Articles tagged with Centromeres
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A research team at The University of Osaka has identified a parallel pathway involving CENP-C for centromere specification and function. This process is vital for ensuring chromosomes are structured and genes are expressed appropriately.
Researchers have discovered how key molecules coordinate chromosome alignment in cell division. Dual inhibition of KIF18A and CENP-E selectively kills cancer cells, suggesting a new therapeutic avenue for cancer treatment. This study highlights the importance of targeting specific proteins to develop more effective anticancer therapies.
Researchers at Stowers Institute for Medical Research have identified the precise location where human chromosomes break and recombine to form Robertsonian chromosomes. The study reveals that repetitive DNA sequences play a central role in genome organization and evolution, explaining how these rearrangements form and remain stable.
The corona is a crucial structure in the kinetochore that ensures correct chromosome alignment and regulation of segregation. Scientists have discovered a dual-pathway assembly mechanism that drives corona formation from just two initial proteins.
Researchers found that G9a/H3K9me2 localizes to centromeres to promote di-methylation, essential for proper chromosome segregation. It activates Aurora B and prevents repressive marks from encroaching into core centromeric domains.
Researchers have finally pinned down the genomic, epigenomic, and cellular landscape of the enigmatic arrow worm, connecting its unique genetic markup to specialized cell-types. The study reveals an unprecedented rate of gene genesis and duplication, as well as a unique method of chromosomal organization.
Researchers discovered how dogroses use larger centromeres to ensure unpaired chromosomes are passed on via the egg cell, enabling a unique reproductive system. This study provides new insights into plant genetics and could lead to more robust crops.
The study reveals that centromeric R-loops play a critical role in ensuring chromosome alignment during oocyte meiotic divisions. Disruption of R-loop homeostasis leads to spindle assembly defects and chromosomal misalignment, highlighting the importance of R-loops in maintaining genomic stability.
The study clarifies the mechanism of protein docking onto centromeres, essential for correct chromosome separation. DNA-binding regions adjacent to known motifs are necessary for interaction with centromeric DNA.
A joint research group clarifies a key mechanism of how retrotransposons preferentially insert in the centromere. The findings reveal strong integration biases for certain genetic elements, shedding light on rapid genome evolution.
Researchers at MPI unveiled PLK1's crucial role in replenishing CENP-A proteins per centromere, a process critical for cell division. PLK1 initiates a cascade of events by binding to specific machinery components and inducing phosphorylation changes.
Researchers found that plants use both DDM1 and RNAi to control chromosome division, providing a 'backup plan' when one molecule is lost. This discovery may lead to better treatments for human diseases such as ICF syndrome and cancer progression.
Researchers have characterized cucumber centromeres, identifying key sequences and retrotransposons. The study highlights differences in centromeric DNA between wild and cultivated cucumbers, providing valuable information for improving genetic maps and breeding programs.
A groundbreaking study has revealed that the centromere consists of two subdomains, which play a crucial role in ensuring proper chromosome segregation during cell division. This discovery provides new insights into the mechanisms underlying erroneous divisions in cancer cells.
Researchers have determined the molecular level function of free-forming structures in plant cells that help sense light and temperature, enabling plants to distinguish a range of different light intensities. The formation of these organelles is not random but is linked to specific locations within the cell, particularly near centromeres.
Researchers used medaka fish, CRISPR and new imaging techniques to study embryonic mitosis. They discovered unique spindles assemble in early embryos and found Ran-GTP plays a decisive role in spindle formation, which diminishes later in development. The study paves the way for further exploration of embryonic mitosis.
A genomic study has revealed the unimaginable diversity of human and nonhuman primate centromeres, highlighting their speed of evolutionary change. Centromeres differ vastly in size, structure, and epigenetic makeup, with unique sequences and organization emerging from different evolutionary forces.
A study published in Nature Plants reveals that chromosome pairing plays a crucial role in regulating genetic material distribution in plants. Researchers found that the telomeres, specifically located at the ends of chromosomes, are the key players in controlling crossing-over activity, which ensures genetic diversity among offspring.
Researchers identify a unique centromere structure in Chionographis japonica with 7-11 evenly spaced units, similar to monocentric species but larger than others. This arrangement enables more stable and robust chromosomes during cell division.
A team at Osaka University identified a crucial protein facilitating proper chromosome movement when cells divide. The research revealed that the Cupin domain of CENP-C is essential for its function, supporting centromere/kinetochore assembly and maintaining genomic integrity.
Researchers at Osaka University identified two key genes, Srr1 and Skb1, involved in gross chromosomal rearrangement. These genes play a crucial role in preventing the formation of isochromosomes, a type of structural mutation in chromosomes.
Researchers at Osaka University used cryogenic electron microscopy to study the structural change of the centromere during cell division. The study revealed a complex interaction between proteins involved in cell division, providing new insights into the correct division of chromosomes.
Holocentric chromosomes have been found to promote rapid genome evolution by allowing the formation of new species through chromosome fusions. This non-classical mode of chromosome organization also stabilizes chromosomal fragments and facilitates DNA gene swapping, making it an exciting area for plant breeding.
Researchers from the University of Tokyo have proposed a two-step regulatory mechanism that shapes centromere distribution, revealing its role in maintaining genome integrity. The study found that precise control of centromere spatial arrangement is required for organ growth in response to DNA damage stress.
The IPK research team has classified a key gene for cell division, highlighting its role in maintaining genome stability in plants. The study reveals that plant-specific duplicated genes have a significant impact on the centromere and kinetochore.
Researchers from Max Planck Institute have determined the 3D structural details of the human CCAN complex, highlighting its unique features and implications for interactions with centromere protein A. This discovery raises fundamental questions about creating artificial chromosomes.
A complete, gapless genome sequence has been completed for scientists and physicians, revealing new details about the region around the centromere. The newly sequenced genome provides insights into human genetic variation and may hold clues to the evolution of our ancestors in Africa.
The completed human genome assembly has revealed new insights into human evolution and diseases. Researchers found that highly repetitive regions, including segmental duplications, contain genes critical for brain development and function. These findings shed light on the genetic factors that make humans distinct from other primates.
The new reference genome provides a more complete sequence of the human genome, shedding light on long-running mysteries surrounding centromeres and heterochromatin. This breakthrough enables researchers to better understand gene expression, variation, and epigenetic mechanisms.
Researchers fill in gaps in Human Reference Genome, discovering repetitive sections are a major source of human variation and genetic diversity. The Telomere-2-Telomere project reveals complex architectural features with significant consequences for understanding human evolution and biological function.
Researchers at the University of California, Davis, have discovered a mechanism to eliminate half the genome in plants, making it easier to breed crops with desirable traits like disease resistance. This breakthrough could shorten breeding times by several generations.
Researchers have sequenced the Arabidopsis genome at unprecedented detail, shedding light on centromere evolution and revealing genetic and epigenetic topography. The findings provide insights into the genomic equivalent of black holes, a region that has long been challenging to analyze.
Researchers at HKU have discovered the cellular proteins used to process foreign DNA fragments into an artificial chromosome. The study provides insights into the mechanisms of DNA assembly and centromere formation, facilitating the engineering of artificial chromosomes for cloning and gene therapy.
Research from the University of Pennsylvania suggests that certain proteins have evolved to reduce biased chromosome inheritance, potentially avoiding mistakes and birth defects. The study found a parallel pathway suppressing selfish chromosomes, indicating an evolutionary arms race.
Researchers at UNIGE found that chromosomal site location is transmitted through an epigenetic process, allowing offspring to inherit correct positions even without gene information. This epigenetic memory only lasts for one generation and affects the survival of mutant worms.
Researchers discovered that stem cells have smaller and weaker centromeres compared to differentiated cells. This finding highlights a possible mechanism for the errors in cell division that limit the potential of stem cells in regenerative medicine.
Researchers at the University of Tsukuba identified a novel protein complex, NWC, involved in regulating Aurora B localization to ensure correct chromosome separation. The study found that NWC functions in mitotic chromosome stability by allowing Aurora B to accumulate at centromeres.
DNA repair mechanisms choose between pathways to limit harmful chromosomal combinations that may be predisposed to cancer and genetic diseases. The study found Rad52-dependent single-strand annealing leads to gross chromosomal rearrangements at centromeres, while Rad51 promotes conservative non-crossover recombination.
Scientists at Leibniz Institute of Plant Genetics and Crop Plant Research discovered a new type of centromere in the European dodder, Cuscuta europaea. Unlike typical monocentric or holocentric species, the unique centromere in C. europaea was found to be independent of CENH3 histone distribution.
Researchers from the Leibniz Institute of Plant Genetics and Crop Plant Research have discovered a chaperone protein that affects CenH3 loading to centromeres, crucial for kinetochore assembly. This finding has potential applications in plant breeding, particularly in haploid induction, which can speed up breeding processes.
A Waseda University-led research reveals that SET/TAF1, a proto-oncogene, functions as a tension sensor to regulate Aurora B kinase activity and maintain even chromosome distribution. This discovery sheds light on the molecular mechanism of cancer-causing oncogenes and their role in leukemia development.
Researchers have streamlined the construction of human artificial chromosomes by bypassing the need for DNA from the centromere. This breakthrough enables improved delivery of drugs and gene therapies.
New human artificial chromosomes (HACs) have been developed to overcome the limitations of previous versions by removing repetitive elements and utilizing epigenetic markers. These advancements enable more thorough studies of chromosome function and open doors to complex synthetic biological systems.
Researchers have discovered big chunks of ancient Neanderthal and other ancient DNA in the dark centers of human chromosomes, which can be used to study chromosome behavior during cell division and evolutionary descent. The findings also suggest that certain centromere haplotypes may influence differences in sense of smell.
HKU biologists discovered centromeric DNA produces essential non-protein coding centromeric RNA (cenRNA) for chromosome stability. Excessive or deficient cenRNA leads to defective centromeres and lost chromosomes, causing genetic errors.
Researchers use cutting-edge sequencing technology and microscopy to discover the sequences of all centromeres in the fruit fly Drosophila melanogaster. They found that centromeres contain a high number of transposable elements, including retroelements, which may play a role in centromere function across species.
Researchers at Osaka University found that heterochromatin helps prevent large chromosomal rearrangements by repressing transcription of centromere repeats. The team's study reveals a key mechanism for maintaining chromosomal integrity and could lead to new methods for securing genome stability.
Researchers discovered a novel defence mechanism in yeast cells that uses centromeres to detect and neutralize foreign genetic material. This mechanism ensures that potentially harmful DNA is confined within one cell, while the daughter cell contains only reliable DNA.
Researchers fused yeast chromosomes to study reproductive isolation and its effects on breeding. The team found that viable sex cells could not be produced when the difference between chromosome numbers became too great, leading to reproductive isolation.
Scientists have used nanopore long-read sequencing to generate the first complete and accurate linear map of a human Y chromosome centromere. This milestone marks the beginning of a new era in human genetics and genomics, where gaps in the genome reference will no longer be tolerated.
Researchers at University of Michigan develop new PCR-based approach to study chromosomes' centers, yielding clues about Down syndrome. The technique accelerates analysis of centromere DNA, potentially leading to breakthroughs in birth defects and cancers.
A team from the University of Pennsylvania discovered how chromosomes bias their chance of getting into a sex cell by exploiting asymmetry in the cell-division process. This bias can lead to errors in gamete formation, causing miscarriages and conditions like Down's syndrome.
Researchers at Osaka University have identified distinct factors regulating crossover-type recombination at yeast centromeres and non-centromeres. The study suggests that centromeres are protected from chromosomal rearrangements due to specific proteins, ensuring DNA fidelity.
Researchers mapped evolutionary turning points that transformed a fungus with tens of thousands of mating types to one with only two. They found that translocations brought together separate chunks of sex-determining genes onto a single chromosome, mimicking the human X or Y chromosome.
Researchers from Osaka University have found that the interaction between M18BP1/KNL2 and CENP-A proteins is crucial for cell division in various species except mammals, including humans. This essential protein interaction allows new CENP-A deposition into centromeres to maintain genome information equally during mitosis.
Researchers found that intron sequences promote heterochromatin structure formation, leading to improved chromosome segregation during cell division. This discovery has significant implications for understanding diseases caused by chromosomal abnormalities, such as Down syndrome.
A recent study published in Nature Communications has shed light on the structures that contain our genetic material. Researchers at the University of Edinburgh created an artificial chromosome to investigate cell division and found a complex series of steps that form a protective barrier inside chromosomes.
Researchers have discovered a potential new biomarker that can predict cancer patient prognosis and response to treatment. The biomarker is based on the degree of gene overexpression in genes regulating genome integrity.
A new study reveals that variation in repetitive genetic code, once considered 'junk', can affect genome stability and lead to an increased risk of cancer, birth defects, and infertility. The research found that genomic variation at specific regions determines the location of centromeres on human chromosomes.
Researchers have revealed the architecture of a protein complex called CCAN, which plays a foundational role in chromosome segregation during cell division. The study found that each subcomplex needs to touch many others to be functional, forming a mesh structure crucial for kinetochore assembly and stability.