Articles tagged with Clinical Research
Researchers at Vanderbilt University have developed a new method to grow healthy lungs in mice, which could potentially heal lungs damaged by premature birth. The study uses four-dimensional microscopy to visualize the formation of lung tissue and identify key molecules that drive repair.
A Mount Sinai-led research team has identified stem cell populations and mechanisms underlying age-related degeneration in meibomian glands, which secrete lipid-rich meibum to prevent tear evaporation. The findings suggest that targeting Hh and EGFR signaling could be a potential therapeutic option for evaporative dry eye disease.
A large-scale study has found huge variation in GP practices on prostate cancer testing, with one in five patients diagnosed without symptoms. The study suggests a need for more consistent approach to testing people without symptoms to redress the imbalance.
Researchers at Karolinska Institutet discovered a fundamental mechanism linking breathing to pupil size, which affects vision. The study shows that the pupil is smallest during inhalation and largest during exhalation, impacting visual perception.
Recent research suggests that select athletes with cardiovascular abnormalities can safely participate in competitive sports after shared decision-making with their clinicians. The new scientific statement reviews best clinical practices for athletes with certain cardiovascular conditions and provides an evidence-based path for safe re...
A new mobile health app-based intervention, BEST-U, is expanding to train non-mental health professionals in delivering the treatment. The 11-week program has shown 'most participants were fully recovered from their eating disorder' at the University of Kansas.
Dr. Gordon Keller's groundbreaking research on directed differentiation of human pluripotent stem cells has illuminated the path to transforming human health. His lab's world-first discovery and pioneering efforts have pushed the boundaries of what is possible, offering hope for regenerating heart, liver, and blood cells.
US outpatient prescriptions for ivermectin and hydroxychloroquine increased significantly during the COVID-19 pandemic, with usage being three times higher among adults aged 65 and older. The study's findings highlight the need for policy reforms to combat misinformation and mistrust in scientific institutions.
Dr. Paola Arlotta's groundbreaking research on stem cell-derived brain organoids has redefined human brain development and neurological disease understanding. Her work provides access to the complexities of developing human brains, making her a deserving recipient of the ISSCR Momentum Award.
Dr. Yonatan Stelzer has made significant contributions to understanding epigenetic mechanisms and embryonic development, challenging conventional knowledge with innovative approaches. His research aims to establish fully data-driven quantitative models of spatiotemporal processes in mammals.
Researchers at Dana-Farber Cancer Institute found that combining navtemadlin with DNA-damaging chemotherapy can increase efficacy in treating glioblastoma. Navtemadlin activates the p53 pathway, killing glioblastoma cells more effectively than other treatments.
A rare case of adenomyosis in an 81-year-old postmenopausal woman closely resembles invasive endometrial cancer, emphasizing the challenges of diagnosing this condition. Further studies are needed to refine diagnostic protocols and determine risk factors for postmenopausal patients.
A recent MSU study highlights the challenges of diagnosing episodic disabilities like epilepsy, where symptoms fluctuate and can be unpredictable. The research found that 52% of participants experienced delayed diagnoses, while others faced quick confirmations within days of their first seizure.
BGI Genomics' Indonesian joint venture signed a partnership agreement to advance prenatal genetic screening technology in Indonesia. The collaboration focuses on extended Non-Invasive Prenatal Test (NIPT-Pro) and Copy Number Variation Sequencing (CNVseq) for early detection of fetal genetic disorders.
Nanomaterials conjugated with drugs improve therapeutic efficacy, reduce toxicity, and enable targeted delivery for neglected tropical diseases. This approach enhances diagnosis with rapid, sensitive, and cost-effective biosensors.
A new study found that artificial sweetener aspartame triggers insulin spikes leading to blood vessel inflammation in mice, which can contribute to atherosclerosis and increased risk of heart attacks and stroke. The researchers identified an immune signal called CX3CL1 that plays a key role in this process.
A new classification system for SJS/TEN divides the disorder into five types based on causative factors and diagnostic algorithms. This typology aims to bring clarity to diagnosis and treatment by providing consistent criteria for identifying underlying causes.
Ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant depression, often within hours of administration. However, the long-term efficacy and safety of ketamine therapy remain uncertain, with potential risks including cognitive impairment and cardiovascular effects.
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
A new device has been designed to effectively treat cerebral venous sinus thrombosis (CVST) by navigating complex venous anatomy and removing large thrombi. The device features controllable axial and longitudinal maneuverability, improving clinical outcomes for patients with CVST.
A study published in Mayo Clinic Proceedings found that patients who can exercise during cardiac stress testing have a lower mortality rate than those who cannot. The researchers discovered that assessing a patient's ability to exercise during testing provides a stronger distinction between high- and low-risk patients.
A new study reveals US hospital occupancy has surpassed pre-pandemic levels, driven mainly by a 16% reduction in staffed hospital beds. This could lead to a bed shortage as early as 2032, posing significant risks to patient safety and mortality rates.
The University of Texas MD Anderson Cancer Center received nearly $23 million in CPRIT funding to advance cancer research, translational science, and clinical trials. The funding will support the recruitment of a first-time tenure-track faculty member and enhance the understanding of cancer biology.
A new study in mice found that young adults are more susceptible to nicotine addiction than middle-aged adults, with a greater acute response to nicotine. The effects of nicotine on the body change over the lifespan, affecting how medications and other chemicals are processed.
The joint venture aims to build the world's preeminent pediatric cancer center, increasing access to care and clinical trials. Collaborative operations will launch in early 2026, featuring a focus on new facilities with latest medical technology.
The joint venture will unite the nation's largest comprehensive pediatric system with a top pediatric cancer program and the nation's leading comprehensive cancer center. The collaboration aims to accelerate improved outcomes for patients in Texas and around the world, increasing access to clinical trials and innovative treatments.
The Childhood Obesity Prevention, Evaluation and Treatment Toolkit provides healthcare providers with practical guidance for preventing, evaluating, and treating childhood obesity. The toolkit is grounded in scientific evidence and offers actionable treatment approaches for children and adolescents dealing with overweight and obesity.
A groundbreaking study published in eBioMedicine has shown that a new mRNA vaccine is effective in boosting immunity against tuberculosis. The vaccine demonstrated potent immune responses in infected mice and improved long-term protection when combined with the BCG vaccine.
Researchers found that a combination of Panitumumab and low-dose Capecitabine is an effective and well-tolerated maintenance regimen for patients with wild-type KRAS metastatic colorectal cancer. The treatment delayed disease progression while managing side effects, improving patients' quality of life.
Researchers are testing noninvasive electrical stimulation of the spinal cord to treat major depressive disorder. The trial, funded by the National Institute of Mental Health, aims to confirm whether this method reduces signaling in specific pathways related to depression.
A deficiency of LRP1 in skeletal progenitor cells leads to severe and lasting skeletal defects, including joint fusion and impaired mobility. LRP1 regulates the non-canonical Wnt/planar cell polarity pathway, essential for proper bone formation.
Researchers at UCF aim to create mobile robotic assistants that offer easier control and a better robot-human interface. The project, supported by a $600,000 grant, will focus on testing and user feedback, with initial trials conducted with students and adults with upper body paralysis.
The Lung Cancer Research Foundation and Israel Cancer Research Fund are partnering to test an innovative new treatment for lung cancer. The project aims to explore the effects of a drug that targets IGF2BP1, a protein involved in cancer cell growth.
Amplified Sciences has received CLIA certification for its PanCystPro test, which helps risk stratify patients with pancreatic cystic lesions. The company plans to commercialize the test through an early access program and a clinical utility trial in 2025.
Researchers analyzed data from three trials and found nerinetide provided a clinically significant benefit to patients. The findings suggest that treating early, fast, and administering the drug can lead to improved patient outcomes.
The Wnt signaling pathway is essential for HCC development, promoting cell proliferation, migration, and immune evasion. Targeting this pathway holds significant promise for therapeutic strategies, including small molecule inhibitors, monoclonal antibodies, and gene therapies.
A recent study reveals genes that may help predict prostate cancer outcomes, including androgen receptor AR-V7 and p160 gene family. The research suggests these genes could serve as potential prognostic biomarkers for prostate cancer, highlighting the importance of androgen signaling in disease progression.
A new study published in Annals of Neurology found that lower concentrations of vitamin B12 in healthy, older adults led to signs of neurological and cognitive deficiency. These individuals showed slower processing speeds, brain lesions, and delayed responses to visual stimuli compared to those with higher B12 levels.
A study by University of Bath researchers found that stopping anticoagulants for patients aged 75 and over does not significantly affect the risk of major bleeding, but increases the risk of serious events like stroke and death. This highlights the need for clinicians to carefully consider the risks of stopping anticoagulation therapy ...
Emboa Medical creates a microstructured catheter called TRAP, which mimics a boa constrictor's teeth arrangement to grab onto blood clots without tearing them. The TRAP design has shown significant benefits in removing clots on the first attempt and improving outcomes for stroke patients.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
A team of researchers from the University of Arizona College of Medicine – Tucson found that an FDA-approved osteoporosis treatment, risedronate, can correct a gene mutation and normalize heart function in animal models. The study provides hope for treating other rare diseases using precision treatments tailored to individual mutations.
Researchers from Flinders University applied gene editing to explore the role of enzyme ACE2 in healthy placental development. They found that ACE2 plays a key role in helping cells grow properly and that a genetic variation is linked to major pregnancy complications.
A new study by the University of Birmingham found that everyday stress, loneliness, and childhood trauma are significant risk factors for dissociation in teenagers and young adults. The research identified four key risk factors, with everyday stress being the most significant.
A new laparoscopic imaging technique uses stereo depth estimation and speckle-illumination SFDI to accurately map the optical properties of biological tissue. The device provides detailed optical property maps, enabling surgeons to identify critical tumor margins and improve clinical outcomes.
A new global guideline has been published to manage fungal infections caused by Candida, affecting millions worldwide annually. The guideline establishes standards for prevention, diagnosis, and innovative treatment approaches.
A new clinical trial will evaluate whether adding ketamine to standard treatment can improve outcomes for patients suffering from status epilepticus. The trial, called KESETT, hopes to determine whether ketamine can terminate the seizures in more patients than current treatments.
Osteosarcoma cells often have extra copies of the SETDB1 gene, making the cancer more aggressive and harder to treat. Blocking SETDB1 may help the immune system recognize and attack osteosarcoma cells, offering a promising new way to treat this type of bone cancer.
A comprehensive review explores the diverse roles of extracellular vesicles in oral health, highlighting their potential in disease detection, targeted therapies, and tissue regeneration. Engineered exosomes show significant clinical potential in areas such as tumor treatment and repair.
Researchers have developed a 'gut-on-chip' model that replicates intestinal inflammation and predicts response to immunotherapy in melanoma patients. The device differentiates between major intestinal populations and reproduces realistic environments.
A new blood test has shown promise in improving the accuracy of Alzheimer's Disease diagnosis, with results comparable to established CSF biomarkers. The study found that measuring plasma p-tau217 was over 90% accurate, potentially replacing invasive diagnostic methods for up to half of patients.
A new medication approved to treat type 2 diabetes and kidney disease also significantly reduces the risk of heart attacks and strokes among these patients. Sotagliflozin, a sodium-glucose cotransporter inhibitor, blocks proteins that help control blood sugar levels and has been shown to reduce cardiovascular events by 23%.
Researchers created optimized DNA hydrogels with fewer nucleic acids, achieving efficient and sustained drug release. The new hydrogel units showed prolonged persistence of at least 168 hours post-administration in mice, contributing to anti-tumor effects.
Researchers have identified changes in brain rhythms that indicate seizure activity in Alzheimer's patients. High-frequency oscillations (HFOs) occur at rates two to three times higher in Alzheimer's patients than in cognitively normal individuals.
A new treatment, datopotamab deruxtecan, has been approved by the FDA for people with metastatic ER-positive breast cancer. Researchers at Memorial Sloan Kettering Cancer Center have also discovered a new strategy to overcome resistance in prostate cancers, suggesting that targeting mTOR may restore sensitivity. Additionally, an MSK re...
Researchers created a Spanish-language Android app called Impacto to support Hispanic smokers in quitting. The app's pilot test shows promising results, decreasing daily smoking rates and improving cessation rates among participants.
Researchers found a biomarker, RNA Polymerase II (RNAPII), associated with tumor aggressiveness and recurrence in meningioma and breast cancers. The study developed a novel profiling technology, Cleavage Under Targeted Accessible Chromatin (CUTAC), to measure gene transcription activity from DNA, which predicted cancer outcomes.
Researchers discovered a link between neuroactive steroids in pregnant women's blood and the risk of developing postpartum depression. Measuring these molecules via a blood test could enable doctors to provide treatment sooner. The study may lead to a preventive treatment using existing prescription drugs.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
The Colorectal Cancer Alliance has awarded new grants to researchers, convened top scientists at the Cure CRC Summit, and launched K-SPY, a groundbreaking multi-center platform trial for high-risk colorectal cancer cases. The initiative aims to improve outcomes for millions affected by the disease.