Articles tagged with Stem Cell Differentiation
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New research demonstrates that Aurora-A kinase suppresses neuroblast self-renewal and promotes differentiation in fruit fly stem cells. This finding may provide new clues to the molecular basis of Aurora-A involvement in human cancers, including brain tumors.
A Pittsburgh-based research team has created an innovative ink-jet system to print bio-inks that direct muscle-derived stem cells to differentiate into both muscle and bone cells. This technology could revolutionize the design of replacement body tissues, benefiting millions of people with damaged tissues due to various conditions.
A study by University of California - San Francisco researchers found that the GATA-3 gene plays a crucial role in maintaining the mature state of breast cells. Without this gene, mammary ductal cells regress to an undifferentiated state characteristic of aggressive cancer. The discovery may lead to new ways of understanding and treati...
A study published in Proceedings of the National Academy of Sciences reveals that SOX9 and RUNX2 are two master transcription factors involved in differentiating skeletal progenitor cells into bone or cartilage. The researchers found that SOX9 appears to be the dominant player, suppressing RUNX2 activity to promote cartilage formation.
Massachusetts General Hospital researchers have discovered a master cardiac stem cell capable of differentiating into three types of heart cells. This finding offers new prospects for drug discovery and genetically based models of human disease, as well as a novel strategy for the regeneration of cardiac muscle and associated structures.
A type of stem cell has been identified that gives rise to both myocardial cells and vascular smooth muscle cells, challenging previous notions of how the heart develops. This discovery could lead to the development of new treatments for congenital heart defects and damage caused by heart attacks.
Researchers at the University of Minnesota have successfully differentiated umbilical cord blood stem cells into type II alveolar cells, which can secrete surfactant and repair airways. This breakthrough may lead to new treatments for lung diseases like cystic fibrosis.
Researchers at UC Berkeley used mechanical stretching to guide bone marrow stem cells towards becoming smooth muscle tissue, similar to that found in blood vessels. The study suggests that a combination of chemical and mechanical factors will be needed to achieve efficient cell differentiation.
St. Jude researchers discover that the Six2 gene prevents kidney stem cells from differentiating, maintaining a source of undifferentiated stem cells needed for kidney growth. The absence of Six2 leads to smaller, non-functional kidneys in developing mice.
Researchers have identified Tcf3, a transcription factor that regulates skin stem cells, as a key repressor switch. Activating this gene can prevent skin stem cells from maturing into adult skin cells, potentially providing insights for lab-grown stem cells and therapies.
Researchers at UW-Madison have developed DNA-coated stents that release gene-based therapy to prevent restenosis, a common problem with metal stents. Additionally, they've created microwell arrays to grow undifferentiated human embryonic stem cells with defined sizes and shapes.
Researchers at University of Pennsylvania discovered that adult stem cells depend on physical microenvironment clues to differentiate into various tissue types. By manipulating the firmness of the gel, scientists can guide stem cells towards specific fates.
Researchers uncover a unique population of cells within the sebaceous gland, which produce and maintain the oily mixture called sebum. The discovery sheds new light on how stem cells renew and differentiate, with implications for understanding sebaceous gland disorders.
Researchers discovered that Bruli protein plays a crucial role in maintaining stem cells in planarians, enabling their remarkable ability to regenerate lost body parts. The study provides new insights into the fundamental mechanisms of stem cell self-renewal and its potential applications in human therapy.
Scientists at the University of Pennsylvania School of Medicine have isolated a novel population of multipotent adult stem cells from human hair follicles. These cells can differentiate into nerve cells, smooth muscle cells, and melanocytes, offering potential treatments for various disorders.
Researchers from Gladstone Institutes have gained a better understanding of the use of stem cells to generate replacement cells for damaged heart muscle and vessels. The study highlights several challenges ahead, including guiding stem cells into cardiac lineage and integrating them safely within patients' heart tissue.
Researchers at the Salk Institute for Biological Studies have discovered a DNA-binding protein called Nanog that coaxes mouse ES cells back into an immature state, regaining pluripotency. This finding has significant implications for regenerative medicine and could potentially be used to regenerate stem cells from differentiated cells.
Researchers developed an effective treatment using embryonic stem cells to restore motor function in paralyzed rats. GDNF was found to be a focal attractive cue for transplanted axons, facilitating the establishment of neuromuscular junctions and resulting in noticeable recovery.
Researchers used RNA interference to silence genes regulating muscle cell formation and osteogenic signals. The study found that turning off these inhibitors increased the cells' bone-forming potential, with 60% of mice developing radiologically detectable bone after implantation.
Researchers have discovered that a specific neural stem cell gene, SOX2, is crucial for the normal development of the eye. The study found that disruption of this gene leads to abnormalities in eye formation and microphtalmia, a condition affecting 10% of human cases. The severity of the condition depends on the degree of SOX2 disruption.
Human embryonic stem cells (hESCs) can be grown using a simple mix called hESC cocktail, or HESCO, containing purified human factors. The recipe maintains normal cell chromosome profiles and supports differentiation into all three basic cell lineages.
University of Wisconsin-Madison researchers have created a liquid crystal-based cell culture system to control the uncontrolled differentiation of human embryonic stem cells. The system uses mechanical strain to guide stem cells along well-defined lineages, enabling real-time monitoring and reducing the mixture of cells of little medic...
Researchers identified altered expression of proteins involved in muscle differentiation, leading to reduced myoblast differentiation potential. Forced expression of MyoD or desmin restored this defect, providing new mechanistic insight into LMNA mutations contributing to muscular dystrophy.
A Phase I clinical trial is underway to test the safety and potential of using child's own bone marrow stem cells to treat traumatic brain injury. The study aims to establish the safety of the procedure and observe possible therapeutic effects.
Researchers at Gladstone Institutes have made a breakthrough discovery about the role of miRNA-1 in the early stages of heart development. They found that miR-1 helps determine heart progenitor cells and maintain them until later embryonic stages, which could lead to new strategies for cardiac regenerative medicine.
A team of researchers has uncovered a remarkable developmental pathway in stem cells, revealing a natural compensatory mechanism that could affect their therapeutic applications. This self-regulatory system helps stem cells differentiate into specific tissues, and disrupting it may be necessary to induce the desired outcome.
Researchers at Oregon Health & Science University (OHSU) have identified a critical gene, Brg-1, that regulates the differentiation of stem cells into neurons and glial cells in the brain. This discovery could lead to new therapies for brain injuries, Parkinson's disease, and other conditions affecting brain function.
Feather stem cells are distributed in a ring configuration around the inner wall of the vase-shaped feather follicle. This unique arrangement allows for continuous growth, shedding, and regeneration of feathers.
Researchers have discovered that adult fruitflies have the same stem cells controlling cell regulation in their gut as humans do. This finding is significant for understanding digestive disorders, including some cancers, and developing cures. The similarity between insect and human gut stem cells suggests a common evolutionary origin.
Scientists study flatworms to understand how adult stem cells regenerate tissues, finding key genes involved in the process. Researchers discovered that a specific gene, piwi, plays a crucial role in producing daughter cells capable of restoring damaged tissues.
Researchers discover smedwi-2 plays critical role in regulating daughter cell differentiation for tissue maintenance. Silencing this gene leads to animal death, despite intact stem cells, highlighting early specification of progeny
Scientists discovered that some adult stem cells express characteristics of muscle and heart cells, suggesting they could be the 'footprints' of evolution. The researchers believe these cells may be incomplete or 'rudiments' of earlier embryonal differentiation processes.
Researchers at the University of Toronto have identified a key component blocking stem cell growth and developed a system to expand cord blood stem cells, potentially treating adult patients with leukemia. The discovery may lead to clinical trials within the next year.
The UW-Madison MRSEC center will focus on designing materials with controlled chemical functionality and physical properties, enabling new sensors and cell differentiation capabilities. The center's interdisciplinary approach brings together experts from various departments to advance nanotechnology research and technology transfer.
A new study by UCI researchers shows that adult human neural stem cells can differentiate into new oligodendrocyte cells and neurons, restoring myelin and improving motor function in mice with spinal cord injuries. The treatment also leads to behavioral improvements, including the ability to step using hind paws.
A study by University of Michigan researchers reveals the critical genetic switch that allows preadipocytes to become full-blown fat cells, highlighting the importance of balance in fat production. The discovery sheds new light on the role of integrin alpha 6 in regulating fat cell formation and its potential link to metabolic disorders.
The Gladstone Institutes' team supplied original stem cells for the exhibit and trained museum staff on techniques to activate cells. The exhibit showcases the development of cardiac myocytes from undifferentiated state to pulsating heart cells.
Researchers have made significant progress in understanding stem cells and their role in reproduction and the nervous system. Studies suggest that therapeutic cloning may become unnecessary once body cells can be re-programmed into stem cells.
Scientists at EMBL and IRB-PCB found that disrupted genes in stem cells can lead to deadly tumors. The study shows that specific molecules control cell division and differentiation, and their disruption can result in cancer.
A new study by Christof Westenfelder's team found that stem cells improve kidney function and reduce tissue injury in acute renal failure. The benefits are primarily mediated by paracrine mechanisms, not differentiation, and are induced by the release of growth factors and cytokines.
Researchers have created a novel method to propagate mouse brain stem cells, which can either multiply without differentiating or become normal brain cells at the flip of a genetic switch. The technique combines epidermal growth factor and fibroblast growth factor to promote cell growth, enabling scientists to study basic properties an...
Researchers have discovered cells in discarded placentas that can develop into specialized cells like liver, pancreas, and nerve cells. The amniotic epithelial cells express genes similar to those of embryonic stem cells, but with limitations, offering a potentially new source for regenerative medicine.
Researchers identify NF-Ya as a master-regulatory gene controlling stem-cell division programs. Overexpressing NF-Ya increases stem cell production by ten- to twenty-fold.
G-CSF has potent cell protective effects on mature neurons, driving neuronal differentiation of adult neural stem cells. It doubles hippocampal neurogenesis even in normal animals, making it a potential treatment for stroke and neurodegeneration.
A new study reveals how the GDF11 protein controls retinal-cell differentiation during development, making it an attractive therapeutic target. By manipulating this process, researchers may be able to harness the power of existing stem cells in the retina to replace damaged or diseased cells and potentially cure visual disorders.
Researchers have successfully cloned mice using direct nuclear transfer from terminally differentiated natural killer T cells. The cloned pups and their placentas exhibit rearranged T cell receptor genomic loci specific to NKT cells, demonstrating that fully differentiated cell nuclei can support embryo and placenta development.
Researchers have discovered a link between mutations in the MRTF-B gene and congenital heart disease in mice, which mimics human conditions such as truncus arteriosis. The study found that defects in cardiac neural crest cells lead to impaired blood vessel development and outflow tract defects.
Researchers have created patient-specific stem cell lines using somatic cell nuclear transfer, enabling the study of human disease in laboratory cells. The new cell lines displayed signs of immunological compatibility with patients' cells.
Researchers have discovered that skeletal precursors of cardiomyocytes (Spoc cells) can transform into beating cardiac muscle cells, offering hope for developing cell-based treatments for heart disease. These cells were isolated from adult mice and showed spontaneous rhythmic beating and expressed cardiac markers.
Researchers found that Pax3 plays dual roles in adult stem cells, directing them to become melanocytes while preventing complete differentiation. This discovery opens new avenues for understanding stem cell biology and its potential role in cancer development.
Researchers at WiCell Research Institute and University of Wisconsin-Madison develop method to eliminate need for feeder cells, simplifying culture of human ES cells. The new approach uses protein FGF2 to preserve undifferentiated state and reduce differentiation.
A new study found that the transcription factor c-Myb regulates hematopoiesis at multiple points, controlling HSC self-renewal and proliferation. This breakthrough has significant implications for developing compounds to regulate stem cell fate decisions, a potential game-changer for stem cell therapy.
Researchers find that adult stem cells are maintained by local environment signals that block gene expression, preventing differentiation. The microenvironment captures cells and prevents them from becoming other types of cells.
Researchers at Duke University Medical Center discovered regulatory genes in niche cells instruct stem cells to determine their future path, involving proteins acting as 'on-off' switches for stem cell division. This understanding is crucial for developing stem cell therapies and addressing disorders like infertility and cancer.
Researchers at the University of California, San Diego, have developed a technique to identify the precise mix of extracellular matrix proteins that optimally prompts mouse embryonic stem cells to begin differentiating into liver cells. This breakthrough enables scientists to use inexpensive and widely available reagents and machinery ...
Scientists at the Vollum Institute have developed a technique to understand gene regulation, uncovering 6,300 regulatory regions that map to distinct sites on the genome. This breakthrough may help unravel the genomic instruction set governing gene expression in different cell types.
A lipid called ceramide helps eliminate potentially harmful cells during brain development, improving the safety and efficacy of stem cell transplants. Researchers found that adding ceramide to embryonic stem cells reduces the risk of teratoma formation, a type of tumor.
Researchers at Mount Sinai School of Medicine discovered a new mechanism that contributes to the development of some breast and ovarian cancers, involving the Wnt pathway. Compounds blocking this receptor can make cancer cells more sensitive to agents that induce cell death.
A team of scientists has created an artificial immune system that can mimic the human immune response, allowing for faster and easier production of flu vaccines. The technology uses inverted colloidal crystals as three-dimensional cell scaffolds, enabling researchers to study the artificial immune system's reactions to biological hazards.
International society agrees on fat stem cell clinical applications for repairing bone defects, promoting blood vessel growth in tissues and treating cardiac diseases. The best use of this technology is expected to be developing therapies using patients' own cells.