Articles tagged with Clinical Research
A cohort study of 12,480 mother-offspring pairs found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy are associated with increased offspring blood pressure. These risk factors may also promote a faster rate of blood pressure change from age 2 to 18 years.
Researchers have discovered that mature liver cells transform into immature states and divide rapidly in response to damaged tissue, a process similar to what occurs in human patients with drug-induced liver injury. This understanding could lead to more effective treatments for liver failure by targeting the regenerative program.
The Psychedelics journal has expanded its focus to include all psychoactive drugs, challenging traditional classifications and embracing a broader understanding of consciousness-altering substances. This move aims to reveal novel therapeutic applications and deepen human knowledge of the mind.
The ISSCR 2026 Annual Meeting will bring together global stem cell experts to discuss key scientific themes and applications. The meeting will take place at the Palais des congrès de Montréal from July 8-11, 2026.
A pilot program was conducted in South Africa to provide harm reduction and medications for opioid use disorder among people living with HIV and illicit opioid use. The study found low uptake of medication-assisted treatment after release, citing perceived ineffectiveness and delays in initiation.
A new study has found that people with celiac disease can safely kiss their partners without worrying about gluten transfer. In a two-part study, researchers found minimal gluten in the saliva of partners with celiac disease, even when they kissed after consuming gluten.
A new study introduces the RAPID-RT study, which uses a rapid-learning approach to evaluate the impact of treatment modifications in radiotherapy. The technique aims to reduce cardiac toxicity and improve survival in lung cancer patients by minimising dose to the top of the heart, a previously identified risk area.
The Society for Cardiovascular Angiography & Interventions (SCAI) has recognized the expertise of its top interventionalists, who demonstrate excellence in clinical care, innovation, publication, and teaching. The MSCAI designation is awarded to outstanding individuals who have made significant contributions to the field.
The Society for Cardiovascular Angiography and Interventions recognized several individuals for their exceptional leadership, research, and contributions to advancing interventional cardiology. Dr. Dean Kereiakes received the Helping Hearts Lifetime Service Award for his outstanding service, while Dr. Alexandra Lansky was honored with ...
This study found that intestinal depletion of TM6SF2 exacerbates high-fat diet-induced MASLD by altering the gut microbiota and liver lipid content. The absence of TM6SF2 also led to increased serum biomarkers associated with MASLD progression.
Researchers investigated the clinical outcomes of concurrent TTFields therapy with CRT in patients with newly diagnosed glioblastoma, finding no significant difference in survival outcomes compared to adjuvant therapy. The study also showed comparable safety profiles for both treatment groups.
A digital cognitive screening tool and flexible workflow helped seven primary care clinics integrate dementia screening, increasing screening rates to at least 20%. Clinics adapted the process to fit their settings while maintaining alignment with a shared core model.
New research published in the New England Journal of Medicine shows that semaglutide effectively treats liver disease in two-thirds of patients with MASH. The substance has been found to halt and even reverse the disease, reducing steatohepatitis and improving liver fibrosis.
Researchers developed promising α-synuclein PET tracers that can visualize protein aggregates in living patients, enabling earlier diagnosis and treatment monitoring. Tracers like [18F]C05-05 and [18F]ACI-12589 showed significant results in distinguishing synucleinopathies from healthy controls.
Researchers identified unique biological mechanisms that cause premature aging in the brains of individuals with alcohol, opioid, and stimulant use disorders. Different substances appear to hijack the brain's natural aging rhythm through distinct molecular mechanisms, though some pathways are shared across different substance types.
Dr. Seymour Reichlin's remarkable career spanned five decades, marked by scientific excellence, mentorship, and generosity. His influence on neuroendocrinology has been profound, with ongoing contributions at age 100 revealing new insights into Alzheimer's disease and ecstatic mysticism.
This study explored the immune dynamics across different phases of HBV infection, identifying key factors influencing T cell function and liver priming. The research team uncovered distinct types of intrahepatic T lymphocytes and dual roles of DC-SIGN+ macrophages in modulating immune responses.
Research found that negative expectations have a stronger and longer-lasting impact on pain perception than positive ones. The study showed that nocebo effects, where participants expect a negative outcome, were more powerful and persistent than placebo effects, with implications for patient-practitioner communication.
A non-risk-based lung cancer screening approach using low-dose computed tomography (LDCT) in Chinese populations detects a significant number of early-stage lung cancers. The study found that incorporating non-high-risk individuals into screening programs can lead to a greater detection rate and improved patient outcomes.
A new curriculum framework helps train future family physicians to integrate AI into their practice, addressing a critical gap in medical training. The AIFM-ed framework provides a structured road map for medical educators to bridge the AI gap, ensuring that future doctors are clinically competent and technologically fluent.
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
A new CAR-T therapy, HSP-CAR30, has achieved positive results in a high proportion of patients with refractory CD30+ lymphoma. The treatment promotes the expansion of memory T cells, leading to durable responses and improved clinical outcomes.
A novel approach to analyzing human blood plasma's low-abundant N-glycoproteome has been developed, enabling the reliable identification of rare and modified glycans. This workflow can detect glycoproteins with concentrations as low as 6.31 pg·mL−1, expanding the range by five orders of magnitude.
A new study presents RMC-6236, a powerful inhibitor of RAS genes, showing promise in combination with other treatments. The study suggests that combining RMC-6236 with chemotherapy and targeted therapies could overcome therapy resistances and improve therapeutic outcomes in pancreatic cancer.
The MyoStep project represents a significant advancement in pediatric mobility aids for children with cerebral palsy, addressing motor impairments that restrict participation in physical activities. The soft power suit provides a lightweight, discreet solution tailored to fit seamlessly into the lives of children and their families.
A study by Emory University researchers has found that spiritual health practitioners' personal experiences with psychedelics drive their careers in the emerging field of psychedelic-assisted therapy. The study introduced a novel training approach, emphasizing self-literacy and reflective learning to balance personal experience with cl...
Dr. Ulrich Steidl, a leading expert in blood diseases, has been elected to the Association of American Physicians for his groundbreaking research on myelodysplastic syndromes and acute myeloid leukemia. His work seeks to understand the characteristics of pre-leukemic stem cells and develop drugs to interrupt their progression.
The GlycoPro platform offers a novel approach to multi-glycosylation-omics analysis by integrating multiple steps into a single workflow. It has been successfully applied in breast cancer research, identifying a panel of five N-glycan biomarkers with high sensitivity and specificity.
A global research initiative analyzing data from nearly 2 million people in diverse populations worldwide has uncovered multiple new genes associated with osteoarthritis. The study also identified key genetic pathways and 69 genes whose protein products are targeted by approved drugs, paving the way for repurposed treatments.
Researchers found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of immune-related markers PD-L1 and FOXP3. These findings suggest that HPV may begin avoiding the immune system early in infection, allowing infected cells to grow and potentially leading to cancer.
The RFS Awards in Science 2024 recognize outstanding peer-reviewed research by women and underrepresented minorities in STEM. The awards honor the best papers written in 2024, with winners receiving a $1,000 cash prize and free access to their publications for 90 days.
The BNT162b2 vaccine not only targets the COVID-19 virus but also helps reduce and control innate inflammation to other bacterial and fungal pathogens. By reprogramming innate immune cells, the vaccine reduces pro-inflammatory mediators, providing potential benefits beyond its primary target.
A virtual crisis prevention program for autistic children and their families has shown significant improvement in confidence, preparedness, and knowledge around crisis management. The 3-session program guided caregivers through a four-stage framework, equipping them with practical tools to navigate challenging situations.
A study from Weill Cornell Medicine found that healthcare providers working together in Accountable Care Organizations (ACOs) saved Medicare between $4.1 billion and $8.1 billion from 2012 to 2019. The program incentivized clinicians and organizations to improve patient care, resulting in lower medical spending per patient over time.
A highly sensitive bone marrow test has shown to double survival rates for patients with AML mutations in NPM1 and FLT3 genes, allowing for early detection of potential relapse. This trial indicates that regular molecular testing can improve long-term survival rates by restarting treatment earlier.
A new gene expression atlas from single-cell RNA sequencing data reveals normal hematopoietic cell differentiation patterns and identifies novel AML cell states. Researchers cataloged multiple ways aberrant differentiation leads to AML, with potential biomarkers and drug targets emerging.
A novel topical BRAF inhibitor gel called LUT014 has been shown to significantly reduce the severity of an acne-like rash in patients undergoing anti-EGFR therapies for colorectal cancer. The treatment's safety and effectiveness have been confirmed, offering a potential solution to managing this common side effect.
The American Association for Cancer Research (AACR) announces its 2025 Scientific Achievement Award recipients, honoring outstanding contributions to cancer research. This year's awardees include Rakesh K. Jain, PhD, FAACR, and Han Liang, PhD, recognized for their groundbreaking work on tumor microenvironment and cancer bioinformatics,...
A Phase II trial found durable antitumor activity in patients with BRCA1/2 mutations treated with olaparib and pembrolizumab, with 8.3% complete response rate
Researchers developed a new DNA-reading technology that identified more genomic imprinting in DNA, contributing to rare pediatric diseases. The study used HiFi long-read sequencing to analyze over 200 genetic samples and found widespread parent-of-origin effects on methylation at thousands of novel loci.
Researchers found that antibiotic exposure in the first two years of life was significantly associated with a higher body mass index (BMI) in childhood. The study followed 33,095 vaginally born children in Finland to see if antibiotics before pregnancy, during pregnancy, and after birth were linked to higher BMI at age two and age 12.
Researchers identified five blood proteins that can predict liver disease up to 16 years before symptoms. The combined levels of these proteins achieved high accuracy in predicting disease onset and progression, suggesting potential for early diagnosis and treatment.
A multinational study found that erythropoietin treatment does not prevent death or disability in newborns with critically low levels of oxygen or blood supply to the brain. The research compared outcomes between babies treated with controlled cooling and those receiving both erythropoietin and cooling, but showed no benefit from the a...
Researchers used umbilical cord blood to analyze genetic changes linked to metabolic dysfunction in children. The study found multiple regions of altered DNA associated with metabolic issues later in childhood.
A recent study found that children with chronic conditions are hospitalized for respiratory syncytial virus (RSV) at twice the rate as healthy children. Researchers recommend that these children receive immunization against RSV in their first season to increase protection, regardless of maternal vaccination status.
A recent study found that telehealth visits in pediatric primary care significantly reduced antibiotic prescriptions for acute respiratory tract infections. The research analyzed over 540,000 visits and showed that children treated with telehealth were less likely to receive antibiotics than those examined in person.
A new study found that artificial intelligence can better estimate the prevalence of physical abuse in children seen in emergency departments. The AI model correctly identified child abuse in over 35% of cases, outperforming traditional methods that relied solely on diagnostic codes entered by providers or administrative staff.
Researchers at Ohio State University have identified new targeted therapies for treating small cell lung cancer, predicting melanoma spread, and reducing endometrial cancer risk. A 31-gene expression profile has been developed to identify patients at high risk of melanoma spread, allowing for closer monitoring and earlier treatment.
A new study finds that pregnant women treated with buprenorphine have significantly better health outcomes, including reduced preterm birth rates and lower risk of NICU admission. The research highlights the urgent need for expanded treatment access to vulnerable populations.
Researchers found that 90% of participants had at least one sign of dry eye disease, with significant progression after one year. The study highlights the need for early detection and advice on managing the condition through simple methods such as taking screen breaks and maintaining a healthy lifestyle.
Dr. Robert C. Bast, Jr., a pioneer in cancer science, receives the AACR-Daniel D. Von Hoff Award for his decades-long dedication to nurturing the next generation of cancer research leaders. His groundbreaking discoveries have saved countless lives and transformed ovarian cancer detection and management.
Bonn researchers found higher numbers of type 3 innate lymphoid cells in duodenum tissue of FAP patients, producing interleukin-17A which stimulates ROS production and DNA damage. This suggests a local environment favoring cancer development, prompting a new approach to preventing duodenal cancer.
Methyl eugenol has demonstrated notable antioxidant and antiproliferative activity, with potential therapeutic benefits for diseases like Alzheimer's disease and cancer. However, its toxicological risks, including hepatotoxicity and alterations in the gut microbiota, pose concerns for its application.
A new study reports on five patients with Canavan disease who have a novel variant identified through targeted long-read sequencing, revealing an SVA_E retrotransposable element that disrupts gene function. The findings enhance genetic diagnostics and enable improved guidance for families.
A new study from the University of Missouri highlights how 'smoothed' graphs can help doctors better manage patients with hypertension. The findings suggest that these graphs can reduce errors in assessing blood pressure control, potentially alleviating pressure on the healthcare system.
The Society for Cardiovascular Angiography & Interventions (SCAI) meeting will highlight advances in interventional cardiology, including novel treatments and techniques. The conference features over 500 faculty, 700 posters, and 86 oral abstracts, with a focus on improving patient care and outcomes.
Researchers developed a new method to determine optimal threshold time for restricted mean survival time analysis, improving statistical power in clinical and epidemiological studies. The method outperformed traditional statistical analysis methods in real-world scenarios, revealing clear differences between treatment groups.
A multi-site clinical trial found that both low and moderate-high intensity exercise reduced cognitive decline in sedentary older adults with mild memory loss. The study showed that even low-intensity exercise may be beneficial for brain health, suggesting a promising new strategy to prevent or delay dementia.
Researchers identified a potential new treatment, lorundrostat, which reduced systolic blood pressure in individuals with uncontrolled or treatment-resistant hypertension. The study found a significant 15-point reduction in systolic blood pressure compared to placebo.
Researchers at Pennington Biomedical Research Center investigated tirzepatide's effects on weight loss and metabolic health. The study found that tirzepatide decreased calorie intake and increased fat oxidation, leading to significant weight loss. However, the drug did not decrease the slowing down of metabolic rate usually observed wi...