Articles tagged with Crisprs
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at NC State University have made significant advancements in the genome editing technique CRISPR-Cas, identifying key molecular elements that drive its activity. The study sheds light on how guide RNAs interact with the Cas9 endonuclease, enabling more precise genetic modifications.
UCSF researchers develop SunTag technology to precisely turn genes on and off, revolutionizing CRISPR applications. The technique has broad implications for reprogramming cells and understanding diseases.
Researchers have found an alternative way to model cancer using CRISPR, a gene-editing system that can introduce cancer-causing mutations into the livers of adult mice. This method enables scientists to screen these mutations much more quickly than traditional breeding methods.
Researchers found that a mutated CRISPR system in Francisella novicida bacteria makes them more vulnerable to antibiotics and immune responses. The study suggests the regulatory role of Cas9 in envelope integrity and membrane permeability, potentially impacting bacterial virulence.
Scientists have observed the process by which CRISPR enzymes bind and alter DNA structure, paving the way for correcting genetic diseases in humans. The study provides a vital piece of the puzzle for genome editing tools to be used in humans.
Researchers successfully used CRISPR gene-editing to correct a defective gene in adult mice, allowing them to survive without treatment. The study offers promising hope for treating genetic disorders, including hemophilia and Huntington's disease.
Researchers developed a new method to control genes by targeting transcription, allowing for positive and negative regulation with the same protein. The technique has the potential to enable complex synthetic biology circuits and applications such as disease detection and drug production.
Scientists discovered that certain bacteria require parts of the CRISPR system to stay infectious, using it to shut off a gene that triggers detection by the immune system. This finding could accelerate vaccine development, but also highlights the dangers of defensive tools being co-opted for stealth.
Scientists at UC San Francisco have developed a more precise way to turn off genes using a protein from bacteria to fight off viruses. The new technology, called CRISPR interference, allows researchers to selectively perturb gene expression on a genome-wide scale and identify key proteins that control cellular events.
Researchers from Indiana University have conducted the most in-depth genetic analysis of defense systems used by trillions of micro-organisms to fend off viruses. The study identifies 64 known and 86 novel types of CRISPRs, providing a history of past exposures to outside invaders like plasmids and bacteriophages.
Berkeley lab researchers have discovered a complex protein structure in E.coli that plays a critical role in defending against viruses and other invaders. The 'Cascade' complex acts as a surveillance system, detecting and inactivating invading pathogens using RNA-guided target binding.
Scientists have analyzed the evolution of CRISPR bacterial immune systems in human saliva over time, revealing unique and traceable defenses against viruses. The study's findings suggest that the development of resistance to viruses occurs frequently, even daily, and could lead to more personalized oral health care.
Rice University scientists analyze how bacteria acquire immunity from disease through the CRISPR system, which uses RNA interference to silence viral genes. The study's findings have implications for biotechnology and drug development.
Researchers have identified Csy4 as the enzyme responsible for producing CRISPR-derived RNAs, which target and silence invading viruses and plasmids. The discovery sheds light on how microbes use CRISPR to acquire immunity from future invasions.
Northwestern University researchers have discovered a CRISPR locus that can impede the spread of antibiotic resistance in pathogenic staphylococci by blocking plasmid transfer. This mechanism could provide a means to limit the spread of antibiotic resistance genes and virulence factors in bacteria.
Researchers identified a number of cas genes associated with CRISPR clusters, potentially involved in RNA-processing mechanisms. They propose that all CRISPR inserts are derived from viruses or plasmids, transcribed and silenced via Cas proteins.