Articles tagged with Clinical Research
Researchers have found that B7-H4 helps ACC tumors evade the immune system, leading to poor survival outcomes. A new drug targeting B7-H4 showed promising results in shrinking tumors in aggressive cases.
Researchers at the University of Bonn are developing an AI foundation model to improve radiology and detect Parkinson's disease earlier. The 'Re-Start PD' project aims to identify the condition before symptoms appear, with potential applications in diagnosis, treatment, and prevention.
A scoping review found associations between myositis disease activity and gluten exposure in patients with inflammatory myopathies and celiac disease. The study suggests that gluten may act as an exogenous antigen driving myositis in genetically predisposed patients.
Researchers have identified UBA1 enzyme as key mediator for immune response to tumors, inhibiting its activity increases T-cell recruitment and lowers tumor resistance. Pairing UBA1 inhibitors with immune checkpoint blockade therapies may make immunotherapy more effective for patients with 'cold' tumors.
Mass General Brigham researchers presented research discoveries and outcomes from clinical trials on immune thrombocytopenia, early phase therapies, myeloproliferative syndromes, advances in treatment of lymphomas and leukemias. A novel prognostic score for relapsed/refractory mature T-cell and NK-cell lymphomas was also developed.
Dr. Seymour Reichlin's centennial celebration highlights his ongoing scientific impact, with recent collaborations yielding new insights into hormone therapies for cognitive enhancement and emotional homeostasis. His work has established neuroendocrinology as a distinct field, bridging neuroscience, endocrinology, and clinical medicine.
PCORI awards $156 million for new CER studies on sleep interventions, care for people with intellectual disabilities, and maternal health. The funding will support evidence gaps in these areas, enabling patients to make informed decisions about their health.
The FAU Marcus Institute of Integrative Health will broaden its services, enhance educational programs, and expand community wellness initiatives with the new grant. The institute aims to demonstrate the effectiveness of comprehensive integrative health as the optimal approach for achieving overall well-being.
A new study will evaluate the benefits and risks of endovascular thrombectomy for patients presenting beyond 24 hours. The trial aims to provide deterministic evidence of clinical benefit due to addition of endovascular thrombectomy to standard medical care.
Combining PVA with a boron-containing compound improved the effects of radiation therapy for cancer, making it more selective of tumor cells and prolonging drug retention. This breakthrough could lead to more effective treatment options for challenging cancers.
Researchers identified iTBS over the left dorsolateral prefrontal cortex as the most effective method for treating adults with schizophrenia, improving negative and cognitive symptoms. The treatment approach was well-accepted and well-tolerated by participants.
A retrospective study of over 6,200 patients found that spinal manipulative therapy significantly reduced the need for butalbital prescriptions and medication overuse headache. Patients receiving SMT were also less likely to develop MOH, with only 1.7% prescribed butalbital compared to 3.8% in non-SMT groups.
A study at Hospital for Special Surgery found that both robotic-assisted navigation and augmented reality techniques demonstrate superior accuracy in pedicle screw placement, with 99.6% of robotic screws rated as Grade A or B and 92.6% of augmented reality screws achieving the top rating.
Researchers found that tumor cell secreted DNA in extracellular vesicles acts as a 'danger' signal to activate an anti-tumor response in the liver, reducing liver metastasis risk. The discovery improves understanding of cancer progression and anticancer immunity.
Professor Lavretsky's pioneering work integrates conventional psychiatric treatments with mind-body interventions, developing novel therapeutic combinations for treatment-resistant depression and cognitive disorders. Her research has transformed approaches to mental health and aging, emphasizing whole person health and prevention.
A team of researchers discovered a novel cause of cytokine storm in fatal COVID-19 cases, linking the renin-angiotensin-aldosterone system (RAAS) to the hyperinflammatory response. This finding holds potential for identifying patients at risk and developing targeted interventions.
The ESMO Immuno-Oncology Congress 2024 will present key findings on new therapeutic opportunities and management of treatment-related toxicities. Leading experts will share their research advancements in the rapidly evolving field of immuno-oncology.
A Kennesaw State University professor has received a grant to analyze the relationship between access to cancer treatment and patient outcomes in Kenya. The research aims to identify cost-effective and sustainable treatment protocols that improve survival rates and address financial barriers to care.
A new study reveals that lung cancer screening CTs can detect coronary artery disease in 83% of cases, with high levels found in 30%. This finding highlights the potential benefits of lung cancer screening for identifying and managing cardiovascular risk factors.
Researchers found that increasing levels of the naturally occurring endocannabinoid 2-AG can counteract the rewarding properties of opioids, reducing addiction-like behaviors in mice. The study suggests a potential new therapeutic strategy to alleviate pain while minimizing opioid addiction risk.
A large-scale clinical trial involving over 9,000 patients reveals that text message reminders failed to improve medication refill adherence over a year. The study included diverse representation from subgroups, including females, Hispanic ethnicity, and Spanish-speaking patients.
SynGAP Research Fund appoints Virginie McNamar as President and COO, bringing extensive Rare Disease advocacy experience. The organization aims to accelerate progress with robust organizational structure and strategic focus.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
CNIO researchers have identified significant inaccuracies in widely used epigenetic clocks, which are now being refined by the team. The new epigenetic clock model provides more accurate measurements, reducing errors by up to 25 years for some tests.
This editorial introduces persistence landscapes as a mathematical method to identify and correct biases in medical imaging. Persistence landscapes offer a way to reduce random noise while preserving important details, making it easier for clinicians to focus on meaningful image parts.
The SONIA trial found that delaying and shortening CDK4/6 inhibitor treatment in patients with hormone receptor-positive advanced breast cancer leads to similar survival outcomes while reducing toxicity and cost by €45 million per year. This innovative approach could reduce the burden on healthcare systems worldwide.
A recent clinical trial has revealed a twice-yearly injection of Lenacapavir to be 96% effective in preventing HIV infection, surpassing daily oral PrEP. The study included racially and ethnically diverse participants, highlighting the need for more options in HIV prevention.
A clinical study found increased permeability of the small intestine and inflammation in the gut, linked to higher body weight and insulin resistance. The researchers emphasize the need for further investigations into carrageenan's effects on human health.
The review explores the pathophysiological relationship between OSA and MetS, revealing a complex cycle of increased cardiovascular risks. Treatment options, including CPAP, weight management, and metabolic surgery, are discussed for improving patient outcomes.
A comprehensive epigenetic database of over 200 malignant cell lines has been developed, offering valuable insights into leukemia and lymphoma. The database allows researchers to predict drug sensitivity based on epigenetic lesions, aiding in tumour diagnosis and treatment.
A systematic review of 18 randomized controlled trials found that drinking enough water can help with weight loss and prevent kidney stones. Drinking eight cups a day significantly decreased the likelihood of getting another kidney stone, while six cups a day helped adults lose weight.
Researchers develop gene therapy to improve placental function, which can lead to healthier babies and adults. The treatment involves nanoparticles loaded with DNA that encodes for a human protein, and has shown promise in short-term studies with monkeys.
Researchers found impaired PD-1 activity can significantly reduce antibody diversity and quality in memory B cells. This may explain the increased rates of infection reported in patients with cancer receiving checkpoint inhibitor therapy.
Researchers developed MoPEDE, a method combining genetic data and brain activity to pinpoint epileptic seizure origins. This approach offers deeper insights into epilepsy mechanisms, potentially leading to personalized treatments.
Children's Hospital of Philadelphia researchers discovered a gene signature that identifies patients with T-ALL at high risk of relapse. The study found a potential therapeutic treatment, venetoclax, which targets specific cells associated with poor outcomes.
Researchers found pandrug-resistant Klebsiella pneumoniae in Ukrainian war victims, showing high virulence and rapid spread. The bacteria's ability to cause disease remains despite antibiotic resistance.
The Gustave Roussy Prize recognizes scientists whose work improves cancer treatment and patient outcomes. Established by Pierre Fabre Laboratories, the €200,000 award aims to push boundaries of oncology and offer personalized treatments.
Researchers developed a platform to produce mature, uniform organoids using a three-dimensional engineered membrane. This breakthrough enables consistent quality and improved efficiency for practical applications in clinical trials and drug development.
A new study published in JAMA found that women who experience severe maternal morbidity during their first pregnancy are less likely to have more children. The research, which studied over a million women in Sweden, revealed that such events can have a lasting impact on fertility.
Researchers used fitness tracker data and machine learning to detect bipolar disorder mood swings with 80.1% accuracy for depression and 89.1% accuracy for mania. The study's findings move the field toward personalized algorithms suitable for all patients, regardless of compliance or device access.
Researchers developed an adapted nominal group technique (aNGT) to efficiently build consensus among diverse stakeholders, prioritizing key domains and identifying new care indicators. The approach was effective in reaching a consensus on prioritizing symptoms, functioning, and quality of care.
The Deutsche Forschungsgemeinschaft is establishing seven new Collaborative Research Centres (CRC) with a total funding of €92 million. The CRCs focus on innovative research projects in sustainable construction, electronic systems, and ecosystem services. Seven new Transregios are also being funded to tackle long-term challenges.
The ECOG-ACRIN Cancer Research Group has appointed seven researchers to lead committees in its scientific program, focusing on breast cancer, genitourinary cancer, and immunotherapeutics. The appointments underscore the group's commitment to cancer research excellence and premier professional opportunities for researchers.
University of Würzburg researchers Hermann Einsele, José Pedro Friedmann Angeli, Ronny Thomale, and Christoph Wanner have been named Highly Cited Researchers by Clarivate Analytics. Their work in medicine and cell biology has garnered significant attention, with Einsele's research on cancer immunotherapy and Angeli's studies on ferropt...
Researchers found that middle meningeal artery embolization reduces treatment failure rates in chronic subdural hematoma patients without increasing short-term stroke risk. The study's findings emphasize the need to update treatment protocols in the field, making MMAE a beneficial adjunctive treatment for eligible patients.
Researchers explore adapting agricultural techniques, such as integrated pest management, to treat cancer. By managing cancer as a chronic condition, adaptive therapy aims to overcome treatment resistance and improve patient outcomes.
Researchers at Mass General Brigham developed an AI tool called EVOLVEpro that can engineer proteins to be more stable, precise, and efficient. The tool has shown promise in improving medications used for treating autoimmune diseases, genetic diseases, and cancer.
A cohort study found that a prenatal diet aligned with US Dietary Guidelines was linked to slower infant growth rates and lower obesity risk. The study suggests that improving prenatal nutrition may also benefit children's growth trajectory in the long term.
A $6 million grant from the California Institute for Regenerative Medicine is driving research into a new treatment for dry age-related macular degeneration, a leading cause of blindness in older adults. The therapy aims to halt or reverse disease progression using stem cell-derived healthy retinal pigment epithelium cells.
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
A study by the American Academy of Neurology found that people with neurological conditions face disparities in telemedicine use based on their age, race, ethnicity, and neighborhood. The research showed that white people were more likely to use telemedicine than Black and Hispanic populations.
A team of researchers at the University of California San Diego has developed a clinically validated, wearable ultrasound patch for continuous and noninvasive blood pressure monitoring. The device offers precise, real-time readings of blood pressure deep within the body, providing detailed trends in blood pressure fluctuations.
New research highlights additional therapies being tested for hypoxic-ischemic encephalopathy (HIE) in newborns, including agents blocking glutamate receptor activation and antioxidant drugs. While therapeutic hypothermia is effective in high-income countries, its efficacy is uncertain in low- and middle-income nations.
A new UCLA study categorizes people with chronic liver disease into four unique risk groups based on barriers to outpatient care, increasing the likelihood of hospitalization. The study highlights the need for interventions aimed at reducing avoidable hospitalizations among the highest-risk individuals.
Research from the University of Surrey found a clear association between high nurse and doctor turnover rates and increased patient mortality rates. A one standard deviation increase in nurse turnover is associated with 35 additional deaths per 100,000 hospital admissions within 30 days.
Researchers at UVA discovered the heart reacts to viral infections in one of three ways, with specific gene patterns indicating healing or damage. This finding may lead to better treatments for people at risk of heart failure and other chronic conditions linked to viral infections.
A clinical trial testing muvalaplin, a novel oral medication, safely and effectively lowered high levels of Lp(a), a type of inherited cholesterol. The study found that muvalaplin disrupted the formation of the Lp(a) particle, acting as an effective approach to lowering Lp(a) levels.
Researchers developed a novel model predicting mood episodes using only sleep-wake pattern data from wearable devices. The study found daily changes in circadian rhythm are key predictors of mood episodes, offering new possibilities for tracking individual changes to prevent future episodes.
Researchers developed a novel lentivirus-based gene therapy strategy in CD34+ hematopoietic progenitor cells, which showed therapeutic levels of expression of the anti-sickling beta globin protein. Cyclosporin improved transduction efficiency and preserved cell viability.
A new study from Karolinska Institutet found that long-term use of common cardiovascular drugs is associated with a lower risk of dementia. The study, which analyzed data from over 880,000 people, shows that these medications can reduce dementia risk by 4-25%.