Articles tagged with Clinical Research
Researchers have identified signs of neuroinflammation and blood-brain barrier dysfunction in patients with Down syndrome Regression Disorder (DSRD). The study, published in Annals of Clinical and Translational Neurology, reveals a potential immune-related cause for DSRD.
Fidaxomicin and fecal microbiota transplantation are effective treatments for Clostridioides difficile infection, reducing recurrence rates. Emerging strategies like vaccines, bacteriophage therapies, and AI-based risk models hold promise for better management and prevention of CDI.
A new stem cell therapy trial at UTHealth Houston aims to reduce neuroinflammation in patients with presymptomatic Alzheimer's disease. The study, which is sponsored by Weston Brain Institute, will enroll 12 patients and use PET imaging to determine whether stem cells reduce brain inflammation before symptoms develop.
Researchers discover edonerpic maleate enhances neural plasticity, supporting cortical reorganization and improving motor control in non-human primates with SCI. The compound promotes AMPA receptor movement to areas responsible for motor control, strengthening existing neural connections.
Researchers identified nine distinct types of T cells that harbor inactive HIV cells, and persistent T cells with HIV even after antiretroviral therapies. This discovery brings medical experts closer to a cure for the infection affecting nearly 40 million people globally.
Researchers found that semisynthetic bile acid NorUDCA inhibits pro-inflammatory T helper 17 cells and promotes anti-inflammatory regulatory T cells in the intestine. This could lead to new therapies for inflammatory bowel diseases such as ulcerative colitis or Crohn's disease.
A new study challenges the long-held belief that fear is primarily communicated through facial expressions, suggesting instead that situational context plays a critical role in fear recognition. The research involved analyzing real-life fear reactions in videos and found that facial expressions alone fail to reliably signal fear.
Researchers developed a portable system using AI to spot cognitive impairment by measuring subtle differences in motor function. The device accurately identified 83% of participants with mild cognitive impairment (MCI), offering potential for early intervention and improved outcomes.
A combination therapy of FTH-001 (serabelisib) and FTH-003 (sapanisertib) with paclitaxel is being investigated in a Phase 2 trial for patients with advanced or recurrent endometrial cancer. The trial aims to target the PI3K/AKT/mTOR pathway, which is frequently mutated in cancer.
Recent research suggests that some invasive cancers diagnosed in early-stage breast cancer may not need immediate surgery, highlighting the importance of more precise screening methods for DCIS. The COMET trial found that at least half of invasive breast cancers take years to progress or may never progress at all.
Researchers at MD Anderson have made significant breakthroughs in understanding pancreatic cancer's evolutionary process and developing new treatment strategies. They also discovered that surgical resection can enhance antitumor response in patients receiving immune checkpoint therapy for advanced kidney cancer.
Researchers have developed a new method to deliver antibiotics directly into the bladder tissue, eliminating over 90% of bacteria from the bladder. The nanogel-based drug delivery system shows promise in treating UTIs and could potentially lead to an eventual cure.
A major clinical trial has identified ensitrelvir as an effective medication to prevent symptomatic COVID-19 in people exposed within households. The trial showed a 67% reduction in risk of illness among participants taking the antiviral compared to those given a placebo.
Researchers at Waseda University develop a new imaging technique that uses neutron activation to transform gold nanoparticles into radioisotopes, enabling long-term tracking of their movement in the body. This breakthrough could lead to more effective cancer treatments and precision monitoring of drug distribution.
The Bronchiectasis and NTM Care Center Network facilitates access to specialized care and support for hundreds of thousands of people with bronchiectasis and NTM lung disease. The network aims to improve quality of life and advance a cure for these conditions.
The UMass Amherst nurse-engineer team, led by Elaine Marieb Center for Nursing and Engineering Innovation, has developed an innovative IV pole designed to enhance patient safety and reduce errors. The award-winning design features a smart pump that can detect potential problems and alert medical staff, improving overall care.
A cross-sectional survey revealed high costs, inadequate training, and poor financing as major challenges to gastrointestinal endoscopy practice in Nigeria. Locally developed innovations have eased the practice, preventing it from collapsing.
A new type of antibody that stimulates the immune system to target cancer cells has shown promise in reducing tumor growth in treatment-resistant breast and ovarian cancers. The study found that the antibody, IgE, uniquely stimulated otherwise inactive immune cells to directly target HER2-expressing cancer cells.
Dr. Ronald Newbold has been appointed as the permanent CEO of Empire Discovery Institute (EDI), a non-profit drug discovery and development accelerator. With over 30 years of business development experience, Dr. Newbold will lead EDI's growth and expansion, including the addition of new programs and partnerships.
Researchers used 3D imaging to study the neurovascular architecture of the murine calvarium, finding significant age-related changes in nerves and blood vessels. These findings could lead to new insights into bone fragility and regenerative capacity.
Repeated esophagogastroduodenoscopy and colonoscopy enhance lesion detection, particularly in cases with active bleeding or poor visualization. The diagnostic accuracy of these procedures increases patient outcomes.
A new Clinical Research Center of Excellence will improve care for individuals with SYNGAP1-related disorders and expand the Natural History Study to include Prospective Multidisciplinary Multisite Study. The center, established at Children's Hospital Colorado, aims to accelerate research and provide specialized care.
The Camden Study, a 4,765-woman pregnancy cohort from the US's poorest city, has yielded significant findings on adolescent growth during pregnancy. New research at Rutgers University aims to explore this data and develop new projects, attracting global collaborations.
A recent study reveals that reduced SOX9 expression leads to impaired Wnt signaling and EMT in tissues affected by hypospadias. This finding provides new insights into the molecular underpinnings of the condition, potentially leading to innovative therapies.
Researchers found that PRP treatment increased gene expression related to metabolism, cell survival, and communication between cells in cumulus cells. This suggests that PRP may help support egg development and fertility in women with poor ovarian response.
Research finds that certain viral antibodies and genetic risk factors can increase MS risk, with elevated antibody levels combined with a specific gene variant associated with strong increased risk. The study also identifies potential biomarkers for early diagnosis.
A study published in Human Gene Therapy found that over half of individuals with Niemann-Pick disease type C1 lacked neutralizing antibodies against AAV2 and AAV9. This absence of antibodies may impact the effectiveness of gene therapy treatments for this rare disorder.
The TTUHSC Graduate School of Biomedical Sciences hosted the 37th Student Research Week, showcasing student researchers' work and presentations from distinguished national speakers. The event featured an increase in abstract submissions and lightning talk sessions.
Researchers will apply anonymized data from electronic health records to an artificial intelligence-based decision-making system to guide personalized drug dosing and treatments. The goal is enhanced blood pressure control, reduced cardiovascular risks, and improved quality of life for Type-2 diabetes patients.
Researchers at Saarland University have developed smart implants that can monitor and promote healing in fractured bones. The miniaturized technology, part of the EU-funded SmILE project, enables the use of thin intramedullary nails to support bone stability during healing.
A new study found that Black Americans are more willing to participate in medical studies led by Black doctors and researchers. Diversifying clinical trial leadership could improve enrollment of underrepresented groups and ensure the benefits and risks of treatments are understood across populations.
A new study from Weizmann Institute of Science reveals an immune mechanism involving proteasome products, which can kill bacteria and offer a promising treatment for infections. The researchers discovered that certain peptides produced by the proteasome have antibacterial properties and can be used to develop personalized treatments.
Researchers at Kyushu University have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs. By analyzing cerebrospinal fluid, they identified specific proteins associated with an immune response that can affect the central nervous system after therapy.
A study of nearly 2,500 postmenopausal women found that taking more daily steps and engaging in moderate-to-vigorous physical activity were associated with a significantly reduced risk of death from cardiovascular disease. Even walking fewer than 5,000 steps per day showed a risk reduction.
A new drug formulation called Rhenium Obisbemeda has been shown to significantly extend the median survival and progression-free time of glioblastoma patients, with a median overall survival time of 17 months. The treatment, which uses convection-enhanced delivery, shows promise as a potential cure for this deadly brain tumor.
Researchers investigated the effects of electroacupuncture on gut microbiota and metabolomics in ALS patients, finding a reduction in Eisenbergiella abundance and improvements in Lachnospiraceae levels. The study suggests that this treatment may be beneficial for patients with ALS.
This theme issue explores digital health solutions to address social isolation, health literacy, and cultural influences on aging health. Contributors are encouraged to submit their work by September 30, 2025.
A genomics blood test has improved diagnosis and treatment plans for children with rare diseases, including epilepsy. The test provides genetic diagnoses for 43% of children in under three weeks, leading to significant impacts on treatment.
A new study by researchers at UCSF has found that long-acting injectable treatments can be transformative for patients who struggle to take daily HIV pills, resulting in undetectable viral loads and improved health outcomes. The treatment approach could help stop the spread of HIV by keeping more patients from being infectious.
Researchers found that p-tau proteins in blood are elevated in both Alzheimer's and ALS patients, making them less specific for Alzheimer's diagnosis. However, they also show promise as potential biomarkers for early detection of ALS or monitoring disease progression.
Researchers have developed circadian-based gene circuits that align with the body's natural rhythm, delivering anti-inflammatory drugs on a daily basis. The technology has the potential to reduce symptoms and prevent joint damage, potentially changing the course of the disease.
Rentosertib, a breakthrough drug candidate for idiopathic pulmonary fibrosis (IPF), has been granted an official generic name by the USAN Council. The drug's development was accelerated using generative AI, identifying TNIK as a promising target and designing small-molecule compounds in just 18 months.
Researchers at UC San Francisco have enabled a paralyzed man to control a robotic arm through a device that relays signals from his brain to a computer. The device, known as a brain-computer interface (BCI), worked for a record 7 months without needing to be adjusted.
A new study found that female professional footballers' lactate levels can be predicted by their finger length and height. Research showed that tall women and those with a long ring finger relative to their index finger produced low levels of lactate during exercise.
A randomized clinical trial found that a customized smartphone app, Silvia Program, significantly improved cognitive functioning among residents with mild cognitive impairment. The program's combination of daily goal setting, cognitive training, and AI-generated conversations showed promising results.
Research suggests that higher levels of essential minerals such as copper, manganese, and vitamin B12 during pregnancy may reduce the risk of developing high blood pressure in middle age. The study analyzed data from over 500 women and found a significant association between these mineral levels and lower blood pressure risk.
A new study analyzing health records from 2012 to 2022 found significant differences in cardiovascular disease risk factors among Asian American, Native Hawaiian, and Pacific Islander populations. The research suggests that regular monitoring of risk factors may help prevent cardiovascular disease among these groups.
Researchers are conducting a clinical trial to find the optimal combination of pain management tools for patients undergoing mastectomy procedures. The study will enroll approximately 100 patients and examine various combinations of pectoralis nerve blocks, non-opioid analgesics, and administration methods.
A review concludes that exposing preschool-aged children to small amounts of food allergens is safer than avoiding them, reducing the risk of severe reactions. Delaying exposure can prolong unnecessary dietary restrictions and increase anxiety related to food allergies.
The new AI model leverages hypergraphs to quickly and accurately identify therapeutic gene targets for diseases. HIT outperformed existing models in all tested metrics, demonstrating its accuracy in classifying therapeutic gene targets with great precision.
A new study found that the proportion of visceral fat, rather than the absolute amount, is a stronger predictor of high triglyceride levels and inflammation. Lowering visceral fat proportion during weight loss can lead to better metabolic health outcomes.
Recent developments in fluorescent probes offer improved specificity and sensitivity for detecting hepatocellular carcinoma (HCC). Next-generation probes are being developed to enhance tissue penetration depth and probe specificity, potentially improving surgical outcomes.
Researchers develop a potential new treatment for rare genetic diseases characterized by low levels of specific proteins. By adding an artificial poly(A) tail to mRNA, they boost protein production and aim to improve symptoms in people with protein-deficient disorders.
Core-shell nanoparticles offer effective drug encapsulation, shielding from degradation, and controlled release. This innovation enables targeted drug delivery, improving treatment outcomes and reducing side effects. The versatility of these nanoparticles allows for tailored materials to suit different therapeutic needs.
Researchers create microfluidic device to sort tumor cells based on adhesive strength, revealing potential method to predict aggressive cancer behavior. The study's findings offer a promising approach for personalizing treatment plans and identifying high-risk patients.
Researchers at the University of Missouri have identified a small molecule drug that targets a specific serotonin receptor, showing promise as a treatment for sarcopenia. The study suggests that this neurotherapeutic can improve muscle strength by activating motor neurons to fire more effectively.
The Whole Health Consortium at Virginia Tech has funded several research projects, including one that uses geospatial analysis to improve healthcare access for veterans. Another project aims to develop a 'just-in-time' intervention for chronic pain and opioid use disorder in Appalachia.
The Mount Sinai Hospital has become the first in the US to perform a deep brain stimulation (DBS) implantation procedure as part of a clinical trial investigating its effectiveness for treatment-resistant depression. The study aims to gather evidence on the impact of DBS systems developed by healthcare company Abbott.
A new study by Weill Cornell Medicine researchers has identified a potential biomarker for joint inflammation in Crohn's disease patients, the bacterium Mediterraneibacter gnavus. The study found that M. gnavus is associated with increased immune cell responses and disease activity scores in patients with joint inflammation.
A new study highlights the need for more diversity in genomics research, as a commonly found gene variant was mistakenly linked to heart disease in people from Oceanian communities. The researchers found that the variant is actually common among healthy individuals from these regions.