Articles tagged with Clinical Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that carrots can enhance the body's ability to regulate blood sugar and positively influence the composition of gut bacteria. The study used mice with type 2 diabetes and found improved glucose tolerance after consuming carrot powder.
Researchers found that participants who received early therapeutic interventions were significantly less likely to develop clinical depression within the first year. The interventions, which typically lasted six to twelve sessions, reduced symptoms and lowered the risk of depression by 42% in the first six months.
A recent study by Columbia University's Mailman School of Public Health found that engaging in volunteering activities can significantly reduce the odds of depression in community-dwelling older adults. The study, which analyzed data from over 2,900 participants aged 65-79, also revealed that older adults with a negative history of dep...
Researchers at UCSF have discovered a new type of stem cell in the young brain that can form cells found in tumors, shedding light on how adult brain cells grow and develop into deadly brain cancers. The study provides a comprehensive roadmap for understanding healthy brain development, which could lead to better treatments for conditi...
A clinical trial found that drinking elderberry juice daily for a week improved glucose tolerance and fat oxidation. The study also showed positive changes in the gut microbiome, with increased beneficial bacteria and decreased harmful bacteria.
Climate change is associated with poorer HIV prevention outcomes, including reduced testing and increased risk behaviors, leading to higher new infections and poorer treatment adherence. Researchers identified links between extreme weather events and HIV-related challenges, emphasizing the need for innovative interventions and strategies.
A new study has identified macrophage activity as a key predictor of which skin cancer patients are most likely to respond to immunotherapy. The findings aim to improve personalized medicine for cancer patients and enable clinicians to select effective treatments, reducing side effects and costs.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
Lewis S. Nelson, M.D., takes helm as dean of FAU's Schmidt College of Medicine, spearheading innovative medical education programs and research initiatives. With over 30 years of leadership experience, Nelson aims to foster innovation, research, and clinical excellence at the college.
Research found that morning coffee drinkers have a lower risk of dying from cardiovascular disease and a lower overall mortality risk. The study included over 40,000 adults who drank coffee at different times of the day and found that timing mattered more than the amount consumed.
The PEERS Clinic at UCLA offers a 20-week dating program called PEERS for Dating, aiming to demystify social rules and empower participants to form lasting connections. Participants will learn practical strategies for initiating and maintaining romantic relationships with support from trained coaches.
A new USC study validates a biomarker linked to vascular dementia and suggests that glymphatic damage drives cognitive decline. The findings provide a potential pathway to explain how cognitive impairment arises, offering a target for clinical researchers seeking treatments for vascular dementia.
Dr. Carrie Bearden's groundbreaking work combines genetic and brain development insights to identify early warning signs of psychosis in adolescents. Her research has exciting implications for personalized medicine and targeted preventive treatments.
The alliance aims to generate evidence supporting national guideline inclusion and healthcare provider adoption of Myriad's Precise MRD test. The studies will explore the test's utility in breast, gastrointestinal, genitourinary and gynecological cancers.
Researchers developed a gene therapy approach to treat chronic hypereosinophilia by delivering an anti-human eosinophil antibody via AAV-based gene therapy. The therapy successfully suppressed blood eosinophil levels in mice, showing promise as a potential treatment for the condition.
NRG Oncology has established a new Theranostics Subcommittee to develop a more robust theranostics program within its portfolio. The subcommittee will serve as a resource for research investigators and collaborate with other organizations to enhance the effects of treatment on targeted cancer.
A recent case series suggests that an extended course of Paxlovid may help some patients with long Covid experience sustained improvements in their symptoms. The study, published in Communications Medicine, found that five out of 13 patients experienced significant symptom relief after taking the antiviral drug for 15 days.
A new model for treating loneliness in borderline personality disorder suggests extending treatment beyond therapeutic relationships to foster social connections with others. This approach aims to provide patients with a sense of self and improve functional roles, promoting overall well-being.
Organoids, derived from stem cells, closely mimic human tissue for biomedical research and drug testing. Standardization is crucial for generating reliable results in organoid construction, requiring approved operating procedures and informed consent from donors.
A large study found that patients with diabetes taking GLP-1 receptor agonist drugs had lower rates of hospital readmission, wound re-opening, and hematoma after surgery. Improved blood sugar control was not the likely mediator, suggesting other mechanisms may be at play.
The DASH Diet has been ranked as the best heart-healthy diet and second-best overall in US News & World Report's 2025 rankings. Developed by Pennington Biomedical Research Center scientists, the diet emphasizes fruits, vegetables, and whole grains, while reducing saturated fat and added sugars.
Researchers at the Allen Institute have developed a new approach called CryoSCAPE, which stabilizes blood samples to preserve molecular composition and lower costs. This technology will enable broader participation in research studies and clinical trials for underserved communities.
Researchers analyzed data from over 700 patients with kidney injury and found that glucarpidase treatment improved kidney recovery rates. Glucarpidase rapidly clears methotrexate from the blood, reducing the risk of kidney toxicity.
A new study has found that rates of chlamydia and syphilis plummet among people prescribed doxycycline for STI prevention in routine clinical care. The study used pharmacy data to determine which HIV PrEP users filled prescriptions for doxyPEP, with 2,253 people receiving the medication within its first year of availability.
A new study found that increased videoconferencing use drives people to scrutinize their appearance, leading to a higher demand for cosmetic treatments. Frequent self-viewing is strongly associated with an interest in obtaining cosmetic procedures.
Researchers at the University of Arizona have made groundbreaking discoveries about levodopa-induced dyskinesia, a common complication in Parkinson's disease patients. The study found that the motor cortex becomes disconnected during dyskinetic episodes, leading to indirect causation rather than direct involvement.
Researchers at NIH have identified a novel class of anti-malaria antibodies that target previously untargeted regions of the parasite. These antibodies have shown promise in providing protection against malaria parasites in animal models and could lead to new prevention methods.
A recent study by Mizzou researchers found that nursing home residents with Alzheimer's disease or related dementias are more likely to experience avoidable hospital transfers due to a mismatch between care provided and personal preferences. Increasing staff support, training, and resources can help improve outcomes for these residents.
A new study found that nearly half of high-risk prostate cancer patients have metastatic disease when evaluated with advanced PSMA-PET imaging, suggesting traditional imaging may underestimate cancer spread. This challenge the interpretation of previous studies like EMBARK trial, and support the inclusion of PSMA-PET for patient select...
A new study published in Nature Medicine shows that AI-based models can accurately identify ovarian cancer in ultrasound images, achieving an accuracy rate of 86.3%. The models also reduce the need for expert referrals and misdiagnosis rates by 63% and 18%, respectively.
Researchers have created a new circuit model that accounts for small changes to the sensor's behavior, allowing it to detect protein or DNA molecules from a sample. The device could lead to earlier diagnosis of diseases and more precise therapies tailored to each patient.
Researchers at the University of Pittsburgh developed a non-invasive nasal swab test that diagnoses specific asthma subtype, or endotype, in children. The test, published in JAMA, shows promise for improving asthma treatment outcomes and paving the way for better treatments for lesser-studied asthma types.
The January issue of the American Journal of Psychiatry explores the use of psychedelic medications in psychiatry, addressing basic pharmacology, clinical efficacy, and public health considerations. The series of articles aims to provide sufficient evidence for therapeutic strategies utilizing psychedelic drugs.
Emory University MD candidate Fayzan Rab's research investigates the economic and public health implications of psychedelic therapy implementation. His work emphasizes making these innovative treatments accessible to traditionally underserved communities.
Researchers found that older adults with weakened immunity developed fewer antibodies against RSV following vaccination compared to healthy individuals. The study suggests that adjuvant-enhanced vaccines could improve immune responses in immunocompromised people, warranting further investigation.
A cohort study found a decrease in localized invasive breast cancer and regional invasive breast cancer since the 2009 guideline changes, but no decrease in advanced cancer stages. Further research is needed to understand these trends.
A study from the University of Gothenburg found that digital healthcare consultations are not reliable enough to assess tonsillitis due to limitations in criteria such as tonsil inspection and lymph node examination. Physical examinations remain crucial for accurate diagnosis and treatment.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
Neuroscientist Inga Neumann discusses groundbreaking research on oxytocin, a neuropeptide that shapes social behavior and emotional responses. Her work has significant implications for treating social anxiety disorders and understanding stress resilience.
The study identified 105 compounds in Shenqi Fuzheng extract, with organic acids and amino acids showing higher concentrations in the bloodstream. Compounds such as Astragalosides promptly enter the bloodstream within 5 minutes after administration.
A study by the National Center for Supercomputing Applications aims to create personalized nutrition plans based on an individual's unique gut microbiome. The researchers used Illinois Computes to analyze metabolomic data and develop a database of metabolites that can help diagnose diseases more efficiently.
A Rutgers-led study of heart-attack patients with anemia found that more liberal blood transfusions can save lives at six months. The analysis combined data from four clinical trials involving 4,311 patients, suggesting a reduced risk of death at six months with more transfusions.
Researchers developed a non-invasive way to assess fat composition around the heart using magnetic resonance imaging. This technique may help doctors identify patients at greatest risk for cardiac problems and predict treatment outcomes.
Early treatment with TNF inhibitors has been shown to prevent complications in kids with Crohn's disease, reducing the risk of perianal fistulas by 82%. The study found that anti-TNF drugs are specifically effective in preventing these debilitating complications, making them a recommended first-line therapy.
A systematic review of data on 2.4 million adults from 69 countries established international norms for handgrip strength, ranking strength into five categories: low, somewhat low, moderate, somewhat high, and high. The new framework enables clinicians to identify people at risk of poor health and track changes in strength over time.
The DFG is investing €30 million in eight new research units tackling pressing issues such as quantum materials, macrophage biology and language convergence. The new units will focus on innovative directions in their respective fields.
Researchers at Karolinska Institutet used AI to analyze brain images from 70-year-olds and found that factors like inflammation and high glucose levels are associated with an older-looking brain. A healthy lifestyle, on the other hand, was linked to brains with a younger appearance.
The RELIEF ureteral stent has achieved FDA clearance as the first and only stent to prevent vesicoureteral reflux. It features a unique suture design that allows natural opening and closing of the ureteral orifice, preventing reflux and discomfort.
NCSA is leading the way in AI research support, partnering with the National Artificial Intelligence Research Resource Pilot and the NSF-Simons SkAI Institute. The organization is also working on healthcare projects like MarginDX, combining optical imaging technologies with AI screening tools to ensure accurate tumor removal during sur...
Researchers have identified three distinct subtypes of osteosarcoma using advanced mathematical modeling and machine learning. This breakthrough could transform clinical trials and patient care by enabling targeted treatment personalized to individual cancer subtypes.
Researchers at Texas A&M University have developed a skin-like material that can mimic human skin textures and elasticity, simulating conditions for bacterial growth. The Ecoflex-based skin replicas can be used to test wearable sensors and improve catheter designs, potentially reducing the risk of catheter-related bloodstream infections.
A Norwegian study investigates the relationship between volunteers and patients, revealing that intimate disclosures can create an imbalanced dynamic. The researchers emphasize the importance of maintaining professional boundaries to avoid emotional burnout and ensure effective support.
A new study reveals that pregnant and postpartum individuals often have low-quality diets, which can impact their short- and long-term health outcomes. The study found that lower-income women and those with higher body mass indexes tend to have lower diet quality scores.
A recent study published in Social Science & Medicine reveals the complexities of conducting cannabis research in Canada, where researchers face structural barriers and concerns about scientific integrity. The study suggests key solutions to increase public funding, enhance transparency, and promote independence in research.
The Buck Institute and Phenome Health have been awarded up to $52M by ARPA-H to develop a groundbreaking research project that aims to predict and prevent diseases using advanced analytics and AI. The project, known as PATH, will utilize machine learning and digital wearables to create personalized recommendations for healthy aging.
Researchers found that protective Lactobacillus microorganisms were present at lower rates in Native American women compared to non-Native women. This disruption in the vaginal microbiome increased the risk of human papillomavirus infection, leading to higher cervical cancer rates among Native American women.
A study led by Henry J. Pownall and Khurram Nasir found a strong link between the amount of free cholesterol in HDL and its accumulation in macrophages, which can contribute to heart disease. The researchers aim to develop new diagnostics and treatments for managing heart disease using HDL-free cholesterol as a biomarker.
A University of Pittsburgh study uses life-cycle assessment to measure the environmental impact of ACL reconstruction and identify opportunities for reduction. The investigation highlights the significant carbon footprint of complex medical processes, emphasizing the need for sustainable innovations in healthcare.
Researchers at Waseda University found that somatosensory electrical stimulation on the wrist can bias subsequent motor decisions, increasing the likelihood of using the stimulated hand. This phenomenon highlights a connection between sensory input and motor choices, with potential implications for individuals with motor impairments.
Researchers have developed a new diagnostic test that uses two markers found in the synovial fluid of patients' joints to differentiate osteoarthritis from inflammatory arthritis. The algorithm, based on the ratio of cartilage oligomeric matrix protein and interleukin-8, has been validated with high accuracy.