Articles tagged with Clinical Research
The Alliance for Clinical Trials in Oncology emphasizes the significance of clinical trials in advancing breast cancer treatments and early detection. The organization's work has led to a 44% decline in breast cancer mortality rates among women since 1989.
Dr. Lorenz Studer is known for his pioneering advances in stem cell biology, regenerative medicine, and the development of stem cell-based therapies for neurodegenerative disease.
Researchers developed a multiprotein approach to predict advanced tau pathology among amyloid-positive individuals, outperforming p-tau217 alone. This study suggests a scalable alternative to tau PET staging for clinical or research settings.
The partnership aims to increase enrollment in clinical trials, making research opportunities more accessible to patients. UCCCC and Lilly will work together to open studies faster and connect more patients with research opportunities.
Researchers analyzed patient data from five clinical trials to evaluate the impact of adding hormone therapy on postoperative radiation outcomes. While traditional pathological features can identify patients at higher risk of recurrence, they do not predict treatment benefit.
The Sylvester Comprehensive Cancer Center has been ranked the No. 1 cancer program in Florida and No. 23 nationally by US News & World Report. The center's multidisciplinary teams provide access to new therapies and innovative clinical trials, making it a destination for patients seeking advanced care.
Massey Comprehensive Cancer Center awarded $2.7M K12 grant to support multidisciplinary cancer research and mentor early-stage clinical investigators. The grant aims to optimize participation by high-risk individuals in Virginia.
The symposium marked the hospital's designation as a research-oriented hospital, featuring discussions on collaborative research ecosystems at various levels. Participants engaged in sessions covering future directions, strengthening regional and industry collaborations, and real-world cases of research commercialization.
Researchers at Terasaki Institute develop a wireless dual-compartment biochemical monitoring platform for real-time tracking of key biomarkers in perfusion fluid and bile during normothermic machine perfusion. The study shows improved interpretation of post-transplant outcomes with combined bile and perfusate data.
Researchers evaluate whether hypoimmune cell engineering can help transplanted insulin-producing cells survive without chronic immunosuppression. The study aims to develop a cell replacement approach that can function without chronic immunosuppression, providing a curative therapy for people with type 1 diabetes.
Researchers present new insights into an iPSC-derived neural progenitor cell therapy for chronic ischemic stroke, demonstrating safety and biological activity over extended follow-up. The findings have the potential to expand treatment options for patients living with chronic stroke disability.
The REGEN4HD study marks a significant milestone in the development of regenerative medicine approaches for Huntington's disease. The Phase 1b/2a trial enrolls early-stage symptomatic patients to evaluate safety and tolerability.
Researchers at ISSCR 2026 present interim clinical findings from the first Phase 1/2a trial of autologous iPSC-derived dopamine neuron precursor cells for Parkinson's disease. The approach uses each patient's own cells, and new genomic quality control methods ensure the manufactured cells are suitable for transplantation.
A Phase 1/2a clinical study demonstrates long-term survival of transplanted human neural progenitor cells in patients with retinitis pigmentosa, maintaining a favorable safety profile. Visual acuity remained stable, and imaging showed cells remaining present in the subretinal space for at least one year.
Early signs of clinical improvement have been observed in patients with treatment-resistant systemic sclerosis treated with investigational stem cell-derived CAR T-cell therapy, known as FT819. The therapy has demonstrated a reassuring safety profile and has the potential to expand access to patients who might otherwise face barriers t...
The STEM-PD trial demonstrated the safety and feasibility of stem cell-derived dopaminergic cell transplantation in patients with moderate to advanced Parkinson's disease. The findings mark an important step in evaluating this approach as a potential treatment strategy for neurodegenerative diseases.
The Robert A. Winn Excellence in Clinical Trials Award Program is training a new generation of physicians to solve healthcare's representation challenge through immersive education and mentorship. The program has grown rapidly, drawing hundreds of applicants annually from medical schools across the country.
Encellin reports non-fibrotic engraftment and host vascularization in Phase 1 trial participants, building on interim results. The findings support the company's approach to deliver cell therapy safely and durably without immunosuppression.
The International Society for Stem Cell Research convenes its 2026 Annual Meeting in Montréal, showcasing groundbreaking discoveries and emerging clinical advances. The meeting features nearly 1,300 scientific posters and presentations spanning every area of stem cell research.
The Damon Runyon Cancer Research Foundation is investing nearly $1.4 million to support three young physician-scientists with innovative ideas about cancer treatment. The awardees will receive funding and freedom to pursue research in the early stages of their careers, which has led to breakthroughs in immunotherapy and other areas.
A nationwide Japanese study of over 82,000 children found that exclusive breastfeeding for six months significantly reduces the risk of short sleep duration at one year of age. The study also suggests that breast milk's adaptability to infant needs and its melatonin content help regulate healthy sleep rhythms.
Researchers have identified IL1RAP as a key player in the tumor-driven inflammatory network that helps pancreatic cancer resist treatment. Blocking this receptor may help break down tumors and improve response to combination therapy.
The Robert A. Winn Clinical Investigator Pathway Program is launching its fifth cohort, welcoming 80 medical students from across the US and Puerto Rico for a six-week immersion in clinical research, community engagement, and improving clinical trial participation. Students will gain hands-on experience at leading institutions nationwide.
A recent study published in JAMA found that prone positioning in infants with moderate to severe bronchiolitis receiving high-flow nasal cannula support did not significantly reduce escalation of care. The study suggests that further research is warranted due to the wide confidence interval around the observed odds ratio.
Researchers developed LiON, a fluorescent reporter that visualizes biologically active iron and oxygen inside living cells. The tool revealed striking differences in iron and oxygen distribution across organs and cells, offering new opportunities to study diseases like cancer, liver disorders, and neurodegenerative conditions.
The FDA has accepted Genentech's supplemental Biologic License Application for atezolizumab, supported by phase III ATOMIC trial results. The trial showed a 50% reduction in cancer recurrence or death and 86.3% disease-free survival rate.
Eighty medical students from across the US and Puerto Rico are selected for a six-week summer experience to introduce them to clinical research early in their careers. The program aims to develop the next generation of clinical investigators equipped to engage communities and improve participation in clinical trials.
The ACT-CHIK project will conduct a Phase Ib/III clinical trial to evaluate the safety and immunogenicity of a measles-virus-based chikungunya vaccine in four African countries. The project also aims to strengthen Africa's vaccine ecosystem by transferring the vaccine manufacturing process to an African manufacturer.
Researchers will investigate the link between SYNGAP1 protein deficiency, cilia dysfunction, and clinical symptoms of SYNGAP1-Related Disorders. The study aims to inform rational drug design and provide new insights for targeted therapies.
A study published in JAMA Network Open found that maternal RSV vaccination reduces hospitalization risk in young infants by nearly 70%. The vaccine also showed effectiveness against severe lung infections caused by the virus.
A new study shows that targeted cancer drug selpercatinib can significantly reduce the risk of lung cancer returning in patients with a rare genetic subtype. After two years, 92% of patients remained cancer-free, compared to 61% who received a placebo.
A landmark EORTC trial with over 20 years of follow-up found that irradiation of internal mammary and medial supraclavicular lymph nodes reduces breast cancer mortality, but does not improve overall survival. Long-term cardiac and pulmonary toxicity was reported more frequently after IM-MS irradiation.
The ASTRO Annual Meeting will take place in Boston from September 26-30, featuring research presentations, keynote addresses, and panel discussions on critical cancer care issues. The meeting aims to foster meaningful conversations about radiation therapy's value in advancing patient care.
The LAMECS 2026 symposium will feature keynote lectures on astrobiology, infectious disease, public health, and science policy. Early career scientists can showcase their work, expand networks, and explore career options in microbiology.
Research by Dr. Hanim Diktas at Pennington Biomedical Research Center shows that combining GLP-1 receptor agonists with behavioral intervention leads to a greater reduction in 'food noise', a persistent thought about food disrupting daily life and healthy behaviors. The study found significant decreases in food noise for participants u...
At ASCO 2026, City of Hope experts will present research on innovative treatments for various types of cancer. Their findings include the efficacy and safety of immunotherapy combinations, as well as the potential use of CBM588 to enhance immune checkpoint blockade in metastatic renal cell carcinoma.
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
Glioblastoma is a highly aggressive brain tumor that has seen modest improvements in survival rates over the past decade. Researchers at UCLA's Jonsson Comprehensive Cancer Center are part of a national effort to develop more personalized approaches to care, combining advanced imaging and analysis of tumor tissue samples and blood test...
Young scholars explore how to make clinical decisions from biomarkers to immunotherapy. They present innovative approaches for targeted therapy sensitivity and guidelines, shedding light on neoadjuvant care.
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
Five fellows will receive funding for four years to study hard-to-treat pediatric cancers, reduce treatment toxicity, and develop innovative therapies. Their research focuses on Ewing sarcoma, leukemia, kidney cancer, and immune system vulnerabilities.
The American Geriatrics Society has honored 18 leaders in the field of geriatric medicine for their outstanding contributions to high-quality, person-centered care for older adults. These awards recognize individuals who have made significant impacts through education, research, and clinical practice.
The Alliance for Clinical Trials in Oncology has several active trials specifically designed to help people with head and neck cancers. Trials include testing high-dose prophylactic gabapentin to prevent opioid use during treatment, as well as immunotherapy with nivolumab and cabozantinib for mucosal melanoma and nasopharyngeal carcino...
Researchers found that squalene-based adjuvants activate distinct pathways for vaccine protection and reactogenicity, including the role of IL-1β in enhancing efficacy and IL-1α in triggering local swelling. The study's findings could lead to safer vaccine design by targeting specific immune mechanisms.
Dr. Ariel Green will receive the award for her work on deprescribing research, focusing on optimizing medication use for older adults with multiple chronic conditions. She has garnered several grants as Principal Investigator and serves as Chair of the AGS Clinical Practice Committee.
Researchers develop dynamics-driven models to identify disease transitions before symptoms appear, transforming real-time care and personalized treatment. AI systems analyze health data to detect
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
Dr. Cudjoe's research examines the influence of social connection on health and developing interventions to address social isolation in older adults. He is a recipient of several awards, including the National Institute on Aging GEMSSTAR award and the Robert Wood Johnson Foundation Amos award.
A study published in BMC Public Health found an association between antibiotic use and maternal mental health during pregnancy. Researchers analyzed data from over 94,000 pregnant women and discovered a stepwise pattern of psychological distress linked to increasing antibiotic exposure. The findings suggest that avoiding unnecessary an...
Researchers evaluated the performance of the Phoenix Sepsis Score for predicting in-hospital mortality among pediatric ICU patients in China. They found that a modified version, PSS+, showed substantially improved discrimination without sacrificing clinical usability.
The San Antonio Breast Cancer Symposium generated nearly $40 million in economic impact and drew over 11,000 attendees from 104 countries. The symposium also produced $1.5 million in local tax revenue and supported more than 6,800 jobs.
NRG Oncology has appointed Dr. John Nakayama as Vice Chair of the NRG Ancillary Projects Committee, Dr. Ibrahim Nassour as Vice Chair of the Surgical Oncology Committee, and Dr. Scott Okuno as Vice Chair of the Sarcoma Subcommittee. Dr. Angeles Alvarez Secord was also appointed Chair of the Investigator & Career Development Committee.
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
The Accelerating Cancer Cures Research Symposium brings together Damon Runyon scientists and industry partners to foster communication and collaboration. The symposium features updates on research aimed at developing more precise targeted therapies for cancer treatment.
Researchers explore pragmatic pharmacist-led deprescribing interventions, including ALIGN, to improve medication management in older adults with cognitive impairment. Validation of hospitalization, death, and hospice care data from skilled nursing facility EHRs and Medicare claims shows promise for improved care coordination.
A new study has estimated pediatric sepsis in the US, revealing a significant impact on pediatric hospitalizations. The study found that sepsis affects approximately 1.3% of hospitalizations, resulting in over 18,000 cases and more than 1,800 deaths annually.
Researchers develop new approach to prevent chemotherapy-related leukemia by analyzing blood samples from four clinical trials, showing a 26-36% reduction in blood cell growth with mutated TP53 gene. They also discover that monoclonal antibodies can turn neutrophils into cancer killers and induce tumor eradication in preclinical models.
Dr. Ludwig Kappos has made enormous contributions to MS research, advancing clinical trial conduct and outcome measures, and leading international collaborations. He will formally receive the award at the American Academy of Neurology Annual Meeting in Chicago on April 19, 2026.
A new clinical study aims to improve communication between patients and families about genetic risks of colorectal cancer. The trial will compare two methods of sharing genetic test results with close relatives, with the goal of learning which approach helps more family members get necessary genetic testing.
A new Cochrane review found that sucrose can effectively reduce pain in newborn babies during painful procedures like venepuncture. The study examined 29 clinical trials involving over 2,700 babies and showed that a small amount of sucrose given before the procedure significantly reduces pain when combined with non-nutritive sucking.