Articles tagged with Clinical Research
Brandi Fink's Personal Alcohol Management System (PALMS) uses iPad-based assessments to identify patients with an alcohol use disorder and provide personalized feedback. The system has shown promise in improving patient-provider discussions and reducing drinking levels, with plans for integration into electronic health records.
A meta-analysis of 14 studies reveals that combination lipid-lowering therapy using statins and ezetimibe significantly lowers LDL cholesterol levels and diminishes cardiovascular risks. Early integration of this approach in treatment protocols can substantially curtail mortality and CVD events.
Scientists at Sanford Burnham Prebys developed a new method of generating antibodies by fusing two immune system proteins, enabling the creation of stable monoclonal antibodies. This breakthrough has potential applications in diagnosing and monitoring diseases such as lupus and cancers.
A team of researchers has identified a common brain network that generalized seizures hijack, which is located in the region where deep brain stimulation (DBS) electrodes are placed. This finding could help explain why DBS is effective in alleviating generalized seizures and potentially improve treatment outcomes.
The National Initiative for RNA Biology and Its Applications (NIRBA) aims to strengthen Singapore's RNA research capabilities, focusing on human health and diverse applications. The program will integrate leading institutions and promote interdisciplinary collaborations to achieve groundbreaking scientific discoveries.
Researchers have developed a way to activate adult stem cells from human bone marrow, enabling their expansion outside the body for use in bone marrow regeneration. The new method significantly improves transplant success rates for patients with genetic disorders or those who require a bone marrow transplant.
UC San Diego Health has earned The Joint Commission's Gold Seal of Approval for Advanced Certification in Spine Surgery, reflecting its dedication to patient safety and surgical innovation. The health system continues to provide consultation to other organizations exploring the certification.
A family-based approach to lifestyle interventions significantly improves weight management and cardiovascular health among individuals with a family history of premature coronary heart disease. The study found that participants who received structured lifestyle counseling experienced notable reductions in weight, BMI, and waist circum...
A study confirms plasma p-tau217 as a blood-based biomarker for early Alzheimer's detection in Asian populations. Higher levels correlate with faster cognitive decline, suggesting its potential role as both diagnostic and predictor tool.
A simple urine test has shown promising results in detecting early-stage kidney cancer recurrence, with a high sensitivity and specificity rate. The GAGome test can accurately identify patients at risk of recurrence, potentially reducing the need for invasive scans and enabling faster treatment access.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A new review article identifies major themes in AI application to neurosciences, including a 5-fold increase in AI-related publications. The study also notes a surge of over 13-fold in clinical neurology AI-related publications in the past decade.
A new study found that recombinant adeno-associated virus (rAAV) capsids contain single-stranded DNA impurities derived from plasmid and host cell DNA. The researchers suggest that the adverse effects of these impurities may differ from those of double-stranded DNA, highlighting the need for further evaluation.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
A new study suggests that nearly half of depression diagnoses could be considered treatment-resistant, with 48% of patients trying at least two antidepressants and 37% trying four or more. This highlights the need for better treatment options to support patients who don't respond to first-line medications.
Dr. Amit Bar-Or is awarded the 2025 John Dystel Prize for his contributions to neuroimmunology and precision medicine in multiple sclerosis research. His work has led to significant advancements in disease mechanisms, treatment approaches, and biomarker studies.
Researchers developed DeepCeres, a software that uses AI tools to measure 27 structures of the cerebellum with improved precision. This will help in studying neurological pathologies such as ALS, schizophrenia, and Alzheimer's diseases.
The updated guidelines substantially increased lung cancer screenings overall, but disparities persist among people with limited access to healthcare. Barriers include cost, knowledge, and lack of primary care providers, with mobile units and patient navigators offering potential solutions.
Direct-acting antivirals have reduced HCV-related morbidity and mortality, but hepatocellular carcinoma (HCC) risk persists in certain populations. Risk factors include pre-treatment cirrhosis, metabolic disorders, and advanced fibrosis, highlighting the need for tailored surveillance strategies.
A new AR navigation system for EVD placement shows improved accuracy and reduced complications compared to the freehand technique. The system enables precise 3D guidance and real-time feedback during drilling, reducing errors and improving outcomes.
Researchers have confirmed the presence of xylazine in Tijuana's illicit drug supply, posing severe health risks due to sedation, withdrawal syndromes, skin infections, and wounds. The study highlights the need for public health intervention and expanded surveillance to mitigate the spread of xylazine in the region.
Research suggests flavonoids improve insulin sensitivity, enhance β-cell function, modulate the gut microbiota, inhibit gluconeogenesis, and regulate enteroendocrine hormones in type 2 diabetes management. Flavonoid-specific effects on GLP-1, GIP, PYY, and CCK secretion contribute to improved glycemic control.
Recent research highlights the crucial role of circadian rhythms in tumor biology, demonstrating their contribution to tumorigenesis, progression, and metastasis. Disruptions in these rhythms also influence the tumor immune microenvironment and the efficacy of anticancer therapies.
UTEP researchers have developed a new diagnostic method that significantly enhances the sensitivity of parasite detection in blood samples, making it a more reliable indicator of parasites in the blood. The method uses magnetic beads to extract parasitic DNA from blood samples, outperforming traditional silica columns.
The Systems Metabolomics Centre will focus on three key areas: profiling populations of healthy people and those living with specific illnesses, leveraging state-of-the-art metabolomic technologies to drive biomarker discovery and metabolism research. The centre aims to develop non-invasive tests, detect diseases earlier and guide doct...
Dr. Kiely N. James received the 2025 Richard King Award for her published article on genome sequencing and its clinical relevance. The award aims to encourage high-quality research in Genetics in Medicine, an official journal of the American College of Medical Genetics and Genomics.
Dr. Monica Wojcik, a neonatologist and clinical geneticist, receives the prestigious award for her innovative research and clinical practice focused on rare diseases affecting fetuses and newborns. Her work aims to improve diagnosis, treatment, and health services for families affected by these conditions.
A new study suggests that ACLR patients have a higher riding patella, shifting load-bearing areas and potentially contributing to osteoarthritis. This finding is observed in both the injured knee and the uninjured contralateral knee.
A study of top 100 ADHD TikToks found that fewer than half of claims about ADHD symptoms aligned with clinical standards. Young adults' perceptions of the informational value of these videos differed from those of psychologists, leading to a potential spread of misinformation.
Researchers found that patients who received non-compliant care had more complex medical conditions and were more likely to present with unusual symptoms. The study's findings challenge the assumption that SEP-1 compliant care is associated with better survival, highlighting the need for risk-adjusted outcome measures.
A novel fluorescent biosensor captures spatio-temporal dynamics of STING activation in response to aberrant DNA, enabling visualization of single cell and population responses. This study reveals new insights into the immune response to chromosomally unstable tumours and potential avenues for treatment.
The Chinese Medical Association has released updated guidelines for pediatric mycoplasma pneumoniae infection, emphasizing a multi-faceted diagnostic approach and evidence-based treatment strategies. The guidelines highlight the importance of accurate diagnosis and responsible antibiotic use to combat rising resistance.
A University of Cincinnati study found that machine learning models can aid clinicians in treating patients with spreading depolarizations (SDs), a condition that can cause significant brain damage. The algorithm was able to identify SD events with high sensitivity and specificity, detecting many events not identified by human scoring.
Researchers developed an automated MRI processing and machine learning software to diagnose Parkinson’s disease, reducing diagnostic time by up to 96%. The software uses diffusion-weighted MRI and a noninvasive biomarker technique to identify neurodegeneration in the brain, providing more precise diagnoses.
Researchers found that digital games effective in reducing drinking, smoking, and illicit drug use among adolescents when personalized to individual players, had social components, and included content encouraging behavior change.
Scientists have developed a low-cost and easy-to-use diagnostic tool for assessing cardiovascular disease risk using molecular blood screening. The technology enables high-throughput analysis of key lipoprotein markers in under 15 minutes, providing clinicians with a rapid and reliable diagnostic tool.
A new Concordia-developed app, iSurgARy, uses augmented reality to guide catheter insertion into the brain, improving ventriculostomy safety and accuracy. The app provides spatial awareness of patient anatomy, allowing surgeons to better aim at their target points.
CHEST MedCast offers over 400 videos and podcasts with personalized content recommendations, available on-demand and at any time from any device. The platform features an algorithm-based recommendation engine and up to 100 available CME credits/MOC points.
The Endocrine Society calls for the reinstatement of the Diabetes Prevention Program, which has been halted by government funding cuts. The program, spanning three decades, found that lifestyle changes or metformin could prevent or delay type 2 diabetes in at-risk individuals, with a notable 58% risk reduction through 5%-7% weight loss.
A study of 733 older female participants found that those with increasing sleepiness had double the risk of stable sleepers. Poor sleep quality in midlife and delayed dream phase are also linked to a higher risk of dementia. The study adds to recent research on the relationship between sleep patterns and dementia.
A new study found that doctors and patients agree on the urgency level of emergency department visits only about 38% to 57% of the time. Researchers explored concordance between discharge diagnoses and reasons for visit, finding that nearly 40% of visits are not medical emergencies.
Researchers found that lower doses (20mg) and higher doses (100mg) of doxycycline were equally effective in treating lymphocytic scarring alopecia, a rare skin condition causing permanent hair loss. The low-dose regimen resulted in fewer side effects and no compromise on efficacy or anti-inflammatory benefit.
Researchers from HKU discover critical molecular changes that drive metastasis to lymph nodes and suppress immune responses, offering promising avenues for new treatment approaches. The study highlights the role of the protein POSTN and TGF-β signaling in tumor progression and immune evasion.
Researchers found that curcumin enhances the effectiveness of bedaquiline in combating M. abscessus infections, with the combination showing synergistic enhancement of antibacterial activity. The study suggests potential new treatment pathways for resistant infections, particularly in immunocompromised populations.
Researchers developed an AI tool called Unfold AI to accurately estimate prostate tumor volume and identify patients likely to benefit from partial gland cryoablation. This approach shows promise in reducing treatment failures by over 70% and improving patient outcomes.
Researchers have identified distinct protein degradation patterns in key brain regions for individuals who witnessed trauma, differing from those who experienced it firsthand. Sex-specific differences also emerge, with implications for targeted treatments and a better understanding of PTSD development.
A new study confirms that a shorter, higher-dose-per-day radiation course is as effective as conventional radiotherapy for treating early-stage prostate cancer without increasing side effects. The study found similar cancer control rates and fewer gastrointestinal issues with the new approach.
Researchers found that giving plasma, rather than whole blood, improves outcomes in patients with traumatic brain injury (TBI) or shock. Plasma recipients had distinct proteomic profiles associated with later stages of clot formation, neuron survival, and wound repair.
Researchers at the University of Virginia Health System have developed a computational tool called LogiRx that can predict how drugs will affect biological processes in the body. The tool has demonstrated its potential by identifying a promising candidate to prevent heart failure, a leading cause of death worldwide.
The WIN Consortium is transforming cancer care through personalized medicine, leveraging AI, molecular profiling, and clinical trials. The organization's innovations, including N-of-1 clinical trials and WINTHER and WINGPO trials, are helping clinicians make more precise treatment decisions and improving outcomes for cancer patients.
A Rice University statistician has received a $1 million CPRIT award to advance AI-powered precision medicine for prostate cancer. The project aims to identify lethal forms of prostate cancer earlier and improve treatment selection using AI tools and advanced imaging techniques.
A new study from Karolinska Institutet found that patients with heart failure who stop taking medications like RASi, ARNi, or MRA have a higher risk of heart-related death or hospitalization. Despite improved symptoms and pump function, continued medication is crucial to prevent complications.
A new study found that adenotonsillectomy, a surgical procedure for enlarged tonsils and adenoids, significantly reduces medical office visits and prescription medicine use in children with mild sleep-disordered breathing. The surgery was associated with a 32% reduction in healthcare encounters and a 48% reduction in prescriptions.
A new study by Penn State researchers found that consuming pecans instead of usual snacks improved cholesterol levels and enhanced overall diet quality. Participants who ate pecans demonstrated reductions in cholesterol measurements linked to poorer heart health and higher adherence to the Dietary Guidelines for Americans.
Researchers found that suppressing ZNF638 triggers an antiviral immune response in glioblastoma patients, making them more susceptible to treatment. This finding offers a potential new treatment strategy for the disease, which has remained challenging despite recent advances in immunotherapy.
Virginia Tech researchers Pamela VandeVord and Gunnar Brolinson received a $2.17 million grant to investigate cranial osteopathic manual manipulation as a potential treatment for traumatic brain injury symptoms, particularly headaches. The noninvasive technique aims to enhance brain fluid motion and balance the autonomic nervous system.
A recent NIH-supported clinical trial found that adenotonsillectomy significantly reduces medical office visits and prescription medicine use in children with mild sleep-disordered breathing. The surgery was tied to a 32% reduction in health care encounters and a 48% reduction in prescriptions used among participants.
Researchers from HKUMed identified Chchd10 as a novel regulator of adipose tissue homeostasis, accelerating subcutaneous fat formation and regulating antioxidant capacity. The study suggests that targeting Chchd10 levels could be a potential therapeutic strategy for treating obesity.
A study published by HKUMed has found that C-reactive protein (CRP) can worsen inflammation in diabetic kidney disease through the Smad3-NLRP3 inflammasome-dependent mechanism. The research suggests that targeting CRP or the Smad3-NLRP3 pathway may provide new treatment options for patients with DKD.
Researchers at NIH identified characteristic symptoms of topical steroid withdrawal (TSW), including elevated nicotinamide adenine dinucleotide (NAD+) levels, which can be diagnosed using provisional criteria. TSW treatment may involve mitochondrial complex I-blocking drugs, such as metformin or berberine.