A new screening method combining CRISPR genome editing with single-cell RNA sequencing enables the simultaneous analysis of thousands of genes in individual cells. This approach, called CROP-seq, allows researchers to study complex biological mechanisms and identify novel drug targets more efficiently than traditional methods.
SourceCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences·JournalNature Methods·DateJan 19, 2017
UCSF researchers have identified anti-CRISPR proteins that can switch off the widely used CRISPR-Cas9 gene-editing system, reducing unintended edits and improving precision. The discovery has the potential to revolutionize CRISPR applications in both basic research and clinical settings.
SourceUniversity of California - San Francisco·JournalCell·DateDec 29, 2016
Researchers have combined CRISPR gene editing with single-cell genomic profiling to understand nuanced cellular processes. The new technology enables precise manipulation of genes in individual cells, revealing previously unknown functions and advancing the field of genetic engineering.
SourceWeizmann Institute of Science·JournalCell·DateDec 15, 2016
Researchers have developed a new enzyme called TevCas9, which cuts DNA in two places instead of one, making it more difficult for DNA-repair to regenerate the site of the cut. This modification shows promise at being more specific in targeting genes and less likely to cause off-target effects.
SourceUniversity of Western Ontario·JournalProceedings of the National Academy of Sciences·DateDec 12, 2016
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Scientists have isolated three families of proteins that can turn off CRISPR-Cas9 systems specifically used for gene editing. This discovery offers a new strategy to prevent unintended changes in the genome, making gene editing more precise and controlled.
Researchers at UGA aim to expand and refine the use of CRISPR-Cas for research and biomedicine, particularly in combating pathogenic bacteria and diseases such as cancer and diabetes.
Duke researchers have successfully converted mouse fibroblasts into neuronal cells using a modified CRISPR technique. This breakthrough could lead to improved models for neurological disorders and personalized medicine. The study's findings suggest that the newly generated neurons retain their properties even after the CRISPR activator...
SourceDuke University·JournalCell Stem Cell·DateAug 11, 2016
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Researchers at IBS Center for Genome Editing demonstrate Cpf1's superior specificity in precision genome editing, generating mutant mice with targeted mutations. The study reveals that Cpf1 has virtually no off-target effects, opening up new possibilities for therapeutic treatments and agricultural products.
SourceInstitute for Basic Science·JournalNature Biotechnology·DateJun 6, 2016
Researchers have characterized a new CRISPR system that targets RNA, enabling temporary changes to be made with greater specificity. This approach has the potential to accelerate progress in understanding, treating, and preventing disease by manipulating gene function more broadly.
SourceBroad Institute of MIT and Harvard·JournalScience·DateJun 2, 2016
Researchers have developed a new method called SLENDR that allows precise labeling of proteins in brain cells using CRISPR/Cas9. This enables scientists to study brain development and function with unprecedented accuracy, revealing previously undescribed behaviors of protein kinase C.
SourceMax Planck Florida Institute for Neuroscience·JournalCell·DateMay 12, 2016
A team of researchers developed a CRISPR-based technique to rapidly identify gene variants, improving efforts to map genes and determine their function. The method induces mitotic recombination, allowing for detailed mapping of trait variants, as demonstrated by identifying a genetic mutation affecting yeast sensitivity to manganese.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateMay 5, 2016
Researchers have developed a new method to identify protospacer-adjacent motifs (PAMs) for CRISPR-Cas systems, which are crucial for unlocking the system's functionality. The tools allow for rapid identification of PAM sequences across various CRISPR-Cas systems, revealing that some systems have multiple PAMs of varying strength.
SourceNorth Carolina State University·JournalMolecular Cell·DateMar 31, 2016
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Five scientists, including Jennifer Doudna and Emmanuelle Charpentier, received the Warren Alpert Foundation Prize for their work on CRISPR, a powerful tool for rapidly determining gene function and democratizing gene editing. The discovery has enormous potential for developing new therapies, including treatments for genetic diseases.
Scientists have developed a process to improve the efficiency of CRISPR, allowing for greater consistency in deleting unwanted genes. By tweaking the sequence of single guide RNA, researchers achieved knockout efficiency of over 50% and hope to increase adoption of this technology.
SourceTexas Tech University Health Sciences Center El Paso·JournalGenome Biology·DateMar 2, 2016
Researchers from Montana State University and collaborators from Cornell and Johns Hopkins universities have made a breakthrough in understanding how bacteria's CRISPRs distinguish between self and non-self DNA. This discovery has significant implications for the development of novel technologies to treat genetic diseases.
SourceMontana State University·JournalNature·DateFeb 19, 2016
MIT researchers have developed a way to deliver CRISPR genome repair components more efficiently and safely, correcting mutated genes in 6 percent of liver cells in mice. The new approach has the potential to treat a range of diseases, including metabolic disorders and liver conditions.
SourceMassachusetts Institute of Technology·JournalNature Biotechnology·DateFeb 1, 2016
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Researchers used CRISPR to repair a genetic mutation responsible for retinitis pigmentosa, an inherited condition causing blindness in at least 1.5 million cases worldwide. The study marks the first time researchers have replaced a defective gene associated with a sensory disease in stem cells derived from a patient's tissue.
SourceColumbia University Irving Medical Center·JournalScientific Reports·DateJan 27, 2016
Duke University researchers successfully treated an adult mouse model of Duchenne muscular dystrophy using CRISPR gene editing. The treatment involved delivering the gene-editing system directly to the affected tissues through a non-pathogenic carrier called adeno-associated virus, overcoming several delivery challenges.
The CRISPR genome editing technique has been hailed as a breakthrough due to its ability to deliver genes precisely, low cost, and ease of use. It has enabled the creation of gene drives, human embryo editing, and the deletion of retrovirus DNA in pig genomes.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateDec 17, 2015
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Researchers at the John Innes Centre successfully edited genes in two UK crops using CRISPR technology. The edits were preserved in subsequent generations, allowing for the development of disease-resistant crops. Additionally, the study found that off-target edits occurred occasionally but could be minimized by using specific guide RNAs.
SourceJohn Innes Centre·JournalGenome Biology·DateNov 29, 2015
Researchers have developed a CRISPR system that can precisely turn on and off specific genomic regions, potentially revolutionizing the study of human diseases. This technique has shown exceptional specificity, enabling precise control over gene expression.
SourceDuke University·JournalNature Methods·DateOct 26, 2015
Researchers have grown mini-kidney organoids in a laboratory by combining stem cell biology with leading-edge gene-editing techniques. These engineered mini-kidneys contain tubules, filtering cells and blood vessel cells, and can mimic both healthy and diseased kidneys.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalNature Communications·DateOct 23, 2015
A new CRISPR-Cpf1 system offers a simpler approach to genome engineering with precise DNA cutting capabilities. The system, discovered by Feng Zhang and his colleagues, has potential to advance genetic engineering and cancer research.
SourceBroad Institute of MIT and Harvard·JournalCell·DateSep 25, 2015
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Scientists have created a nanoscale vehicle made of DNA to shuttle the CRISPR-Cas9 gene-editing tool into cells. This 'nanoclew' ensures precise control over the dosage of editing, reducing unintended edits. The researchers successfully tested the system in cancer cell cultures and tumors in mice, achieving promising results.
SourceNorth Carolina State University·JournalAngewandte Chemie·DateAug 28, 2015
Researchers at UGA have successfully edited the genome of a tree species using CRISPR/Cas technology, reducing lignin and condensed tannin concentrations by 20% and 50%, respectively. This breakthrough opens up new possibilities for rapid and reliable gene editing in plants.
SourceUniversity of Georgia·JournalNew Phytologist·DateJun 4, 2015
Researchers discovered how bacteria differentiate between self and foreign DNA using the CRISPR system, which involves identifying rapidly replicating DNA and utilizing DNA repair processes to create immune memory.
SourceWeizmann Institute of Science·JournalNature·DateApr 13, 2015
A Broad Institute-MIT team has identified a highly efficient new Cas9 nuclease that overcomes the primary challenge to in vivo genome editing, expanding therapeutic and experimental applications of CRISPR. The new tool is expected to improve scientists' ability to screen for gene mutations and understand gene function using animal models.
SourceBroad Institute of MIT and Harvard·JournalNature·DateApr 1, 2015
Researchers at Walter and Eliza Hall Institute developed a new genome-editing technology to target and kill blood cancer cells. The CRISPR/Cas9 system was used to delete an essential gene for cancer cell survival, showing promise for treating human diseases arising from genetic errors.
SourceWalter and Eliza Hall Institute·JournalCell Reports·DateMar 12, 2015
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Researchers created a CRISPR system that recognizes and cuts the HIV virus, effectively inactivating it. The technology has shown success in both treating active infections and removing dormant copies of the virus from cells.
SourceSalk Institute·JournalNature Communications·DateMar 10, 2015
Scientists at Gladstone Institutes have discovered a way to enhance CRISPR's precision while boosting its efficiency using small molecules. This breakthrough has important implications for correcting disease-causing genetic mutations and creating personalized therapeutics.
SourceGladstone Institutes·JournalCell Stem Cell·DateFeb 5, 2015
Researchers at Johns Hopkins Medicine have successfully used CRISPR to precisely and efficiently alter human stem cells, showcasing its potential for treatment and disease research. The findings suggest that CRISPR may be a useful tool for editing genes in human-induced pluripotent stem cells with minimal risk of off-target effects.
SourceJohns Hopkins Medicine·JournalMolecular Therapy·DateJan 5, 2015
Researchers used iPS cells to correct genetic mutations in Duchenne muscular dystrophy (DMD), a severe muscular degenerative disease. Engineered nucleases TALEN and CRISPR were successfully used to edit the genome of iPS cells generated from DMD patient skin cells, resulting in the disappearance of the mutation responsible for DMD.
SourceCenter for iPS Cell Research and Application - Kyoto University·JournalStem Cell Reports·DateNov 26, 2014
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Researchers at Harvard University have used CRISPR technology to edit out the CCR5 receptor in human blood stem cells, which could provide a new approach to treating HIV/AIDS. The edited cells showed no unwanted mutations and retained their functionality.
SourceHarvard University·JournalCell Stem Cell·DateNov 6, 2014
Researchers have developed a technique that uses the bacteria's own CRISPR-Cas system to turn off specific genes or sets of genes, creating a powerful tool for future research on genetics. This approach allows researchers to better understand the role of individual genes and identify gene sets associated with problems such as multidrug...
SourceNorth Carolina State University·JournalNucleic Acids Research·DateOct 28, 2014
Researchers at NC State University have made significant advancements in the genome editing technique CRISPR-Cas, identifying key molecular elements that drive its activity. The study sheds light on how guide RNAs interact with the Cas9 endonuclease, enabling more precise genetic modifications.
SourceNorth Carolina State University·JournalMolecular Cell·DateOct 21, 2014
UCSF researchers develop SunTag technology to precisely turn genes on and off, revolutionizing CRISPR applications. The technique has broad implications for reprogramming cells and understanding diseases.
SourceUniversity of California - San Francisco·JournalCell·DateOct 13, 2014
Researchers have found an alternative way to model cancer using CRISPR, a gene-editing system that can introduce cancer-causing mutations into the livers of adult mice. This method enables scientists to screen these mutations much more quickly than traditional breeding methods.
SourceMassachusetts Institute of Technology·JournalNature·DateAug 6, 2014
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Researchers found that a mutated CRISPR system in Francisella novicida bacteria makes them more vulnerable to antibiotics and immune responses. The study suggests the regulatory role of Cas9 in envelope integrity and membrane permeability, potentially impacting bacterial virulence.
SourceEmory Health Sciences·JournalProceedings of the National Academy of Sciences·DateJul 14, 2014
Scientists have observed the process by which CRISPR enzymes bind and alter DNA structure, paving the way for correcting genetic diseases in humans. The study provides a vital piece of the puzzle for genome editing tools to be used in humans.
SourceUniversity of Bristol·JournalProceedings of the National Academy of Sciences·DateMay 26, 2014
Researchers successfully used CRISPR gene-editing to correct a defective gene in adult mice, allowing them to survive without treatment. The study offers promising hope for treating genetic disorders, including hemophilia and Huntington's disease.
SourceMassachusetts Institute of Technology·JournalNature Biotechnology·DateMar 30, 2014
Researchers developed a new method to control genes by targeting transcription, allowing for positive and negative regulation with the same protein. The technique has the potential to enable complex synthetic biology circuits and applications such as disease detection and drug production.
SourceMassachusetts Institute of Technology·JournalACS Synthetic Biology·DateSep 3, 2013
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Scientists discovered that certain bacteria require parts of the CRISPR system to stay infectious, using it to shut off a gene that triggers detection by the immune system. This finding could accelerate vaccine development, but also highlights the dangers of defensive tools being co-opted for stealth.
Scientists at UC San Francisco have developed a more precise way to turn off genes using a protein from bacteria to fight off viruses. The new technology, called CRISPR interference, allows researchers to selectively perturb gene expression on a genome-wide scale and identify key proteins that control cellular events.
SourceUniversity of California - San Francisco·JournalCell·DateMar 7, 2013
Researchers from Indiana University have conducted the most in-depth genetic analysis of defense systems used by trillions of micro-organisms to fend off viruses. The study identifies 64 known and 86 novel types of CRISPRs, providing a history of past exposures to outside invaders like plasmids and bacteriophages.
SourceIndiana University·JournalPLOS Genetics·DateJun 13, 2012
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Berkeley lab researchers have discovered a complex protein structure in E.coli that plays a critical role in defending against viruses and other invaders. The 'Cascade' complex acts as a surveillance system, detecting and inactivating invading pathogens using RNA-guided target binding.
SourceDOE/Lawrence Berkeley National Laboratory·JournalNature·DateSep 22, 2011
Scientists have analyzed the evolution of CRISPR bacterial immune systems in human saliva over time, revealing unique and traceable defenses against viruses. The study's findings suggest that the development of resistance to viruses occurs frequently, even daily, and could lead to more personalized oral health care.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateDec 12, 2010
Rice University scientists analyze how bacteria acquire immunity from disease through the CRISPR system, which uses RNA interference to silence viral genes. The study's findings have implications for biotechnology and drug development.
SourceRice University·JournalPhysical Review Letters·DateSep 15, 2010
Researchers have identified Csy4 as the enzyme responsible for producing CRISPR-derived RNAs, which target and silence invading viruses and plasmids. The discovery sheds light on how microbes use CRISPR to acquire immunity from future invasions.
SourceDOE/Lawrence Berkeley National Laboratory·JournalScience·DateSep 9, 2010
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Northwestern University researchers have discovered a CRISPR locus that can impede the spread of antibiotic resistance in pathogenic staphylococci by blocking plasmid transfer. This mechanism could provide a means to limit the spread of antibiotic resistance genes and virulence factors in bacteria.
SourceNorthwestern University·JournalScience·DateDec 18, 2008
Researchers identified a number of cas genes associated with CRISPR clusters, potentially involved in RNA-processing mechanisms. They propose that all CRISPR inserts are derived from viruses or plasmids, transcribed and silenced via Cas proteins.
SourceBMC (BioMed Central)·JournalBiology Direct·DateMar 15, 2006