Researchers find unique mode of whole body regeneration (WBR) in sea squirts, which arises from systemically induced signals and may travel through circulation. RA signaling plays a vital role in WBR, with overexpression leading to accelerated regeneration.
Scientists at The Forsyth Institute have discovered that programmed cell death is necessary for regeneration to occur. Apoptosis plays a critical role in development and a novel role in regeneration, allowing medically therapeutic regeneration. The study uses the Xenopus tadpole as a model organism.
SourceForsyth Institute·JournalDevelopmental Biology·DateDec 13, 2006
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A research team at the Salk Institute has successfully regenerated a wing in a chick embryo by activating Wnt signaling, a powerful system controlling vertebrate regeneration. The study opens up new areas of research into the ability of stem cells to build new human body tissues and parts.
SourceSalk Institute·JournalGenes & Development·DateNov 17, 2006
The research aims to harness the body's natural regenerative abilities to heal limb wounds, using salamanders as a model. The goal is to develop techniques for restoring damaged or lost digits and limbs.
A team of UCI researchers, led by Ken Muneoka, will focus on harnessing the body's natural healing process to heal deep wounds involving bone, muscle, nerves and other soft tissues. The goal is to recreate a regeneration process in mouse models that could lead to breakthroughs in wound healing and limb regeneration.
Researchers are studying salamanders and MRL mice to identify the types of cells, molecular signals, genes, and cellular scaffolding required for regenerative cell growth. They hope to develop a blueprint for regenerative growth, which could help overcome the formation of scar tissue in humans.
SourceUniversity of Pittsburgh Medical Center·DateMay 2, 2006
Scientists used fruit fly larvae to study regeneration and discovered a key gene involved in adapting stem cells to different tissue types. The research challenges old concepts of regeneration and opens new avenues for stem cell research.
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Susan Bryant, a leading researcher in limb regeneration, was elected a 2005 Association for Women in Science fellow for her efforts to increase women faculty at UCI. Her work led to a significant increase in the percentage of women recruited to tenure-track positions across campus.
Researchers discovered a significant increase in arm regeneration frequency among fossil crinoids during the Middle Paleozoic Marine Revolution, coinciding with the diversification of predators and prey adaptations. The findings suggest that broken arms may be collateral damage, rather than direct targets of predation.
SourceUniversity of Michigan·JournalScience·DateSep 3, 2004
Researchers have discovered that bone formation in a regenerated forelimb combines elements of embryonic development and adult wound healing. MicroCT imaging reveals that bone formation does not occur in the same order as previously thought, but rather follows a pattern similar to normal fracture recovery.
SourceNorthwestern University·JournalDevelopmental Dynamics·DateJan 22, 2003
Researchers at UC Irvine have developed a method to study the function of genes necessary for limb regeneration in salamanders, a finding that may provide key information for treating ailments like spinal cord injury and deep wounds. By understanding the process of regeneration, researchers may find new approaches and therapies for rep...
SourceUniversity of California - Irvine·JournalDevelopmental Biology·DateFeb 9, 2000