Articles tagged with Clinical Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at NCSA and UICOMP have created an improved, automated screening method for anxiety and depression disorders using machine learning and acoustic analysis of verbal fluency data. The new tool offers promise for overcoming barriers to diagnosis and treatment.
The Pediatric Long COVID Extension for Community Healthcare Outcomes (ECHO) program has successfully trained nearly 100 healthcare professionals across the US, equipping them to diagnose and manage long COVID in children. The program aims to bridge access gaps and empower community providers.
A study estimated the epidemiology of hepatitis D virus (HDV) in China, finding a prevalence of HDV antibody positivity among 4,936 patients with chronic HBV infection. The rate was 0.24%, with only one patient having both anti-HDV antibody and HDV RNA positivity.
A new virtual reality-based system shows promise in improving psychiatric diagnosis by differentiating between common mental health conditions. The system uses immersive scenarios and physiological measurements to elicit emotional responses, suggesting enhanced diagnostic accuracy.
A new study by researchers at McGill University found that annual COVID-19 vaccine booster doses help avoid breakthrough infections in people with immune-mediated inflammatory diseases. The study tracked 366 patients across Canada and used saliva PCR tests and antibody measurements, offering a more precise picture of infection risks.
A recent study published by CU Center for COMBAT Research investigators found that targeting slightly lower levels of oxygen saturation, from 90-96%, had similar outcomes for adult trauma patients. This approach resulted in fewer days spent on supplemental oxygen and reduced hospital stays.
Dr. David Winchester will lead the American College of Cardiology's Board of Governors, guiding chapters representing all 50 states and promoting heart health improvement in communities. His term aims to address practice challenges through advocacy and chapter support.
Dr. Christopher Kramer began a one-year term as head of the American College of Cardiology, addressing workforce issues, health equity and AI-driven solutions to improve cardiovascular care. With over 35 years of membership and leadership roles, Kramer brings experience in cardiovascular magnetic resonance imaging.
Researchers developed a novel blood test that accurately indicates spinal cord injury (SCI) severity and predicts potential recovery. The test identifies multiple biomarkers, including DNA and proteins, to rapidly diagnose SCI and project long-term neurological functional recovery.
A study found that patient navigators significantly improved one-year follow-up colonoscopy completion rates by 12% and reduced time to follow-up by 27 days. The researchers emphasize the importance of timely follow-up colonoscopies for patients with abnormal stool test results.
The SUMMIT trial shows tirzepatide reduces the risk of cardiovascular death or worsening heart failure in patients with obesity, chronic kidney disease, and heart failure, while improving kidney function. Researchers found significant improvements in both patient groups with and without chronic kidney disease.
The ALL ALS Consortium has recruited over 300 participants across two studies, ASSESS and PREVENT, aiming to disrupt traditional ALS research by making data and samples available worldwide. The consortium seeks to discover new drug targets and approaches for effective treatments.
Patients with low surgical risk undergoing transcatheter (TAVR) or surgical aortic valve replacement (SAVR) show comparable death, stroke, and reintervention rates at five years. The study found that TAVR is as effective as surgery in improving symptoms, functional class, and overall quality of life.
A novel AI-powered imaging technique, AngioFFR, has been shown to be comparable to conventional FFR assessment in evaluating patients for PCI. The study found that patients treated with AngioFFR-guided PCI had similar clinical outcomes as those treated with IVUS-guided PCI.
A study found that pulse oximeter readings underestimated blood oxygen levels in patients with dark skin pigment, but also showed a positive bias in 20% of observations. The results suggest that future devices could be designed to indicate uncertainty and improve accuracy across different skin pigmentation categories
Patients with severe triple-vessel heart disease showed no significant difference in outcomes between CABG and PCI at five years. The FAME-3 trial enrolled 1,500 patients with triple-vessel disease and found that both procedures performed similarly well, considering recent advances in surgical and minimally invasive techniques.
A large randomized controlled trial found no significant difference in health status between patients with restricted and unrestricted fluid intake. Despite this, patients on fluid restriction reported more thirst and had lower overall health scores at baseline compared to those with liberal fluid intake.
A new clinical trial found that oral semaglutide can significantly reduce cardiovascular events in people with type 2 diabetes and pre-existing cardiovascular disease. The medication decreased the risk of major cardiac events by 14% compared to placebo, with nonfatal myocardial infarction seeing the greatest reductions in risk.
A new study found that three months of dual antiplatelet therapy (DAPT) was better than one month for reducing heart attacks, strokes, and other adverse events without increasing bleeding risk in high-risk patients. For low-risk patients, three months of DAPT was comparable to 12 months in reducing adverse events, while being better th...
Researchers studied women with ischemia symptoms without blockages in their heart arteries. The five-year trial found no significant difference between intensive medical therapy and usual care for serious cardiovascular events.
A study found that semaglutide significantly improved maximal walking distance in people with symptomatic peripheral artery disease (PAD) and Type 2 diabetes. Patients taking semaglutide also experienced improvements in symptoms and quality of life compared to those on a placebo.
Researchers propose GLDH as a more liver-specific biomarker for detecting liver injury, offering greater specificity than current ALT and AST tests. The test performed similarly to ALT for detecting liver injury but was not impacted by associated muscle injury.
Researchers at Karolinska Institutet have developed a new method to diagnose COPD by analyzing protein levels in nasal lavage. The study found that elevated IL-26 levels can indicate an early phase of the disease, and may lead to new treatment strategies targeting this cytokine.
A single-center retrospective study analyzed clinical data, imaging, histopathological manifestations, genetic testing results, and treatment effects in 48 WD patients. The study found age at diagnosis, K-F ring presence, and higher immunoglobulin G levels were associated with cirrhosis risk factors.
Researchers have identified six promising biomarkers that can detect drug-induced kidney injury earlier than traditional markers, enabling more timely monitoring during drug development. These biomarkers could lead to the development of safer medications and improve patient outcomes.
The American College of Cardiology recognizes Jennifer Mateo Soto and Opeyemi Olalekan Oni for their innovative cardiovascular research projects in low- and middle-income countries. The awardees will receive $25,000 to support their research, which aims to improve the care of people at risk or living with cardiovascular disease.
The American College of Cardiology recognizes exceptional peer reviewers contributing to JACC's mission to publish impactful clinical research. The 2025 Simon Dack Award recipients and Elite Reviewers have made significant contributions to advancing cardiovascular care.
The American College of Cardiology has recognized 10 young researchers with the Young Author Achievement Award, showcasing their groundbreaking work published in JACC journals. The awardees will be recognized during ACC.25 in Chicago, March 29-31, 2025.
The study found significant improvements in symptoms for participants with major depressive disorder, generalized anxiety disorder, and eating disorders. Participants reported trusting and communicating with Therabot comparable to working with a therapist.
Dr. Bing Ren, a renowned expert in genomics and epigenetics, joins the New York Genome Center as its new scientific director and CEO. His groundbreaking contributions will focus on translating genomic research into actionable insights for improving human health.
Researchers James Berger and Gregory Dale Kirk, from Johns Hopkins Medicine, have been elected 2024 AAAS Fellows. They are recognized for their distinguished efforts to advance science in biophysics and infectious diseases epidemiology.
The Weill Cancer Hub East will unite world-class experts in cancer biology, immunology, nutrition and metabolism to drive pioneering research. The hub aims to improve the effectiveness of immunotherapy, a promising approach for many types of cancers.
Researchers at MD Anderson Cancer Center made several key discoveries, including the spatial organization of cancer-associated fibroblasts across various cancers and a study on treatment resistance in SMARCA4-mutant lung cancer. These findings highlight the importance of investigating cell populations in their spatial context to better...
The American Heart Association and University of North Carolina Chapel Hill are building virtual care resources together. They share common priorities in advancing telehealth programs through evidence-based research and education.
Research presented at #AGS25 sheds light on the impact of aging on physical resilience, with declines linked to mitochondrial function. Family caregiver distress also shows a significant association with care outcomes, including nursing home placement and psychotropic medication prescribing.
Researchers found that mRNA-based COVID-19 vaccines cause persistent epigenetic changes in monocyte-derived macrophages, enabling a sustained immune response. These changes were preserved for six months after vaccination and required multiple doses to maintain long-term immunity.
Researchers developed a sensor platform that tracks multiple metabolites continuously, offering a window into disease onset and health status. The technology harnesses natural biochemical processes, enabling reliable detection of over 800 metabolites, with potential applications in diagnosing metabolic disorders and optimizing fitness.
A new study found that smartwatches paired with a health app can encourage people with newly diagnosed Type 2 Diabetes to start and maintain purposeful exercise, leading to improvements in blood sugar levels and systolic blood pressure. The programme also helped participants lower cholesterol and improve their quality of life.
A new rapid diagnostic test can accurately identify pregnant women with high levels of the hepatitis B virus, allowing for early detection and intervention. This breakthrough test could have a significant impact on hepatitis B management in low- and middle-income countries, reducing the spread of the infection.
A study published in Nutrients found that men and women eat differently, with women taking longer to finish meals and chewing more. Increasing the number of chews per bite and taking smaller bites can extend meal duration, which is positively associated with reduced food consumption.
Researchers discovered that PCSK9 and APOA4 are key regulators of TMAO-induced cholesterol metabolism, leading to gallstone formation. Targeting these genes may be a promising approach for preventing and treating cholelithiasis.
The rate of maternal mortality related to cardiovascular causes has more than doubled between 1999 and 2022 in the US. Researchers attribute the increase to factors such as socioeconomic disadvantages, limited access to healthcare, and higher prevalence of risk factors.
The American Society for Nutrition will host NUTRITION 2025, bringing together experts to explore topics such as diet, sleep, cardiovascular health, adolescence, and chronic pain. The event features original research studies, scientific symposia, and networking events, offering a platform for the latest nutrition science findings.
Dr. Vikaas Sohal's research focuses on cognitive flexibility and prefrontal gamma oscillations to improve cognitive function in individuals with SYNGAP1-related disorders. The grant aims to confirm findings in Syngap1 mutant mice and explore new therapeutic strategies.
People with heart failure who can travel outside their home without assistance are less likely to be hospitalized or die within a year. Life-space mobility, a measure of how far patients move in their communities, is a reliable marker of risk for adverse outcomes in chronic diseases.
A growing body of evidence suggests a significant link between human papillomavirus (HPV) and heart disease. Researchers pooled data from nearly 250,000 patients in seven studies, finding HPV-positive individuals had a 40% higher likelihood of developing cardiovascular disease.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
A special issue of Academic Emergency Medicine examines the science of errors in emergency care, highlighting the need for a systemic approach to address gaps in knowledge, communication, and awareness. The journal's findings propose actionable solutions to minimize diagnostic errors and enhance patient safety.
Brandi Fink's Personal Alcohol Management System (PALMS) uses iPad-based assessments to identify patients with an alcohol use disorder and provide personalized feedback. The system has shown promise in improving patient-provider discussions and reducing drinking levels, with plans for integration into electronic health records.
A meta-analysis of 14 studies reveals that combination lipid-lowering therapy using statins and ezetimibe significantly lowers LDL cholesterol levels and diminishes cardiovascular risks. Early integration of this approach in treatment protocols can substantially curtail mortality and CVD events.
Scientists at Sanford Burnham Prebys developed a new method of generating antibodies by fusing two immune system proteins, enabling the creation of stable monoclonal antibodies. This breakthrough has potential applications in diagnosing and monitoring diseases such as lupus and cancers.
A team of researchers has identified a common brain network that generalized seizures hijack, which is located in the region where deep brain stimulation (DBS) electrodes are placed. This finding could help explain why DBS is effective in alleviating generalized seizures and potentially improve treatment outcomes.
The National Initiative for RNA Biology and Its Applications (NIRBA) aims to strengthen Singapore's RNA research capabilities, focusing on human health and diverse applications. The program will integrate leading institutions and promote interdisciplinary collaborations to achieve groundbreaking scientific discoveries.
Researchers have developed a way to activate adult stem cells from human bone marrow, enabling their expansion outside the body for use in bone marrow regeneration. The new method significantly improves transplant success rates for patients with genetic disorders or those who require a bone marrow transplant.
UC San Diego Health has earned The Joint Commission's Gold Seal of Approval for Advanced Certification in Spine Surgery, reflecting its dedication to patient safety and surgical innovation. The health system continues to provide consultation to other organizations exploring the certification.
A family-based approach to lifestyle interventions significantly improves weight management and cardiovascular health among individuals with a family history of premature coronary heart disease. The study found that participants who received structured lifestyle counseling experienced notable reductions in weight, BMI, and waist circum...
A study confirms plasma p-tau217 as a blood-based biomarker for early Alzheimer's detection in Asian populations. Higher levels correlate with faster cognitive decline, suggesting its potential role as both diagnostic and predictor tool.
A simple urine test has shown promising results in detecting early-stage kidney cancer recurrence, with a high sensitivity and specificity rate. The GAGome test can accurately identify patients at risk of recurrence, potentially reducing the need for invasive scans and enabling faster treatment access.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A new review article identifies major themes in AI application to neurosciences, including a 5-fold increase in AI-related publications. The study also notes a surge of over 13-fold in clinical neurology AI-related publications in the past decade.