Articles tagged with Clinical Research
The foundation has awarded eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, including five early-career researchers with initial grants of $400,000 over two years. The awardees aim to develop novel cancer therapies using innovative approaches such as engineered skin bacteria and small molecule-boosted drug delivery.
A new video game, CAMI, uses motion-tracking technology to detect differences in motor imitation skills, distinguishing children with autism from neurotypical children and ADHD patients with 80% accuracy. The tool has the potential to transform autism diagnoses worldwide by providing a quick, low-cost, and easy-to-use alternative.
Researchers developed MUNIS, a deep learning tool that predicts CD8+ T cell epitopes with high accuracy, potentially accelerating vaccine development. The tool was validated using experimental data from influenza, HIV, and EBV, demonstrating its potential to streamline vaccine design.
Researchers identified a unique genetic signature that can predict bacterial antibiotic resistance. The finding could help develop precision-based treatments and reduce overuse of antibiotics.
The open-source AI model analyzes medical images, generates detailed reports, and answers clinical questions to streamline diagnostics and improve accuracy. BiomedGPT aims to democratize healthcare and reduce disparities amongst patients by providing easily accessible data to bolster underserved hospitals.
Researchers tracked cfDNA levels before, during, and after colorectal cancer surgery, revealing significant increases associated with age, comorbidities, and surgical manipulation. The study suggests that cfDNA could serve as a non-invasive biomarker to monitor patient outcomes and evaluate surgical effectiveness.
A new therapy using Talimogene Laherparepvec (TVEC) has been successfully tested on patients with locally advanced basal cell carcinomas. The study showed that the treatment led to a significant reduction in tumour size and complete regression of some cases, improving surgical removal outcomes.
Children with severe malaria are at risk of serious health complications, higher mortality rates, and long-term cognitive impairment due to elevated uric acid levels. The study suggests that lowering uric acid may reduce hospital deaths and improve treatment strategies.
A study found that people with delayed REM sleep have higher levels of toxic proteins amyloid and tau, and lower levels of healthy protein BDNF, which can increase the risk of developing Alzheimer's. Practicing healthy sleep habits may help mitigate this risk.
The study establishes a consensus nomenclature and characterization framework to advance mitochondria transfer and transplantation biology. It defines types of mitochondrial transfers and reviews methods to define and enforce these processes.
A support program increased rural primary care clinics' buprenorphine prescribing by fivefold, with clinic completion rates for treatment milestones also showing significant improvements.
The American Academy of Family Physicians recommends guiding principles for AI use in research and publishing, emphasizing full disclosure, accountability, and understanding of AI limitations. AI can improve efficiency and accessibility but risks perpetuating bias and generating inaccurate information.
New research suggests that patients who see the same GP regularly need fewer follow-up appointments in practices and hospitals. This results in reduced workload for general practices and emergency departments, potentially freeing up NHS appointments.
Dr. Joseph F. Sabik III, MD, has been elected as the President of The Society of Thoracic Surgeons for the 2025 term, aiming to enhance data quality, support innovative studies, and provide cutting-edge training for cardiothoracic surgeons.
A study of 252 patients who underwent the Ross procedure found that survival rates were 95.8% at 5 years, 94.3% at 10 years, and 90.3% at 20 years. The procedure offers excellent long-term survival rates with low risk of re-intervention, making it an alternative to mechanical valve replacement.
A recent study analyzing over 100,000 patient data from the STS Adult Cardiac Surgery Database reveals that mechanical aortic valve replacements provide significant long-term survival benefits for patients under 60 compared to bioprosthetic valves. The study highlights the importance of individualized treatment plans and challenges cur...
Research presented at the 2025 STS Annual Meeting reveals that anatomic lung resections such as lobectomy and segmentectomy are associated with improved long-term survival compared to wedge resection for stage 1A NSCLC. Lobectomy offered the highest survival rates, with a 71.9% 5-year OS and 44.8% 10-year OS.
A blood test using Signatera detected tiny fragments of tumor DNA in the blood, which showed that adding celecoxib to treatment may improve disease-free survival for patients with stage III colon cancer. The analysis found significantly improved outcomes for those taking celecoxib compared to placebo.
A study analyzing over a million Medicare patients found that those receiving multi-arterial grafts had improved survival compared to single-arterial graft recipients. However, when accounting for unmeasured confounding variables using surgeon preference as an instrumental variable, no difference in long-term survival was observed.
A new study published in Nature Medicine shows a promising approach to preventing metastases in breast cancer patients. Researchers found that administering digoxin reduced circulating tumour cell clusters by an average of 2.2 cells, significantly decreasing the risk of metastasis.
A phase III trial found that combining radiotherapy with cetuximab improved disease-free survival in patients with HPV-negative head and neck cancer, but not overall survival. The treatment was also associated with higher rates of acute toxicity.
A new microdosing approach using low doses of buprenorphine has been tested on patients with opioid use disorder, but most found it ineffective. The study, which included 126 participants, showed that only 34% were able to work up to a full dose of buprenorphine.
A cohort study found city-level sugar-sweetened beverage taxes associated with reduced mean body mass index (BMI) among adults. These associations were seen in demographic subgroups, including young adults who consumed the most SSBs.
Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.
A cognitive science professor at UC Merced proposes a suite of video games to accelerate cancer research using artificial intelligence and gamified citizen science. The 'Cancer Wars' initiative aims to harness the collective problem-solving power of millions of gamers to tackle complex scientific problems.
Genetic testing using high-throughput sequencing (HTS) technology has significantly improved detection rates for thalassemia, offering a valuable model for high-prevalence regions. HTS-based genetic testing offers greater sensitivity and specificity without adding significant costs.
A study found that patients with AMA/anti-sp100/anti-gp210 positivity and elevated liver enzymes can manifest conditions beyond primary biliary cholangitis. Etiological treatments improved or resolved cholestatic biochemistry in these patients, justifying their initiation over ursodeoxycholic acid therapy.
Researchers found AI-based imaging technology improves disease diagnosis accuracy, particularly in cardiology, oncology, neurology, and ophthalmology. The technology also enhances diagnostic efficiency and reduces healthcare disparities by delivering high-quality diagnostics to underserved areas.
The ISSCR has appointed Lizhong Liu, Kate MacDuffie, and Mubeen Goolam as the third cohort of Lawrence Goldstein Science Policy Fellows. The fellows will serve for three years and focus on science policy and advocacy work in regenerative medicine.
A new study aims to characterize the human virome, exploring its role in health and disease. The project will investigate nonpathogenic viruses and their potential impact on human phenotypes over time. Researchers hope to discover novel biomarkers for health and disease, as well as new therapeutic approaches.
The TARIPH Centre will conduct patient-centric translational research on respiratory health in collaboration with nine institutions, focusing on factors unique to Asia. The five-year programme aims to provide a clearer understanding of lung disease in Asians and develop effective national strategies for improvement.
Researchers tracked nearly 1,000 people with post-COVID-19 syndrome, finding persistent physical and cognitive impairments that worsened with exercise intolerance. The study's findings support the inclusion of cognitive and exercise testing in clinical evaluation for patients with suspected post-COVID-19 syndrome.
University of Oklahoma Health Sciences is part of a new NIH program integrating clinical research into primary care practices in medically underserved areas. The program aims to increase access to vital health care and speed up the adoption of new evidence-based guidelines.
Dr. Jared M. Kutzin has been elected President of the Society for Simulation in Healthcare (SSH), a position he will hold for one year. He aims to expand affiliations and strategic partnerships worldwide and develop relationships with emergency medical services partners.
A systematic review and meta-analysis of over 15,000 patients found that exercise and nutritional enhancement were the most promising components of prehabilitation, reducing complications and length of hospitalization. The study's lead author notes that prehabilitation is promising but still unclear how to implement it across hospitals.
Researchers developed a precision medicine approach that uses high-tech microscopy to analyze individual immune cells and identify cellular phenotypes correlated with disease activity and therapeutic response. This study represents a major step forward in tailoring therapies for rheumatoid arthritis and other autoimmune diseases.
BioChatter bridges the gap between large language models and biomedical research by providing a transparent and adaptable framework for custom research tasks. The platform can integrate with knowledge graphs and bioinformatics tools, making it easier for researchers to analyze complex datasets.
Researchers developed a pioneering skin organoid model using air-liquid interface culture, significantly enhancing hair follicle growth and maturation. The study offers refined models for studying skin diseases and crafting innovative therapeutic solutions.
Researchers investigate how sex-specific immune responses affect disease outcomes in obesity and helminth infections, aiming to develop new treatments for metabolic disorders and parasitic infections. The study focuses on macrophage-eosinophil interactions and the role of RELMalpha protein.
Researchers at Kennedy Krieger Institute found elevated suicide risk in children as young as eight years old, emphasizing the importance of universal screening. The study suggests that children with neurodevelopmental differences have comparable risks to their peers, highlighting the need for inclusive screenings.
A research team from the University of Minnesota Medical School received a $1.2 million grant to study the use of TMS in addition to CBIT as a treatment for children with Tourette syndrome. The trial found that this new treatment improved brain circuits involved in tics, and the researchers hope it could lead to a future treatment option.
Researchers explore HER2-low breast cancer, a new clinical subtype that benefits from novel treatments and personalized care. Current testing methods are not always accurate, calling for better detection methods to correctly identify patients who can benefit from these new therapies.
Researchers found that integrating optometrists into community clinics reduces patient wait times and lower costs for the NHS. Local optician practices handle conditions like nAMD and glaucoma, delivering quality care while optimizing resources.
UCSF researchers found that when brain cells of female mice express only a maternal X chromosome, their memory and cognitive skills deteriorate faster. This study could explain the variation in brain aging between the sexes and individual women.
A team of researchers at Johns Hopkins Medicine has developed a biomarker algorithm that can detect Barrett’s esophagus and esophageal cancer using a noninvasive method. The algorithm uses methylation patterns in genes to identify biomarkers, achieving an AUC of nearly 0.97 in distinguishing healthy tissue from esophageal cancer.
This study investigated the feasibility of electroacupuncture-assisted ribavirin dosing in patients with long COVID, using Voll's electropuncture diagnostics. The results demonstrated that EAV can identify meridians with decreased electrodermal activity at acupuncture points, followed by medicament testing to measure daily doses.
UCSF researchers identify a molecular timer controlling mouse birth timing, which could lead to new tests for human preterm labor risk and interventions. DNA packaging during pregnancy plays a crucial role in regulating gene expression, with KDM6B working as a 'timer' that winds down over time.
Researchers analyzed data from the SPRINT MIND trial and found that intensive blood pressure control significantly reduced the risk of mild cognitive impairment or dementia. The study also showed sustained benefits over seven years, contradicting earlier results.
A study identified unique microbiome signatures associated with Nonalcoholic Fatty Liver Disease (NAFLD), allowing for precise diagnoses and new therapeutic approaches. These signatures predict bacterial metabolites and are linked to the development of NAFLD, providing insights into disease mechanisms.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
A study by Brown University researchers found that only 0.8% of clinical drug trials involving women aged 18-45 included pregnant participants, while 75% excluded them. This gap in research leaves critical questions about medication safety and efficacy unanswered for maternal and child health.
Researchers found that qualitative properties of lipoproteins, such as LDL and HDL, play a crucial role in the development and progression of cardiovascular diseases. The study reveals that therapeutic interventions can partially reverse harmful effects of these alterations, offering opportunities to develop new treatments.
Researchers found that most parents (78%) who worried about their child's weight were open to support and nearly all (98%) accepted a referral to relevant children's services. Parents preferred individualized support and focused on being healthy rather than just weight loss.
Researchers found that short-course antibiotics can be as effective as traditional longer treatments in preventing death and recurrence of pneumonia. This approach offers significant value for healthcare systems by reducing hospital expenditure while maintaining excellent patient outcomes.
This study investigates the biological mechanisms underlying incomplete immune reconstitution and evaluates Dihydroartemisinin's potential as a therapeutic agent. DHA effectively inhibits T cell activation in individuals with incomplete immune reconstitution, presenting a promising treatment strategy.
A new study published in Cell reveals significant differences in the immune response of children and adults to cancer, with potential implications for targeted therapies. The research shows that children's tumours are generally less inflammatory and have fewer mutations, making them appear less foreign to their immune system.
The study developed floating nanoballoons to improve ibuprofen's bioavailability and sustained release its anti-inflammatory effects. The formulation showed superior edema inhibition in acute inflammation studies, reducing TNF-α, hs-CRP, and IL-6 levels, while increasing anti-inflammatory IL-10 levels.
Researchers at Uppsala University found that people with psoriasis have invisible inflammation in their small intestine, which can lead to gastrointestinal problems and an increased risk of developing Crohn's disease. Half of the study participants had a leaky gut, allowing bacteria and harmful substances to leak through the intestinal...
Research published in the European Heart Journal found that people with high amounts of intermuscular fat are more likely to develop coronary microvascular dysfunction and future serious heart disease. The study's lead author suggests that existing measures of obesity may not be accurate for all individuals, particularly women.
A real-world multicenter study evaluated the effectiveness and safety of tenofovir amibufenamide in treating chronic hepatitis B. The study found that TMF was comparable to TDF in terms of treatment effectiveness, with improved renal safety and no impact on lipid levels.