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Science News for March 22, 2025


Evaluating DNA impurities in recombinant adeno-associated virus

A new study found that recombinant adeno-associated virus (rAAV) capsids contain single-stranded DNA impurities derived from plasmid and host cell DNA. The researchers suggest that the adverse effects of these impurities may differ from those of double-stranded DNA, highlighting the need for further evaluation.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·TypeExperimental study·DateMar 22, 2025

Major themes and growth areas in the application of AI in the neurosciences shown in inaugural issue of AI in neuroscience

A new review article identifies major themes in AI application to neurosciences, including a 5-fold increase in AI-related publications. The study also notes a surge of over 13-fold in clinical neurology AI-related publications in the past decade.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalAI in Neuroscience·TypeData/statistical analysis·DateMar 22, 2025

Results of the INHALE-3 extension study: inhaled technosphere insulin plus insulin degludec in T1D

The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalDiabetes Technology & Therapeutics·TypeRandomized controlled/clinical trial·DateMar 22, 2025

Uncomfortable bladder tests for female incontinence can be avoided, say researchers

A new study shows that comprehensive clinical assessments (CCAs) are equally effective to guiding treatment for women with overactive bladder or urinary incontinence, avoiding invasive urodynamics testing. CCA includes a medical questionnaire, physical examination, and tests such as urinalysis, revealing similar patient-reported outcom...

SourceEuropean Association of Urology·JournalThe Lancet·TypeRandomized controlled/clinical trial·DateMar 22, 2025