Articles tagged with Embryonic Stages
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Researchers have made significant discoveries about early human embryo development, finding that genes on the X chromosome are regulated differently in humans than in mice. This new understanding is crucial for the use of embryonic stem cells in regenerative medicine.
Researchers developed a mouse model of aneuploidy to investigate the fate of abnormal cells in early-stage embryos. They found that even when half of the cells are abnormal, the embryo can fully repair itself through programmed-cell death.
Researchers explore small molecule replacement therapy to rescue craniofacial defects by manipulating Wnt and Eda/Edar signaling pathways. The study provides novel candidates for therapeutic treatment of patients with craniofacial defects.
Zebrafish exposed to atrazine during embryonic development exhibited reproductive problems, including swollen abdomens and breeding complications, in their young. The study also found physical deformations, such as decreased head length to body length ratio, and increased progesterone levels in affected parents.
Scientists have discovered that deactivating the MYC oncogene can induce a dormant state in embryonic stem cells, similar to diapause, allowing them to survive without growth or metabolism. This finding has implications for controlling cancer stem cells and metastasis.
Researchers have identified a single gene, TLE6, responsible for human embryonic lethality at an earlier stage of development than previously documented. The mutation impairs the binding of components of the sub-cortical maternal complex, leading to arrest in early embryonic development.
A new study led by King's College London found that splitting human embryos to produce twins for IVF may not be viable due to delays in development. The research suggests that a 'developmental clock' plays a critical role in earliest stages of human development, which can be interrupted by the splitting process.
Researchers from INSERM have successfully induced totipotent cells, capable of producing an entire embryo and placenta, in collaboration with the Max Planck Institute. The team discovered that down-regulating a protein complex called CAF1 leads to chromatin reprogramming into a less condensed state.
Researchers discovered that chromosomal abnormalities in human embryos can be predicted within the first 30 hours of development. This finding could improve IVF success rates, which have hovered around 30-35 percent worldwide. By analyzing a single cell level, they identified 12 genes that are activated prior to the first cell division.
Scientists at TUM have characterized a small heat shock protein essential for embryonic development in nematodes, which may have implications for human health. The Sip1 protein regulates itself via pH value and prevents clotting of important proteins.
A new IVF technique uses open microwell setup to screen embryos before implantation, potentially increasing success rates. The method allows researchers to select the most viable embryos on a case-by-case basis, reducing the number of cycles and costs.
Researchers have discovered two protein 'architects', MOZ and BMI1, which play opposing roles in guiding embryonic development. These proteins regulate Hox gene expression, ensuring the correct formation of body segments and tissues. The study sheds new light on how environmental factors can impact early embryo development.
French scientists have discovered that vertebrate formation is guided by a pattern present from early development stages, with folds along boundaries of elastic contrast forming the final shape. This finding explains how complex structures like vertebrates emerged during evolution.
Scientists have discovered a novel mechanism regulating maternal miRNAs in early embryos, with the enzyme Wispy playing a key role in miRNA adenylation and reducing its abundance. This finding provides new insights into the regulation of gene expression during embryonic development.
Researchers at the University of California, San Diego, used single-cell RNA sequencing to analyze gene expression in mouse embryos and found that a handful of genes are signaling to each other at the two-cell and four-cell stage. This discovery could provide insight into early miscarriages and birth defects.
New research reveals distinct differences in early human embryo development among overweight and obese women compared to those of a healthy weight. These differences may have long-term health implications for their children.
Researchers have successfully reproduced morphological changes in mice teeth that occurred over millions of years, mirroring those found in fossil records. The study used genetic modifications to induce changes in tooth development, providing insight into the mechanisms driving evolutionary transitions.
Researchers found that DNA sequences called enhancers find their targets hours before activation during embryonic development, with surprising complexity in fruit fly embryos comparable to vertebrates. The study reveals a primed system ready to spring into action when needed.
A new study suggests that using computer-automated, time-lapse embryo photography during in-vitro fertilization can improve embryo selection, leading to a higher chance of pregnancy. The technology allowed researchers to assess embryo development and predict which embryos were more likely to become viable blastocysts.
Researchers at the University of Notre Dame have developed the largest data set on developmental proteomics for any organism, analyzing nearly 4,000 proteins in African clawed frog embryos. The study reveals unexpected discordance between messenger RNA and protein levels, shedding light on key events during early development.
Researchers have discovered that polyunsaturated fatty acid metabolism plays a crucial role in embryonic development and tissue organization. The study found that ACSL4 enzyme activity regulates a specific protein in the Bmp signaling pathway, which is essential for proper embryo organization.
A CNIO team has discovered that senescence, which makes cells stop dividing, also takes place during embryo development to eliminate unnecessary cells. This process, known as programmed senescence, helps shape the body's tissues and organs.
Researchers from the Carl-Philipp Heisenberg group have identified a key mechanism for limiting tissue tension during cell division, enabling epithelial closure and wound healing. By orienting cell division through mechanical tension, cells can maintain their integrity and ensure proper tissue development.
Physicist Lisa Manning and her team created a model to study tissue organization during embryonic development. They found that embryonic tissue behaves like a viscoelastic liquid, with cells packed tightly together like a cage of neighbors.
A recent study by MBL researchers has identified ZIP12 as a critical transporter for zinc uptake in the brain, essential for embryonic development. Impaired zinc uptake leads to neuronal growth impairment, fatal to developing embryos. The discovery highlights the importance of periconceptional and prenatal nutrition for promoting healt...
Researchers at The Wistar Institute discovered a mechanism by which long non-coding RNA-activators promote gene expression in early embryonic development. These RNA molecules help create a loop of DNA, opening up genes for transcription.
Researchers have discovered that congenital heart defects could be linked to the development of cells in the embryo as early as 12-14 hours after fertilization. The study's findings provide new insights into the causes of cardiac malformations and may lead to better treatments for affected families.
Researchers identified a group of proteins that play a key role in methylation, a process that silences genes in embryonic development. This phenomenon can be accidentally reactivated in tumor cells, leading to the formation of cancer.
A study found that abnormal endocannabinoid signaling in mouse embryos can disrupt placental development and lead to pregnancy problems. Researchers hope the findings will inform studies on the causes of preeclampsia, a medical condition affecting mothers and children.
Biologists at Caltech created a computational model of gene networks that control the development of sea-urchin embryos. The model accurately reproduces experiments and allows for virtual experiments, revealing unprecedented detail about gene regulatory networks.
A study by Harvard School of Public Health found that women with higher intakes of dietary saturated fats have fewer mature oocytes available for collection in IVF, leading to lower live birth rates. On the other hand, polyunsaturated fat consumption is inversely related to embryo quality.
A new study by A*STAR scientists reveals that the protein TRIM28 plays a crucial role in preserving epigenetic marks during nuclear reprogramming, ensuring proper development of the embryo. The absence of TRIM28 leads to severe developmental defects and multiple pregnancy failures.
A team led by Professor Kevin Shakesheff has created an artificial 'womb' that allows for the growth of embryos outside the body, revealing new aspects of embryonic development. By observing critical stages in real-time, scientists have gained insights into the process of head formation and the role of pioneer cells in leading migration.
Researchers have developed a method to overcome the barrier of implantation into the womb and study embryonic development for the first 8 days. This allows them to understand how clusters of extra-embryonic cells signal where to make the head of the embryo.
A recent study published in Developmental Cell suggests that the reach of parental control in embryonic development may be longer than thought. The research found evidence that genetic marks from sperm can be passed on to embryos, influencing gene expression later in development.
New York University and University of Iowa biologists have identified a critical protein called Zelda that orchestrates gene networks in an exquisitely coordinated fashion. The researchers found that Zelda is essential for the proper order of gene interactions, leading to drastic changes in body plan formation if absent.
Embryos avoid fatal chaos through a synchronized cell cycle mechanism triggered by the calcium wave, which sets cells to the same developmental timetable. The researchers' simulation shows that this rapid spread of oscillation is crucial for preventing disarray and ensuring the embryo's survival.
A mouse model of focal dermal hypoplasia has been developed to study the cause of a rare human birth defect and its relation to the Wnt signaling pathway. The model reveals the essential role of PORCN in embryonic development and highlights the disorder's connection to cancer research.
Researchers found that early embryos with chromosomal abnormalities can undergo a process of genetic normalization, leading to the correction of errors. This discovery has significant implications for preimplantation genetic screening and future stem cell treatments.
In flowering plants, maternal gene activity dominates early embryogenesis, silencing paternal genes. This finding may be crucial for maintaining species boundaries and could aid in developing novel crop varieties.
Researchers found that auxin promotes the breakdown of an inhibitor, leading to increased gene activity and maintaining embryonic development. The study revealed a regulatory network controlled by auxin, which boosts gene activity even after auxin concentration declines.
A new microfluidic device enables the rapid orientation of hundreds of embryos, allowing for large-scale quantitative analyses of protein positional information along the dorsoventral axis. This innovation facilitates studies on complex structures from single cells and has the potential to adapt for other model organisms.
Australian scientists discovered that changes to the SOX3 gene can lead to testis formation and male genitalia in an otherwise female embryo. This breakthrough will improve diagnosis and treatment for patients with disorders of sex development, which occur when the testes or ovaries do not develop properly.
A recent study has identified DEDD protein as essential for the formation of a functional decidua in mice. Defective DEDD function may be responsible for female infertility. The researchers suggest further investigation into the relationship between DEDD dysfunction and infertility in women.
Researchers found that marsupial embryos develop forelimbs earlier than expected, using a unique genetic program. This breakthrough suggests that developmental processes may be more flexible than previously thought, allowing for adaptability in marsupials.
Two methods for culturing and imaging Caenorhabditis elegans embryos are described, enabling researchers to visualize dynamic form and function of molecules, cells, tissues, and whole embryos. Meanwhile, a method for isolating and culturing early mouse embryos is also presented, allowing time-lapse imaging of cell movements.
Auxogyn acquired exclusive license to develop noninvasive embryo assessment technology that can predict human embryo fate at the four-cell stage, allowing for improved IVF procedures and higher live birth rates. The licensed technology demonstrates a high degree of accuracy in predicting blastocyst formation.
Researchers at Stanford University School of Medicine have developed a method to predict embryo survival with 93% accuracy, allowing for improved selection of embryos for transfer during in vitro fertilization. This breakthrough could reduce the likelihood of miscarriage and improve pregnancy rates.
Researchers at EMBL identified a new Polycomb group complex, PR-DUB, which surprisingly removes the same gene-silencing tag as another complex. This unexpected behavior may be a case of fine-tuning to maintain optimal levels of chemical tagging.
Researchers found differences in brain patterning as early as 48 hours after fertilization, before neurogenesis begins. They successfully altered the brain of a rock-dwelling fish embryo to resemble a sand-dwelling fish embryo using chemical manipulation.
A mathematical model predicts complex signaling patterns in fruit fly embryos, shedding light on stem cell differentiation and potential applications in tissue engineering. The study aims to better understand how to control similar cells in a laboratory setting.
Researchers at EMBL developed an integrated approach to forecast CRM activity, predicting gene expression patterns in fruit fly development. The study identifies flexibility in genetic regulation, enabling organism development without essential transcription factors.
Researchers found a distinct 'DNA signature' in human sperm, which recognizes an egg's species-specific DNA, enabling fertilization. This discovery explains male infertility and pregnancy failures.
Researchers at the University of Pittsburgh have identified an enzyme inhibitor that increases cardiac progenitor cells and influences heart development in zebrafish. The findings have broad implications for understanding heart development and improving treatments for damaged or diseased tissues.
Researchers have found that transferring a single embryo at a time after preimplantation genetic diagnosis (PGD) and freezing at the blastocyst stage results in comparable pregnancy rates to those for non-biopsied embryos. This approach can reduce multiple pregnancies and their associated complications.
A new embryo test can detect both genetic and chromosomal abnormalities, offering a faster and cheaper alternative to current fertility treatments. The test, known as genome-wide karyomapping, can identify diseases caused by specific gene mutations and aneuploidy at the same time.
A study published by Cincinnati Children's Hospital Medical Center identified a critical gene, SHP2, essential for normal heart and skull formation. Neural crest cells' differentiation failure leads to severe anatomical and functional deficits.
Researchers found that alpha-fetoprotein is highly expressed in developing rat colons, particularly at embryonic day 18.5, and decreases significantly as the animal matures. The protein is localized to mesenchymal cells throughout different developmental stages of the colon.
A team of researchers at Worcester Polytechnic Institute has identified a new component of the bone morphogenetic protein (BMP) pathway, which is essential for proper wing development in fruit flies. The discovery of Kekkon5 reveals its role as an extracellular regulator of BMP signaling.
Scientists at the University of Warwick have discovered a thermodynamic switch that enables the pairing of X chromosomes in female cells during embryo development. The discovery sheds light on the complex mechanism behind X-chromosome inactivation and its role in preventing medical conditions such as Down's Syndrome and Turner's Syndrome.