Articles tagged with Ossification
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Researchers investigated the role of PLAGL1 in postnatal condyle development and found that it regulates osteogenesis through the IGF2 pathway. The study reveals a critical driver of jaw bone formation, offering opportunities for therapeutic exploration and a deeper understanding of craniofacial biology.
Researchers developed sicXer, a mesoporous silica-collagen xerogel that mimics mineralized collagen and promotes bone healing. BoXer, a drug-loaded version of sicXer, releases anti-myeloma medication locally at bone lesions, demonstrating potential for stabilization and healing of fracture-prone bones.
A 10-year follow-up study reports significant and lasting improvement in outcomes with posterior decompression and fixation surgery for patients with Thoracic Ossification of the Posterior Longitudinal Ligament (T-OPLL). Decompression and fixation yielded long-term benefits in neurological function, quality of life, and pain management.
Researchers found that treatment with tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO), a common complication of abnormal bone formation. The study showed a significant reduction in HO risk, with an odds ratio of 0.49 and a 50% lower risk compared to patients not receiving TXA.
A study published at Tokyo Medical and Dental University found that Mkx regulates cellular heterogeneity and gene expression in the PDL, revealing its importance in homeostasis. The results showed that a deficiency of Mkx promotes ossification in the PDL and suggests a compensatory mechanism via Scx to maintain homeostasis.
Researchers have discovered that heterotopic ossification, a painful complication of trauma, is caused by macrophages sending errant signals to bone-forming stem cells. A new study suggests that targeting TGF-beta expressing macrophages may prevent this abnormal bone formation
Researchers have developed a new approach to improving spinal fusion procedures and repairing broken bones. By delivering a potent bone-forming protein called BMP using a heparin mixture, they significantly reduced undesired bone growth outside of targeted repair areas in rat femurs.
A new meta-analysis found that fabella prevalence varies by region (Asia > Africa), age (older individuals more likely) and sex (men more likely). Fabellae can ossify in people of almost any age, from children to adults over 70.
Researchers have described a new treatment that could cope with Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva using a PI3-kinase inhibitor. The study shows promising results in preclinical models, potentially leading to improved treatment options for patients.
Researchers from Northwestern University have discovered a brain chemical, Substance P, that causes abnormal bone growth in injured muscles. This discovery offers a potential molecular target for preventing and treating heterotopic ossification.
Researchers at URMC discovered a defect in cellular pathways regulating bone formation at the stem cell level, leading to premature closure of skull sutures and craniosynostosis. This finding sheds light on the complex system controlling stem cell fate and has implications for understanding skeletal disorders and cancer.
Researchers studied 243 wounded Marines to identify risk factors for heterotopic ossification, a condition where bone forms in soft tissues. The study found that age, traumatic brain injury, amputation, and multiple injuries are key contributors to the development of this abnormal bone growth.