GIST scientists utilized latest advances in single molecule detection to observe the enzymatic activity of gene repair. The study revealed that ExoIII has an affinity for damaged DNA sites, creating a gap that Pol I fills. Understanding this mechanism may lead to technologies for targeted gene repair and drug development.
A new system for sampling fragments of DNA from marine organisms drifting in the ocean has been developed, enabling researchers to monitor biodiversity and conservation efforts on a global scale. The innovative approach uses water collected from engine cooling systems on commercial vessels, allowing for large-scale surveys of marine ec...
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
Researchers at Osaka University have developed a new method for detecting single DNA molecules directly from individual cells, eliminating the need for subsequent steps. The 3D-integrated nanopore allows for efficient delivery of released DNA molecules to the sensing zone, enabling robust detection and analysis.
A new genosensor, developed by a Brazilian research team, can detect the genetic sequence of SARS-CoV-2 in saliva or other body fluids with high sensitivity. The device can analyze samples in 30 minutes for a cost of less than $1 per genosensor.
Foresight Diagnostics is presenting its proprietary PhasED-Seq technology at ICML for improved minimal residual disease (MRD) detection rates in diffuse large B-cell lymphoma (DLBCL) patients. The technology has been shown to detect relapsing disease 200 days earlier than current methods.
Researchers used environmental DNA (eDNA) to detect the presence of invasive New Zealand mud snails in waters they inhabited incognito, revealing a new population in central Pennsylvania. The eDNA technique allowed for early detection of the snail's invasion, even when traditional methods would not have found them.
A new plasmofluidic chip enables fast and accurate PCR tests in under 13 minutes, offering a significant improvement over current RT-PCR methods. The device uses gold nanoislands to rapidly heat and cool samples, reducing testing time without sacrificing amplification efficiency.
Researchers at Harvard's Wyss Institute develop programmable DNA self-assembly strategy for ultrasensitive diagnostic biomarker detection and scalable fabrication of micrometer-sized structures. The 'crisscross polymerization' approach enables robust nucleation control and growth to large sizes.
A novel culture-free self-driving DNA nanosensor can accurately detect lethal superbugs like MRSA with high sensitivity, enabling rapid and precise sensing of a microorganism's DNA. The detection time is reduced to just 10 seconds, making it a cost-effective tool for timely diagnosis and treatment.
A new sensor can detect RNA and DNA in less than a second, providing a quick way to distinguish between 'healthy' and 'sick' samples. The sensor could be used to measure DNA metabolism and predict rapid infections, potentially improving disease diagnosis and treatment.
An international team detected DNA from ambrosia beetles trapped in recent tree resin for less than seven years. The study challenges previous fails in finding DNA in older samples and opens up new possibilities for genetic research.
Researchers at KAUST have developed an approach to detect rare gene mutations in a pool of cells, which is crucial for early cancer detection and evaluating CRISPR/Cas9 editing outcomes. The technique, called IDMseq, accurately detects single mutations and analyzes large DNA deletions with high accuracy and sensitivity.
A new portable DNA detection method can identify tree pests and pathogens like the Asian gypsy moth and sudden oak death pathogen in under two hours. The device uses PCR testing to analyze tiny amounts of DNA and has been tested on multiple destructive invasive species.
Researchers at the University of Illinois created a crumpled graphene sensor that detects ultra-low concentrations of disease markers in blood or serum, improving sensitivity ten thousand times over current designs. This breakthrough enables rapid diagnosis and could lead to portable, handheld devices for monitoring various biomarkers.
Researchers developed SABER, a method to multiplex imaging of specific molecules, allowing visualization of rare and low-abundance molecules. The technique enables detection of multiple proteins, DNAs, or RNAs in a single tissue sample, advancing basic biology, biomarker discovery, and clinical diagnostics.
Australian scientists have developed a genetic probe to detect eDNA of the endangered Gouldian finch, revealing its habitat and distribution. The test uses a PCR primer to amplify mitochondrial DNA and a species-specific probe to identify Gouldian finch DNA, increasing knowledge on population trends.
Scientists have developed a personalized platform called TARDIS that accurately detects circulating tumor DNA and signs of residual disease in breast cancer patients. The assay demonstrated a significant improvement in sensitivity, enabling earlier detection of tumors and monitoring patient response to chemotherapy.
Researchers at North Carolina State University have developed a new microneedle technique for rapid plant disease detection, extracting DNA from plant tissues in under a minute. The method promises to revolutionize on-site plant disease detection and diagnosis.
Researchers report an assay that uses cell-free DNA mutations and protein biomarkers to detect hepatocellular carcinoma in asymptomatic individuals. In a sample of 331 hepatitis B virus-infected individuals, the assay correctly identified 17% who had liver cancer without symptoms.
A new biosensor has been developed to detect fetal Down syndrome DNA in pregnant women's blood, offering a fast, sensitive, and cost-effective alternative to traditional tests. The sensor can detect DNA concentrations as low as 0.1 fM/L, making it more sensitive than other reported field-effect transistor DNA sensors.
Researchers developed a genetic probe to identify DNA of alewife and blueback herring, finding that eDNA abundance data corresponded well with traditional field methods. The study created a map of where river herring are spawning across the Chesapeake Bay watershed.
Skin cells can detect damaged DNA in the absence of infection and trigger an immune response similar to that observed during viral infections. This discovery could lead to new cancer treatments and preventive measures against skin cancers.
Researchers have developed a CRISPR-based method, DETECTR, to detect viral DNA, including cancer-causing HPV types. The system uses a molecular flare gun to identify specific DNA targets, enabling fast and reliable medical tests with minimal equipment requirements.
Researchers have developed a CRISPR-based diagnostic tool called SHERLOCK, which has been enhanced to detect multiple targets at once and show results on a paper strip. The new feature increases sensitivity 100-fold, allowing for the detection of low concentrations of genetic material in samples.
Researchers at TUM investigated environmental factors affecting eDNA analysis, revealing that specific conditions can hinder detection success. Organic substances and algae were found to interfere with molecular analysis.
A novel DNA detector was developed using ultrathin layers, including a nanoporous silicon nitride membrane that serves as a prefilter and a biosensor membrane with a single nanopore. The device creates a nanocavity filled with less than a femtoliter of fluid, improving the precision and reproducibility of DNA detection.
Scientists have developed a new method for detecting extremely small amounts of DNA using associating and dissociating nanodimer analysis (ADNA). The method can differentiate true signals from noise and detect deviations of individual bases, with a detection limit of about 46 DNA copies.
Researchers at the University of Illinois used a new technique called eDNA to detect and monitor the Hay's Spring amphipod, an endangered species found in seepage springs in Rock Creek Park. The method successfully detected the creature's DNA in water samples from three sites where it had been previously seen.
Researchers developed a novel method to detect environmental DNA in groundwater, extending the known range of the olm by discovering 12 new sites. This breakthrough allows for better conservation management and protection of this globally threatened species.
A new study published in Genetic Testing and Molecular Biomarkers found that analyzing cell-free DNA using next-generation sequencing is more accurate than the current standard approach of Sanger sequencing. This method can detect genetic abnormalities responsible for myelodysplastic syndrome (MDS) with greater sensitivity.
A new platform harnesses DNA as the engine of a microscopic nanomachine, detecting trace amounts of substances such as viruses, bacteria, and metals. The technology uses selectively triggered DNA molecules to create a signal, enabling ultra-sensitive detection and potential clinical testing.
A new approach using DNA nanomachines can detect specific antibodies in five minutes, enabling rapid and affordable point-of-care diagnostics for infectious diseases like HIV. This technology promises to reduce healthcare costs and treatment initiation delays.
The study found that persistent HPV16 DNA detection after treatment was associated with worse disease-free survival and overall survival. This could be a useful tool for long-term tumor surveillance, potentially reducing the need for costly imaging and intensifying visits.
A study found that cell free DNA analysis is less effective than sequential screening for detecting all fetal chromosomal abnormalities. Sequential screening detected an 81.6% success rate and a 4.11% false positive rate, while cell free DNA detection had a lower 68% success rate at a one percent screen positive rate.
A new study from the University of Notre Dame develops a more sensitive and affordable tool for detecting Asian Carp DNA using environmental DNA (eDNA) monitoring. The new method detects Asian Carp eDNA 95% of the time, compared to less than 5% with current methods.
Researchers at Johns Hopkins have identified a highly sensitive means of analyzing tiny amounts of DNA. The new analytical method compares favorably with existing techniques, enabling the detection of small amounts of DNA in samples.
23andMe's new HaploScore algorithm improves IBD detection accuracy, enabling more accurate genetic relationships and ancestry reports. The open-source algorithm can be applied to existing IBD segments, differentiating between true and false positives.
Researchers used DNA from water samples to identify and determine the relative abundance of 13,000 fish species in the tank. The technique has potential for cost-effective and time-saving methods for monitoring aquatic habitats and detecting invasive species.
Researchers have developed a DNA clamp that can detect genetic mutations in cancer with greater efficiency than current methods, paving the way for rapid screening and new nanotechnology tools. The technology uses triple helices to improve specificity and has potential applications in diagnostic tests and DNA-based nanostructures.
EPFL researchers have developed a new method for detecting individual DNA molecules using graphene nanoribbons, offering improved precision and potential for DNA sequencing. The technology has the potential to detect other types of proteins and provide information on their size and shape.
Researchers at University of Michigan and Jiangnan University have developed a new method for detecting DNA using twisted light, achieving 50 times better sensitivity than current methods. This technology has the potential to aid in diagnosing patients, solving crimes, and identifying biological contaminants.
Researchers from the University of Notre Dame and The Nature Conservancy found no evidence of widespread Asian carp presence in the Great Lakes, contrary to recent reports. Instead, they detected DNA only in areas where Asian carp have been caught, suggesting that live fish are the most likely source of the invasive species.
Scientists from Hong Kong have developed a DNA barcoding method that can detect fraudulent deer products, regardless of their physical state. The method confirms that DNA barcoding alone is sufficient to detect such substitution for deer in all tendon products, except for glue.
Researchers at Drexel University have developed a sensor technology that can detect DNA in liquid samples, allowing for quick identification of harmful cells and bacteria. The 'diving board' sensors use electric current to measure the vibration frequency of a cantilever, enabling sensitive and timely tests.
The new method, called Direct Molecular Recognition, uses atomic force microscopy to take nanoscopic pictures of DNA molecules and identify sequence differences. This technique has the potential to be used for sensitive detection of DNA molecules in genomic research and medical diagnostics.
The Notre Dame research team has demonstrated a novel DNA detection method called laser transmission spectroscopy (LTS) that can rapidly determine the size, shape, and number of nanoparticles in suspension. The technique is highly sensitive and takes only a few seconds to score a sample for species presence or absence, making it a prom...
A Danish research team has developed a new DNA-based method to monitor rare and threatened animal species in freshwater environments, showing it can be effective even for extremely rare populations. The study found a clear correlation between DNA detection and population density, enabling the estimation of population sizes.
Researchers have successfully used nanoscale transistors to detect the binding of DNA double helix halves, directly amplifying single biomolecule charge. This technique offers a powerful tool for studying single molecule interactions and has potential applications in protein assays, DNA sequencing and other areas.
A team of researchers from the University of Notre Dame and The Nature Conservancy has successfully validated their environmental DNA (eDNA) technique for detecting invasive Asian carp in the Chicago-area waterway. This breakthrough method, which uses genetic material from aquatic organisms to identify species presence, has been hailed...
Researchers at Delft University of Technology have developed a novel technique to fabricate graphene nanopores that can detect individual DNA molecules as they pass through. This technology has the potential to significantly impact DNA sequencing by reading off the sequence base by base in real-time.
Researchers have developed a new lab-on-a-chip test that detects DNA with excellent sensitivity, eliminating the need for amplification, and enabling wider use of DNA testing. The nanogap sensor technology overcomes current limitations of PCR-based tests, making it a faster and more practical alternative.
Scientists developed a novel electronic sensor array to rapidly detect DNA for disease diagnosis and biological research, with ultrasensitive detection capabilities and cost-effectiveness. The Nanogap Sensor Array technology has the potential to speed up efforts in detecting debilitating diseases such as cancer and infectious viruses.
Scientists use fluorescent in situ hybridization (FISH) to detect microdeletions in embryos, which can predispose children to certain cancer syndromes. The technique has the potential to test patients with other genetic conditions as well, and opens up new possibilities for families affected by these disorders.
A team of researchers from Arizona State University has developed a biosensing nanodevice that can detect diseases at the single molecule level. The device uses a biological engine to emit a signal when it detects a target DNA, resulting in high sensitivity and portability.
A portable DNA sequencer could aid environmental scientists, clinicians, and medical researchers in detecting genetic disorders. A new type of electronic device, the ion-selective field-effect transistor (ISFET), is being integrated into a DNA biosensor to measure changes in conductivity.
Researchers have developed DNA-wrapped carbon nanotube sensors that can detect low concentrations of mercury ions in whole blood, opaque solutions, and living mammalian cells. The sensors work by detecting changes in the DNA's shape structure, which is triggered by the presence of target ions.
A novel pathway for detecting intracellular DNA has been identified, suggesting a unique immune response differs from RNA viruses. This discovery sheds light on the mechanisms of antiviral responses and how cells discern viral and self-DNA.
The new technique involves an unusual blend of organic and inorganic components, using quantum dots as a DNA sensor to detect specific parts of a DNA sequence. It can identify genetic defects and mutations quickly and relatively simply.
Researchers have identified a gene marker called vimentin that detects colon cancer with 46% accuracy using DNA stool tests. The marker has potential to be used in combination with other DNA markers to detect 100% of colon cancers.