Articles tagged with Bacterial Genomes
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Researchers have identified an unusual biosynthetic pathway in bacteria that can produce a key feature of a phosphonate compound, which has antifungal properties. By deciphering this process, scientists aim to accelerate the search for new natural products with potential pharmaceutical and industrial applications.
Researchers create standardized model by reclassifying bacteria into 121 separate genus groups across 29 different families. The study uses metagenomics and genome sequencing technology to overcome historical difficulties in classifying microbial species.
Scientists analyzed genomes of bioluminescent bacteria living in anglerfish bulbs, revealing a new paradigm of symbiosis. The bacteria have lost genes for making amino acids and breaking down nutrients, suggesting the fish supplies them with essential compounds.
Researchers discovered that bacteria associated with beetles can produce an antifungal substance similar to one found in marine tunicates. The commonality is likely due to lateral gene transfer between unrelated microorganisms. This finding highlights the potential of defensive symbionts for innovation and human use.
Researchers have sequenced the genome of a tiny fern species, Azolla filiculoides, which has been found to have significant environmental applications. The fern's unique gene provides insect resistance and can be used as a sustainable fertilizer, while its symbiotic relationship with cyanobacteria allows for nitrogen fixation.
A recent study published in Eurosurveillance confirms that NDM bacteria can be transmitted between dogs and humans, with the owner of two Finnish dogs also carrying the bacterium. The transmission was established through genome analysis, which revealed identical bacterial isolates from dogs and humans.
Researchers sequenced the first fern genome, enabling insights into land plant evolution and cyanobacterial symbioses. The study revealed genes specific to Azolla's interaction with Nostoc, a cyanobiont, and an important insecticidal gene that provides protection against insect pests.
Researchers have recovered ancient syphilis genomes from skeletal remains in Mexico, distinguishing between the subspecies that cause syphilis and yaws. The findings shed new light on the evolutionary history of syphilis, suggesting a complex history that challenges previous hypotheses.
Researchers at Cornell University developed a new method to monitor urinary tract infections using cell-free DNA profiling, providing valuable information about the infection's dynamics and patient response. This technique has the potential to diagnose rare infections earlier and improve outcomes in kidney transplantation.
Researchers sequenced the genomes of every microbe in a teaspoon of soil and found hundreds of complex molecules with potential antibiotic or antifungal activity. The discovery is significant as disease-causing bacteria become increasingly resistant to current drugs.
Researchers at Indiana University have made the first direct observation of bacteria using a 'DNA harpoon' process to rapidly evolve new traits, including antibiotic resistance. The study revealed that pili act like microscopic harpooners to cast their line through pores in the cell's wall and reel in DNA fragments.
The study reveals that flea-borne plague existed for at least 4,000 years, with key virulence factors acquired in the Bronze Age. The researchers hope their findings will help predict future evolution of epidemics and better understand the spread of the deadly bacteria.
A study published in Foodborne Pathogens and Disease suggests that farm animals may play a role in helping to combat drug-resistant infections. Researchers analyzed the transfer of resistant E. coli between farm animals and humans, highlighting the need for more robust data and state-of-the-art genome analysis.
Ticks cannot survive without bacterial symbionts that synthesize B vitamins from scarce nutrients in blood. A study discovered a key bacterium that produces vital B vitamins, such as biotin and folic acid, for ticks' survival.
Researchers have discovered a previously unknown mechanism used by Xanthomonas citri to resist amoebae, which is controlled by a signaling pathway that enhances its resistance. The study confirms the bacterium's arsenal of mechanisms to withstand environmental competitors and predators.
Researchers discovered a genetic signature in Nasonia wasps that suppresses Wolbachia bacteria transmission to eggs, giving the wasp an evolutionary benefit. This finding provides insight into how animals may evolve to control their transmitted bacteria, highlighting unique defense strategies across species.
A new workflow has been developed to accelerate gene function assignments in bacteria, enabling large-scale assays of gene importance across many conditions. The study identified thousands of genes with previously unknown functions and provided an anchor for other researchers to make informed inference about protein function.
A new study on ancient leprosy DNA found diverse leprosy strains circulating in Medieval Europe, contradicting previous assumptions about the disease's origin. The research sequenced 10 medieval genomes, including the oldest to date from around 400 AD, revealing complex transmission dynamics.
The Earth BioGenome Project proposes sequencing genomes of all known eukaryotic species, an undertaking estimated to take 10 years and cost $4.7 billion. This initiative aims to create a complete digital library of life that will guide future discoveries, building on the success of previous genomics projects like the Human Genome Project.
Researchers at the University of Leicester have found that antimicrobial therapy can prevent sepsis and life-threatening disease in people suffering from pneumonia. By targeting specific immune cells, this treatment can abort the phase of intracellular replication that protects bacteria from antibiotics.
Researchers at INRS have identified a non-pathogenic marine bacterium that can effectively degrade petroleum products in soil and water. The bacteria's enzymes have been shown to break down benzene, toluene, and xylene with high efficiency, offering an eco-friendly method for decontaminating oil sites.
Scientists have identified genetic patterns in Haemophilus influenzae that make certain strains more dangerous than others. This discovery may lead to the development of new treatments and vaccines for Chronic Obstructive Pulmonary Disease (COPD) patients.
The study presents a reference catalog of rumen microbial genomes and isolates, targeting economically and environmentally relevant microbes. The collection contains nearly 33,000 degradative Carbohydrate-Active Enzymes that can break down plant cell walls.
A team of researchers from Ruhr-University Bochum has discovered that the bacterium Streptomyces chartreusis produces 1,044 different substances, exceeding expectations. Many of these substances have pharmaceutical potential and could lead to new treatments for patients who suffer from iron overdose or aluminium toxicity.
Researchers have developed a novel technology platform to genetically modify phage genomes systematically, providing additional functionality. The new phage workbench allows for the creation of custom bacteriophages with various functions, overcoming constraints associated with naturally occurring phages.
A comparative genome study between two corals, Stylophora pistillata and Acropora digitifera, reveals significant genetic disparities. The findings suggest that corals exhibit high levels of genetic variation within the same species, affecting their resilience to climate change.
Researchers identify a new source of botulinum toxin in Enterococcus faecium bacteria, which can be transferred between species and has implications for protein therapeutics and monitoring emerging pathogens.
A recent study has shed new light on the biology of M. leprae, revealing genes associated with antibiotic resistance and potentially leading to new treatments. The research also suggests that leprosy originated in the Far East, challenging long-held assumptions about its origins.
A comprehensive study has identified just a handful of bacterial taxa that dominate the Earth's soil globally. These abundant bacteria can be grouped based on five key environmental preferences, providing new insights into their roles in regulating nutrient cycles, plant productivity, and terrestrial carbon dynamics.
Researchers at the Babraham Institute have discovered that good bacteria in the gut can control gene expression by producing short chain fatty acids, which increase crotonylations and affect gene activity. This process may help prevent cancer and fight infections, highlighting the importance of a healthy diet and gut bacteria.
A functional genomics database has been developed to study the plant microbiome, revealing key genes involved in bacterial adaptation to plants. The database combines 3837 genomes from various organisms, including plants and human gut bacteria, allowing researchers to identify genes that aid in bacterial colonization.
Researchers at Scripps Research Institute have discovered a family of compounds, leinamycin (LNM), with potential as anti-cancer agents. By mining bacterial genomes, the team identified 49 bacteria with genes that code for LNM compounds, offering new avenues for cancer treatment.
Bioengineers examine genomic diversity of microbes, exploring how mutation and recombination influence evolution. They find a balance between opposing forces that determine whether a species remains stable or diverges.
Researchers from Bigelow Laboratory discovered nitrite-oxidizing bacteria to be key players in the global carbon cycle, capturing more than 1.1 gigatons of CO2 annually. These large, relatively rare bacteria outperform archaea in carbon capture, highlighting a significant shift in our understanding of oceanic carbon cycling.
Researchers sequenced ancient plague genomes from 4,800 to 3,700 years ago, revealing a possible introduction of Yersinia pestis into Europe during the Neolithic period. The study suggests that the plague spread along with the migration of steppe nomads and may have played a role in genetic turnover of European populations.
Researchers at Harvard's Wyss Institute have developed two new types of kill switches for engineered microbes, ensuring biocontainment and stable autonomous control. The Essentializer and Cryodeath systems use toxin/anti-toxin combinations to regulate bacterial growth and confine them to specific environments.
A bacterium in a species of leaf beetles provides the beetle with enzymes required to break down certain plant cell wall components. The symbiotic bacteria reside in special organs near the gut and have the smallest genome ever sequenced outside a host cell.
A leaf-eating beetle has evolved a symbiotic relationship with bacteria that allows it to break down pectin, a plant cell wall component. The bacterium, which has a tiny genome, has the power to degrade pectin, enabling the beetle's digestive system to access nutrients.
Researchers have identified a different strain of Salmonella Typhimurium in the UK that is less severe and susceptible to antibiotics compared to the strain causing high levels of disease in sub-Saharan Africa. The genomic differences between the two strains may hold clues to why the African strain causes such high mortality rates.
Researchers tracked MRSA transmission through detailed genome sequencing and epidemiological data, finding clusters of closely related bacteria linked to specific individuals and hospital transfers. The study reveals MRSA strains thought to be strictly hospital-associated are spreading in the general community.
Researchers discovered that Mycoplasma agalactiae uses a molecular stealth mechanism to evade the immune system. The bacteria can compensate for gene inactivation through an alternative mechanism, allowing them to survive and persist in infected hosts.
Researchers discovered that oyster shells contain unique microbial communities with higher denitrification activities than sediments. This finding has important implications for oyster restoration efforts, which may reduce nutrient levels in coastal waters by leveraging the shell microbiomes' active removal of fixed nitrogen.
Researchers developed a genome-scale model that predicts how E. coli cells respond to temperature changes and genetic mutations, highlighting the importance of chaperone networks in adaptive cell modeling for precision medicine.
Researchers used computer modeling to understand how E. coli bacteria can unlink tangled DNA by a local reconnection process. The study found that undoing one link at a time is the preferred route to separate the circles of DNA, with implications for other complex systems in nature.
University of Delaware researchers studied microbes from James Cameron's Deepsea Challenge Expedition, revealing a new branch on the microbial family tree. The Parcubacteria were found to have a simple metabolism but with extra features, indicating they may be able to perform anaerobic respiration and adapt to cold environments.
The study recovers 8,280 bacterial and 623 archaeal genomes from environmental samples, increasing the number of known life forms by nearly 10%. This represents a significant boost to our understanding of microbial diversity and its role in critical biogeochemical processes.
New research at Los Alamos National Laboratory develops a DNA detection method that can accurately distinguish virulent bacteria from harmless look-alikes. The study identifies specific plasmid features in environmental species that differentiate pathogenic Francisella tularensis strains from non-threat agents.
Researchers at ETH Zurich have discovered a mechanism used by bacteria Amoebophilus to shoot micro-daggers that pierce the digestive compartment of an amoeba, allowing it to escape digestion and thrive. The study reveals new insights into bacterial evolution and opens up possibilities for other structural biology investigations.
Researchers have identified a novel botulinum neurotoxin, BoNT/X, with potential to treat various medical conditions, including muscle spasms and chronic migraine. The discovery enables the development of diagnostic methods and treatments, facilitating countermeasures against exposure to toxic amounts of the substance.
Researchers have developed a new CRISPR-based approach to store digital information in living cells, which can be used to record complex biological events and propagate information over time. The system encodes complex data, such as images and videos, into the genomes of bacteria, allowing for reconstruction of the original information.
Researchers encoded and played back a primitive movie in DNA using CRISPR technology, enabling the potential to record changing internal states of neurons. The 'molecular recorder' could one day allow for non-intrusive tracking of events over time, revolutionizing brain development studies.
Researchers describe for the first time the exact chain of events as the CRISPR complex loads target DNA and prepares it for cutting by the Cas3 enzyme. The study reveals a molecular redundancy that prevents unintended genomic damage, providing insights into ways to improve CRISPR-Cas systems for precision gene editing.
A research team at Berkeley Lab identified principal oil-degrading bacteria and their mechanisms for degrading crude oil components. They also discovered a new bacterium, Bermanella macondoprimitus, which plays a crucial role in oil degradation.
Rachel Whitaker, Associate Professor of Microbiology at the University of Illinois, receives a $1.5 million award to study mobile genetic elements and their role in microbial evolution. Her research aims to develop a new evolutionary paradigm to combat antimicrobial resistance.
Scientists have found that random diversification and extinction of cells can organize bacteria into taxonomic units as effectively as traditional ecological forces. This discovery challenges current models of microbial classification, highlighting the need for a reevaluation of the task.
The U.S. Department of Energy Joint Genome Institute has released 1,003 phylogenetically diverse bacterial and archaeal reference genomes, which will aid in understanding the functions of genes, enzymes, and metabolic pathways with wide applications in bioenergy, biomedicine, agriculture, and environmental sciences.
Researchers found that metformin increases growth of bacterial species linked to improved metabolism, leading to better blood glucose control. The study suggests that the gut microbiota plays a key role in metformin's effectiveness and may hold promise for reducing adverse events.
Researchers have successfully integrated cutting-edge technologies to produce novel yeast strains for industrial use, as well as reveal a more sophisticated understanding of the yeast genome. The new method enables exploration of all genes in yeast, identifying previously unknown functions.
Researchers are using gene-editing platform Crispr-Cas9 to investigate the poisoning power of ancient silver remedy. They aim to create effective antimicrobials and avoid antimicrobial resistance pitfalls.
A Florida Museum study reveals that lice and their vitamin-producing bacterial partners have coevolved continuously for at least 20 to 25 million years. The bacteria's tiny genomes are a result of extensive genome remodeling over time, with genes critical to symbiosis being close together.