Articles tagged with Clinical Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A novel topical BRAF inhibitor gel called LUT014 has been shown to significantly reduce the severity of an acne-like rash in patients undergoing anti-EGFR therapies for colorectal cancer. The treatment's safety and effectiveness have been confirmed, offering a potential solution to managing this common side effect.
The American Association for Cancer Research (AACR) announces its 2025 Scientific Achievement Award recipients, honoring outstanding contributions to cancer research. This year's awardees include Rakesh K. Jain, PhD, FAACR, and Han Liang, PhD, recognized for their groundbreaking work on tumor microenvironment and cancer bioinformatics,...
A Phase II trial found durable antitumor activity in patients with BRCA1/2 mutations treated with olaparib and pembrolizumab, with 8.3% complete response rate
Researchers developed a new DNA-reading technology that identified more genomic imprinting in DNA, contributing to rare pediatric diseases. The study used HiFi long-read sequencing to analyze over 200 genetic samples and found widespread parent-of-origin effects on methylation at thousands of novel loci.
Researchers found that antibiotic exposure in the first two years of life was significantly associated with a higher body mass index (BMI) in childhood. The study followed 33,095 vaginally born children in Finland to see if antibiotics before pregnancy, during pregnancy, and after birth were linked to higher BMI at age two and age 12.
Researchers identified five blood proteins that can predict liver disease up to 16 years before symptoms. The combined levels of these proteins achieved high accuracy in predicting disease onset and progression, suggesting potential for early diagnosis and treatment.
A multinational study found that erythropoietin treatment does not prevent death or disability in newborns with critically low levels of oxygen or blood supply to the brain. The research compared outcomes between babies treated with controlled cooling and those receiving both erythropoietin and cooling, but showed no benefit from the a...
Researchers used umbilical cord blood to analyze genetic changes linked to metabolic dysfunction in children. The study found multiple regions of altered DNA associated with metabolic issues later in childhood.
A recent study found that children with chronic conditions are hospitalized for respiratory syncytial virus (RSV) at twice the rate as healthy children. Researchers recommend that these children receive immunization against RSV in their first season to increase protection, regardless of maternal vaccination status.
A recent study found that telehealth visits in pediatric primary care significantly reduced antibiotic prescriptions for acute respiratory tract infections. The research analyzed over 540,000 visits and showed that children treated with telehealth were less likely to receive antibiotics than those examined in person.
A new study found that artificial intelligence can better estimate the prevalence of physical abuse in children seen in emergency departments. The AI model correctly identified child abuse in over 35% of cases, outperforming traditional methods that relied solely on diagnostic codes entered by providers or administrative staff.
Researchers at Ohio State University have identified new targeted therapies for treating small cell lung cancer, predicting melanoma spread, and reducing endometrial cancer risk. A 31-gene expression profile has been developed to identify patients at high risk of melanoma spread, allowing for closer monitoring and earlier treatment.
A new study finds that pregnant women treated with buprenorphine have significantly better health outcomes, including reduced preterm birth rates and lower risk of NICU admission. The research highlights the urgent need for expanded treatment access to vulnerable populations.
Researchers found that 90% of participants had at least one sign of dry eye disease, with significant progression after one year. The study highlights the need for early detection and advice on managing the condition through simple methods such as taking screen breaks and maintaining a healthy lifestyle.
Dr. Robert C. Bast, Jr., a pioneer in cancer science, receives the AACR-Daniel D. Von Hoff Award for his decades-long dedication to nurturing the next generation of cancer research leaders. His groundbreaking discoveries have saved countless lives and transformed ovarian cancer detection and management.
Bonn researchers found higher numbers of type 3 innate lymphoid cells in duodenum tissue of FAP patients, producing interleukin-17A which stimulates ROS production and DNA damage. This suggests a local environment favoring cancer development, prompting a new approach to preventing duodenal cancer.
Methyl eugenol has demonstrated notable antioxidant and antiproliferative activity, with potential therapeutic benefits for diseases like Alzheimer's disease and cancer. However, its toxicological risks, including hepatotoxicity and alterations in the gut microbiota, pose concerns for its application.
A new study reports on five patients with Canavan disease who have a novel variant identified through targeted long-read sequencing, revealing an SVA_E retrotransposable element that disrupts gene function. The findings enhance genetic diagnostics and enable improved guidance for families.
A new study from the University of Missouri highlights how 'smoothed' graphs can help doctors better manage patients with hypertension. The findings suggest that these graphs can reduce errors in assessing blood pressure control, potentially alleviating pressure on the healthcare system.
The Society for Cardiovascular Angiography & Interventions (SCAI) meeting will highlight advances in interventional cardiology, including novel treatments and techniques. The conference features over 500 faculty, 700 posters, and 86 oral abstracts, with a focus on improving patient care and outcomes.
Researchers developed a new method to determine optimal threshold time for restricted mean survival time analysis, improving statistical power in clinical and epidemiological studies. The method outperformed traditional statistical analysis methods in real-world scenarios, revealing clear differences between treatment groups.
A multi-site clinical trial found that both low and moderate-high intensity exercise reduced cognitive decline in sedentary older adults with mild memory loss. The study showed that even low-intensity exercise may be beneficial for brain health, suggesting a promising new strategy to prevent or delay dementia.
Researchers identified a potential new treatment, lorundrostat, which reduced systolic blood pressure in individuals with uncontrolled or treatment-resistant hypertension. The study found a significant 15-point reduction in systolic blood pressure compared to placebo.
Researchers at Pennington Biomedical Research Center investigated tirzepatide's effects on weight loss and metabolic health. The study found that tirzepatide decreased calorie intake and increased fat oxidation, leading to significant weight loss. However, the drug did not decrease the slowing down of metabolic rate usually observed wi...
The American Geriatrics Society (AGS) has honored 21 leaders in the field of geriatrics, representing various medical disciplines. The award recipients have made significant contributions to high-quality, person-centered care for older adults.
Researchers have discovered genetic properties in prostate cancer that can be targeted to improve patient outcomes, particularly for Chinese men. The findings highlight the potential of precision medicine and more effective treatments.
This study examines primary reasons for traditional Chinese medicine adoption among Chinese cancer patients and their communication with oncologists. Key findings highlight the importance of culturally sensitive care, patient education programs, and addressing misconceptions about TCM.
A study published in JAMA found that metformin reduced knee arthritis pain over six months in patients with symptomatic knee osteoarthritis and overweight or obesity. The treatment was shown to have a moderate effect on pain reduction, with the metformin group reporting a 31.3 point decrease compared to the placebo group.
The HKUMed AI model achieves over 90% accuracy in classifying both thyroid cancer stage and risk category. The model reduces pre-consultation preparation time for frontline clinicians by approximately 50%, making it a significant advancement in precision management of the disease.
Colm Nestor's research aims to understand genetic differences in men's and women's health, with potential applications in disease treatment and prevention. His unique approach combines basic research with clinically relevant issues, aiming to uncover new insights into the mysteries of the X chromosome.
A team of Singaporean scientists has released a comprehensive long-read RNA sequencing dataset, SG-NEx, to accelerate biomarker discovery and precision medicine. The dataset offers deeper biological insights into RNA complexity, enabling researchers to detect clinically relevant biomarkers and develop better treatments.
This review compares the bioactive components and medicinal properties of natural and cultivated O. sinensis, highlighting differences in composition and effectiveness for specific therapeutic uses. Polysaccharides, nucleosides, sterols, and amino acids contribute to their health benefits, with natural specimens often exhibiting higher...
A new study reveals promising progress toward predicting how patients with major depressive disorder will respond to antidepressant medications. Brain connectivity patterns were found to significantly improve predictions of treatment response across two large, independent clinical trials.
The ERA4TB project aims to develop new antibiotics against TB, while TAINT-TB focuses on contrast agents for precise diagnosis. The TCOLF-TC312 project uses humanized mice to study TB and its interactions with the immune system.
Researchers found that B cells guide CD8 T cells to mount lasting defenses after vaccination, but their absence weakens immunity. The discovery could lead to new strategies to enhance vaccine effectiveness for those with compromised immune systems.
A University of Cincinnati study explores the link between health literacy and fear surrounding cataract surgery, revealing no correlation between the two. The research emphasizes the importance of open communication and building relationships to overcome fear.
A new precision treatment approach for depression gives patients personalized recommendations based on multiple characteristics such as age and gender. The study, published in PLOS One, examined the outcomes of clinical trials involving over 10,000 patients to develop a clinical decision support tool.
The AChemS 47th Annual Meeting features cutting-edge research on chemosensory perception, including taste and smell dysfunction in cancer patients and potential associations with learning and memory decline. The conference also highlights the impact of GLP-1 Receptor Agonists on human taste ability.
A study of nearly 11,000 individuals found that men with panic disorder are more vulnerable to developing problematic drinking behaviors than women, potentially due to self-medication. The research highlights the need for sex-specific assessment and intervention strategies in treating comorbid conditions
A new study provides a method to estimate sample size required for microbiome studies based on effect sizes and analysis methods. For strong associations, around 500 participants were needed to achieve 80% statistical power, while weaker associations may require thousands of samples.
The American Heart Association funds research teams to investigate how risk factors for cardiovascular and kidney diseases impact women differently. The project aims to understand the biological significance of certain life cycles and societal factors on disease development.
The journal will publish research exploring digital health and advance care planning for older adults, including caregiver integration and technological innovation support. JMIR Aging boasts a strong impact in the field, with a Journal Impact Factor of 5.0 and a CiteScore of 6.5.
Dr. Rameau's cross-cutting research combines clinical expertise with AI to improve detection and treatment of swallowing disorders in older adults. She has made significant contributions to the field, including developing innovative tools for early diagnosis and intervention.
A new analysis found that oral hormone therapy can lower levels of lipoprotein(a), a genetic risk factor associated with higher risk of heart attack and stroke. Hormone therapy also improved biomarkers of cardiovascular health, including cholesterol levels.
The Kosair for Kids Center for Pediatric NeuroRecovery is expanding its facilities to increase treatment capacity by 50%, allowing up to 24 children per day to receive life-changing therapies. The new 12,500-square-foot space will also enhance research collaboration and improve patient care.
Researchers at Tulane University identified a potential new way to treat idiopathic pulmonary fibrosis (IPF) using an FDA-approved cancer drug. The treatment works by blocking the CTLA4 protein, which blocks overactive T cells, allowing the immune system to clear out damaged cells that cause lung scarring.
Researchers at UCLA Health are launching a clinical trial to test whether wearable nerve stimulation can ease ADHD symptoms in children with prenatal alcohol exposure. The study aims to improve focus and behavior by gently stimulating the trigeminal nerve, which is linked to attention and executive function.
A recent study found that people with plaque in their neck arteries have higher amounts of tiny plastic particles compared to those with healthy arteries. The concentration of these plastics was significantly higher in individuals who had experienced a stroke, mini-stroke, or temporary vision loss due to clogged blood vessels.
The Colorectal Cancer Alliance is strengthening its commitment to Project Cure CRC, a nonprofit dedicated to ending the disease through innovative research and patient navigation. The organization has awarded three new grants and will present two poster sessions at the AACR Annual Meeting.
A clinical trial found that using EEG to monitor consciousness safely reduced anesthetic use in children, resulting in quicker recovery, reduced delirium, and lower healthcare costs. The study also showed a significant reduction in pediatric anesthesia emergence delirium.
The Pediatric Academic Societies have awarded 33 Trainee Travel Grants to recognize and support emerging talent in pediatric research. The grants include complimentary registration to the PAS 2025 Meeting and a $500 travel grant to encourage participation.
Adding an experimental cancer drug to standard TB treatment reduces lung damage and prevents post-TB lung disease in mice. Researchers found that the drug doubled pulmonary apoptosis and reduced lung scarring by 40% compared to standard treatments.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
A new study found that both oral and injectable forms of naltrexone are effective in reducing heavy drinking among hospitalized patients. The medication was administered before discharge, resulting in a significant decrease in heavy drinking within the last 30 days of the three-month follow-up period.
A recent meta-analysis found that generative AI's diagnostic accuracy is lower than that of specialist doctors, with an average accuracy of 52.1%. The study suggests that while generative AI has the potential to support non-specialist doctors in diagnostics, further research is needed to improve its capabilities.
A Phase 3 clinical study found that adding hydronidone to entecavir resulted in significant reversal of liver fibrosis. The trial aimed to identify the antifibrotic effect and safety of hydronidone for CHB patients with significant liver fibrosis.
Researchers have discovered that pyrvinium pamoate, a common pinworm medication, can inhibit cancer cell growth and reverse neuroendocrine features in Merkel cell carcinoma. The medication also reduced tumor growth in mouse models of the disease.
This study found that inhibiting cyclooxygenase-2 reduces liver ferroptosis and fibrosis by upregulating the Nrf2 signaling pathway. COX-2 inhibition also restored antioxidant defenses in hepatocytes, reducing oxidative stress and lipid peroxidation.
This study investigates the protective effect of N-acetylcysteine (NAC) on acyclovir (ACV)-induced nephrotoxicity in adult Wistar rats. The results show that NAC supplementation significantly reduces kidney damage caused by ACV, restoring normal kidney function.
John N. Weinstein, MD, PhD, chair of Bioinformatics and Computational Biology at MD Anderson Cancer Center, has been elected Fellow of the American Association for Cancer Research (AACR) Academy. He made significant contributions to advancing our knowledge of molecular profiles of cancer through multi-omic studies and data analysis.