Articles tagged with Clinical Research
A new study reveals that pregnant and postpartum individuals often have low-quality diets, which can impact their short- and long-term health outcomes. The study found that lower-income women and those with higher body mass indexes tend to have lower diet quality scores.
A recent study published in Social Science & Medicine reveals the complexities of conducting cannabis research in Canada, where researchers face structural barriers and concerns about scientific integrity. The study suggests key solutions to increase public funding, enhance transparency, and promote independence in research.
The Buck Institute and Phenome Health have been awarded up to $52M by ARPA-H to develop a groundbreaking research project that aims to predict and prevent diseases using advanced analytics and AI. The project, known as PATH, will utilize machine learning and digital wearables to create personalized recommendations for healthy aging.
Researchers found that protective Lactobacillus microorganisms were present at lower rates in Native American women compared to non-Native women. This disruption in the vaginal microbiome increased the risk of human papillomavirus infection, leading to higher cervical cancer rates among Native American women.
A study led by Henry J. Pownall and Khurram Nasir found a strong link between the amount of free cholesterol in HDL and its accumulation in macrophages, which can contribute to heart disease. The researchers aim to develop new diagnostics and treatments for managing heart disease using HDL-free cholesterol as a biomarker.
A University of Pittsburgh study uses life-cycle assessment to measure the environmental impact of ACL reconstruction and identify opportunities for reduction. The investigation highlights the significant carbon footprint of complex medical processes, emphasizing the need for sustainable innovations in healthcare.
Researchers at Waseda University found that somatosensory electrical stimulation on the wrist can bias subsequent motor decisions, increasing the likelihood of using the stimulated hand. This phenomenon highlights a connection between sensory input and motor choices, with potential implications for individuals with motor impairments.
Researchers have developed a new diagnostic test that uses two markers found in the synovial fluid of patients' joints to differentiate osteoarthritis from inflammatory arthritis. The algorithm, based on the ratio of cartilage oligomeric matrix protein and interleukin-8, has been validated with high accuracy.
Researchers have discovered that dextromethorphan, an FDA-approved ingredient found in many cough syrups, has potential to treat fibrotic lung disease. The study, published in Science Translational Medicine, showed how dextromethorphan can impede collagen formation, reducing lung scarring and stiffness.
A study found significant racial disparities in child abuse identification, with Black children suspected at higher rates. The findings highlight the need for further research to understand these disparities and reduce them in child abuse treatment.
A new study published in the Journal of the American Geriatrics Society found that older adults with multiple chronic conditions are at a higher risk of declining kidney function. The study followed 3,094 older individuals for 15 years and found an independent dose-response relationship between the number of chronic conditions and kidn...
Dr. Gerta Hoxhaj has been recognized with the 2025 Mary Beth Maddox Award and Lectureship for her groundbreaking work on cancer metabolism. Her research focuses on understanding the connections between signaling networks and metabolic pathways in cancer cells, revealing new mechanisms crucial for tumor growth.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
The new therapy significantly improves three-year disease-free survival for children with B-ALL, with 96% being disease-free for at least three years. Blinatumomab is now being used in most patients due to its practice-changing breakthrough, offering improved quality of life and reduced side effects.
A recent study from Trinity researchers uncovers the mechanisms behind COVID-19 disease severity, highlighting the critical role of low-density neutrophils. The findings suggest that lingering immune abnormalities after recovery could contribute to long-term health effects or complications.
The Davos Alzheimer's Collaborative is partnering with Janssen Research & Development and Beckman Coulter Diagnostics to advance the validation of blood-based biomarkers (BBMs) for Alzheimer's disease. This collaboration aims to develop globally generalizable blood tests that can be used in diverse populations, including those from low...
Researchers at MD Anderson Cancer Center have made significant breakthroughs in smoking cessation treatments, with a study finding that varenicline plus counseling is the most effective treatment for individuals with major depressive disorder. Additionally, a new radiotherapy technique demonstrates effectiveness in treating metastatic ...
A scoping review of community health indices has identified a broad range of indicators covering health outcomes and vulnerabilities. These indices offer potential for multi-factorial assessments to inform regional and local policy strategies, aiming to reduce social inequities and improve community health.
A review of 3,000 studies suggests microplastics in the air may cause serious health problems, including colon cancer, poor lung function, and infertility. The tiny plastic particles are believed to contribute to chronic pulmonary inflammation, increasing the risk of lung cancer.
A new blood-based biomarker, placental growth factor (PlGF), has been identified as a potential tool for detecting early brain changes associated with cognitive impairment and dementia. Elevated PlGF levels were found to be linked to increased vascular permeability, leading to white matter injury and subsequent cognitive decline.
Scientists at the University of Plymouth are creating a humanised meningioma model to study interactions between immune cells and tumour cells, enabling the development of effective therapies for NF2-related schwannomatosis. The model will be made available worldwide to test new treatments and reduce clinical trial delays.
A researcher has defined kindness in healthcare as a set of actions to help others flourish, informed by empathy or proactively chosen. This definition aims to improve patient safety, experiences, and outcome measures by enhancing communication within healthcare teams and with patients.
A new tool developed by Penn State researchers uses computer vision and artificial intelligence to analyze placenta images, detecting abnormalities and risks such as neonatal sepsis. The PlacentaCLIP+ model has the potential to transform neonatal and maternal care in low- and high-resource settings.
A new study found that low to moderate wine drinking reduces the risk of serious cardiovascular disease by 50% in people at high risk who follow a Mediterranean diet. The researchers measured tartaric acid in urine to provide an objective measure of wine consumption, showing a greater protective effect than previous studies.
A study by UCSF researchers found that language, education, and age affect someone's ability to engage with digital health tools. Young English speakers are most comfortable using digital health tools, but others face barriers due to limited education or language proficiency.
A phase 1/2 clinical trial has demonstrated the safety and effectiveness of the AEF0217 molecule in improving cognitive function in people with Down syndrome. Measured outcomes showed significant improvements in behavioral skills, social interactions, and cognitive flexibility.
A new study published in Psychedelics found that psychedelic therapy facilitators express optimism about benefits while maintaining awareness of potential risks. The research highlights the need for robust safety protocols while maintaining optimism about therapeutic potential.
The Keck School of Medicine of USC has joined the Ryght Research Network to leverage AI tools and optimize cancer clinical trials. The collaboration aims to offer more clinical trials to patients, build new AI tools, and speed up the development of medical treatments.
A study by HKUMed researchers found that patients with poorly controlled type 2 diabetes are more susceptible to severe viral infections due to impaired immune function. Effective glycaemic control is crucial for bolstering anti-viral immunity and reducing health risks.
A new study explores whether CBD can reduce scan-related anxiety in advanced breast cancer patients, finding it was safe but did not significantly change anxiety levels. However, participants who consumed CBD experienced lower anxiety levels after treatment.
A six-year study examining 38 clinical isolates of Cryptococcus found genes and gene alleles associated with disease severity. The research aims to develop new treatments targeting these genetic variations, predicting disease outcomes and improving patient care.
Researchers at Brigham and Women's Hospital and Wyss Institute receive grant to expand diagnostic biomarker search, shedding light on asthma's unexplained causes. The team aims to develop a test distinguishing different forms of asthma, improving treatment courses.
WashU Medicine receives a $10.8 million grant to support cutting-edge leukemia research and renew its SPORE program in blood cancer. The grant will fund four major research studies and a career-enhancement program to train the next generation of physician-scientists.
The five-year national research study will examine the effectiveness of medically tailored meals in reducing gestational diabetes and Type 2 diabetes prevalence among pregnant and postpartum women from historically marginalized communities. Nearly 1,000 participants will be assessed for maternal health outcomes.
Researchers developed an ultra-compact transparent ultrasonic transducer for simultaneous high-resolution ultrasound and photoacoustic imaging. This technology improves diagnostic sensitivity by providing detailed information about tissue vasculature, thereby enhancing early cancer detection.
A new scientific statement emphasizes the need to integrate palliative care into all stages of stroke care, addressing symptoms, psychosocial needs, and end-of-life care. Palliative care can help manage pain and improve quality of life for stroke survivors and their family members.
Researchers aim to advance eye transplantation through cutting-edge technologies and techniques, including cell-based therapies and device development. The six-year project, led by Kia Washington at the University of Colorado Anschutz Medical Campus, seeks to overcome current limitations in whole-eye transplant success rates.
Sylvester Comprehensive Cancer Center offers expert advice on coping with holiday loss and grief. Biological age can predict early colorectal cancer risk, while research advances may lead to a cure for multiple myeloma. Blood cancer experts share insights into new treatments.
A social work graduate has published her research on cognitive decline among refugees, finding that those who have experienced trauma are more likely to suffer from mild cognitive impairment. The study highlights the need for interventions that address these gaps in care and promote healthier aging.
Sage has acquired Mary Ann Liebert, Inc., expanding its portfolio of peer-reviewed journals in biotechnology and life sciences. The acquisition enhances reach and impact, ensuring high-quality science continues to make a difference.
A new AI tool called PlacentaVision can rapidly evaluate placentas at birth to detect abnormalities associated with infection and neonatal sepsis. This could lead to improved health outcomes for both mothers and babies, particularly in areas with limited medical resources.
A new study found that exposure to remote wildfire smoke drifting across the US led to a 20% increase in medical visits for heart and lung conditions. Patients who were older, non-smokers, and more socio-economically affluent were at higher risk on poor air quality days.
A new study detects pre-malignant pancreatic lesions using Diffusion Tensor Imaging (DTI), a form of MRI, which could enable early diagnosis and effective therapies. The detection was successful in both transgenic mice and human samples, opening the way to non-invasive diagnostic tools for PanINs.
A study published in Journal of Pain and Symptom Management found that Reiki therapy resulted in clinically significant improvements in pain, fatigue, anxiety, nausea, and well-being among outpatients with cancer. The study involved 392 Reiki sessions for 268 unique patients, showing a mean improvement of 1.78 in pain and 2.09 in anxiety.
A new study has identified a specific connectivity pattern of brain atrophy in schizophrenia, distinct from brain networks associated with other psychiatric disorders. The findings suggest that this network may be a core characteristic of schizophrenia and could inform treatment plans.
Researchers from Kessler Foundation will evaluate the efficacy of Brain.Q's 'Q Therapeutic System' in a two-year study. The therapy involves electromagnetic stimulation and low-intensity fields to optimize brain adaptation and healing after stroke.
A new study introduces an emotion-based evaluative framework to address the impact of moral distress on professional identity. The research aims to provide insights into how clinicians can navigate moral challenges and calls for institutional education and support.
Researchers found that children with primary ciliary dyskinesia (PCD) are 22 times more likely to have asthma compared to those without PCD characteristics. The study suggests that some children diagnosed with asthma may have undiagnosed PCD, particularly if they exhibit unique respiratory symptoms.
Researchers found that soil contains antibiotic resistance genes that can be transmitted to humans, making it a pressing public health threat. The study reveals how these genes spread through the environment and highlights the importance of understanding soil ecosystems to control antibiotic resistance.
A new study published in Lancet Gastroenterology and Hepatology found that a combined screening approach can detect liver damage in people with type 2 diabetes. The method involves elastography, an ultrasound-based technique, which was found to be willing to be adopted by most patients. Early detection of liver fibrosis is crucial, as ...
Longidaza significantly reduced exertional desaturation and dyspnea, as well as improved distance walked during the six-minute walk test. The drug's effects on exercise tolerance were sustained for over 100 days after treatment.
The discovery of ferroptosis has renewed interest in non-apoptotic cell death mechanisms. While initially studied in cancer, ferroptosis is increasingly implicated in various diseases, including liver injury. However, the liver's robust antioxidant defenses question its widespread applicability.
The University of Arizona Health Sciences has received a second vote of support from Maricopa County, doubling its investment in the Center for Advanced Molecular and Immunological Therapies (CAMI) to $8 million. CAMI will accelerate novel therapies for cancers, autoimmune conditions, and infectious diseases, including COVID-19.
A new study finds that a blood test using phosphatidylethanol (PEth) can detect liver disease caused by excessive drinking, offering a more reliable alternative to self-reported measures. The test has shown strong correlation with Fibrosis 4, an indicator of liver risk, and could be included in routine blood tests.
Five Texas researchers have been honored with the 2025 Edith and Peter O'Donnell Awards for their innovative breakthroughs in small cell lung cancer, lithium-ion battery technology, and galaxy discovery. Lauren Averett Byers is being recognized for her work on novel therapeutic strategies for SCLC, while Caitlin M. Casey is exploring p...
Researchers at Chung-Ang University have identified a crucial role for specific tRNA fragments in cancer progression, revealing their ability to regulate gene expression and influence tumor growth. The study suggests that these fragments could serve as biomarkers for early-stage cancer detection and targets for therapeutic interventions.
A new noninvasive imaging method developed by MIT researchers can penetrate deeper into living tissue than previous techniques, producing richer and more detailed images. This breakthrough enhances biological research capabilities, enabling scientists to study immune responses and develop new medicines with greater accuracy.
Consuming 20-30% of daily energy at breakfast is associated with lower body mass index, smaller waist circumference, significantly lower triglyceride levels, and higher HDL cholesterol. A high-quality breakfast with proper balance of proteins, fats, fiber, and nutrients also contributes to reducing cardiovascular risk factors.
Fogarty's research aims to monitor language function and recovery in post-stroke patients using DOT. She hopes to establish the feasibility of brain-computer interfaces to restore inter-personal communication for post-stroke patients.
MELD 3.0 builds upon previous variants by incorporating serum albumin and gender to correct disparities in organ allocation, particularly for women. It demonstrates improved prognostication for various chronic liver diseases, including cirrhosis, hepatocellular carcinoma, and acute-on-chronic liver failure.