Articles tagged with Clinical Research
A multi-institutional study identified the specific milk protein triggering a patient's case of eosinophilic esophagitis, an inflammatory disease of the esophagus. The findings represent the first time any research team has described molecular details of food antigen recognition in EoE.
Research reveals East Asian adults have greater risk of elevated iron stores, increasing the likelihood of heart disease, Type 2 diabetes, and liver disease. Genetic influences suggest a need for tailored dietary guidelines to prevent iron-related toxicity.
Sucosky's research aims to build a device replicating the bicuspid aortic valve to investigate how unusual stress leads to its hardening. The goal is to uncover molecular pathways that could be targeted with pharmaceutical treatments.
Dental implant surgeries require optimal mechanical stress levels for successful bone healing and long-term implant success. Researchers are developing a hybrid biomechanical model using machine learning to provide precise, patient-specific predictions of mechanical stress.
A new Weizmann Institute study identified all proteins in a stool sample – those from the microbiome, human body, and food – revealing secrets of the intestines and their impact on human disease. The method, dubbed IPHOMED, decodes microbiome activity by showing which proteins come from bacterial strains and amounts.
A new study from the University of Chicago Medicine challenges conventional notions about alcohol's effects in depressed people who drink excessively. Participants with AUD and depression reported feeling acute, sustained positive and rewarding alcohol effects similar to non-depressed counterparts.
The NIH-funded clinical trial aims to evaluate the safety and ability of AV-1 to lessen symptoms in people suffering from dengue. The study will expose adult volunteers to a weakened strain of dengue virus and administer AV-1 at various doses.
A recent study published in Lancet Oncology reveals a significant link between early side effects from radiation therapy for prostate cancer and long-term complications. Men who experience moderate acute urinary or bowel side effects during treatment are nearly twice as likely to develop late urinary or bowel issues, respectively. This...
A recent study investigated hybrid diffuse optics to monitor changes in blood flow and oxygen levels noninvasively. The technology provided detailed insights into how oxygen is delivered and utilized in the body, suggesting improved outcomes for critically ill patients undergoing red blood cell transfusions.
Researchers from The Mount Sinai Hospital analyzed an AI system to detect heart defects on fetal ultrasound exams, finding it significantly improved detection rates. The study aimed to improve prenatal detection of congenital heart defects, a leading cause of infant morbidity and mortality.
A new nanotechnology-based drug delivery system has been developed to save patients from repeated surgeries. The approach, called Pericelle, uses a paste of nanoparticles containing hydrogel on transplanted veins to prevent blockages, which can lead to repeated surgeries in heart and dialysis patients.
Researchers propose systems immunology to tackle sepsis, identifying early warning signs and potential subtypes, which can lead to improved diagnostics and treatment. Targeted funding is urgently needed to develop large-scale omics studies and translate these insights into clinical results.
Rush is creating a data warehouse to identify 'hot zones' of chronic diseases and inspire solutions, leveraging data from various sources to address health inequities. The project aims to make healthcare more equitable by providing insights into the root causes of poor health outcomes.
A new research project funded by a $600,000 grant is exploring the mechanics behind episiotomies, with the goal of developing safer and more effective surgical practices. The study uses advanced experimental techniques and computational simulations to understand how incisions spread and potentially lead to tears.
A new national study has found that homicide and suicide are the leading causes of maternal death in the US, with firearm deaths contributing to a significant portion. The study also highlights the disproportionate impact on Black birthing people and suggests that firearm legislation can reduce maternal mortality rates.
A new study suggests that AI can significantly improve a clinician's ability to detect cases suspicious for congenital heart defects, regardless of their experience or training. The AI system also increased confidence levels and reduced diagnosis time among clinicians.
A team of researchers at Duke University has developed a novel AI-based platform that can design and match small peptides with complex proteins, previously considered unreachable. The PepPrCLIP platform utilizes generative large language models to create peptide guide proteins and an algorithm framework to screen and test the peptides.
A recent study found that electric fans provide little cooling relief for older adults indoors during extreme heat due to their limited sweat production. Dr. Fergus O'Connor from Griffith University suggests using air conditioning at a higher temperature in conjunction with a fan to provide effective cooling and reduce operating costs.
The study highlights significant mental health disparities between participants in sexual and gender minority groups and cisgender heterosexual populations. The findings underscore the need for tailored mental health interventions to improve well-being among these populations, reflecting stigma and minority stress.
A new study found that adults with newly diagnosed sciatica who received chiropractic spinal manipulation experienced significantly lower rates of opioid-related adverse drug events compared to those receiving usual medical care. The study highlights the potential benefits of non-pharmacological approaches in managing pain.
Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
A predictive model developed by Ochsner Health researchers uses data-driven insights to determine whether urgent carotid-intervention patients will regain functional independence. The model has been shown to have a 93% accuracy rate and can help physicians tailor treatment plans and optimize intervention timing.
The D-CARE study found no differences in patient behavioral symptoms or caregiver strain between health system and community-based care approaches. However, comprehensive care improved caregiver self-efficacy, which remained consistent throughout the 18-month period.
A major clinical trial has identified three new safe and effective regimens for treating drug-resistant tuberculosis, offering faster, safer, and more accessible care. The new treatments show promise in reducing treatment duration and side effects, making them a significant breakthrough in the fight against this infectious disease.
The study discovered new microbial species and never-before-reported metagenomes from African sites, shedding light on the importance of geography in shaping microbiome differences. The research highlights the need for site- and region-specific approaches to gut health interventions.
A new trial will test whether taking HMB can improve patients' physical function and quality of life. The BOOST study aims to recruit 124 patients with cirrhosis and measure its effects on liver disease, mental wellbeing, and physical function over 24 weeks.
A new study found that oxytocin treatment can improve apathy symptoms in patients with frontotemporal dementia. The trial, conducted across 11 sites in Canada and the US, showed a significant improvement in apathy levels when patients received oxytocin compared to placebo.
A new study reveals striking similarities and critical gaps in how three major countries measure healthcare quality, with an emphasis on family medicine and process-focused metrics. The findings underscore the need for a more balanced approach that includes all aspects of medical care, from infrastructure to patient outcomes.
The new center aims to translate discoveries into better diagnostics and treatments, benefiting patients worldwide. HonorHealth's research institute is investing in cutting-edge clinical trials and collaborations to develop novel therapies.
The foundation has awarded eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, including five early-career researchers with initial grants of $400,000 over two years. The awardees aim to develop novel cancer therapies using innovative approaches such as engineered skin bacteria and small molecule-boosted drug delivery.
A new video game, CAMI, uses motion-tracking technology to detect differences in motor imitation skills, distinguishing children with autism from neurotypical children and ADHD patients with 80% accuracy. The tool has the potential to transform autism diagnoses worldwide by providing a quick, low-cost, and easy-to-use alternative.
Researchers developed MUNIS, a deep learning tool that predicts CD8+ T cell epitopes with high accuracy, potentially accelerating vaccine development. The tool was validated using experimental data from influenza, HIV, and EBV, demonstrating its potential to streamline vaccine design.
Researchers identified a unique genetic signature that can predict bacterial antibiotic resistance. The finding could help develop precision-based treatments and reduce overuse of antibiotics.
The open-source AI model analyzes medical images, generates detailed reports, and answers clinical questions to streamline diagnostics and improve accuracy. BiomedGPT aims to democratize healthcare and reduce disparities amongst patients by providing easily accessible data to bolster underserved hospitals.
Researchers tracked cfDNA levels before, during, and after colorectal cancer surgery, revealing significant increases associated with age, comorbidities, and surgical manipulation. The study suggests that cfDNA could serve as a non-invasive biomarker to monitor patient outcomes and evaluate surgical effectiveness.
A new therapy using Talimogene Laherparepvec (TVEC) has been successfully tested on patients with locally advanced basal cell carcinomas. The study showed that the treatment led to a significant reduction in tumour size and complete regression of some cases, improving surgical removal outcomes.
Children with severe malaria are at risk of serious health complications, higher mortality rates, and long-term cognitive impairment due to elevated uric acid levels. The study suggests that lowering uric acid may reduce hospital deaths and improve treatment strategies.
A study found that people with delayed REM sleep have higher levels of toxic proteins amyloid and tau, and lower levels of healthy protein BDNF, which can increase the risk of developing Alzheimer's. Practicing healthy sleep habits may help mitigate this risk.
The study establishes a consensus nomenclature and characterization framework to advance mitochondria transfer and transplantation biology. It defines types of mitochondrial transfers and reviews methods to define and enforce these processes.
A support program increased rural primary care clinics' buprenorphine prescribing by fivefold, with clinic completion rates for treatment milestones also showing significant improvements.
The American Academy of Family Physicians recommends guiding principles for AI use in research and publishing, emphasizing full disclosure, accountability, and understanding of AI limitations. AI can improve efficiency and accessibility but risks perpetuating bias and generating inaccurate information.
New research suggests that patients who see the same GP regularly need fewer follow-up appointments in practices and hospitals. This results in reduced workload for general practices and emergency departments, potentially freeing up NHS appointments.
Dr. Joseph F. Sabik III, MD, has been elected as the President of The Society of Thoracic Surgeons for the 2025 term, aiming to enhance data quality, support innovative studies, and provide cutting-edge training for cardiothoracic surgeons.
A study of 252 patients who underwent the Ross procedure found that survival rates were 95.8% at 5 years, 94.3% at 10 years, and 90.3% at 20 years. The procedure offers excellent long-term survival rates with low risk of re-intervention, making it an alternative to mechanical valve replacement.
A recent study analyzing over 100,000 patient data from the STS Adult Cardiac Surgery Database reveals that mechanical aortic valve replacements provide significant long-term survival benefits for patients under 60 compared to bioprosthetic valves. The study highlights the importance of individualized treatment plans and challenges cur...
Research presented at the 2025 STS Annual Meeting reveals that anatomic lung resections such as lobectomy and segmentectomy are associated with improved long-term survival compared to wedge resection for stage 1A NSCLC. Lobectomy offered the highest survival rates, with a 71.9% 5-year OS and 44.8% 10-year OS.
A blood test using Signatera detected tiny fragments of tumor DNA in the blood, which showed that adding celecoxib to treatment may improve disease-free survival for patients with stage III colon cancer. The analysis found significantly improved outcomes for those taking celecoxib compared to placebo.
A study analyzing over a million Medicare patients found that those receiving multi-arterial grafts had improved survival compared to single-arterial graft recipients. However, when accounting for unmeasured confounding variables using surgeon preference as an instrumental variable, no difference in long-term survival was observed.
A new study published in Nature Medicine shows a promising approach to preventing metastases in breast cancer patients. Researchers found that administering digoxin reduced circulating tumour cell clusters by an average of 2.2 cells, significantly decreasing the risk of metastasis.
A phase III trial found that combining radiotherapy with cetuximab improved disease-free survival in patients with HPV-negative head and neck cancer, but not overall survival. The treatment was also associated with higher rates of acute toxicity.
A new microdosing approach using low doses of buprenorphine has been tested on patients with opioid use disorder, but most found it ineffective. The study, which included 126 participants, showed that only 34% were able to work up to a full dose of buprenorphine.
A cohort study found city-level sugar-sweetened beverage taxes associated with reduced mean body mass index (BMI) among adults. These associations were seen in demographic subgroups, including young adults who consumed the most SSBs.
Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.
A cognitive science professor at UC Merced proposes a suite of video games to accelerate cancer research using artificial intelligence and gamified citizen science. The 'Cancer Wars' initiative aims to harness the collective problem-solving power of millions of gamers to tackle complex scientific problems.
Genetic testing using high-throughput sequencing (HTS) technology has significantly improved detection rates for thalassemia, offering a valuable model for high-prevalence regions. HTS-based genetic testing offers greater sensitivity and specificity without adding significant costs.
A study found that patients with AMA/anti-sp100/anti-gp210 positivity and elevated liver enzymes can manifest conditions beyond primary biliary cholangitis. Etiological treatments improved or resolved cholestatic biochemistry in these patients, justifying their initiation over ursodeoxycholic acid therapy.
Researchers found AI-based imaging technology improves disease diagnosis accuracy, particularly in cardiology, oncology, neurology, and ophthalmology. The technology also enhances diagnostic efficiency and reduces healthcare disparities by delivering high-quality diagnostics to underserved areas.
The ISSCR has appointed Lizhong Liu, Kate MacDuffie, and Mubeen Goolam as the third cohort of Lawrence Goldstein Science Policy Fellows. The fellows will serve for three years and focus on science policy and advocacy work in regenerative medicine.
A new study aims to characterize the human virome, exploring its role in health and disease. The project will investigate nonpathogenic viruses and their potential impact on human phenotypes over time. Researchers hope to discover novel biomarkers for health and disease, as well as new therapeutic approaches.
The TARIPH Centre will conduct patient-centric translational research on respiratory health in collaboration with nine institutions, focusing on factors unique to Asia. The five-year programme aims to provide a clearer understanding of lung disease in Asians and develop effective national strategies for improvement.