Articles tagged with Clinical Research
A new study reveals that delta opioid receptor agonist KNT-127 has a rapid and effective antidepressant effect with minimal side effects. The research highlights the molecular mechanisms underlying its action, including mTOR signaling pathways and Akt activation in the medial prefrontal cortex.
The NIH-funded RECOVER Initiative study reveals a significant association between SARS-CoV-2 infection and an increased incidence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), with 4.5% post-COVID participants meeting ME/CFS diagnostic criteria, compared to 0.6% non-infected participants.
This review highlights the transformative capabilities of single-cell and spatial genomics, providing critical insights into disease mechanisms and developing innovative therapies. The technologies enable comprehensive cell atlases, tracing the evolution of sequencing methods and incorporating multi-omics approaches, which significantl...
Overexpressing hepatic SLC7A11 leads to glutamate and serine deficiency, promoting MASLD progression through ferroptosis. Serine supplementation rescues the disease phenotype.
A new position paper from the International Osteoporosis Foundation and International Federation of Clinical Chemistry proposes a unified nomenclature for bone status indices to enhance diagnostic consistency and clarity. The guidelines offer a comprehensive framework to unify terminology and improve comparability across studies.
The PEARLDIVER project aims to develop a Europe-wide research infrastructure to accelerate the discovery of effective treatments for depression. By building a shared platform, researchers can quickly assess the safety and efficacy of new and existing medications, allowing clinicians to make informed decisions about treatment options.
A new UC San Francisco study found that most 11- and 12-year-olds use TikTok and other social media platforms against the rules, showing signs of addiction. The study also revealed a quarter of children reported elements of addiction while using social media, linked to depression, eating disorders, ADHD, and disruptive behaviors.
Research led by University of Pittsburgh scientists found that exposure to long-wavelength red light reduces blood clots in humans and mice. The study's findings have the potential to reduce deaths and disabilities caused by blood clots worldwide.
The American Academy of Neurology has launched a new open access journal called Neurology Open Access. The journal publishes high-quality, peer-reviewed articles in all areas of neurology and clinical neurosciences, aiming to improve decision-making by clinicians and promote brain health. Amy Kunchok is the editor-in-chief of the journal.
The UK Biobank has launched a groundbreaking study to measure over 5,400 proteins in 600,000 samples, offering unprecedented insights into disease development and progression. This massive dataset will enable researchers to explore how changes in protein levels influence diseases and develop personalized treatments.
A groundbreaking UK study found that using procalcitonin (PCT) to guide treatment decisions did not reduce antibiotic duration in hospitalized children. The PCT test was safe but costlier than standard methods, and healthcare teams faced challenges integrating it into their decision-making processes.
Researchers discovered a key role for neutrophils in cancer cell colonization of abdominal fat through the release of DNA webs called NETs. Additionally, a new biomarker study found that dose-dense chemotherapy improved disease-free survival by 20% and overall survival by 15% for women with early-stage ER-positive breast cancer.
Stephania Cormier and colleagues lead a Frontiers in Immunology research collaboration to explain RSV's complex interplay with host immune responses. The team identifies gaps in knowledge, hindering therapeutics and vaccines development.
Researchers found that carrots can enhance the body's ability to regulate blood sugar and positively influence the composition of gut bacteria. The study used mice with type 2 diabetes and found improved glucose tolerance after consuming carrot powder.
Researchers found that participants who received early therapeutic interventions were significantly less likely to develop clinical depression within the first year. The interventions, which typically lasted six to twelve sessions, reduced symptoms and lowered the risk of depression by 42% in the first six months.
A recent study by Columbia University's Mailman School of Public Health found that engaging in volunteering activities can significantly reduce the odds of depression in community-dwelling older adults. The study, which analyzed data from over 2,900 participants aged 65-79, also revealed that older adults with a negative history of dep...
Researchers at UCSF have discovered a new type of stem cell in the young brain that can form cells found in tumors, shedding light on how adult brain cells grow and develop into deadly brain cancers. The study provides a comprehensive roadmap for understanding healthy brain development, which could lead to better treatments for conditi...
A clinical trial found that drinking elderberry juice daily for a week improved glucose tolerance and fat oxidation. The study also showed positive changes in the gut microbiome, with increased beneficial bacteria and decreased harmful bacteria.
Climate change is associated with poorer HIV prevention outcomes, including reduced testing and increased risk behaviors, leading to higher new infections and poorer treatment adherence. Researchers identified links between extreme weather events and HIV-related challenges, emphasizing the need for innovative interventions and strategies.
A new study has identified macrophage activity as a key predictor of which skin cancer patients are most likely to respond to immunotherapy. The findings aim to improve personalized medicine for cancer patients and enable clinicians to select effective treatments, reducing side effects and costs.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
Lewis S. Nelson, M.D., takes helm as dean of FAU's Schmidt College of Medicine, spearheading innovative medical education programs and research initiatives. With over 30 years of leadership experience, Nelson aims to foster innovation, research, and clinical excellence at the college.
Research found that morning coffee drinkers have a lower risk of dying from cardiovascular disease and a lower overall mortality risk. The study included over 40,000 adults who drank coffee at different times of the day and found that timing mattered more than the amount consumed.
The PEERS Clinic at UCLA offers a 20-week dating program called PEERS for Dating, aiming to demystify social rules and empower participants to form lasting connections. Participants will learn practical strategies for initiating and maintaining romantic relationships with support from trained coaches.
A new USC study validates a biomarker linked to vascular dementia and suggests that glymphatic damage drives cognitive decline. The findings provide a potential pathway to explain how cognitive impairment arises, offering a target for clinical researchers seeking treatments for vascular dementia.
Dr. Carrie Bearden's groundbreaking work combines genetic and brain development insights to identify early warning signs of psychosis in adolescents. Her research has exciting implications for personalized medicine and targeted preventive treatments.
The alliance aims to generate evidence supporting national guideline inclusion and healthcare provider adoption of Myriad's Precise MRD test. The studies will explore the test's utility in breast, gastrointestinal, genitourinary and gynecological cancers.
Researchers developed a gene therapy approach to treat chronic hypereosinophilia by delivering an anti-human eosinophil antibody via AAV-based gene therapy. The therapy successfully suppressed blood eosinophil levels in mice, showing promise as a potential treatment for the condition.
NRG Oncology has established a new Theranostics Subcommittee to develop a more robust theranostics program within its portfolio. The subcommittee will serve as a resource for research investigators and collaborate with other organizations to enhance the effects of treatment on targeted cancer.
A recent case series suggests that an extended course of Paxlovid may help some patients with long Covid experience sustained improvements in their symptoms. The study, published in Communications Medicine, found that five out of 13 patients experienced significant symptom relief after taking the antiviral drug for 15 days.
A new model for treating loneliness in borderline personality disorder suggests extending treatment beyond therapeutic relationships to foster social connections with others. This approach aims to provide patients with a sense of self and improve functional roles, promoting overall well-being.
Organoids, derived from stem cells, closely mimic human tissue for biomedical research and drug testing. Standardization is crucial for generating reliable results in organoid construction, requiring approved operating procedures and informed consent from donors.
A large study found that patients with diabetes taking GLP-1 receptor agonist drugs had lower rates of hospital readmission, wound re-opening, and hematoma after surgery. Improved blood sugar control was not the likely mediator, suggesting other mechanisms may be at play.
The DASH Diet has been ranked as the best heart-healthy diet and second-best overall in US News & World Report's 2025 rankings. Developed by Pennington Biomedical Research Center scientists, the diet emphasizes fruits, vegetables, and whole grains, while reducing saturated fat and added sugars.
Researchers at the Allen Institute have developed a new approach called CryoSCAPE, which stabilizes blood samples to preserve molecular composition and lower costs. This technology will enable broader participation in research studies and clinical trials for underserved communities.
Researchers analyzed data from over 700 patients with kidney injury and found that glucarpidase treatment improved kidney recovery rates. Glucarpidase rapidly clears methotrexate from the blood, reducing the risk of kidney toxicity.
A new study has found that rates of chlamydia and syphilis plummet among people prescribed doxycycline for STI prevention in routine clinical care. The study used pharmacy data to determine which HIV PrEP users filled prescriptions for doxyPEP, with 2,253 people receiving the medication within its first year of availability.
A new study found that increased videoconferencing use drives people to scrutinize their appearance, leading to a higher demand for cosmetic treatments. Frequent self-viewing is strongly associated with an interest in obtaining cosmetic procedures.
Researchers at the University of Arizona have made groundbreaking discoveries about levodopa-induced dyskinesia, a common complication in Parkinson's disease patients. The study found that the motor cortex becomes disconnected during dyskinetic episodes, leading to indirect causation rather than direct involvement.
Researchers at NIH have identified a novel class of anti-malaria antibodies that target previously untargeted regions of the parasite. These antibodies have shown promise in providing protection against malaria parasites in animal models and could lead to new prevention methods.
A recent study by Mizzou researchers found that nursing home residents with Alzheimer's disease or related dementias are more likely to experience avoidable hospital transfers due to a mismatch between care provided and personal preferences. Increasing staff support, training, and resources can help improve outcomes for these residents.
A new study found that nearly half of high-risk prostate cancer patients have metastatic disease when evaluated with advanced PSMA-PET imaging, suggesting traditional imaging may underestimate cancer spread. This challenge the interpretation of previous studies like EMBARK trial, and support the inclusion of PSMA-PET for patient select...
A new study published in Nature Medicine shows that AI-based models can accurately identify ovarian cancer in ultrasound images, achieving an accuracy rate of 86.3%. The models also reduce the need for expert referrals and misdiagnosis rates by 63% and 18%, respectively.
Researchers have created a new circuit model that accounts for small changes to the sensor's behavior, allowing it to detect protein or DNA molecules from a sample. The device could lead to earlier diagnosis of diseases and more precise therapies tailored to each patient.
Researchers at the University of Pittsburgh developed a non-invasive nasal swab test that diagnoses specific asthma subtype, or endotype, in children. The test, published in JAMA, shows promise for improving asthma treatment outcomes and paving the way for better treatments for lesser-studied asthma types.
The January issue of the American Journal of Psychiatry explores the use of psychedelic medications in psychiatry, addressing basic pharmacology, clinical efficacy, and public health considerations. The series of articles aims to provide sufficient evidence for therapeutic strategies utilizing psychedelic drugs.
Emory University MD candidate Fayzan Rab's research investigates the economic and public health implications of psychedelic therapy implementation. His work emphasizes making these innovative treatments accessible to traditionally underserved communities.
Researchers found that older adults with weakened immunity developed fewer antibodies against RSV following vaccination compared to healthy individuals. The study suggests that adjuvant-enhanced vaccines could improve immune responses in immunocompromised people, warranting further investigation.
A cohort study found a decrease in localized invasive breast cancer and regional invasive breast cancer since the 2009 guideline changes, but no decrease in advanced cancer stages. Further research is needed to understand these trends.
A study from the University of Gothenburg found that digital healthcare consultations are not reliable enough to assess tonsillitis due to limitations in criteria such as tonsil inspection and lymph node examination. Physical examinations remain crucial for accurate diagnosis and treatment.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
Neuroscientist Inga Neumann discusses groundbreaking research on oxytocin, a neuropeptide that shapes social behavior and emotional responses. Her work has significant implications for treating social anxiety disorders and understanding stress resilience.
The study identified 105 compounds in Shenqi Fuzheng extract, with organic acids and amino acids showing higher concentrations in the bloodstream. Compounds such as Astragalosides promptly enter the bloodstream within 5 minutes after administration.
A study by the National Center for Supercomputing Applications aims to create personalized nutrition plans based on an individual's unique gut microbiome. The researchers used Illinois Computes to analyze metabolomic data and develop a database of metabolites that can help diagnose diseases more efficiently.
A Rutgers-led study of heart-attack patients with anemia found that more liberal blood transfusions can save lives at six months. The analysis combined data from four clinical trials involving 4,311 patients, suggesting a reduced risk of death at six months with more transfusions.
Researchers developed a non-invasive way to assess fat composition around the heart using magnetic resonance imaging. This technique may help doctors identify patients at greatest risk for cardiac problems and predict treatment outcomes.
Early treatment with TNF inhibitors has been shown to prevent complications in kids with Crohn's disease, reducing the risk of perianal fistulas by 82%. The study found that anti-TNF drugs are specifically effective in preventing these debilitating complications, making them a recommended first-line therapy.
A systematic review of data on 2.4 million adults from 69 countries established international norms for handgrip strength, ranking strength into five categories: low, somewhat low, moderate, somewhat high, and high. The new framework enables clinicians to identify people at risk of poor health and track changes in strength over time.
The DFG is investing €30 million in eight new research units tackling pressing issues such as quantum materials, macrophage biology and language convergence. The new units will focus on innovative directions in their respective fields.
Researchers at Karolinska Institutet used AI to analyze brain images from 70-year-olds and found that factors like inflammation and high glucose levels are associated with an older-looking brain. A healthy lifestyle, on the other hand, was linked to brains with a younger appearance.