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Advances and applications in single-cell and spatial genomics

This review highlights the transformative capabilities of single-cell and spatial genomics, providing critical insights into disease mechanisms and developing innovative therapies. The technologies enable comprehensive cell atlases, tracing the evolution of sequencing methods and incorporating multi-omics approaches, which significantl...

SourceScience China Press·JournalScience China Life Sciences·DateJan 12, 2025

Fish-friendly dentistry: New method makes oral research non-lethal

Researchers at OIST have developed a customizable method for studying detailed dental characteristics of living fish and vertebrates without harming them. This approach allows for non-destructive examination of tooth replacement and development over time, revealing valuable information on feeding habits and comparative anatomy.

SourceOkinawa Institute of Science and Technology (OIST) Graduate University·JournalJournal of Morphology·TypeExperimental study·DateDec 26, 2024

World’s only bonobo sanctuary helps orphaned apes overcome trauma to develop social skills and empathy

A study by Durham University found that bonobos orphaned by the illegal trade in bushmeat and pets can develop social abilities despite early life trauma. Researchers observed 83 bonobos at different stages of their lives, finding that female bonobos' social skills increased with age, while males' decreased, similar to wild interactions.

SourceDurham University·JournalRoyal Society Open Science·TypeObservational study·DateDec 17, 2024

Biological diversity is not just the result of genes

Researchers from UNIGE found that mechanical forces, linked to tissue growth, drive the emergence of diverse biological structures. They demonstrated this using computer modeling and microscopy, revealing how variations in skin growth rates and stiffness generate distinct scale forms among different crocodilian species.

SourceUniversité de Genève·JournalNature·TypeNews article·DateDec 11, 2024

Autonomous imaging robot plays a crucial role in assessing embryos’ response to environmental change

The LabEmbryoCam is a robotic instrument that autonomously monitors embryonic development in aquatic species, providing insights into how environmental conditions impact early life stages. The open-source instrument enables scientists to track key features such as heart rate and growth in large numbers of embryos simultaneously.

SourceUniversity of Plymouth·JournalHardwareX·TypeExperimental study·DateDec 6, 2024

Welcome Evo, generative AI for the genome

Evo, a generative AI model, uses patterns in microbial genomes to write new genetic code, expanding the length of sequences models can process and improving resolution. Researchers use Evo to understand microbial and viral genomes, fashion new proteins, and reprogram microbes for remarkable tasks.

SourceStanford University·JournalScience·DateDec 4, 2024

The origin of stem cells

Researchers identified critical proteins involved in animal stem cell regulation, including SOX and POU transcription factors, which existed in single-celled organisms over 700 million years ago. These ancient proteins retained functional properties that enabled them to induce stem cell reprogramming in mouse cells.

SourceMax-Planck-Gesellschaft·JournalNature Communications·DateNov 21, 2024

Climate change can cause stress in herring larvae

Exposure to multiple environmental stressors simultaneously impairs the ability of herring larvae to react at a molecular level, reducing their capacity for acclimatization. This can lead to increased protein damage and cell injury, potentially affecting growth and survival.

SourceUniversity of Oldenburg·JournalScience of The Total Environment·TypeExperimental study·DateNov 18, 2024

The high cost of complexity

A new study led by Arizona State University researcher Michael Lynch explores the substantial energy demands required to maintain and evolve multicellular life. Multicellular organisms require a tenfold increase in energy compared to protists, highlighting how respiration and metabolic processes are crucial for advanced life forms.

SourceArizona State University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 4, 2024

International project will explore how molecular evolution enables animals to adapt to extreme cold

The international project will analyze temperature-sensitive proteins in animals adapted to different thermal environments to understand how they perceive temperature changes. The study aims to uncover the molecular mechanisms underlying cold perception in animals, enabling them to initiate physiological responses crucial for survival.

Megadiverse flowering plant family on isolated islands

Researchers discovered a massive number of evolutionary events in the Asteraceae family on remote islands, resulting from rapid speciation over short time periods. The findings confirm that larger, isolated islands harbor unique species and highlight the importance of protecting this diverse group of plants.

SourceUniversity of Göttingen·JournalNature Communications·TypeObservational study·DateSep 30, 2024

These fish use legs to taste the seafloor

Researchers discovered that sea robins' legs are covered in sensory papillae with taste receptors, allowing them to detect and uncover food. The findings reveal an ancient gene controlling leg development and sensory organ formation, shedding light on the evolution of complex traits in wild organisms.

SourceCell Press·JournalCurrent Biology·TypeExperimental study·DateSep 26, 2024

Stowers scientists uncover a critical component that helps killifish regenerate their fins

A recent study published in iScience found that the length of time cells spend engaged in the repair process is also key to regulating regeneration in African killifish. The researchers discovered that skin cells launch a genetic program that primes the whole animal to prepare for a repair response, guiding repair cells to get to work.

SourceStowers Institute for Medical Research·JournaliScience·TypeExperimental study·DateSep 26, 2024

Flowers use adjustable ‘paint by numbers’ petal designs to attract pollinators

Researchers at the University of Cambridge found that flowers like hibiscus use an invisible blueprint to dictate the size of their bullseyes, which can significantly impact their ability to attract pollinating bees. Larger bullseyes are preferred by bees and can potentially boost efficiency for both bees and blossoms.

SourceUniversity of Cambridge·JournalScience Advances·TypeExperimental study·DateSep 13, 2024

Beyond needles: Introducing a new, nature-based approach for delivering cargo into egg cells

A new method called VitelloTag has been developed at the Marine Biological Laboratory, allowing researchers to deliver miniature research tools into egg cells and embryos. The approach uses a yolk protein found in most animals to bind to the receptor on the egg cell surface, enabling efficient delivery of CRISPR-Cas9.

SourceMarine Biological Laboratory·JournalDevelopment·TypeExperimental study·DateSep 10, 2024

Evolving the framework of cancer theory

Researchers propose a new approach to understanding cancer evolution, acknowledging the importance of environmental influences and epigenetic changes. By refining the clonal evolution model, they aim to develop more effective cancer therapies that consider the full complexity of cancer cell evolution.

SourceArizona State University·JournalNature Reviews Cancer·TypeLiterature review·DateSep 10, 2024

Ancient gene gives spiders their narrow waist

A previously unstudied ancient gene called 'waist-less' is required for the development of a spider's narrow waist, according to researchers. The discovery sheds light on the formation of the distinctive body plan in spiders and highlights the function of new genes in ancient groups of animals.

SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateAug 29, 2024

Size doesn’t matter for mammals with more complex brains, according to new study

A recent study published in Nature Communications found that mammals with more developed brains tend to exhibit smaller sexual size dimorphism (SSD), meaning there is less difference in size between males and females. This suggests that complex brain development may be linked to other traits such as social behavior and mate selection.

SourceUniversity of Bath·JournalNature Communications·TypeObservational study·DateJul 25, 2024

Eyes for Love: Searching for light and a mate in the deep, dark sea, male dragonfishes grow larger eyes than the females they seek

Researchers at Boston College found male dragonfish have evolved larger eyes to detect females who produce less light, closing a bioluminescent detection gap. This is the second known case of sexually dimorphic eye-size in fishes and highlights the unique adaptations of deep-sea species.

SourceBoston College·JournalBiology Letters·TypeObservational study·DateJul 23, 2024

Exposing dengue’s invasion strategies

Researchers at Stowers Institute for Medical Research have identified the dengue virus genome's use of less efficient codons in its host's machinery to replicate and spread. This discovery has implications for developing novel antiviral treatments and vaccines, as well as understanding the relationship between viruses and their hosts.

SourceStowers Institute for Medical Research·JournalMolecular Systems Biology·TypeExperimental study·DateJul 22, 2024

Using AI to scrutinize, validate theories on animal evolution

A new study uses machine learning to analyze the genetic diversity of two amphibian species, finding that different processes shaped their evolution. The research suggests that population demographic events and contemporary landscape factors played a significant role in shaping the genetic variation of these species.

SourceOhio State University·JournalMolecular Phylogenetics and Evolution·TypeCase study·DateJul 18, 2024

The evolution of firefly lights

A genomic analysis overturned the leading hypothesis on firefly light origin, revealing that lucibufagins, a toxic compound, evolved after bioluminescence development. Fireflies' ancestors diversified during a period of rising atmospheric oxygen levels, suggesting a similar path to glowing millipedes.

SourcePNAS Nexus·JournalPNAS Nexus·DateJun 25, 2024

How cells boost gene expression

A research team from Göttingen University has discovered that antisense RNA (asRNA) plays a crucial role in cell transport, allowing cells to accelerate gene expression and produce proteins quickly in response to environmental stress or harm. This new understanding sheds light on the function of asRNAs and their potential link to disea...

SourceUniversity of Göttingen·JournalNature·TypeExperimental study·DateJun 24, 2024