showed significant increases in flow-mediated dilation and nutrient-dense nutrients without changes in calo...
The International Society for Stem Cell Research has awarded the 2026 ISSCR Lifetime Achievement Award to Dr. Allen Eaves and late Dr. Connie Eaves, recognizing their groundbreaking work on blood stem cell biology, leukemia, and cancer stem cells. Their research and mentorship have profoundly influenced the field of stem cell science.
A new study published in JAMA Network Open reveals that neighborhoods with high housing costs and crowded households are associated with shorter breast cancer survival among women. The research team identified four specific variables that drive this relationship, including financial toxicity and stress.
A new UCLA study found that adding immunotherapy to standard chemotherapy before surgery is safe and shows promise for some patients with borderline-resectable pancreatic cancer. The combination treatment helped patients live long enough to reach surgery, shrank tumors, and produced encouraging survival outcomes.
Researchers developed antibody–drug conjugates that combine CD4 mimic and neutralizing antibodies to target HIV entry, showing seven times better efficacy than existing approaches. The strategy aims to block HIV before it enters the host cell, offering a more targeted therapeutic profile and potentially reducing adverse effects.
A new study externally validates the NOFI model, which uses three clinical variables to predict feeding intolerance and stratify patients by 28-day mortality risk. The analysis found that patients in the high-risk group experienced substantially higher 28-day mortality compared with those in lower-risk groups.
Aviv Regev, a pioneering computational biologist, will deliver a keynote address on tissue stem cells at the ISSCR 2026 Annual Meeting. Her work has transformed our understanding of cell and tissue function in health and disease.
A comprehensive scientific review highlights pecans' positive effects on cardiovascular health, including improved lipid metabolism and antioxidant defenses. While findings on blood sugar control are mixed, the review suggests pecans may support better diet quality and satiety.
A new clinical trial shows that treating desmoplastic melanoma with immunotherapy before surgery dramatically shrinks or eliminates tumors, improving quality of life for patients. The study found that 71% of patients had no detectable cancer remaining at the time of surgery.
Researchers are expanding options for patients with hard-to-treat cancers using a personalized approach that identifies effective therapies by testing large libraries of drugs on living tumor cells. The approach has shown stronger responses than initial findings, suggesting it can reveal opportunities missed by traditional methods.
New MSK research reveals that the gut uses immune cells to sense bacteria, triggering protective responses. A subtype of glioma-associated macrophages may play a pivotal role in tumor progression. Additionally, reduced thyroid surgery is an option for some patients.
NRG Oncology has added several new leadership members to its Brain Tumor, Breast Cancer, Genitourinary Cancer, Lung Cancer, Medical Oncology, and Translational Science committees. Deborah K. Armstrong will lead the NRG Medical Oncology Committee, while Daniel P. Cahill will serve as Surgical Oncology Vice Chair of the NRG Brain Tumor C...
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
The American Pediatric Society has reinstated the APS Howland Visiting Professor Program at Vanderbilt University School of Medicine, enabling renowned pediatric leader Bonnie W. Ramsey, MD, to share her expertise and engage with academic professionals.
The International Society for Stem Cell Research published its most downloaded papers of 2025, reflecting the field's scientific range from pluripotency to regenerative medicine. The journal's mission is to publish rigorous, transparent, and consequential science advancing discovery while informing clinical translation.
The University of Texas at San Antonio has received a $7 million gift commitment from Ed and Linda Whitacre to advance research, student success, and athletics. The gift will fuel groundbreaking discovery in metabolic health and strengthen the institution's role in improving health outcomes for South Texans.
Boston Children's Hospital will provide clinical research coordination for the IMPACT Network, a multisite clinical trial infrastructure enabling rapid and effective therapeutic development for autism. The grant, from ARIA, will support the development of study design protocols, recruitment strategies, and efficient workflows.
Researchers have compiled a comprehensive list of 166 human pluripotent stem cell lines available for clinical applications, guiding researchers and developers in selecting optimal cell lines. The study aims to drive hPSC-derived products towards the clinic, addressing a knowledge gap in off-the-shelf product development.
A novel approach to chronic pain management uses induced pluripotent stem cell-derived peripheral pain-sensing neurons to treat osteoarthritis joint pain. The therapy, SN101, sequesters inflammatory pain factors without transmitting pain signals, preserving joint tissues and relieving chronic pain.
A new clinical trial suggests that combining bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may significantly enhance one-year progression-free survival for people with aggressive lymphoma. The study found that 90% of patients were in complete remission at day 90, and about 80% remained in remission at one y...
The 48th San Antonio Breast Cancer Symposium brings together over 10,000 global experts to share cutting-edge research on breast cancer discovery, therapeutics, and standard of care. Key findings include the effectiveness of active monitoring for low-risk DCIS patients and a new estrogen-blocking pill that slows cancer progression.
Researchers at UCLA present several new studies on emerging blood-based surveillance tools, new approaches to predicting treatment response, and tailoring therapies across the disease spectrum for patients with breast cancer. The findings highlight the potential of precision medicine in improving quality of life.
A new review emphasizes the importance of smell health, highlighting its role in nutrition, cognitive function, and psychological resilience. Researchers call for a global campaign to promote smell health through education, awareness, and targeted public health policies.
A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
A national survey of over 47,000 healthcare professionals found that engaging care teams remains the biggest challenge for concrete improvements in quality of care. The study highlights the importance of valuing teams and promoting a good experience for both patients and healthcare workers.
Four researchers from LSU's Pennington Biomedical Research Center have been named among the world's most highly cited scientists. Dr. Steven Heymsfield, Dr. Peter Katzmarzyk, Dr. Eric Ravussin and Dr. Donna Ryan are recognized for their significant and broad influence in their respective fields.
The Vaccine Innovation Center at Korea University College of Medicine has been selected as the lead institution for a health security research initiative focused on developing broad-spectrum antiviral agents and combination therapies to prevent severe disease in future pandemics. The project aims to create advanced therapeutics capable...
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
The new clinical cancer research center will support lung and genitourinary cancers, serving as a central hub for seven VA medical centers. The grant aims to improve access to precision oncology trials and patient care for veterans diagnosed at later stages.
Researchers have identified three distinct immunotypes in EPTB patients, revealing new insights into disease mechanisms. Additionally, gene expression-based biomarkers have been developed to reliably diagnose both pulmonary and extrapulmonary tuberculosis.
This study confirms the role of negative reinforcement in chronic opioid use, contributing to addiction development. The findings suggest that this mechanism is present even after regular opioid use, highlighting potential for more effective prevention and treatment strategies.