Articles tagged with Axon Regeneration
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A new study suggests that regenerative abnormalities associated with diabetes are widespread, affecting not only nerves but also blood vessel growth and Schwann cell proliferation. By promoting blood vessel and Schwann cell growth, researchers may be able to speed up axon regeneration and repair damaged nerves and blood vessels.
Researchers found that hydrogen peroxide released by damaged skin cells coordinates regeneration of sensory fibers, promoting wound healing and restoring touch sensation. The study demonstrates the healing power of hydrogen peroxide in zebrafish larvae.
Researchers at the University of California, San Diego School of Medicine found that removing three key inhibitory molecules from myelin did not significantly improve axon regeneration in damaged spinal cords. The study suggests that successful regeneration will require a combination of many approaches and techniques.
A study published in Neuron found that deleting a gene called SOCS3 allows mouse axons to regenerate vigorously after injury. The research suggests that the mTOR pathway and JAK/STAT signaling pathway can be manipulated to promote axon regeneration, potentially leading to improved recovery from brain or spinal cord injuries.
A new study published in Neuron suggests that deleting a suppressor of inflammatory signaling in mice promotes vigorous axon regeneration after injury. The research also identifies a key growth factor involved in the process and provides potential therapeutic targets.
Scientists at the University of California, San Diego School of Medicine report that regeneration of central nervous system axons can be achieved in rats even when treatment is delayed by more than a year after the original spinal cord injury. The team used a combination of treatments to coax chronically injured axons to regenerate and...
A study published in Nature Neuroscience reveals that Mst3b, an enzyme previously identified in the lab, is essential for regenerating damaged axons in both peripheral and central nervous systems. The findings suggest that activating Mst3b could lead to a possible treatment for brain and spinal cord injuries.
Researchers successfully guided regenerating sensory axons to their correct targets and formed synapses, but not electrically active connections due to lack of myelin sheath. The study suggests that restoring the myelin sheath is crucial for fully restoring function in injured spinal cords.
Scientists at UC San Diego School of Medicine have clearly shown regeneration of critical nerve fibers required for voluntary movement. The breakthrough uses genetically engineered neurons to over-express receptors for BDNF, enabling corticospinal axon regeneration.
Researchers silenced genes that prevent mature neurons from regenerating, causing them to recover and re-grow vigorously after damage. Up to 50% of injured neurons survived, and up to 10% showed significant re-growth of axons over long distances.
Researchers have developed a simple model to study injured brain tissue, enabling the induction of regeneration of axons. The fruit fly model has shown that activation of the JNK signaling pathway promotes nerve bundle repair.
Researchers use nanotechnology to enhance nerve cell regeneration, bypassing inhibitory environments. Magnetic nanoparticles create mechanical tension, while aligned nanofibers provide a bioactive matrix for growth.
Researchers at Boston Children's Hospital have isolated a previously unknown molecule called oncomodulin that stimulates axon regeneration in the optic nerve. The discovery offers new possibilities for treating conditions such as glaucoma, stroke, and spinal cord injury.
Researchers have developed a femtosecond laser nanosurgery technique to study genetic and molecular factors controlling nerve regeneration in C. elegans worms. The technique allowed for precise axon severing, enabling rapid recovery of function and new insights into neural regeneration.
Researchers have found that nerve degeneration in spastic paraplegia is associated with abnormal mitochondria and impairment of axonal transport, highlighting a potential target for therapeutic interventions. The study suggests that preserving mitochondrial function may help prevent axonal loss in this devastating condition.
In an effort to improve regeneration, Emory scientists treated severed nerves with enzymes that degrade proteoglycans. Axons regenerated through enzyme-treated tissues more effectively, extending over twice as far as untreated tissues.
A Stanford team has discovered a permanent signal that controls the growth of axons in neurons, which can lead to paralysis. This finding suggests that age is not the key to an axon's inability to regenerate, but rather an outside signal from retinal cells.
Researchers previously thought mature nerve cells couldn't regenerate after damage. However, a new study reveals that altering naturally occurring compounds can restore regenerative ability in mature cells. The study's findings offer hope for developing new treatments for optic and spinal cord disorders.