Articles tagged with Chromatin
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The study created a critical framework for understanding the architecture of the genome and its association with gene function in cells. The 4DN Consortium integrated data from over a dozen techniques to compile an extensive catalogue of looping interactions between genes and regulatory elements.
Chromatin accessibility maps reveal that MDS stem cells gradually lose their normal identity and acquire characteristics typical of myeloid progenitors. A 'progenitor score' developed by the team tracks cell movement toward a progenitor-like state, correlating with disease severity and prognosis.
Researchers found that DNA loops facilitate homologous recombination, a key DNA repair process linked to cancer. These loops enable the repair machinery to scan for an intact copy of the damaged region more efficiently.
Researchers have captured the most detailed images yet of molecules inside synthetic chromatin condensates, allowing them to understand how these droplet-like structures form and function. The team found that linker DNA length affects structure arrangement, which in turn dictates interactions between chromatin fibers.
Researchers at MBL propose a model for how properties of individual molecules emerge to form liquid droplets called condensates. By combining imaging and computer simulations, they reveal the importance of linker DNA in determining condensate structure.
Cancer researchers at Cold Spring Harbor Laboratory have identified key proteins that determine the behavior of two hard-to-treat carcinomas, pancreatic cancer and tuft cell lung cancer. These findings could lead to new therapies targeting specific vulnerabilities in these cancers.
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that inflexible DNA within nucleosomes regulates the positioning of INO80, a chromatin remodeling complex. This unique mechanism allows INO80 to position itself on the surface of nucleosomes at the right location.
Researchers have discovered that stress hormones can silence crucial neuronal genes by interacting with long noncoding RNAs and the polycomb repressive complex 2. This mechanism may provide a new understanding of how stress affects gene expression, particularly in relation to synaptic function and calcium signaling.
Researchers have identified a new histone variant, macroH2A1.1, as a potential therapeutic target for treating Acute Myeloid Leukaemia. The study found that targeting this variant is safe for patients and may lead to new treatment options.
Researchers at Chinese Academy of Sciences identify a key gene and protein involved in controlling DNA looping, leading to increased grain yield and nitrogen efficiency. The discovery paves the way for future crop breeding strategies to improve sustainability.
Researchers used CRISPR technology to identify HMGN1, a nuclear binding protein that contributes to trisomy 21-related CHDs. The study found that an overabundance of HMGN1 leads to abnormal heart development and gene expression.
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
Telomeres, which cap chromosomes, are inherited from parents in a parent-of-origin effect, with mothers contributing short telomeres and fathers long ones. This process is linked to cancer risk and aging, and researchers hope to study it further using human genome sequencing.
A new '3D genome organizer' has been discovered, crucial for sperm production in mice, and highly expressed in human immune cells and blood cancers. Blocking this complex may slow cancer growth and lead to new infertility treatments.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
Researchers analyzed centromeres in onion, garlic, and Welsh onion using CENH3-targeted antibody to map centromere regions. They found significant variations in size and position/mobility between species, challenging the static view of centromeres.
Scientists have found that nucleosomes act as gatekeepers for p53's molecular partners, controlling its access to the genetic code. This discovery reveals a new layer of regulation over p53's activity and opens possibilities for developing cancer therapies that restore or control p53 function.
By reprogramming chromatin to prevent cancer cells from adapting to evade treatment, researchers have doubled chemotherapy effectiveness in animal experiments. This approach restores cellular memory, making existing drugs more effective against cancer.
Professor Eran Meshorer's groundbreaking research in epigenetics and stem cell biology has uncovered critical insights into chromatin structure and gene expression. His work has broad implications for regenerative medicine, developmental biology, and understanding neurological disorders.
A study on hybrid fish found that allelic genes and testis-specific genes play a crucial role in maintaining fertility, while orphan genes facilitate adaptation to new genetic environments. The research used long-read sequencing and Hi-C technology to construct high-quality genomes for reciprocal hybrids.
Researchers developed an AI system called Image2Reg that can identify genetic perturbations in cell images, potentially leading to new drugs. The system uses machine learning and molecular networks to analyze patterns in chromatin structure, revealing links between genes and their functions.
Researchers used genetic data and computational tools to identify genetic variants associated with asthma, finding differences between childhood- and adult-onset forms of the disease. The study provides insights into potential treatment targets for both types of asthma.
Researchers at King's College London have developed a complex model of molecular 'wear-and-tear' that sheds light on how proteins age. The study found that chromatin, the DNA-protein mix, is more resilient to aging than previously thought, suggesting new avenues for anti-aging treatments.
Researchers use generative AI to predict chromatin structures in single cells, overcoming limitations of existing experimental methods. The technique can generate thousands of structure predictions in minutes, enabling faster study of how 3D genome organization affects gene expression.
Scientists from Gladstone Institutes developed a new method called RASAM, which made a surprising discovery that large sections of newly formed DNA are hyperaccessible for many hours. This finding holds important implications for basic understanding of biology and the development of new medicines.
A UC Riverside-led team, funded by the NIH, aims to uncover molecular factors governing gene regulation and chromatin organization in P. falciparum. The project focuses on long non-coding RNAs, which play a crucial role in regulating gene expression and influencing disease progression.
A new study reveals how transcription factors navigate DNA and chromatin structures to determine cellular identity. Researchers discovered novel DNA elements as genomic signposts guiding TFs to specific genetic switches.
Researchers at Gladstone Institutes and UCSF identified MED12 as a crucial switch that regulates T cell rest and activation. The study found that MED12 promotes rest in resting cells and activation in activated cells, and its removal led to blurred lines between rest and activation.
The study found that DNA packaging sends signals through an unusual pathway, affecting cell division and growth. Chromatin acts as a guide, telling the cell how to read and use the information in the DNA.
Gladstone researchers have identified a complex molecular connection between immune cells and fibroblasts that contributes to fibrosis in the heart, which may lead to new treatments for heart disease and other fibrotic conditions.
Researchers at UC San Diego have developed a faster and more affordable method to study chromatin organization, which influences gene activation and cell function. The droplet Hi-C technique has been successfully deployed to analyze chromatin organization in mouse brain cells and human tumors.
A team of scientists developed an advanced computational technique to predict gene architecture through nucleosome position, combining experimental approaches with machine learning techniques. The study demonstrates that nucleosomal architecture is greatly influenced by DNA sequence information and physical signals.
Researchers at MPI unveiled PLK1's crucial role in replenishing CENP-A proteins per centromere, a process critical for cell division. PLK1 initiates a cascade of events by binding to specific machinery components and inducing phosphorylation changes.
A mouse model study led by Ohio State University researchers reveals the importance of DNA loops and protein complex cohesin in nerve cell regeneration. The study's findings could lead to new treatments for nerve injuries by understanding how chromatin organization affects gene expression.
Scientists have found a way to rearrange DNA strands using light, enabling precise control over gene expression and potential new treatments for disease. The new method uses liquid-like droplets to manipulate DNA, revealing the material nature of chromosomes.
A new study has identified NSD2 as a fundamental factor in early stages of prostate cancer development, found to alter androgen receptor function leading to rapid cell division and growth. The study may suggest a new way to therapeutically target prostate cancer by targeting the epigenetic component NSD2.
Kumamoto University researchers discovered HMGA2's crucial role in regulating stress responses in hematopoietic stem cells. The gene enhances blood cell production recovery under stressful conditions, such as chemotherapy and infections.
Researchers employed AI to analyze epigenetic impact of chromatin and transcriptional changes during winter dormancy in axillary apple buds. The study revealed genes related to cellular response to hypoxia, defense response to ABA, and circadian rhythm were activated during bud dormancy.
A study found that chromatin's spatial structure plays a key role in the evolution of social behavior in dogs. The researchers examined an intronic section of the GTF2I gene, which influences chromatin's spatial structure and causes differences in gene expression.
A new study from Michigan Medicine suggests that inhibiting the SWI/SNF epigenetic complex can therapeutically target oncogenic transcription factors. The research, led by Arul Chinnaiyan, builds on previous work to find genetic vulnerabilities in transcription factor-driven cancers.
Researchers found that epigenetic state affects neurons' recruitment into memory trace formation. Open chromatin states enable more efficient learning. The study opens new avenues for understanding learning and may lead to medication for improving cognitive disorders.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Scientists at Salk Institute discover a molecular mechanism that helps macrophages mount a coordinated response tailored to a specific immune challenge. The discovery reveals new immune system mechanisms that could be targeted with therapeutics to regulate inflammation.
Researchers found that increased activity of the SIX2 protein contributes to increased cell plasticity and treatment resistance in prostate cancer cells. Silencing the SIX2 gene reduces malignancy and cancer spread in hormone therapy-resistant types of cancer.
Researchers have developed a modular epigenome editing platform to study the impact of chromatin modifications on transcription. The system allows for precise programming of nine biologically important chromatin marks, enabling the discovery of causal relationships between chromatin marks and gene regulation.
Scientists discovered that p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response, identifying 340 target genes and strengthening the role of cohesin complex in this process. This new mechanism may inspire new therapeutic approaches for cancer treatment.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
Researchers identified a key chromatin modifier-centered pathway for grain size regulation in rice, showing that HHC4 and bZIP23 interact and enhance grain size. Phosphorylation of HHC4 by TGW3 triggers negative influences on the pathway, leading to increased rice yield.
Researchers have found that the BCG vaccine can enhance innate immunity in individuals with dormant immune cells, predicting a positive response to vaccination. Trained immunity responders exhibited increased production of inflammatory mediators after vaccination.
Scientists at Paul Scherrer Institute achieve breakthrough in detecting developing tumors at an early stage and monitoring therapy success. They used artificial intelligence to analyze blood cell chromatin, distinguishing between healthy and sick cells with high accuracy, and identifying tumor types with over 85% precision.
Researchers developed a new technique called MAbID to study multiple mechanisms of gene regulation simultaneously, enabling the connection between different gene expression processes. This technology can be applied to various fields, including human development and disease research.
A study by Max Planck researchers has discovered an epigenetic regulator MSL2 that ensures the expression of both alleles of haploinsufficient genes, crucial for human health. This mechanism allows for tissue- and cell-type specificity in gene dosage, opening new directions for understanding diseases and developing potential treatments.
Researchers created a comprehensive chromatin map to understand gene regulatory networks contributing to differences between pediatric acute lymphoblastic leukemia subtypes. The study identified key transcription factor footprints and chromatin accessibility patterns, which can predict leukemia subtype with 89% accuracy.
Research reveals chromatin's role in preventing DNA-RNA hybrid formation, which causes genomic instability and cancer. DNA-RNA hybrids are a risk factor in tumour development, suggesting potential use as an indicator of carcinogenic risk.
Salk researchers identify Foxp3 as the protein that determines regulatory T cell genome structure and fate, enabling manipulation to treat autoimmunity or fight cancer. The study reveals Foxp3's essential role in creating unique chromatin architecture of regulatory T cells.
Researchers have identified a new method to distinguish histidine methylation in histone proteins, revealing its role in regulating genomic DNA folding. The study found histidine methylation at specific residues in histones H2A and H3, primarily affecting lysine residues.
Researchers developed Genome Architecture Mapping (GAM) to study DNA interactions, revealing novel three-dimensional configurations that were invisible to Hi-C. This technique provides a more comprehensive understanding of genome organization and its impact on health and disease.
Researchers discover cBAF protein complex plays crucial role in controlling T cell fate during infection. The study reveals how chromatin remodeling and genetic code accessibility influence the development of cytotoxic T cells into effector and memory subtypes.
Scientists at St. Jude Children's Research Hospital discovered that subunits of the SWI/SNF chromatin remodeling complex act as bookmarks to safeguard cell identity during mitosis. This finding provides new insights into how cancers develop and how they can be treated.
Researchers discovered that MSH2-MSH3 plays a crucial role in selecting the right DNA repair process by interacting with other proteins during DSB repair. This interaction facilitates error-free homologous recombination and blocks error-prone polymerase theta-mediated end-joining.