Articles tagged with Genetic Disorders
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Researchers identified a novel gene, FUS/TLS, associated with inherited amyotrophic lateral sclerosis (ALS), the fourth gene implicated in familial forms of the disease. Mutations in this gene lead to abnormal protein deposits in motor neurons and are linked to varying inheritance patterns and severity.
A specific gene called protein kinase C beta (PKC beta) plays a crucial role in the weight-gain response to a high-fat diet. Mice genetically engineered to lack PKC beta showed minimal health effects and resisted fat-induced obesity, insulin resistance, and liver damage. The study suggests that blocking this gene could be a therapeutic...
Nearly all US babies are now screened for 21+ life-threatening disorders, thanks to increased mandates and advocacy efforts. This expansion has significantly improved public health outcomes.
Researchers at the University of Montreal have identified gene mutations in the SYNGAP1 gene that affect learning and memory in children with non-syndromic mental deficiency. The study found that three percent of affected children had new deleterious mutations, leading to delays in language and mental development.
Researchers suspect a novel gene is causing restless legs syndrome in a large family study, with 30 relatives affected and 60% female prevalence. The discovery could lead to breakthroughs in understanding the disorder and developing new treatments.
Researchers identified three genetic variants associated with delusions in people with schizophrenia, located within the neuregulin 3 gene on chromosome 10. The study suggests that this gene may contribute to the development of delusions and other symptoms of the condition.
Researchers at CAMH have detected evidence that DNA is not the only carrier of heritable information, with epigenetic factors playing a significant role. This finding challenges traditional genetics principles and may provide new insights into human disease causes.
A large-scale study of 9 million Swedish individuals reveals that bipolar disorder and schizophrenia share common genetic causes, with heritability rates of 64% and 59%, respectively. This finding challenges the long-held distinction between the two conditions, suggesting a reappraisal of their diagnostic entities.
Researchers at McGill University and the MUHC have identified a gene crucial for vitamin B12 metabolism, shedding light on a rare genetic disorder. The discovery may lead to earlier diagnosis and treatment options for patients with cblF combined homocystinuria and methylmalonic aciduria.
A new pharmaceutical developed by McGill University researchers may allow PKU sufferers to eat a normal, protein-rich diet, avoiding the need for severe protein restrictions. The treatment, which involves enzyme therapy, aims to reduce phenylalanine levels in the blood and alleviate symptoms such as agoraphobia.
A Mayo Clinic-led international consortium discovered a genetic defect in the dynactin complex that may help explain neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis. The mechanism implicated in Perry syndrome, a rare disorder, may also shed light on common depression and sleep disorders.
Decreasing FKBP12 gene activity in mice disrupted neuron-to-neuron communication, leading to enhanced long-term potentiation and repetitive behaviors. The study provides insight into the molecular mechanisms underlying neurodevelopmental disorders such as autism spectrum disorder and obsessive-compulsive disease.
Researchers at UCSF Ernest Gallo Clinic and Research Center have identified a DNA sequence variation on chromosome 15 associated with the level of response to alcohol. This finding could signal the genetic factors that affect alcohol abuse, and may help develop targeted treatments.
Researchers identified 11 new gene sites associated with cholesterol and triglyceride levels, bringing the total to 30 lipid-associated genes. Common variations in these genes can significantly influence blood lipid levels, potentially identifying individuals at higher risk for heart disease.
A UCLA study shows that microscopic crystals in the inner ear form sound and gravity sensors through cilia movement. The research provides new clues for treating vertigo and hearing disorders related to cilia function, offering a potential gene target for therapy.
Researchers at Indiana University have created a comprehensive map of genes likely involved in bipolar disorder, identifying hundreds of genes that contribute to the illness. The study also lays the groundwork for personalized treatments and preventive measures using genetic risk scores.
Researchers have identified the CNTNAP2 gene as a key player in childhood language disorders, with variants linked to specific language impairment (SLI) and delayed language development in children with autism. The study provides new insights into the molecular basis of language development and its relationship to autism.
Scientists at the University of Liverpool will use models and tissue samples to understand ochronosis development. A potential therapy may be developed if the underlying mechanisms are understood, reducing arthritis risk for Alkaptonuria sufferers.
Researchers at Medical College of Georgia identified a new gene, chromodomain helicase DNA binding protein 7 (CHD7), responsible for some puberty disorders, including idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome. The study found that CHD7 mutations account for about 6% of IHH and Kallmann syndrome cases.
Researchers from Uppsala University have discovered a mechanism that silences several genes on a chromosome domain, leading to the genetic disorder Beckwith-Wiedemann syndrome. The long Kcnq1ot1-RNA molecule mediates silencing by recruiting enzymes that modify DNA-binding proteins, protecting the silenced domain during cell division.
A new genetic association study found associations between six mouse genes and specific human anxiety disorders, including social phobia, generalized anxiety disorder, and panic disorder. The study suggests that these genes may play a role in predisposing individuals to developing an anxiety disorder.
Researchers used a new genetic screening method, MLPA, on children with autism spectrum disorders to identify known genetic causes of cognitive impairment. The study found efficient identification of well-known genetic disorders and novel genetic changes contributing to ASDs, such as microduplications in chromosomes 15 and 22.
Researchers have identified RMI2, a novel protein essential for genome stability and DNA repair in Bloom's syndrome. The study sheds new light on the disease's underlying mechanisms.
Researchers at the University of Iowa and France have discovered a gene variant that causes sinus node disease, a potentially fatal heart rhythm disorder. The study found that variants in the ANK2 gene result in dysfunction in the protein ankyrin-B, leading to variable heart rates and bradycardia.
Research finds disabled gut cells linked to Crohn's disease, with altered genetic activity leading to increased hormone production. The study suggests a potential role for autophagy and Atg16L1 in Paneth cell function, shedding light on the complex mechanisms behind the inflammatory bowel disorder.
A study found a link between a chromosomal aberration at 1q21.1 and various developmental disorders in children, including mental retardation, growth issues, seizures, autism, and heart defects. The researchers suggest that the aberration may contribute to subtle disorders in carriers who appear unaffected.
A gene controlling blood vessel differentiation during embryonic development has been linked to a brain disorder that causes stroke. The study found that the gene, Notch, can induce and reverse the disease's progression in mice, offering new insights into its molecular mechanisms.
Researchers identified genes that show statistical association with specific anxiety disorders, such as panic disorder and social phobias. The study found that environmental factors can trigger an anxiety disorder more easily in people with a genetic predisposition.
The study provides an accurate picture of XXYY syndrome, identifying unique medical and psychological characteristics, including cardiac abnormalities, dental problems, and learning disabilities. Treatment recommendations focus on targeted therapies for behaviors, emotional problems, and community services to support independent living.
A large genetic analysis implicates machinery involved in sodium and calcium balance in brain cells in bipolar disorder. Variation in two genes showed the strongest association with bipolar disorder.
A novel mutation in the nephronophthisis 4 (NPHP4) gene has been identified as a potential cause of cone-rod dystrophy in standard wire-haired dachshunds. This discovery raises hopes for developing treatments for humans with similar eye disorders.
Congenital Tufting Enteropathy (CTE) is a rare, congenital disorder affecting infants, causing severe diarrhea and growth failure. Researchers identified the Epithelial Cell Adhesion Molecule gene as the cause of CTE.
The Alzheimer's Disease Research Center at Washington University School of Medicine will lead a six-year, $16 million international collaboration to study inherited forms of Alzheimer's disease. Researchers hope to identify biomarkers in individuals with known mutations to shorten diagnosis time and develop new treatments.
A recent study published in Biological Psychiatry found four chromosomal regions linked to schizophrenia and bipolar disorder risk factors, suggesting that these disorders may represent different genetic subtypes. The discovery highlights the complexity of psychiatric diagnoses and provides new insights into potential treatment targets.
Researchers found that individuals with tune deafness, an auditory processing disorder, can detect incorrect notes without conscious awareness. This discovery may help scientists study consciousness using genetic research tools.
Researchers discovered a new family of genetic mutations involved in inflammatory intestinal diseases, including coeliac disease and Crohn's disease. The study found common origins for the two diseases and identified eight new areas with genes controlling immune responses.
A study funded by the NIH has transformed scientists' understanding of Rett syndrome, a genetic disorder causing autistic behavior and disabling symptoms. The research found that the MECP2 gene acts as an activator for thousands of genes, suppressing some but activating most.
Researchers found that MeCP2 is a key regulator of genes in the hypothalamus, turning them on and off. Altering MeCP2 levels can cause Rett syndrome or other neurological disorders, highlighting the need for tailored treatments.
Researchers found that carrying alpha-1 antitrypsin deficiency increases lung cancer risk in smokers and nonsmokers, with the genetic disorder explaining up to 12% of lung cancer patients. Individuals who carry the gene should be screened for lung cancer and avoid potential carcinogens.
Researchers identified gene mutations in FIGLA as a cause of premature ovarian failure, which can lead to infertility and other health issues. The study found three types of mutations in the gene, highlighting its importance in ovary function.
Researchers found that faulty RNA plays a key role in the onset and progression of neurodegenerative diseases. They discovered that altering the RNA structure can mitigate toxicity, suggesting a common component between different types of human triplet repeat expansion diseases.
UT Southwestern researchers found gene mutations in mice that control electrical excitability in the brain involved in sleep create a human-like insomnia disorder. The mutant mice slept half as much as normal mice and did not readily get restful sleep even after sleep deprivation.
Researchers have created a genetically altered monkey model that replicates symptoms of Huntington's disease, allowing for a deeper understanding of the disease mechanisms. This breakthrough could lead to major advances in developing new treatments for neurological diseases.
Researchers have successfully treated late infantile neuronal ceroid lipofuscinosis (LINCL) with gene therapy, slowing disease progression in children. The treatment, which replaces the faulty CLN2 gene, demonstrated significant improvements over an 18-month period.
Researchers at Columbia University Irving Medical Center have discovered a previously unknown alteration in microRNA production linked to schizophrenia. By modeling mice with the same chromosome 22q11.2 deletion as humans with schizophrenia, they found that abnormalities in microRNAs can lead to synaptic and behavioral deficits.
A mutated gene has been discovered as the key behind epilepsy and mental retardation specific to women, thanks to new research at the University of Adelaide. The study found that women carry both a 'good' and 'bad' gene, while men only carry the bad gene, leading to the condition affecting only females.
Researchers at Beth Israel Deaconess Medical Center have identified a new gene trigger for preeclampsia, a dangerous pregnancy disorder affecting 5% of pregnancies worldwide. A steroid molecule, 2-ME, may serve as both a diagnostic marker and therapeutic supplement for the treatment of preeclampsia.
Researchers at CAMH have identified a new gene, CC2D2A, associated with a previously unknown form of intellectual disability characterized by retinitis pigmentosa. The mutation affects protein function, leading to faulty cell activity and the disorder.
A collaborative effort by Boston University researchers has discovered the TFAP2A gene is linked to Branchio-Oculo-Facial syndrome (BOFS), a disorder marked by clefting, skin anomalies, and eye abnormalities. The study's findings may lead to more precise diagnostic testing and suggest new research directions.
Recent research has identified seven LRRK2 gene mutations associated with Parkinson's disease, including a rare mutation that doubles the risk in ethnic Chinese. The findings suggest that genetic influences passed down through generations can significantly increase susceptibility to the disease.
Researchers discovered a genetic cause for a rare form of inherited iron deficiency anemia, which may provide insights into iron deficiency in the general population and suggest new treatment approaches. The study identified a gene mutation in the TMPRSS6 protein, leading to excessive hepcidin production and impaired iron absorption.
Researchers identified a genetic defect affecting energy production in muscles of children with autism spectrum disorders, leading to muscle weakness. The study found that 65% of the children had defects in oxidative phosphorylation, highlighting the importance of understanding how genes impact mitochondrial function.
Scientists identified the MMADHC gene responsible for a rare genetic disorder, isolated and combined homocystinuria and methylmalonic aciduria. The research provides clues to how vitamin B12 works in the body and offers earlier diagnosis and treatment options for the serious disease.
Studies find that rare genetic deletions and duplications in schizophrenia patients disrupt genes involved in brain development, potentially implicating hundreds of genes. The findings support a new approach for discovering genes associated with the disorder.
A team of University of Michigan scientists has identified a possible link between genetic mutations and toxic substance exposure in the development of motor neuron disease. The study found that abnormal protein changes caused by organophosphate exposure may contribute to the disease, offering new leads for diagnosis and treatment.
Dr. Peter H. Byers has received the March of Dimes/Colonel Harland Sanders Award for Lifetime Achievement in Genetics for his groundbreaking research on collagen gene mutations and their role in inherited disorders such as Ehlers-Danlos syndrome and osteogenesis imperfecta. His work has significantly advanced our understanding of these...
Researchers at Johns Hopkins have discovered that Bardet-Biedl syndrome and Meckel-Gruber syndrome share the same molecular underpinnings, suggesting a continuum of one disease. This finding could lead to more accurate diagnoses and improved patient management.
Researchers at the University of Manchester have successfully treated mice with Treacher Collins syndrome, a rare genetic disorder, by preventing premature cell death. The breakthrough could lead to early treatment of at-risk babies in the womb.
A genetic defect in the p22phox protein causes a severe immune deficiency in humans, similar to chronic granulomatous disease (CGD). The study found that mice without this protein also develop a severe balance disorder due to the loss of gravity-sensing crystals in the inner ear.
Researchers studying 19 pairs of identical twins discovered that they had virtually identical DNA but still exhibited small genetic variations. These findings may help explain why one twin can develop a disorder while the other remains healthy.