Articles tagged with Aneuploidy
UVa researchers have identified a mechanism that can correct improper microtubule attachments during cell division. A protein called Aurora B loads MCAK onto the chromosome in an inactive state, which is activated to remove improperly attached microtubules.
Pre-implantation genetic diagnosis (PGD) is improving fertility outcomes for couples with genetic conditions, drastically reducing miscarriages and birth defects in older mothers. PGD can detect aneuploidy and translocations, allowing only healthy embryos to be transferred.
A University of California, Berkeley scientist challenges the central tenet of cancer research that genetic mutations drive cancer. Instead, he proposes that aneuploidy, chromosomal duplication, is the primary cause of cancer. Experimental evidence supports this theory, showing cancer cells exhibit massive protein expression changes.