Articles tagged with Clinical Research
Research found that certain diabetes medications associated with weight loss can contribute to muscle mass loss and increased risk of falls. The study identified three significant risk factors for falls: history of falls, use of SGLT2 inhibitors, and advanced age.
Dr. Gadhamshetty, a leading expert in environmental engineering, brings over 25 years of experience to the role. He aims to expand the journal's influence and promote transformative research that addresses critical environmental challenges.
A new study suggests that CT scans could account for 5% of all cancer cases each year, primarily due to radiation exposure. The largest risk is among infants, followed by children and adolescents. To mitigate this risk, reducing the number of scans and doses per scan can help save lives.
Researchers discovered that aging causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium, a vital layer of cells in the eye. This study provides a clearer understanding of why aging leads to eye disease and introduces a reliable laboratory model for testing new therapies.
The study directly compared Droplet-based scRNA (D-scRNA) and Picowell-based scRNA (P-scRNA) platforms for analyzing human mucosal biopsies. D-scRNA provides more detailed insights, but requires resources and may introduce contamination. P-scRNA is gentler, more resource-efficient, but less effective in capturing rare cell types.
Twelve young researchers from around the world receive ESCEO-IOF Young Investigator Awards for their groundbreaking studies on osteoporosis. The prestigious awards were presented during the World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO 2025) in Rome, Italy.
A pioneering study demonstrated that an AI-powered lung ultrasound surpasses human experts by 9% in diagnosing pulmonary tuberculosis. The technology leverages deep learning algorithms to interpret lung ultrasound images in real-time, making it more accessible for TB triage, especially for minimally trained healthcare workers.
Researchers evaluated different types of Glasgow Outcome Scale Extended (GOSE) scores among US trauma center patients. They found that GOSE-All scores capture the combined effect of brain and extracranial injuries, while GOSE-TBI scores exclude extracranial injury effects.
A newly-published Cochrane review found significant gaps in clinical rating scales used to assess pain in newborn babies. The review of 79 studies involving over 7,000 infants across 26 countries revealed that none of the available scales are backed by high-quality evidence.
Researchers found that Schistosoma haematobium parasitic infection triggers cancer-related gene activity in cervical lining, with treatment causing further changes. This study sheds light on how the parasite may contribute to cervical cancer risk at a molecular level.
A new study published in Transfusion journal reveals sex-based disparities in the transfusion of whole blood to traumatically injured patients. Women, particularly younger females and those of childbearing potential, are less likely to receive whole blood transfusions compared to men. This disparity is despite whole blood being associa...
The University of Virginia has appointed Dr. Mark T. Esser as the inaugural head of its Manning Institute, a $350 million facility aimed at transforming healthcare and accelerating new treatments. Esser brings decades of experience in developing new medical breakthroughs and will foster an ecosystem of innovation to attract biotechnolo...
A major Danish nationwide cohort study found that adults with respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) experience significantly worse health outcomes, including a 2.7-fold higher risk of death within one year compared to the general population. RSV-ARI also leads to exacerbations of COPD and asthma, ...
Researchers found that GSK3β becomes increasingly active in melanoma cells during treatment, helping them survive and adapt despite BRAF inhibitors. Treating resistant cancer cells with a GSK3β inhibitor significantly reduced their growth, suggesting blocking this protein could restore sensitivity to treatment.
Professor Atsushi Suzuki, Chair of Endocrinology at Fujita Health University School of Medicine, Japan, received the IOF President's Award for his exceptional contributions to IOF. He has shared his expertise as a mentor and engaged member of the Capture the Fracture Governance.
Insilico Medicine is a pioneer in generative AI-driven healthcare, showcasing its Pharma.AI platform and pipeline portfolio featuring IND clearance molecules. The company will share insights at Abu Dhabi Global Health Week panel discussions, focusing on longevity and precision health.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Researchers at The University of Texas at San Antonio are working on a new AI tool to improve lives after brain injury. They plan to analyze data from 3,000 veterans and develop an interactive dashboard for clinicians to use, providing insights that could revolutionize treatment.
Researchers have shed light on how a new type of antibody treatment works against ovarian cancer by reactivating patients' immune cells. The study shows that MOv18 IgE reverses the suppression of immune cells and induces them to kill cancer cells, providing new insights into this therapy.
Dr. Catherine Champagne, a renowned nutrition expert, has been selected as an Excellence in Nutrition Fellow by the American Society for Nutrition. She is being recognized for her outstanding contributions to the field of nutrition, including her leadership in dietary assessment and nutrition counseling.
A Baycrest study reveals that sleep actively enhances memory for event sequence, improving recall of everyday experiences. This discovery deepens our understanding of the critical role of sleep in integrating experiences into memory.
A study found that marathon runners experience a decrease in brain myelin content, but it recovers fully two months later. Myelin acts as an energy reserve, and the study opens new insights into brain energy metabolism.
The Ontario Institute for Cancer Research (OICR) has launched a yearlong campaign showcasing the personal stories of cancer patients and researchers. The campaign aims to shine a spotlight on the community's achievements in cancer research. OICR brings together scientists, clinicians, and everyday Ontarians to solve cancer together.
Regional mesylate anticoagulation in centrifugation artificial liver support systems is safe for liver failure patients at risk of bleeding. Adjusting the mesylate dose based on pre-R and pre-MA enhances safety.
Natalia S. Rost, a Boston-based stroke neurologist, has been elected as the new president of the American Academy of Neurology. With over 25 years of involvement in the AAN, Rost is renowned for her expertise in vascular neurology and big-data science applications to personalized clinical outcome prediction in stroke.
New research reveals changes in brain connectivity during chemotherapy in breast cancer patients, particularly in the frontal-limbic system and cerebellar cortex. These changes worsen as treatment continues, suggesting that chemotherapy can quickly disrupt brain function in breast cancer patients.
A new study reveals that the US national vaccine strategy saved more money than it spent on testing, buying and delivering COVID-19 vaccines after just one year. The analysis found that the vaccines reduced serious illness and deaths, resulting in significant cost savings.
Researchers found significant disparities in quality of care and outcomes for patients with metastatic pancreatic cancer. Patients with higher social vulnerability indices were less likely to receive guideline-concordant systemic therapy, palliative care, or survive over 12 months.
Researchers have developed a new approach to overcome treatment resistance in estrogen receptor-positive (ER+) breast cancer. Dual aromatase-steroid sulfatase inhibitors (DASIs) show promise in effectively blocking both enzymes involved in oestrogen production, potentially reducing tumour growth.
Researchers have found that people with cannabis use disorder have elevated dopamine levels in a brain region associated with psychosis. This could explain why frequent cannabis use increases the risk of hallucinations and delusions. The study's findings may help doctors educate patients about the potential risks of frequent cannabis u...
Researchers developed a dual-action nanotherapy that converts white fat into beige fat and reduces obesity-related inflammation, significantly improving metabolic health without detectable toxicity.
Researchers have identified a potential precision medicine approach to prevent chronic kidney disease progression by targeting type 5 collagen, a minor component of scar tissue. A repurposed anti-cancer drug, Cilengitide, has been shown to slow kidney scarring and disease progression in high-risk individuals.
STITCHR uses an RNA system to replace entire genes, overcoming CRISPR limitations in targeting every mutation. The tool offers a one-and-done approach for gene therapy, addressing cystic fibrosis and other diseases with thousands of mutations.
The WNFC's player ambassadors will amplify public service announcements, social media content, and local community education events to raise awareness about cardiovascular disease and CPR education in women. The league has also implemented a requirement for all coaches to be certified in CPR, AED, and first aid.
Researchers have initiated a clinical trial using an investigational medicine to lower amyloid precursor protein, targeting Alzheimer's disease in adults with Down syndrome. The study aims to prevent the development of Alzheimer's disease by addressing its underlying genetic cause.
A new analytical method has been developed to measure plasma P-tau217, a blood-based marker that can change several years before Alzheimer's symptoms appear. The fully automated method demonstrated high accuracy of over 90% in various settings, including primary care and specialized memory clinics.
A new study found that both employed people with obesity and employer representatives acknowledge the impact of obesity on future health problems and perceive lifestyle change alongside anti-obesity medications as the most effective approach for maintaining weight-loss reduction. Cost of medication coverage remains a significant barrie...
A new study found that mesenchymal stem cell-derived extracellular vesicles significantly enhance survival and facilitate substantial peripheral blood recovery in mice exposed to high-dose irradiation. The treatment promoted hematopoietic recovery, with increases in red blood cell, platelet, white blood cell, and hemoglobin levels.
A phase 1 clinical trial will evaluate the safety and efficacy of CLBR001 + SWI019 in patients with myositis, systemic sclerosis, lupus and rheumatoid arthritis. The therapy has the potential to reduce side effects and patient burden associated with traditional CAR-T approaches.
A new clinical trial at the University of Miami Miller School of Medicine is testing a novel combination of immunotherapy drugs and an oncolytic virus to treat high-grade neuroendocrine cancer. The trial aims to find safe combination doses and compare effectiveness with standard-of-care treatment.
Dr. Romina Mizrahi's PET-based neuroimaging sheds light on brain workings, integrating genetics, environment and imaging to understand psychiatric illness as a complex biological puzzle. She advocates for precision psychiatry paradigm with customized treatments based on molecular profiles, and calls for diversity in academic leadership.
Professor Tatia Lee's award-winning paper reports a study showing Qigong improves processing speed, sustained attention, and hippocampal volume in healthy older adults. The results suggest that Qigong can benefit brain health through its effects on the immune system.
NGR Oncology has created a new Sarcoma Subcommittee to improve outcomes for adults with cancer, focusing on building a robust program, collaborating with the Children's Oncology Group, and promoting sarcoma research. The subcommittee is led by Chair Dian Wang, MD, PhD, and Vice-Chairs William Tseng, MD, and Brian A Van Tine, MD, PhD.
The Patient-Centered Outcomes Research Institute (PCORI) has announced funding for new patient-centered comparative clinical effectiveness research studies across various conditions. These studies aim to provide patients with evidence needed to make informed health decisions, addressing information gaps in healthcare. Additionally, PCO...
A recent study published in the International Journal of Cardiology analyzed data from multiple clinical trials to assess the therapeutic impact of pulmonary artery denervation (PADN) on pulmonary hypertension patients. PADN showed significant reductions in mean right atrial pressure, mean pulmonary artery pressure, and pulmonary vascu...
A recent study found that children with autism spectrum disorder tend to prefer predictable movements, which could serve as an early indicator of the condition. This preference may be linked to difficulties in learning cause-and-effect relationships and is a key characteristic of repetitive behaviors associated with ASD.
Researchers have discovered a crucial biological mechanism by studying mouse embryo development, revealing how placenta-derived factors promote the expansion of liver progenitor cells. The study uncovers the role of IL1α in enhancing organoid growth under hypoxic conditions.
A new University of Michigan study will test the best way to help people who smoke menthol cigarettes quit. The five-year study will work with 1,200 adults who smoke menthol cigarettes and compare Tobacco Quitline coaching with an incentive program involving daily breath monitoring.
A dual-principal investigator research group led by Dartmouth and the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital will test the effectiveness of video as a communication tool during patient visits for people living with Amyotrophic Lateral Sclerosis (ALS) and their caregivers.
A UCLA study validates the predictive power of PROSTOX, a genetic test that uses microRNAs to identify patients at higher risk of developing long-lasting urinary side effects from radiation therapy. The test helps doctors and patients choose safer treatment options, reducing the burden of long-term complications.
Researchers found that immune molecule IL-17 influences brain regions to induce either anxiety in the amygdala or sociable behavior in the somatosensory cortex. This discovery highlights the interconnectedness of the immune and nervous systems.
A new randomized clinical trial found that mindfulness-based therapy and cognitive behavioral therapy improved physical function, quality of life, and reduced pain among adults with opioid-treated chronic low back pain. The benefits persisted for up to 12 months.
Researchers at Mayo Clinic developed a personalized deep brain stimulation platform to treat drug-resistant epilepsy. The study found that this approach reduced seizures while also improving memory and sleep in patients with temporal lobe epilepsy.
Brienne Miner and Melisa Wong, two emerging investigators, received the Arti Hurria Memorial Award for their work on sleep health and geriatric oncology. Their research aims to improve sleep health and cancer care for older adults.
The CombPlex technology developed at Weizmann Institute allows for the simultaneous imaging and quantification of nearly two dozen proteins within individual cells. This breakthrough enables researchers to measure lots of proteins at the same time, crucial for understanding tissue function and disease processes.
Alice Rossi, Angeliki Spathopoulou, and Gareth D. Chapman received the ISSCR Outstanding Poster Award for their innovative work on quiescent neural stem cells, neural stem/progenitor cell populations, and epigenetic dysregulation in Tatton-Brown-Rahman-Syndrome.
The International Society for Autism Research (INSAR) will hold its 24th Annual Meeting in Seattle, featuring 1600 posters, 28 oral sessions, and keynotes on topics such as daily challenges faced by the autism community and implementation science aimed at enhancing systems of care.
The American College of Cardiology has recognized 2025 winners of its Young Investigator Awards for outstanding contributions to cardiovascular research and medicine. The award recipients include researchers in basic and translational science, clinical investigations, and outcomes research.
The collaboration aims to advance research on brain health with a focus on Alzheimer's disease. Initial projects will use CAS Content Collection and advanced technologies, including AI models and quantum computing to build and train disease-specific models.
A new artificial intelligence-based method detects genetic markers of antibiotic resistance in bacteria, potentially leading to faster and more effective treatments. The method, called Group Association Model, uses machine learning to identify key mutations linked to drug resistance, reducing false positives and misdiagnoses.