Articles tagged with Clinical Research
Researchers tracked nearly 1,000 people with post-COVID-19 syndrome, finding persistent physical and cognitive impairments that worsened with exercise intolerance. The study's findings support the inclusion of cognitive and exercise testing in clinical evaluation for patients with suspected post-COVID-19 syndrome.
University of Oklahoma Health Sciences is part of a new NIH program integrating clinical research into primary care practices in medically underserved areas. The program aims to increase access to vital health care and speed up the adoption of new evidence-based guidelines.
Dr. Jared M. Kutzin has been elected President of the Society for Simulation in Healthcare (SSH), a position he will hold for one year. He aims to expand affiliations and strategic partnerships worldwide and develop relationships with emergency medical services partners.
A systematic review and meta-analysis of over 15,000 patients found that exercise and nutritional enhancement were the most promising components of prehabilitation, reducing complications and length of hospitalization. The study's lead author notes that prehabilitation is promising but still unclear how to implement it across hospitals.
Researchers developed a precision medicine approach that uses high-tech microscopy to analyze individual immune cells and identify cellular phenotypes correlated with disease activity and therapeutic response. This study represents a major step forward in tailoring therapies for rheumatoid arthritis and other autoimmune diseases.
BioChatter bridges the gap between large language models and biomedical research by providing a transparent and adaptable framework for custom research tasks. The platform can integrate with knowledge graphs and bioinformatics tools, making it easier for researchers to analyze complex datasets.
Researchers developed a pioneering skin organoid model using air-liquid interface culture, significantly enhancing hair follicle growth and maturation. The study offers refined models for studying skin diseases and crafting innovative therapeutic solutions.
Researchers investigate how sex-specific immune responses affect disease outcomes in obesity and helminth infections, aiming to develop new treatments for metabolic disorders and parasitic infections. The study focuses on macrophage-eosinophil interactions and the role of RELMalpha protein.
Researchers at Kennedy Krieger Institute found elevated suicide risk in children as young as eight years old, emphasizing the importance of universal screening. The study suggests that children with neurodevelopmental differences have comparable risks to their peers, highlighting the need for inclusive screenings.
A research team from the University of Minnesota Medical School received a $1.2 million grant to study the use of TMS in addition to CBIT as a treatment for children with Tourette syndrome. The trial found that this new treatment improved brain circuits involved in tics, and the researchers hope it could lead to a future treatment option.
Researchers explore HER2-low breast cancer, a new clinical subtype that benefits from novel treatments and personalized care. Current testing methods are not always accurate, calling for better detection methods to correctly identify patients who can benefit from these new therapies.
Researchers found that integrating optometrists into community clinics reduces patient wait times and lower costs for the NHS. Local optician practices handle conditions like nAMD and glaucoma, delivering quality care while optimizing resources.
UCSF researchers found that when brain cells of female mice express only a maternal X chromosome, their memory and cognitive skills deteriorate faster. This study could explain the variation in brain aging between the sexes and individual women.
A team of researchers at Johns Hopkins Medicine has developed a biomarker algorithm that can detect Barrett’s esophagus and esophageal cancer using a noninvasive method. The algorithm uses methylation patterns in genes to identify biomarkers, achieving an AUC of nearly 0.97 in distinguishing healthy tissue from esophageal cancer.
This study investigated the feasibility of electroacupuncture-assisted ribavirin dosing in patients with long COVID, using Voll's electropuncture diagnostics. The results demonstrated that EAV can identify meridians with decreased electrodermal activity at acupuncture points, followed by medicament testing to measure daily doses.
UCSF researchers identify a molecular timer controlling mouse birth timing, which could lead to new tests for human preterm labor risk and interventions. DNA packaging during pregnancy plays a crucial role in regulating gene expression, with KDM6B working as a 'timer' that winds down over time.
Researchers analyzed data from the SPRINT MIND trial and found that intensive blood pressure control significantly reduced the risk of mild cognitive impairment or dementia. The study also showed sustained benefits over seven years, contradicting earlier results.
A study identified unique microbiome signatures associated with Nonalcoholic Fatty Liver Disease (NAFLD), allowing for precise diagnoses and new therapeutic approaches. These signatures predict bacterial metabolites and are linked to the development of NAFLD, providing insights into disease mechanisms.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
A study by Brown University researchers found that only 0.8% of clinical drug trials involving women aged 18-45 included pregnant participants, while 75% excluded them. This gap in research leaves critical questions about medication safety and efficacy unanswered for maternal and child health.
Researchers found that qualitative properties of lipoproteins, such as LDL and HDL, play a crucial role in the development and progression of cardiovascular diseases. The study reveals that therapeutic interventions can partially reverse harmful effects of these alterations, offering opportunities to develop new treatments.
Researchers found that most parents (78%) who worried about their child's weight were open to support and nearly all (98%) accepted a referral to relevant children's services. Parents preferred individualized support and focused on being healthy rather than just weight loss.
Researchers found that short-course antibiotics can be as effective as traditional longer treatments in preventing death and recurrence of pneumonia. This approach offers significant value for healthcare systems by reducing hospital expenditure while maintaining excellent patient outcomes.
This study investigates the biological mechanisms underlying incomplete immune reconstitution and evaluates Dihydroartemisinin's potential as a therapeutic agent. DHA effectively inhibits T cell activation in individuals with incomplete immune reconstitution, presenting a promising treatment strategy.
A new study published in Cell reveals significant differences in the immune response of children and adults to cancer, with potential implications for targeted therapies. The research shows that children's tumours are generally less inflammatory and have fewer mutations, making them appear less foreign to their immune system.
The study developed floating nanoballoons to improve ibuprofen's bioavailability and sustained release its anti-inflammatory effects. The formulation showed superior edema inhibition in acute inflammation studies, reducing TNF-α, hs-CRP, and IL-6 levels, while increasing anti-inflammatory IL-10 levels.
Researchers at Uppsala University found that people with psoriasis have invisible inflammation in their small intestine, which can lead to gastrointestinal problems and an increased risk of developing Crohn's disease. Half of the study participants had a leaky gut, allowing bacteria and harmful substances to leak through the intestinal...
Research published in the European Heart Journal found that people with high amounts of intermuscular fat are more likely to develop coronary microvascular dysfunction and future serious heart disease. The study's lead author suggests that existing measures of obesity may not be accurate for all individuals, particularly women.
A real-world multicenter study evaluated the effectiveness and safety of tenofovir amibufenamide in treating chronic hepatitis B. The study found that TMF was comparable to TDF in terms of treatment effectiveness, with improved renal safety and no impact on lipid levels.
Researchers discover how cigarette smoke alters the function of mucosal-associated invariant T (MAIT) cells, a key type of immune cell in the lungs. This impairment increases susceptibility to respiratory infections and worsens chronic obstructive pulmonary disease (COPD).
A pilot study found that qigong significantly decreases chronic low back pain in US military veterans, improving physical function and reducing sleep disturbance. The holistic practice also showed positive effects on PTSD, depression, anxiety, and social roles, highlighting its potential as a nonpharmacological treatment option.
This study investigated the performance of plasma neurodegenerative biomarkers (NfL, GFAP, tau, and UCHL1) in diagnosing minimal hepatic encephalopathy (MHE) and predicting overt hepatic encephalopathy (OHE) in Chinese patients with hepatic cirrhosis. The results showed that a combination of NfL, GFAP, tau, and UCHL1 was effective in d...
The University Hospitals fundraising campaign, Because of You, has received over $1.5 billion in community support towards its ambitious $2 billion goal. This milestone marks a significant commitment to advancing healthcare services and care for patients across the country.
Researchers found that a lower CD4+/CD8+ T cell ratio after 12-24 weeks significantly predicted HBsAg clearance in IHCs treated with peginterferon alpha. Higher baseline percentages of CD3+CD8+ cells and lower CD4+/CD8+ ratios were also associated with improved outcomes.
A new study found that young nearsighted kids who wear bifocal contact lenses do not lose the benefits of treatment once they stop wearing them, with myopia progression continuing at age-expected rates. The study suggests a lower cost and more options for patients with healthier eyes.
Researchers at UMass Amherst have developed a non-toxic bacterial therapy, BacID, to deliver cancer-fighting drugs directly into tumors. The therapy uses genetically engineered strains of Salmonella that can target tumors and control the release of cancer-fighting drugs inside cancer cells.
A meta-analysis of 19,469 participants found that parents tend to favor daughters and children who are conscientious, agreeable, and responsible. This bias can have lasting consequences for children's mental health and relationships.
A deficiency of TLE6 protein, associated with female infertility, was also linked to abnormal sperm morphology and reduced motility in male mice. The study suggests that TLE6 plays a crucial role in energy production in sperm cells.
The study, published in the Journal of Clinical Oncology, showed no significant difference in patient survival between two-drug and three-drug chemotherapy regimens. The researchers found that the three-drug regimen may increase toxicity but could be a viable option for specific patients with certain types of biliary tract cancers.
Researchers applied ACE questionnaires to select Marvel and DC characters, finding that childhood trauma does not determine heroism or villainy. The study suggests that using fictional characters can help address child abuse and trauma in a non-confrontational way.
A meta-analysis found a dose-dependent relationship between alcohol consumption and the risks of cirrhosis and HCC in HBV patients, with daily alcohol consumption exceeding 12g increasing risk by 6.2% and 11.5% respectively.
A new study published in Aging found that pioglitazone reduced the frequency of skin ulcers in Werner syndrome patients. The research suggests that pioglitazone's anti-inflammatory properties may help wounds heal faster and prevent ulcers from forming.
Dr. Blagosklonny's work introduced a new theory and promoted the use of rapamycin to slow aging and extend healthy life by targeting the mTOR pathway, leading to improved immune responses, heart protection, and potential cancer prevention.
Researchers at Garvan Institute of Medical Research discovered how chronic hepatitis C infection leads to autoimmune disease by identifying 'rogue clone' B cells with harmful autoantibodies. The study found that a triad of genetic mutations is required for the autoimmune disease to develop, opening new paths for treatments.
Researchers found that time in safe blood-sugar range can predict diabetes complications as accurately as hemoglobin A1c levels. The study used advanced machine learning techniques to analyze landmark diabetes data from the DCCT trial.
The phase 3 KATHERINE clinical trial found trastuzumab emtansine to be an effective adjuvant treatment for high-risk HER2-positive breast cancer patients, reducing the risk of death or invasive disease by 46% and improving survival. The study showed consistent benefits across patient subgroups, supporting T-DM1 as a new standard of care.
A novel diagnostic system called TwinDemic Detection offers simultaneous and rapid detection of SARS-CoV-2 and influenza A virus. The system has a detection limit of 0.46 picomolar for CoV and 0.39 pM for IAV, correctly predicting positive and negative samples in high percentages.
Concordia researchers propose a novel method using ultrasound-guided microbubbles to stimulate critical cytokine secretion in T cells, potentially re-activating them and increasing the release of proteins needed to fight cancer. The approach could complement existing treatments and improve outcomes.
Researchers developed a system to monitor tumor-informed circulating tumor DNA (ctDNA) after comprehensive genomic profiling (CGP), enabling accurate prediction of patient outcomes. The study showed that this approach can be effectively used in conjunction with CGP data to predict cancer relapse and treatment response, improving person...
The Aligning Science Across Parkinson’s initiative is launching a new funding opportunity to support collaborative research teams focused on understanding Parkinson’s disease heterogeneity across six focus areas. The grants will provide up to $3 million per year over three years.
The Lancet Commission on Clinical Obesity proposes a new model for diagnosing clinical obesity based on objective measures of illness at the individual level. The proposal aims to settle the ongoing dispute around the idea of obesity as a disease, providing a medically coherent framework for diagnosis.
Researchers identified a novel genetic risk factor for SARS-CoV-2 infection, linking a PTPN2 variant to increased ACE2 expression and susceptibility. The study suggests Tofacitinib may mitigate this risk, offering new treatment options for patients at higher genetic risk.
Critical Path Institute's Translational Therapeutics Accelerator (TRxA) is launching its 2025 global Request for Proposals to support academic researchers in bridging the 'valley of death' in drug development. The program aims to enable the transition of innovative therapeutics from lab to patients.
A large UK trial found that adding procalcitonin (PCT) to routine care did not reduce IV antibiotic use in hospitalized children. The study, part of the BATCH trial, enrolled nearly 2,000 children and tested PCT's effectiveness in guiding treatment decisions.
Researchers developed an AI model to detect brain cancer spread in surrounding tissue using MRI scans, showing 85-per-cent accuracy. This non-surgical method offers insights into patients' cancer without aggressive surgery, potentially improving treatment and survival.
The American Association for Anatomy (AAA) has announced the recipients of its 2025 Spring Awards, honoring excellence in various fields of study. The awards include the Henry Gray Scientific Award, A.J. Ladman Exemplary Service Award, and others.
A new study using a novel mouse strain expressing Halo-tagged SOCS1 reveals that the inhibitor needs to exceed a threshold level to suppress GM-CSF and IFN-gamma signaling. The findings emphasize SOCS1's crucial function in modulating cytokine signaling.
A new study identifies loss-translocation-amplification chromothripsis as a key mechanism driving osteosarcoma tumour development and evolution. This discovery has significant implications for treatment options and patient outcomes, highlighting the importance of investing in studies exploring cancer mechanisms.
Janet Rossant takes over as Editor-in-Chief of Stem Cell Reports, aiming to publish high-quality primary research articles and commentaries that shape the field of stem cell science. She brings extensive experience and scientific expertise to the position, previously serving as ISSCR President.
A new study reveals that delta opioid receptor agonist KNT-127 has a rapid and effective antidepressant effect with minimal side effects. The research highlights the molecular mechanisms underlying its action, including mTOR signaling pathways and Akt activation in the medial prefrontal cortex.