Articles tagged with Clinical Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The University of California, San Diego's Altman Clinical and Translational Research Institute has received a seven-year, $80 million grant to accelerate progress in human health. The award supports workforce development programs, including mentorship opportunities for early-career scientists.
The University of Texas at San Antonio (UTSA) has exceeded its $500 million fundraising goal through the Be Bold: A Campaign for Our Future initiative. The campaign, which aimed to accelerate student success, advance research excellence, and expand community impact, garnered support from over 60,000 donors contributing over 200,000 gif...
The International Society for Stem Cell Research (ISSCR) and STEMCELL Technologies have partnered to develop a free, on-demand course on the ISSCR Standards for Human Stem Cell Use in Research. The course will provide practical guidance on applying the standards to enhance rigor and reproducibility in human stem cell research worldwide.
The ISSCR has released an updated set of guidelines for stem cell research and clinical translation, incorporating advances in human stem cell-based embryo models. The new guidelines aim to provide clear guidance on the development and application of these innovative models.
A coordinated approach is needed to address the scientific value of trial representation of the intended use population. The study aims to provide a strategic framework to ensure scientific validity by operationalizing broad representation at all levels.
Researchers found that billing codes may mistakenly identify diseases in up to 45% of cases, highlighting a significant limitation in using administrative data for clinical research. The study examined records of 1.36 million patients and found discrepancies between coded diagnoses and actual disease presence.
The Weill Cancer Hub West will harness expertise from two world-class institutions to accelerate new discoveries and develop innovative treatments. The initiative aims to drive early detection, diagnoses, and effective treatments through data science and human cell research.
A new study published in JAMA Network Open found no statistical relationship between pathologic complete response (pCR) and overall survival in rectal cancer patients. This challenges the FDA's use of pCR as a surrogate endpoint for drug approval, which may lead to treatments being fast-tracked without evidence of improved long-term su...
The inaugural ESMO Targeted Anticancer Therapies (TAT) Asia Congress 2025 will convene a diverse group of stakeholders to foster collaboration and accelerate the development of innovative cancer therapies. The congress aims to become a catalyst for global collaboration and innovation in oncology.
Research review finds handgrip strength is a reliable predictor of cirrhosis complications and outcomes, including malnutrition, muscle loss, cognitive impairment, hepatic encephalopathy, and mortality. Regular HGS assessments can inform timely personalized interventions to enhance patient quality of life.
A recent study published by Fujita Health University found that poor oral health can increase the risk of lifestyle-related diseases such as diabetes and heart disease. The researchers examined 118 individuals aged 50 or above and found significant links between oral function test results and blood test results.
Researchers highlight the benefits of artificial intelligence in glioblastoma management, including improved diagnosis, treatment planning, and personalized therapy. AI-based models can analyze radiological images, predict tumor characteristics, and suggest effective treatments, promising to improve patient outcomes and survival rates.
Researchers have generated a first large-scale stem cell bank from over 100 individuals with extreme Alzheimer's disease risk. This new resource, called iPSC Platform to Model Alzheimer’s disease Risk (IPMAR), will facilitate studies on the impact of genetic variants in cellular models of AD.
The conference brought together experts to discuss clinical and laboratory medicine hotspots, promoting interdisciplinary innovation and industry collaboration. Delegates exchanged ideas with the editorial team on academic submissions and discipline dynamics.
A team of researchers proposes a novel adaptive platform trial fund to accelerate ALS drug development. The study outlines a financing model that merges efficiencies with an innovative royalty-based investment structure, drawing on data from the HEALEY ALS Platform Trial. This new approach could transform how diseases like ALS are addr...
Hideyuki Okano has been elected President of the International Society for Stem Cell Research (ISSCR), an organization dedicated to promoting excellence in stem cell science. He will champion inclusive excellence, advance discovery, and ensure that the transformative promise of stem cell science benefits the world.
The 2025 NF Conference brings together researchers, patients, and advocates to discuss progress and future prospects in NF treatment and discovery. The event features keynotes on gene therapy, regulatory reform, and next-generation pain treatments.
Researchers found that transcranial magnetic stimulation (TMS) can alleviate some autistic behaviors and improve mental flexibility by reducing neural rigidity. The study's results provide a biological explanation for the coexistence of diverse behavioral traits in ASD.
The National Multiple Sclerosis Society is offering funding opportunities for next-generation researchers and clinicians, as well as projects advancing women's health in MS. The American Brain Foundation and US Department of Defense are also providing grants for neuroinflammation research and clinical trials.
A new set of guidelines for psychedelic clinical trials has been established, taking into account the impact of mindset and surroundings on therapy outcomes. The Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) guidelines aim to make trial outcomes more consistent and comparable across studies.
Moffitt researchers will present numerous oral and poster presentations covering a wide range of cancer types, including lung, breast, cervical and biliary tract cancers. The center's experts are also available to comment on various cancer research and care topics before and during the meeting.
A novel study analyzing the cost-effectiveness of different Down syndrome screening strategies confirms that non-invasive prenatal testing (NIPT) significantly outperforms second-trimester serum screening (STSS). NIPT identifies twice as many DS cases as STSS, offering a more reliable option with lower incremental costs.
Professor Sadaf Farooqi has been awarded the inaugural Joint ‘Endocrinology Across the Life Course Award’ for her groundbreaking research on human eating behaviour and severe childhood obesity. Her work has changed attitudes towards people with severe obesity by demonstrating its biological basis.
Lenacapavir, a groundbreaking HIV treatment, provides six-month protection with each shot, almost completely preventing new infections. The development of this drug involved significant contributions from multiple individuals and organizations, highlighting the importance of collaboration in scientific innovation.
A cohort study of 12,480 mother-offspring pairs found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy are associated with increased offspring blood pressure. These risk factors may also promote a faster rate of blood pressure change from age 2 to 18 years.
Researchers have discovered that mature liver cells transform into immature states and divide rapidly in response to damaged tissue, a process similar to what occurs in human patients with drug-induced liver injury. This understanding could lead to more effective treatments for liver failure by targeting the regenerative program.
The Psychedelics journal has expanded its focus to include all psychoactive drugs, challenging traditional classifications and embracing a broader understanding of consciousness-altering substances. This move aims to reveal novel therapeutic applications and deepen human knowledge of the mind.
The ISSCR 2026 Annual Meeting will bring together global stem cell experts to discuss key scientific themes and applications. The meeting will take place at the Palais des congrès de Montréal from July 8-11, 2026.
A pilot program was conducted in South Africa to provide harm reduction and medications for opioid use disorder among people living with HIV and illicit opioid use. The study found low uptake of medication-assisted treatment after release, citing perceived ineffectiveness and delays in initiation.
A new study has found that people with celiac disease can safely kiss their partners without worrying about gluten transfer. In a two-part study, researchers found minimal gluten in the saliva of partners with celiac disease, even when they kissed after consuming gluten.
A new study introduces the RAPID-RT study, which uses a rapid-learning approach to evaluate the impact of treatment modifications in radiotherapy. The technique aims to reduce cardiac toxicity and improve survival in lung cancer patients by minimising dose to the top of the heart, a previously identified risk area.
The Society for Cardiovascular Angiography & Interventions (SCAI) has recognized the expertise of its top interventionalists, who demonstrate excellence in clinical care, innovation, publication, and teaching. The MSCAI designation is awarded to outstanding individuals who have made significant contributions to the field.
The Society for Cardiovascular Angiography and Interventions recognized several individuals for their exceptional leadership, research, and contributions to advancing interventional cardiology. Dr. Dean Kereiakes received the Helping Hearts Lifetime Service Award for his outstanding service, while Dr. Alexandra Lansky was honored with ...
This study found that intestinal depletion of TM6SF2 exacerbates high-fat diet-induced MASLD by altering the gut microbiota and liver lipid content. The absence of TM6SF2 also led to increased serum biomarkers associated with MASLD progression.
Researchers investigated the clinical outcomes of concurrent TTFields therapy with CRT in patients with newly diagnosed glioblastoma, finding no significant difference in survival outcomes compared to adjuvant therapy. The study also showed comparable safety profiles for both treatment groups.
A digital cognitive screening tool and flexible workflow helped seven primary care clinics integrate dementia screening, increasing screening rates to at least 20%. Clinics adapted the process to fit their settings while maintaining alignment with a shared core model.
New research published in the New England Journal of Medicine shows that semaglutide effectively treats liver disease in two-thirds of patients with MASH. The substance has been found to halt and even reverse the disease, reducing steatohepatitis and improving liver fibrosis.
Researchers developed promising α-synuclein PET tracers that can visualize protein aggregates in living patients, enabling earlier diagnosis and treatment monitoring. Tracers like [18F]C05-05 and [18F]ACI-12589 showed significant results in distinguishing synucleinopathies from healthy controls.
Researchers identified unique biological mechanisms that cause premature aging in the brains of individuals with alcohol, opioid, and stimulant use disorders. Different substances appear to hijack the brain's natural aging rhythm through distinct molecular mechanisms, though some pathways are shared across different substance types.
Dr. Seymour Reichlin's remarkable career spanned five decades, marked by scientific excellence, mentorship, and generosity. His influence on neuroendocrinology has been profound, with ongoing contributions at age 100 revealing new insights into Alzheimer's disease and ecstatic mysticism.
This study explored the immune dynamics across different phases of HBV infection, identifying key factors influencing T cell function and liver priming. The research team uncovered distinct types of intrahepatic T lymphocytes and dual roles of DC-SIGN+ macrophages in modulating immune responses.
Research found that negative expectations have a stronger and longer-lasting impact on pain perception than positive ones. The study showed that nocebo effects, where participants expect a negative outcome, were more powerful and persistent than placebo effects, with implications for patient-practitioner communication.
A non-risk-based lung cancer screening approach using low-dose computed tomography (LDCT) in Chinese populations detects a significant number of early-stage lung cancers. The study found that incorporating non-high-risk individuals into screening programs can lead to a greater detection rate and improved patient outcomes.
A new curriculum framework helps train future family physicians to integrate AI into their practice, addressing a critical gap in medical training. The AIFM-ed framework provides a structured road map for medical educators to bridge the AI gap, ensuring that future doctors are clinically competent and technologically fluent.
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
A new CAR-T therapy, HSP-CAR30, has achieved positive results in a high proportion of patients with refractory CD30+ lymphoma. The treatment promotes the expansion of memory T cells, leading to durable responses and improved clinical outcomes.
A novel approach to analyzing human blood plasma's low-abundant N-glycoproteome has been developed, enabling the reliable identification of rare and modified glycans. This workflow can detect glycoproteins with concentrations as low as 6.31 pg·mL−1, expanding the range by five orders of magnitude.
A new study presents RMC-6236, a powerful inhibitor of RAS genes, showing promise in combination with other treatments. The study suggests that combining RMC-6236 with chemotherapy and targeted therapies could overcome therapy resistances and improve therapeutic outcomes in pancreatic cancer.
The MyoStep project represents a significant advancement in pediatric mobility aids for children with cerebral palsy, addressing motor impairments that restrict participation in physical activities. The soft power suit provides a lightweight, discreet solution tailored to fit seamlessly into the lives of children and their families.
A study by Emory University researchers has found that spiritual health practitioners' personal experiences with psychedelics drive their careers in the emerging field of psychedelic-assisted therapy. The study introduced a novel training approach, emphasizing self-literacy and reflective learning to balance personal experience with cl...
Dr. Ulrich Steidl, a leading expert in blood diseases, has been elected to the Association of American Physicians for his groundbreaking research on myelodysplastic syndromes and acute myeloid leukemia. His work seeks to understand the characteristics of pre-leukemic stem cells and develop drugs to interrupt their progression.
The GlycoPro platform offers a novel approach to multi-glycosylation-omics analysis by integrating multiple steps into a single workflow. It has been successfully applied in breast cancer research, identifying a panel of five N-glycan biomarkers with high sensitivity and specificity.
A global research initiative analyzing data from nearly 2 million people in diverse populations worldwide has uncovered multiple new genes associated with osteoarthritis. The study also identified key genetic pathways and 69 genes whose protein products are targeted by approved drugs, paving the way for repurposed treatments.
Researchers found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of immune-related markers PD-L1 and FOXP3. These findings suggest that HPV may begin avoiding the immune system early in infection, allowing infected cells to grow and potentially leading to cancer.
The RFS Awards in Science 2024 recognize outstanding peer-reviewed research by women and underrepresented minorities in STEM. The awards honor the best papers written in 2024, with winners receiving a $1,000 cash prize and free access to their publications for 90 days.
The BNT162b2 vaccine not only targets the COVID-19 virus but also helps reduce and control innate inflammation to other bacterial and fungal pathogens. By reprogramming innate immune cells, the vaccine reduces pro-inflammatory mediators, providing potential benefits beyond its primary target.
A virtual crisis prevention program for autistic children and their families has shown significant improvement in confidence, preparedness, and knowledge around crisis management. The 3-session program guided caregivers through a four-stage framework, equipping them with practical tools to navigate challenging situations.
A study from Weill Cornell Medicine found that healthcare providers working together in Accountable Care Organizations (ACOs) saved Medicare between $4.1 billion and $8.1 billion from 2012 to 2019. The program incentivized clinicians and organizations to improve patient care, resulting in lower medical spending per patient over time.
A highly sensitive bone marrow test has shown to double survival rates for patients with AML mutations in NPM1 and FLT3 genes, allowing for early detection of potential relapse. This trial indicates that regular molecular testing can improve long-term survival rates by restarting treatment earlier.
A new gene expression atlas from single-cell RNA sequencing data reveals normal hematopoietic cell differentiation patterns and identifies novel AML cell states. Researchers cataloged multiple ways aberrant differentiation leads to AML, with potential biomarkers and drug targets emerging.