Articles tagged with Clinical Research
The new CAMP 2.0 tool provides personalized medicine for managing allergic contact dermatitis by generating safe lists based on individual patch testing results. It offers thousands of product options and interactive tools to help patients find safe products, track their quality of life, and understand their allergens.
A new study introduces the Meuhedet Electronic Frailty Index (MEFI) to assess frailty in older people and identify those at risk for serious health outcomes. The index classifies individuals as 'fit,' 'mildly frail,' or 'severely frail' and has been shown to predict mortality and hospitalization with high accuracy.
Acute interstitial nephritis (AIN) is a common cause of acute kidney injury, often linked to medication use. Johns Hopkins researchers developed an electronic diagnostic model using machine learning to predict AIN in patients, showing improved accuracy in diagnosis and potential benefits for treatment decisions.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with advanced small cell bladder cancer and small cell/neuroendocrine prostate cancer. The study found that the combination treatment resul...
The review explores the impact of extracellular matrix (ECM) geometry on immune cell behavior and treatment efficacy. Specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), create physical barriers that limit immune cell access to tumors.
A new study published in JAMA Network Open found that brief cognitive behavioral therapy via video telehealth reduces suicide attempts and suicidal ideation, providing critical insight into treatment options for those struggling with suicidal thoughts. The study also shows that this therapy is effective in reducing depressive symptoms.
Researchers at Mount Sinai trained an AI algorithm on over 16 million seconds of video footage from newborns in the NICU to predict sedation and cerebral dysfunction. The study shows promise for a minimally invasive, scalable method for continuous neurologic monitoring.
AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.
A recent study presented at the American Heart Association's Scientific Sessions 2024 found that heart attack survivors experience significant fear and anxiety about having another heart attack. The fear can be triggered by various factors, including new health information and lack of follow-up care. The study highlights the need for e...
A new study found that obesity-related heart disease deaths increased by 180% in the US over two decades, with significant disparities among middle-aged men, Black adults, and residents of Midwestern states. The analysis also revealed unexpected patterns, such as Vermont having the highest death rate for obesity-related CVD deaths.
A new version of the MESA heart disease risk score that doesn't include race predicts heart disease risk just as well as the original score. The study aims to assess the implications of including race in clinical risk prediction models and broaden their potential use.
A preliminary study of over 4,000 pregnant individuals found that socioeconomic status during early pregnancy may explain most of the disparities in cardiovascular health among women from different racial and ethnic groups. The study suggests that addressing social determinants of health can help eliminate these disparities.
The editorial highlights how digital tools improve patient outcomes through better monitoring, individualized care, and seamless communication between patients and healthcare providers. Digital health innovations also address key challenges such as data privacy and accessibility.
Research suggests that GLP-1 receptor agonists and SGLT2 inhibitors, commonly prescribed for Type 2 diabetes or weight loss, may lower the risk of heart attack and recurrent stroke in adults who have had an initial stroke. The study analyzed data from over 7,000 adults with ischemic strokes between 2000 and 2022.
Scientists are investigating whether resveratrol, a compound found in red grapes, can prevent bowel cancer. The COLO-PREVENT trial is testing multiple potential prevention drugs, including aspirin and metformin, to see if they can slow down tumour growth and reduce the risk of bowel cancer.
Researchers at Tel Aviv University found that a special protocol of hyperbaric oxygen therapy can improve the condition of PTSD sufferers, reducing typical symptoms such as flashbacks, hypervigilance, and irritability. The study showed improvements in brain connectivity and clinical symptoms, offering new hope for millions of PTSD suff...
The American Heart Association has announced five health technology start-up companies as finalists in its 7th annual Health Tech Competition. The competition aims to drive technological advancements with the potential to transform heart and brain health patient outcomes.
Researchers at MD Anderson Cancer Center present promising new treatments, including a gastric cancer therapy using T cell antigen coupler technology. Additionally, COVID-19 mRNA vaccines are shown to improve responses to immune checkpoint inhibitors in patients with non-small cell lung and melanoma cancers.
Researchers at Mass General Brigham developed an AI algorithm to identify long COVID cases in patients' health records, revealing a higher prevalence rate than previously thought. The tool uses 'precision phenotyping' to sift through individual records and track symptoms over time, reducing bias in diagnosis.
University of Cincinnati researchers highlight the importance of emergency consent in acute stroke trials due to time-sensitive nature and high mortality rate. They argue for more efficient alternatives to traditional informed consent, emphasizing patient autonomy and beneficence.
The institute will accelerate discovery and development of cell therapies, integrating MD Anderson's unique research expertise to advance impactful treatments. Key findings include successful CAR T cell therapy approvals and preclinical studies in solid tumors.
A longitudinal study found that bacteria associated with inflammation in the gut increases ten months before patients develop clinical rheumatoid arthritis. Researchers are exploring potential treatments at this early stage to prevent disease progression.
Researchers identify biomarker Ki67 that indicates whether treatment with vedolizumab will be successful. The biomarker can help predict which patients are more likely to respond to the form of treatment, allowing for more targeted use and potentially improving patient outcomes.
Clinicians should avoid using 'never words' that can scare, offend, or diminish agency in patients and families dealing with serious illness. Researchers recommend alternative language and methods for clinicians to identify their own never words.
Researchers found that hip implants with delta ceramic or oxidised zirconium head and highly crosslinked polyethylene liner or cup had the lowest risk of revision during 15 years after surgery. The study used data from over 1 million hip replacement patients in England and Wales to identify optimal implant materials.
A groundbreaking 25-year research program has unveiled key insights into how our brains age and what factors influence cognitive performance throughout life. Childhood cognitive ability is found to be a significant predictor of intelligence test scores in older age.
A longitudinal cohort study found no significant associations between prenatal SARS-CoV-2 infection and child neurodevelopment outcomes in the first two years of life. Follow-up research is needed to determine if these effects persist into later childhood.
A new hourglass-shaped stent could improve blood flow and alleviate severe chest pain in people with microvascular disease. The study found that 76% of participants experienced improvement in their daily activities, including walking and climbing stairs without pain.
A collaborative study led by Dr. Julie St-Pierre at the University of Ottawa found that promoting mitochondrial elongation in cancer cells hobbles their ability to metastasize. The research team identified a common signature that could help determine which pathways lead to decreased metastasis.
Researchers at UCSD found psilocybin therapy reduces eating disorder psychopathology and improves quality-of-life in patients with anorexia nervosa, but results vary widely among individuals. Genetic variations may influence treatment outcomes.
Dr. Volkow emphasizes the importance of prevention strategies and research on stress, trauma, and social determinants in substance use disorders. She also highlights promising new directions in treatment, including GLP1 medications, to address the treatment gap in addiction.
An independent review highlights complexities in using UK health data to improve people's health and lives, with delays of months or years in accessing data. The Sudlow Review recommends treating health data as critical national infrastructure with leadership and investment to match, enabling safe and secure data use across the UK.
Dr. Silvi Shah has been selected for the 2024 Dr. Nanette K. Wenger Research Goes Red Award for her study 'Sex Differences in Cardiovascular Outcomes in Patients With Kidney Failure', which found women with kidney failure had higher risks of cardiovascular events, but a lower risk of cardiovascular death compared to men.
Dr. Jane Newburger will receive the 2024 Eugene Braunwald Academic Mentorship Award for her extensive mentorship of trainees, early career faculty, and residents, with a focus on pediatric cardiology and Kawasaki disease research.
Researchers at Johns Hopkins Medicine have identified a potential link between donor intestinal epithelial cells and improved outcomes for patients undergoing fecal microbiota transplants. The study found that these cells, which line the intestinal tract, may be responsible for restoring gut health in some patients.
Rice bioengineers create a mathematical model that challenges long-held assumptions about IL-12's behavior in the body, suggesting repeated doses cause immune cells to hoard IL-12 before it reaches the bloodstream. The findings have significant implications for IL-12 therapy design and may lead to more effective dosing regimens.
The new biosensor detects symmetric dimethylarginine in urine, providing a more accurate indicator of kidney health than creatinine. It can identify mild kidney impairment and offers a reliable alternative to blood tests, enabling timely interventions and potential long-term outcomes.
Roderic Pettigrew, a renowned physician, scientist, and engineer, is recognized for his pioneering work in combining medicine and engineering to advance cardiovascular disease research. His recent achievements include developing the Siemens Cima.X MRI scanner to detect heart disease before it occurs.
New research led by the University of Southampton found that vitamin D supplements during pregnancy increase children's bone mineral density in mid-childhood. Children born to mothers who received extra vitamin D supplementation had stronger bones and were less likely to break them.
Dr. Herman Taylor Jr. will receive the Clinical Research Prize for his groundbreaking work on advancing health equity and understanding the interplay between social and physical environments that shape heart disease. His research focuses on the genetic and environmental factors influencing heart disease in Black communities.
Researchers analyzed tumor samples from 64 SCLC patients, identifying promising results for biomarkers DLL3 and TTF-1. These biomarkers showed potential as targets for therapies like Tarlatamab and improved survival rates in patients with TTF-1-positive tumors.
A large multi-ethnic study found that work-related stress was associated with unfavorable cardiovascular health metrics, including lower odds of average and optimal health scores. The study's authors emphasize the need for longitudinal research on stress mechanisms and workplace interventions to improve employee well-being.
A large international study found that very early medication abortion is equally effective and safe as waiting for intrauterine pregnancy confirmation. The study included over 1,500 women who received two drugs – mifepristone and misoprostol – in either a delayed or early abortion group.
Researchers developed a new diagnostic tool called FlowBEAT to measure antibodies in nasal cavities, finding that more than 70% of people with mild or moderate COVID-19 develop protective autoantibodies in the nose. These autoantibodies may play a role in regulating the immune system and preventing excessive inflammation.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
Dr. Gallagher's research focuses on discovering the roles of epigenetic alterations in immune cells, promoting inflammation during disease progression. Her work aims to develop targeted approaches to cardiovascular and cardiometabolic diseases.
A research team led by Sylvain Bouix will analyze data from a clinical trial to better understand the mechanisms of action of new drugs designed to treat psychosis. The development of new data analysis tools could help design clinical trials better adapted to patients' actual needs.
Dr. Lauren Sansing receives the 2024 Basic Research Prize from the American Heart Association for her pioneering work on maximizing potential recovery after stroke and intracerebral hemorrhage. Her research aims to unlock opportunities for people with complex neurovascular diseases to recover their ability to function.
Researchers developed a method to visualize AMPA receptors using PET scans, revealing differences in density and distribution between healthy subjects and those with psychiatric disorders. This discovery may lead to new diagnostic and therapeutic approaches for conditions like schizophrenia, bipolar disorder, and autism spectrum disorder.
Scientists at Johns Hopkins Medicine identified 16 genes that breast cancer cells use to survive in the bloodstream, including MUC1, which is already in clinical trials. The research showed that hypoxic cells are able to migrate to higher oxygen levels and form metastasis in the body, leading to a worse prognosis.
A team of researchers, including Binghamton University's Ahyeon Koh, is working on an innovative project to treat inflammatory bowel diseases like Crohn's and ulcerative colitis. The goal is to create a 'cell factory' in the body that can produce pharmaceuticals to alleviate symptoms.
The JAX-Allentown partnership launches an AI-powered home-cage monitoring system to enhance preclinical research efficiency and improve translatability. The Envision platform captures digital measures of mouse behavior and physiology, promoting animal welfare and superior data quality.
The partnership aims to simplify cooperation in ATMPs and related technologies, promoting research and development within academia, healthcare, and industry. The collaboration will explore opportunities for project and business development, quality-controlled production, and clinical trials.
Dr. Reichlin's groundbreaking work on brain-hormone interactions and his influence on generations of endocrinologists are being celebrated through a Festschrift series in Brain Medicine. The series explores multiple facets of his contributions, including pioneering work on hypothalamic control of pituitary function and early recognitio...
The American Pediatric Society recognizes Dr. Maria Trent's outstanding contributions to advancing child and adolescent health, well-being, and equity through quality improvement, advocacy, practice, or research. Her work has forged many collaborations on various facets of adolescent sexual health across multiple disciplines.
Researchers successfully immortalized lip cells, enabling the development of clinically relevant lab-based models to test treatments for lip injuries and infections. The 3D cell model was tested with Candida albicans yeast, showing promising results for wound healing and infection studies.
Researchers at Case Western Reserve University are studying a new approach to treat multiple sclerosis, focusing on toxic astrocytes that contribute to nerve-cell damage. They aim to develop medicines that prevent the formation of these cells and promote brain repair.
Jeremy D. Walston, MD, of Johns Hopkins University has received the AFAR 2024 Irving S. Wright Award for his groundbreaking contributions to aging research, advancing geriatric medicine and inspiring research across diverse specialties.
A study of over 650,000 patients in Ontario found that nearly a third visited emergency departments in the months leading up to their cancer diagnosis. Most visits were related to symptoms specific to their type of cancer.
The TEDDY study aims to understand the causes of type 1 diabetes in children, finding a connection between enterovirus infection, autoantibodies, and disease development. Probiotics may also reduce risk in infants at high danger of developing diabetes-related antibodies.