Articles tagged with Clinical Research
Researchers investigated the effects of electroacupuncture on gut microbiota and metabolomics in ALS patients, finding a reduction in Eisenbergiella abundance and improvements in Lachnospiraceae levels. The study suggests that this treatment may be beneficial for patients with ALS.
This theme issue explores digital health solutions to address social isolation, health literacy, and cultural influences on aging health. Contributors are encouraged to submit their work by September 30, 2025.
A genomics blood test has improved diagnosis and treatment plans for children with rare diseases, including epilepsy. The test provides genetic diagnoses for 43% of children in under three weeks, leading to significant impacts on treatment.
A new study by researchers at UCSF has found that long-acting injectable treatments can be transformative for patients who struggle to take daily HIV pills, resulting in undetectable viral loads and improved health outcomes. The treatment approach could help stop the spread of HIV by keeping more patients from being infectious.
Researchers found that p-tau proteins in blood are elevated in both Alzheimer's and ALS patients, making them less specific for Alzheimer's diagnosis. However, they also show promise as potential biomarkers for early detection of ALS or monitoring disease progression.
Researchers have developed circadian-based gene circuits that align with the body's natural rhythm, delivering anti-inflammatory drugs on a daily basis. The technology has the potential to reduce symptoms and prevent joint damage, potentially changing the course of the disease.
Rentosertib, a breakthrough drug candidate for idiopathic pulmonary fibrosis (IPF), has been granted an official generic name by the USAN Council. The drug's development was accelerated using generative AI, identifying TNIK as a promising target and designing small-molecule compounds in just 18 months.
Researchers at UC San Francisco have enabled a paralyzed man to control a robotic arm through a device that relays signals from his brain to a computer. The device, known as a brain-computer interface (BCI), worked for a record 7 months without needing to be adjusted.
A new study found that female professional footballers' lactate levels can be predicted by their finger length and height. Research showed that tall women and those with a long ring finger relative to their index finger produced low levels of lactate during exercise.
A randomized clinical trial found that a customized smartphone app, Silvia Program, significantly improved cognitive functioning among residents with mild cognitive impairment. The program's combination of daily goal setting, cognitive training, and AI-generated conversations showed promising results.
Research suggests that higher levels of essential minerals such as copper, manganese, and vitamin B12 during pregnancy may reduce the risk of developing high blood pressure in middle age. The study analyzed data from over 500 women and found a significant association between these mineral levels and lower blood pressure risk.
A new study analyzing health records from 2012 to 2022 found significant differences in cardiovascular disease risk factors among Asian American, Native Hawaiian, and Pacific Islander populations. The research suggests that regular monitoring of risk factors may help prevent cardiovascular disease among these groups.
Researchers are conducting a clinical trial to find the optimal combination of pain management tools for patients undergoing mastectomy procedures. The study will enroll approximately 100 patients and examine various combinations of pectoralis nerve blocks, non-opioid analgesics, and administration methods.
A review concludes that exposing preschool-aged children to small amounts of food allergens is safer than avoiding them, reducing the risk of severe reactions. Delaying exposure can prolong unnecessary dietary restrictions and increase anxiety related to food allergies.
The new AI model leverages hypergraphs to quickly and accurately identify therapeutic gene targets for diseases. HIT outperformed existing models in all tested metrics, demonstrating its accuracy in classifying therapeutic gene targets with great precision.
A new study found that the proportion of visceral fat, rather than the absolute amount, is a stronger predictor of high triglyceride levels and inflammation. Lowering visceral fat proportion during weight loss can lead to better metabolic health outcomes.
Recent developments in fluorescent probes offer improved specificity and sensitivity for detecting hepatocellular carcinoma (HCC). Next-generation probes are being developed to enhance tissue penetration depth and probe specificity, potentially improving surgical outcomes.
Researchers develop a potential new treatment for rare genetic diseases characterized by low levels of specific proteins. By adding an artificial poly(A) tail to mRNA, they boost protein production and aim to improve symptoms in people with protein-deficient disorders.
Core-shell nanoparticles offer effective drug encapsulation, shielding from degradation, and controlled release. This innovation enables targeted drug delivery, improving treatment outcomes and reducing side effects. The versatility of these nanoparticles allows for tailored materials to suit different therapeutic needs.
Researchers create microfluidic device to sort tumor cells based on adhesive strength, revealing potential method to predict aggressive cancer behavior. The study's findings offer a promising approach for personalizing treatment plans and identifying high-risk patients.
Researchers at the University of Missouri have identified a small molecule drug that targets a specific serotonin receptor, showing promise as a treatment for sarcopenia. The study suggests that this neurotherapeutic can improve muscle strength by activating motor neurons to fire more effectively.
The Whole Health Consortium at Virginia Tech has funded several research projects, including one that uses geospatial analysis to improve healthcare access for veterans. Another project aims to develop a 'just-in-time' intervention for chronic pain and opioid use disorder in Appalachia.
The Mount Sinai Hospital has become the first in the US to perform a deep brain stimulation (DBS) implantation procedure as part of a clinical trial investigating its effectiveness for treatment-resistant depression. The study aims to gather evidence on the impact of DBS systems developed by healthcare company Abbott.
A new study by Weill Cornell Medicine researchers has identified a potential biomarker for joint inflammation in Crohn's disease patients, the bacterium Mediterraneibacter gnavus. The study found that M. gnavus is associated with increased immune cell responses and disease activity scores in patients with joint inflammation.
A new study highlights the need for more diversity in genomics research, as a commonly found gene variant was mistakenly linked to heart disease in people from Oceanian communities. The researchers found that the variant is actually common among healthy individuals from these regions.
A risk prediction model was developed to identify patients unlikely to complete HPV vaccination. The model uses patient demographics and clinical characteristics to guide targeted interventions, increasing vaccination rates among high-risk groups.
Researchers discovered that females' dormant X chromosome reactivates in late life, expressing genes related to brain development and cognitive health. This phenomenon may explain why women outlive men and retain their cognitive abilities longer.
Researchers have discovered alarming levels of microplastics in human brain tissue, with concentrations 3-5 times higher in individuals with dementia diagnoses. The study highlights the need for large-scale human studies to determine dose-response relationships between microplastic exposure and chronic health outcomes.
Dr. Nicholas Fabiano's research reveals exercise reduces suicide attempts but shows no connection to thoughts of suicide or deaths by suicide. His work proposes a paradigm shift in mental health treatment, suggesting exercise as a first-line treatment for depression.
Children who frequently miss school due to abdominal complaints are more likely to have gut-brain axis disorders like IBS, which can be missed by medical tests. The study found that frequent absences were nearly five times more likely to be caused by functional GI disorders than specific illnesses.
A study in Plastic and Reconstructive Surgery documents cerebral plasticity after nerve transfer surgery for patients with facial palsy. BoNT-A treatment triggers extensive cortical plasticity, offering a potential explanation for its long-lasting therapeutic impact on patients with facial asymmetry.
A new radiology screening tool can help detect intimate partner violence (IPV) in patients, enabling healthcare providers to identify victims earlier. The study found that imaging studies and injury patterns differ between women who have reported IPV and those who have not.
Researchers have discovered a novel approach to protecting insulin-producing beta cells from glucolipotoxicity, a condition linked to type 2 diabetes progression. The findings could lead to promising treatments targeting beta cell dysfunction, potentially slowing or preventing disease progression.
PARP inhibitors have been found to be effective in treating cancers with BRCA1/2 mutations by blocking DNA repair pathways. The combination of PARPis with chemotherapeutic drugs can also improve treatment efficacy, increasing DNA damage and blocking repair processes.
Researchers found that limiting daytime sleep and getting approximately seven hours of sleep each night in the first week after a concussion may speed up recovery. Youth who sleep more or less than ideal amounts during this period may experience slower symptom resolution.
The university plans to recruit an outstanding researcher for a professorship focused on psychoanalytical approaches, combining psychology and social sciences. This will enable exploration of new research fields and innovative combinations of expertise between Goethe University's Faculty of Psychology and Sports Sciences and Sigmund Fr...
The Blavatnik Awards for Young Scientists in the UK recognize promising scientists under 42 for their work on pressing issues. The three winners are tackling infant mortality, green manufacturing, and predicting long-term climate change. Their prize-winning research will receive £100,000 in unrestricted funds.
The University of Oklahoma Health Sciences has achieved its highest ever ranking in National Institutes of Health funding, improving its ranking to 102 out of 2,838 institutions and receiving $75.2 million in funding. The college's faculty members conduct numerous types of research across various academic departments.
The March issues of The American Journal of Psychiatry and Psychiatric Services bring together new developments in treating depression, obsessive-compulsive disorder, and schizophrenia. These journal publications highlight the latest advancements in digital mental health innovations.
A breakthrough CRISPR-based test has been developed to diagnose Pneumocystis jirovecii pneumonia (PJP), a life-threatening fungal infection. The test detects RNA from live fungi in blood samples and throat swabs, providing a faster and more accurate diagnosis than current invasive bronchoscopy procedures.
Researchers discover engineered TIMP molecules can block cancer cell migration and invasion, offering a targeted approach to treating GBM. The findings also suggest the potential for safe treatment with minimal side effects.
A recent study from the University of Gothenburg found that dental implants continue to function well after nearly forty years. The implants, developed by Professor Per-Ingvar Brånemark, have been shown to remain stable and integrate with bone over an extended period.
BaCell 3D conference to feature original research in organoids and regenerative medicine, published in Stem Cell Reports. The International Society for Stem Cell Research (ISSCR) partners with Stem Cell Reports to promote discoveries with potential to transform regenerative medicine.
Researchers from the University of Southern Denmark found that tattooed individuals are more frequently diagnosed with skin and lymphoma cancers compared to those without tattoos. The study suggests that chronic inflammation in the lymph nodes triggered by tattoo ink may lead to abnormal cell growth and an increased risk of cancer.
Researchers at UTEP secured a patent for anti-malarial drug pyronaridine, which slows cancer cell growth and induces programmed cell death, sparing healthy cells.
The AI-GS network achieves high accuracy with 93.52% sensitivity at 95% specificity, excelling in detecting early-stage glaucoma. The system is portable, requiring minimal computational power and delivering results in under a second.
A survey of 22,864 adults found that people with disabilities were more likely to report negative experiences with their healthcare provider's cultural responsiveness. The study highlights the need for future research on how adverse healthcare experiences affect health outcomes for patients with disabilities.
A study published in The Lancet found that tocolytic drugs after 30 weeks of pregnancy do not improve the baby's health. Premature birth often has a medical cause and delaying childbirth may actually be harmful.
Researchers at Amsterdam UMC and Moffitt Cancer Center found that contact with CLL cells leads to an energy crisis in T cells, making them unable to proliferate. The study suggests that restoring T cell energy could significantly enhance the effectiveness of current treatments for cancer.
Researchers found that omalizumab significantly improved treatment outcomes for multi-food allergy patients compared to oral immunotherapy. A total of 36% of omalizumab recipients could tolerate at least 2 grams of multiple food allergens, while only 19% of oral immunotherapy participants achieved this threshold.
A nationwide study found that COVID-19 hospital patients experienced a higher rate of deaths from any cause and were more likely to be hospitalized for specific conditions, particularly neurological and respiratory problems. The study also identified increased risks of chronic health complications up to 30 months after discharge.
Ursodeoxycholic acid (UDCA) exhibits a broad range of hepatoprotective mechanisms, including antioxidant, anti-inflammatory, and anti-apoptotic properties, which may benefit various types of drug-induced liver injury. In hepatocellular DILI, UDCA reduces inflammation, alleviates ER stress, and protects against mitochondrial damage. In ...
The collaboration aims to close gaps in early recognition and management of IPF by equipping healthcare providers, public health professionals, and patients with necessary resources. The organizations will employ designated activities to build a knowledge base, develop survey tools, and create educational and awareness assets.
SLC transporters contribute to the development of hepatic steatosis by regulating lipid metabolism, particularly with SLC2A2, GLUT4, and GLUT5. These proteins influence processes like de novo lipogenesis and insulin resistance in hepatocytes.
Hepatic biliary adenofibroma (BAF) is a rare, benign tumor with histological characteristics distinct from other biliary tumors. Emerging case reports suggest potential for malignant transformation and overlap with intrahepatic cholangiocarcinoma (iCCA), highlighting diagnostic challenges and need for further research.
A McMaster University research team identified several small molecules in blood that inversely associate with developmental outcomes. The study highlights the complex connections between diet, gut health and a child's growth and cognitive milestones.
A new genetic testing technique is being developed to help young cancer patients receive more targeted and less toxic treatments. The test analyzes DNA released into the bloodstream by cancer cells, offering a less invasive way to monitor tumor progression and identify new treatment targets.
A nasal spray being tested for Alzheimer's disease could also reduce neuroinflammation in traumatic brain injury, according to a Mass General Brigham-led study. The treatment modulates the immune response, reducing anxiety, cognitive decline, and improving motor skills in mouse models of TBI.
A new AI-based system called LILAC can accurately detect changes and predict outcomes in various medical applications. The system has been demonstrated on diverse longitudinal image series covering IVF embryos, healing tissue after wounds, and aging brains.
A new clinical trial will use MDMA in combination with Prolonged Exposure therapy to enhance treatment outcomes for individuals with PTSD. Researchers believe MDMA shows potential in improving PTSD symptoms by increasing neuroplasticity and processing traumatic memories.