Long non-coding RNAs (lncRNAs) play a crucial role in regulating the tumor microenvironment, influencing processes such as immune evasion, angiogenesis, and metastasis. They mediate interactions between tumor cells and their surrounding microenvironment, modulating stromal cell activities and promoting tumor growth and survival.
A new clinical trial will test the effectiveness of two anti-inflammatory medicines as potential treatments for long COVID. The trial, funded by the Schmidt Initiative for Long Covid, will enroll hundreds of people across four continents and examine whether upadacitinib and pirfenidone can reduce or eliminate symptoms.
A study from the University of Missouri found that caregiving stress looks different for adults who are only children compared to those with siblings. Adult only children faced greater emotional and financial strain, while support from friends or extended family improved mental health for caregivers with siblings.
Researchers found that blocking the activity of a protein called erythropoietin (EPO) turns formerly 'cold' liver tumors into 'hot' tumors teeming with cancer-fighting immune cells. The treatment led to complete regression of existing liver tumors in most mice, outperforming immunotherapy alone.
Experts argue that large health care platforms are exhibiting concerning traits similar to big tech, including monopoly power, reduced innovation, and increased costs. They recommend antitrust attention and action to prevent further consolidation and promote vigorous competition.
Researchers have identified differences in neural connectivity patterns between patients with recovered and persistent psychosis. These differences enable the development of new intervention strategies for patients with psychosis, according to a study published in Nature Mental Health.
Researchers at Ateneo de Manila University create hydrophobic surfaces using electrospun polymer fibers to hold water droplets in a dome shape, allowing for dynamic adjustment of magnifying power. This discovery has potential practical applications in science classrooms, remote areas, and research labs.
The study reveals that CBL-CIPK complex senses specific Ca2+ signals, phosphorylates ZIP12, and initiates its partial degradation to fine-tune the plant's response to Zn deficiency environments. This negative feedback mechanism effectively regulates zinc homeostasis and maintains efficient resource utilization.
A study finds that engaging with balanced facts on gun control leads to more moderate policy views, even a month later. The research challenges the idea that people become entrenched in their views due to information, suggesting that accurate information can promote a healthier discourse and depolarize individuals.
Researchers developed quantum sensors capable of precisely detecting single particles, improving time and spatial resolution. The sensors demonstrated efficiency in detecting high-energy beams of protons, electrons, and pions.
Researchers synthesized three porphyrin-based COF materials with tunable structural distortion, revealing correlations between linker distortion and material properties. The NN-Por-COF photocatalyst exhibits exceptional CO2 reduction performance under simulated industrial flue gas conditions.
The study found that serum-derived hsa_circ_101555 showed excellent diagnostic accuracy in differentiating HCC patients from healthy controls. It also demonstrated a prognostic role in predicting tumor progression and response to therapy, with significant correlations with markers of liver inflammation and tumor features.
A study published in Water & Ecology evaluates international practices in water ecological assessment, highlighting its importance for aquatic ecosystems and human activities. The assessment's core indicators and methodologies should retain commonality and uniformity to influence strategies for protection and conservation.
Researchers have developed a new method using CRISPR to identify microorganisms in natural environments, providing a clearer picture of the communities present. This breakthrough could lead to a better understanding of how microbes support ecosystem health and promote sustainable agriculture.
A team of scientists has discovered a new species of snail, Anauchen picasso, named after artist Pablo Picasso. The unique shell shape and features make it stand out from other snails.
Advanced signal detectors have a low success rate detecting underground nuclear tests when seismic signals from nearby earthquakes overlap. Researchers found that even sophisticated multi-channel correlation detectors can only identify explosions with a 37% success rate, contrasting with a 97% success rate without earthquake interference.
A new study developed a method to measure evapotranspiration in the understorey of native forests, which can contribute up to 50% of ecosystem water use. The research aims to improve management decisions for water scarce resources in Australia.
Researchers at UCLA and Princeton discovered that showing people continuous temperature data can lead to a vague impression of gradual change, while presenting binary data like lake freezes causes a striking shift. This approach may overcome climate apathy by creating an emotional connection to local traditions.
Stephen S. Morse has been appointed as the new Editor-in-Chief of Disaster Medicine and Public Health Preparedness Journal, with a focus on building knowledge on preventive measures. Dr. Morse will oversee the journal's content, ensuring it translates science into practice and integrates medical and public health perspectives.
The VTF successfully captured a two-dimensional snapshot of the Sun at specific wavelengths, showcasing its scientific capabilities. The instrument enables scientists to analyze plasma properties and study solar magnetic fields, crucial for understanding solar flares and space weather.
Researchers identified a potential new treatment, lorundrostat, which reduced systolic blood pressure in individuals with uncontrolled or treatment-resistant hypertension. The study found a significant 15-point reduction in systolic blood pressure compared to placebo.
A new approach, called ESGAN, reduces the need for human-annotated data by one-to-two orders of magnitude in machine-learning models for crop breeding. The tool can differentiate between aerial images of flowering and nonflowering grasses with minimal external guidance, increasing the pace of agricultural field research.
Researchers at Carnegie Mellon University developed a cybersecurity lab, CyberSim Lab, that integrates experiential learning, role play, and collaborative learning to support learning outcomes. The lab is designed to bridge the gap between classroom education and real-world workplace skills.
A new robotic system uses cues in a scene to determine a human's objective and quickly identify relevant objects, enabling intuitive assistance in household, workplace, and warehouse settings. The approach achieved 90% accuracy in predicting human objectives and 96% accuracy in identifying relevant objects.
A new study found Haitian immigrant mothers who arrived in the US in 2021 or later experience high blood pressure during pregnancy and financial struggles after giving birth. This highlights serious health risks faced by recent Haitian immigrants, including hypertension and postpartum financial concerns.
A new imaging technique developed by IU scientists allows for the visualization of 25 cellular markers in intact bone marrow tissue without disruption. This advancement could support future drug development and therapies for conditions involving bone marrow.
A multi-site clinical trial found that both low and moderate-high intensity exercise reduced cognitive decline in sedentary older adults with mild memory loss. The study showed that even low-intensity exercise may be beneficial for brain health, suggesting a promising new strategy to prevent or delay dementia.
Researchers developed a lightweight, high-output piezoelectric energy harvester that minimally disrupts insect flight behavior. The device achieves 5.66 V and 1.27 mW/cm³ energy output, making it suitable for environmental monitoring and rescue missions.
Researchers developed dynamicGP, a computational approach that predicts trait dynamics across development in crops. The method outperforms state-of-the-art genomic prediction approaches for multiple traits, especially those with low heritability over time.
A study from the University of Illinois Chicago found that simple consultations during emergency room visits can significantly lower blood pressures and improve hypertension management. The intervention, which included smartphone-paired blood pressure monitors, was particularly effective for patients from underrepresented backgrounds, ...
A recent study published in the New England Journal of Medicine found that gene therapy can significantly reduce the risk of severe motor and cognitive impairment in children with metachromatic leukodystrophy (MLD). The therapy, administered early, preserves motor function and cognitive abilities in most patients.
Researchers developed a next-generation exosome-based combination therapy to effectively treat metabolic dysfunction-associated steatohepatitis (MASH). The therapy regulates metabolic abnormalities, inflammation, and fibrosis simultaneously by attaching FGF21 and miRNA-223 to the surface of exosomes.
A recent study found that only eight percent of papers in the prestigious Nature Physics journal had a woman senior author. This disparity is particularly concerning given Canada's overall underrepresentation of women physicists, with 29% of professionals identified as female in a 2020 physics community survey.
A new study reveals climate change is the leading cause of biodiversity loss among endangered species in the US. Climate change affects 91% of ESA-listed species, with many facing multiple threats simultaneously.
The National Academy of Inventors released its 2024 Top 100 US Universities ranking, highlighting institutions that secure patents to translate inventions into marketable technologies. Collectively, the universities on the list hold over 6,700 patents.
A study found that sediment resuspension triggered by trawling and natural processes releases significant amounts of CO2 into the atmosphere through pyrite oxidation. The research reveals that protecting sensitive seafloor areas with fine-grained sediments is crucial to maintain the region's carbon sink capacity.
A new study has discovered that increasing ocean resolution is key to accurately simulating AMO variability, particularly at multidecadal timescales. High-resolution ocean experiments correctly showed the AMO lasting 40-80 years, while low-resolution ocean experiments showed unrealistic cycles every 10-20 years.
In a groundbreaking study, researchers found that female bonobos form coalitions to defeat males in conflicts, earning them high social status. The team analyzed 30 years of data from six wild bonobo communities and discovered that females' reproductive autonomy, hidden ovulation, and unexpected alliances contribute to their empowerment.
A new study by Simon Fraser University found gaps in BC's extreme heat response plans, with urban greening being the most common mitigation strategy. The research highlights the need for co-operation and co-ordination across jurisdictions to improve neighbourhoods and address socio-economic disparities.
Researchers developed a new method to determine optimal threshold time for restricted mean survival time analysis, improving statistical power in clinical and epidemiological studies. The method outperformed traditional statistical analysis methods in real-world scenarios, revealing clear differences between treatment groups.
Scientists have discovered a 113-million-year-old hell ant fossil in Brazil, representing the earliest undisputable geological record of ants. The find showcases highly specialized anatomical features, suggesting unique hunting behaviors in ancient insects.
Researchers have discovered a promising bioactive compound that can effectively reduce symptoms of conditions like asthma and migraine by blocking a receptor on certain defense cells. The compound is effective in eliminating life-threatening allergic reactions in mice and has shown promise for treating inflammatory conditions.
Researchers developed high-resolution risk maps to predict where charcoal rot occurs in soybean fields. The maps use measurable soil characteristics to assess risk across the landscape and identify hotspots for targeted approaches to managing the disease.
The researchers developed a platform technology that stably attaches functional substances to the surface of exosomes without structural damage or functional degradation. This approach enables the production of tailored exosomes for targeted cancer treatment, improving anticancer efficacy.
Mind blanking is a common experience characterized by lapses in attention, memory issues, and cessation of inner speech. Studies have shown that it's associated with specific neural signatures and changes in arousal levels, leading to malfunctions in key cognitive mechanisms like memory and language.
A novel research project found that greener areas have fewer fatal police shootings, particularly in socially and economically disadvantaged communities. The study suggests that higher levels of greenness can reduce violence through mechanisms such as reduced crime, improved mental health, and increased civic engagement.
Patients who develop epilepsy after a traumatic brain injury are at an increased risk of premature death, with a mortality rate 1.8 times higher than those without epilepsy. The study also found that the risk of developing epilepsy is highest in the first year after the injury.
A new AI algorithm, Viz HCM, can quickly and specifically identify high-risk heart patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The algorithm's findings can help doctors prioritize the highest-risk patients for earlier appointments and treatment.
A recent study discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models. This approach shows promise for treating pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, which is challenging to treat due to its cellular environment.
Scientists demonstrate ultrafast plasmon-enhanced magnetic bit switching, enabling faster and more robust memory devices. The study uses plasmonic gold nanostructures to confine light and achieve magnetization switching with single femtosecond laser pulses.
A new study reveals that farms with more intensive management have lower overall soil functionality, suggesting a shift towards productive deintensification for sustainable agriculture. Soils play a critical role in supporting human well-being and ecological stability, but intensive farming practices can degrade soil health.
The study improves the thermoelectric properties of p-type and n-type single-walled carbon nanotubes, increasing their power factor to twice and three times that of pristine SWCNTs. The underlying mechanisms involve energy filtering and charge transfer processes.
A recent study suggests that aquaculture in the Amazon can be a more sustainable alternative to livestock farming, producing 10 times less greenhouse gases and using 20-100 times less land. This could help achieve food security in the region while minimizing environmental impact.
The Society for Cardiovascular Angiography & Interventions (SCAI) meeting will highlight advances in interventional cardiology, including novel treatments and techniques. The conference features over 500 faculty, 700 posters, and 86 oral abstracts, with a focus on improving patient care and outcomes.
Researchers have developed ionic hydrogel self-powered sensors with sustainable energy supply, converting various external stimuli into electrical signals. The sensors offer unique advantages in structural and performance design due to their excellent flexibility and ease of preparation.
Dr. Uria Alcolombri was named one of the 19 Frontiers Planet Prize 2025 National Champions for his pioneering study on microbial dietary preference and its impact on carbon sequestration in the ocean. His research highlights the critical role of marine bacteria in regulating the Earth's carbon cycle.
Researchers successfully created plant-based calamari with softness and elasticity similar to real seafood. The breakthrough uses 3D printing technology to mimic the characteristic properties of fried calamari rings, using a combination of mung bean protein isolate, powdered microalgae, gellan gum, and canola oil.
The Simons Collaboration on Ecological Neuroscience (SCENE) is a 10-year program that will support projects aiming to uncover how the world shapes representations in the mind and brain. By integrating sensory and motor information, researchers hope to discover fundamental principles of cognition applicable across species.
Researchers used AI-driven methods to analyze thousands of digital images of melanoma tumor tissue, identifying key immune cell structures that boost immunotherapy effects. The presence of these structures was linked to significantly better overall survival for patients with advanced melanoma.
A study published in Food Chemistry: Molecular Sciences found that cinnamaldehyde in cinnamon activates receptors controlling medication clearance, raising concerns about potential interactions. Researchers recommend consulting a doctor before using cinnamon as a dietary supplement to avoid rapid clearance of prescription medicines.